PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3040410-1 1987 The weak bases chloroquine, primaquine, NH4Cl and the ionophore monensin exert similar but not identical effects on sorting, transport and processing of cathepsin D in several human cell lines (fibroblasts, HepG2 cells, U937, monocytes). Ammonium Chloride 40-45 cathepsin D Homo sapiens 153-164 3905406-11 1985 Whereas newly synthesized cathepsin D was found in the lysosomes 1 h after synthesis, alpha-glucosidase was detected only after 2-4 h. When a pulse-chase experiment was carried out in the presence of 10 mM NH4Cl there was a complete inhibition of the transport of cathepsin D and a partial inhibition of that of alpha-glucosidase to the lysosomes. Ammonium Chloride 206-211 cathepsin D Homo sapiens 26-37 3606825-4 1987 In the presence of 10mM NH4Cl approximately half of the produced cathepsin D is secreted in both control and calcitriol-treated cells. Ammonium Chloride 24-29 cathepsin D Homo sapiens 65-76 3905406-11 1985 Whereas newly synthesized cathepsin D was found in the lysosomes 1 h after synthesis, alpha-glucosidase was detected only after 2-4 h. When a pulse-chase experiment was carried out in the presence of 10 mM NH4Cl there was a complete inhibition of the transport of cathepsin D and a partial inhibition of that of alpha-glucosidase to the lysosomes. Ammonium Chloride 206-211 cathepsin D Homo sapiens 264-275 1531012-4 1992 Studies on cells cultured in the presence of drugs known to affect the intracellular transport (deoxynojirimycin, brefeldin A and NH4Cl) indicated that the association with cathepsin D precursor occurs early after the synthesis and is at least partially maintained after secretion. Ammonium Chloride 130-135 cathepsin D Homo sapiens 173-184 1991036-8 1991 In the presence of 10 mM-NH4Cl the intracellular segregation of hamster cathepsin D was strongly inhibited, while the segregation of human cathepsin D was only slightly diminished. Ammonium Chloride 24-30 cathepsin D Homo sapiens 72-83 1991036-8 1991 In the presence of 10 mM-NH4Cl the intracellular segregation of hamster cathepsin D was strongly inhibited, while the segregation of human cathepsin D was only slightly diminished. Ammonium Chloride 24-30 cathepsin D Homo sapiens 139-150 2167847-6 1990 In both cell types, incubation with 10 mM NH4Cl results in a decrease in the uncovering ratio of total cathepsin D. Ammonium Chloride 42-47 cathepsin D Homo sapiens 103-114