PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23981664-0	2013	The beta4 nicotinic receptor subunit modulates the chronic antidepressant effect mediated by bupropion.	Bupropion	93-102	basic helix-loop-helix family, member e23	Mus musculus	4-9	
23981664-1	2013	The objective of the current study is to investigate the role of the nicotinic receptor beta4 subunit in the antidepressant activity of bupropion.	Bupropion	136-145	basic helix-loop-helix family, member e23	Mus musculus	88-93	
23981664-5	2013	Our results indicate that: (1) the acute treatment with bupropion increases the swimming time (i.e., antidepressant effect) in beta4+/+ and beta4-/- mice from both genders, (2) the antidepressant effect after the chronic treatment is seen only in female beta4+/+ mice, and (3) the residual antidepressant effect of bupropion persists only in male beta4+/+ mice after one week withdrawal.	Bupropion	56-65	basic helix-loop-helix family, member e23	Mus musculus	127-132	
23981664-5	2013	Our results indicate that: (1) the acute treatment with bupropion increases the swimming time (i.e., antidepressant effect) in beta4+/+ and beta4-/- mice from both genders, (2) the antidepressant effect after the chronic treatment is seen only in female beta4+/+ mice, and (3) the residual antidepressant effect of bupropion persists only in male beta4+/+ mice after one week withdrawal.	Bupropion	56-65	basic helix-loop-helix family, member e23	Mus musculus	140-145	
23981664-5	2013	Our results indicate that: (1) the acute treatment with bupropion increases the swimming time (i.e., antidepressant effect) in beta4+/+ and beta4-/- mice from both genders, (2) the antidepressant effect after the chronic treatment is seen only in female beta4+/+ mice, and (3) the residual antidepressant effect of bupropion persists only in male beta4+/+ mice after one week withdrawal.	Bupropion	56-65	basic helix-loop-helix family, member e23	Mus musculus	140-145	
23981664-5	2013	Our results indicate that: (1) the acute treatment with bupropion increases the swimming time (i.e., antidepressant effect) in beta4+/+ and beta4-/- mice from both genders, (2) the antidepressant effect after the chronic treatment is seen only in female beta4+/+ mice, and (3) the residual antidepressant effect of bupropion persists only in male beta4+/+ mice after one week withdrawal.	Bupropion	56-65	basic helix-loop-helix family, member e23	Mus musculus	140-145	
23981664-6	2013	We conclude that the beta4 subunit plays a modulatory role in the chronic antidepressant effect mediated by bupropion, and that its effect is gender-specific.	Bupropion	108-117	basic helix-loop-helix family, member e23	Mus musculus	21-26