PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34975483-3 2021 Here, I investigated the effect of an antidepressant drug fluvoxamine on membrane trafficking of the SARS-CoV-2 spike protein and its cell host receptor ACE2 in HEK293T cells. Fluvoxamine 58-69 angiotensin converting enzyme 2 Homo sapiens 153-157 34975483-4 2021 A sub-therapeutic concentration (80 nM) of fluvoxamine rapidly upregulated fluid-phase endocytosis, resulting in enhanced accumulation of the spike-ACE2 complex in enlarged early endosomes. Fluvoxamine 43-54 angiotensin converting enzyme 2 Homo sapiens 148-152 34130375-3 2021 Thus, in this current computational study we carried out molecular docking experiments to assess the bridging potentials of some commercial drugs such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, camostat, famotidine, umifenovir, nitazoxanide, ivermectin, and fluvoxamine at the interface between human ACE2 and the coronavirus spike glycoprotein complex. Fluvoxamine 285-296 angiotensin converting enzyme 2 Homo sapiens 328-332