PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14977870-4	2004	CYP2B6 and CYP3A4 protein and activities were assessed by Western blotting, bupropion hydroxylation, and testosterone 6beta-hydroxylation, respectively.	Bupropion	76-85	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	11-17	
11454731-0	2001	Evaluation of the contribution of cytochrome P450 3A4 to human liver microsomal bupropion hydroxylation.	Bupropion	80-89	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	34-53	
11454731-1	2001	The purpose of this investigation was to evaluate the role of cytochrome P450 (CYP) 3A4 in human liver microsomal bupropion (BUP) hydroxylation.	Bupropion	114-123	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	62-87	
11454731-1	2001	The purpose of this investigation was to evaluate the role of cytochrome P450 (CYP) 3A4 in human liver microsomal bupropion (BUP) hydroxylation.	Bupropion	125-128	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	62-87	
33455055-7	2021	Coadministration of lemborexant with bupropion resulted in 49.9% and 45.5% decreases in S-bupropion Cmax and AUC0-inf , respectively.Comparison of estimated exposures for patients in phase 3 trials who were/were not receiving concomitant weak CYP3A inhibitors substantiated the DDI pharmacokinetic findings.	Bupropion	37-46	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	243-248	
23153057-3	2013	The cocktail strategy (in situ incubation) was used to assess the induction of CYP1A2, CYP2B6, CYP2C9 and CYP3A4 by using the recommended probe substrate, i.e. phenacetin, bupropion, diclofenac and midazolam, respectively.	Bupropion	172-181	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	106-112