PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11588178-10	2001	In addition, proteasome inhibition did not alter the steady-state levels of alpha-synuclein, but addition of the lysosomotropic agent ammonium chloride significantly increased the amount of alpha-synuclein, indicating that lysosomes are involved in degradation of alpha-synuclein.	Ammonium Chloride	134-151	synuclein alpha	Homo sapiens	190-205	
17714183-9	2007	Treatment of the FeCl2-exposed cells with pepstatin A or NH4Cl led to reduced formation of oligomers/inclusions as well as of approximately 10 and 12 kDa truncated alpha-Syn.	Ammonium Chloride	57-62	synuclein alpha	Homo sapiens	164-173	
21303699-4	2011	Moreover, the incubation of cells with ammonium chloride or bafilomycin A1 to produce the lysosomal dysfunction recently reported in Parkinson"s disease led to an increase in the release of alpha-synuclein in exosomes and a concomitant increase in alpha-synuclein transmission to recipient cells.	Ammonium Chloride	39-56	synuclein alpha	Homo sapiens	190-205	
21303699-4	2011	Moreover, the incubation of cells with ammonium chloride or bafilomycin A1 to produce the lysosomal dysfunction recently reported in Parkinson"s disease led to an increase in the release of alpha-synuclein in exosomes and a concomitant increase in alpha-synuclein transmission to recipient cells.	Ammonium Chloride	39-56	synuclein alpha	Homo sapiens	248-263	
11588178-10	2001	In addition, proteasome inhibition did not alter the steady-state levels of alpha-synuclein, but addition of the lysosomotropic agent ammonium chloride significantly increased the amount of alpha-synuclein, indicating that lysosomes are involved in degradation of alpha-synuclein.	Ammonium Chloride	134-151	synuclein alpha	Homo sapiens	190-205	
25176419-8	2015	A statistically significant increase in AO fluorescence intensity was observed in cells treated with STC (1.5, 3 and 6 muM) for 1 h. The DNA strand breaks induced by STC were almost prevented in cells pretreated with NH(4)Cl (10 mM) and NAC (10 mM) for 1 h. Our results thus indicated that STC exerts genotoxic effects on HepG2 cells, most likely through oxidative stress and lysosomal leakage.	Ammonium Chloride	217-224	synuclein alpha	Homo sapiens	237-240	
31481238-6	2019	Activation of the HIF-1 pathway induced by NH4Cl was inhibited by addition of the antioxidant NAC or the NADPH oxidase (NOX) inhibitor apocynin, indicating the involvement of the NOX-induced ROS generation.	Ammonium Chloride	43-48	synuclein alpha	Homo sapiens	94-97