PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10877005-0 2000 Fluvoxamine but not citalopram increases serum melatonin in healthy subjects-- an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin. Fluvoxamine 0-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 98-113 17484519-0 2007 Identification of human cytochrome P450 enzymes involved in the major metabolic pathway of fluvoxamine. Fluvoxamine 91-102 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 24-39 17484519-4 2007 The formation of fluvoxamino alcohol from fluvoxamine in pooled human liver microsomes was significantly inhibited by quinidine, a relatively specific CYP2D6 inhibitor, with a Ki value of 2.2 microM, whereas other several relatively specific CYP inhibitors did not inhibit the formation of fluvoxamino alcohol. Fluvoxamine 42-53 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 151-154 11270913-3 2001 Because fluvoxamine is an inhibitor of several cytochrome P450 (CYP) enzymes, the authors studied the biotransformation of melatonin and the effects of fluvoxamine on the metabolism of melatonin in vitro using human liver microsomes and recombinant human CYP isoenzymes. Fluvoxamine 8-19 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 47-62 11270913-3 2001 Because fluvoxamine is an inhibitor of several cytochrome P450 (CYP) enzymes, the authors studied the biotransformation of melatonin and the effects of fluvoxamine on the metabolism of melatonin in vitro using human liver microsomes and recombinant human CYP isoenzymes. Fluvoxamine 8-19 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-67 11240973-1 2001 BACKGROUND AND OBJECTIVES: Fluvoxamine, a selective serotonin reuptake inhibitor, is known to inhibit several hepatic cytochrome P450 (CYP) isozymes, in particular CYP1A2. Fluvoxamine 27-38 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 118-133 11240973-1 2001 BACKGROUND AND OBJECTIVES: Fluvoxamine, a selective serotonin reuptake inhibitor, is known to inhibit several hepatic cytochrome P450 (CYP) isozymes, in particular CYP1A2. Fluvoxamine 27-38 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 135-138 8944409-8 1996 The increased buspirone concentrations are likely to be due to inhibition of first pass liver metabolism by fluvoxamine acting on the cytochrome P-450 system. Fluvoxamine 108-119 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 134-150 10653206-0 2000 Fluvoxamine-Clozapine drug interaction: inhibition in vitro of five cytochrome P450 isoforms involved in clozapine metabolism. Fluvoxamine 0-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 68-83 10653206-5 2000 Fluvoxamine also inhibited in a concentration-dependent manner the activity of all five cytochrome P450 (CYP) isoforms previously determined to be capable of catalyzing the demethylation of clozapine. Fluvoxamine 0-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 88-103 10653206-5 2000 Fluvoxamine also inhibited in a concentration-dependent manner the activity of all five cytochrome P450 (CYP) isoforms previously determined to be capable of catalyzing the demethylation of clozapine. Fluvoxamine 0-11 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 105-108 8685072-12 1995 This study suggests, that fluoxetine and fluvoxamine differ in their interaction with the metabolism of some other basic psychotropic drugs, by a mechanism which implies CYP2D6 and CYPmeph and possibly other isoformes of cytochrome P-450. Fluvoxamine 41-52 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 221-237 35611779-6 2022 The pharmacokinetics of many antiseizure medications is not influenced by antipsychotics and anxiolytics while some newer antidepressants namely fluoxetine, fluvoxamine and viloxazine, may inhibit CYP enzymes leading to increased serum concentrations of some antiseizure medications including phenytoin and carbamazepine. Fluvoxamine 157-168 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 197-200 8846618-2 1995 The selective serotonin reuptake inhibitors (SSRIs) and venlafaxine display the following rank order of in vitro potency against the cytochrome P450 (CYP) isoenzyme CYP2D6 as measured by their inhibition sparteine and/or dextromethorphan metabolism: paroxetine > fluoxetine identical to norfluoxetine > or = sertraline > or = fluvoxamine > venlafaxine. Fluvoxamine 335-346 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 150-153 8846617-10 1995 The specific cytochrome P450 (CYP) isoenzymes involved in the metabolism of fluvoxamine are unknown. Fluvoxamine 76-87 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 13-28 8846617-10 1995 The specific cytochrome P450 (CYP) isoenzymes involved in the metabolism of fluvoxamine are unknown. Fluvoxamine 76-87 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 30-33 8846618-2 1995 The selective serotonin reuptake inhibitors (SSRIs) and venlafaxine display the following rank order of in vitro potency against the cytochrome P450 (CYP) isoenzyme CYP2D6 as measured by their inhibition sparteine and/or dextromethorphan metabolism: paroxetine > fluoxetine identical to norfluoxetine > or = sertraline > or = fluvoxamine > venlafaxine. Fluvoxamine 335-346 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 133-148 26514046-6 2015 Some antidepressants, such as paroxetine and fluvoxamine, are strong inhibitors of the CYP system. Fluvoxamine 45-56 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 87-90