PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30543144-3	2019	Compared with co-treatment with NGF and fluvoxamine, p-Akt levels were higher than the values without fluvoxamine.	Fluvoxamine	40-51	AKT serine/threonine kinase 1	Rattus norvegicus	55-58	
30543144-6	2019	Fluvoxamine also improved the decrease in the NGF-induced p-Akt level caused by DEX.	Fluvoxamine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	60-63	
30543144-9	2019	These results indicate that the improvement effects of fluvoxamine on NGF-induced neurite outgrowth inhibition by DEX may be attributable to the phosphorylation of Akt and the sigma-1 receptor.	Fluvoxamine	55-66	AKT serine/threonine kinase 1	Rattus norvegicus	164-167	
28410959-4	2017	Chronic haloperidol (1mg/kg) +fluvoxamine (10mg/kg) treatment increased TrkB receptor and BDNF expression levels, and the phosphorylation of AKT/CREB/GSK-3beta, compared to the individual drugs in rat brain.	Fluvoxamine	30-41	AKT serine/threonine kinase 1	Rattus norvegicus	141-144	
28410959-6	2017	In primary neuronal cell cultures, pretreatment with a selective PI3K inhibitor abolished the haloperidol+fluvoxamine-induced phosphorylation of AKT and GSK-3beta, but did not affect the upregulation of CREB phosphorylation.	Fluvoxamine	106-117	AKT serine/threonine kinase 1	Rattus norvegicus	145-148	
27056295-6	2017	Fluvoxamine stimulation in these cells also activated nitric oxide production that was blocked by sigma1-receptor knockdown or Akt inhibition.	Fluvoxamine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	127-130	
27056295-7	2017	Similarly, in the postischemic rat kidney, sigma1-receptor activation by fluvoxamine triggered the Akt-nitric oxide synthase signaling pathway, resulting in time- and isoform-specific endothelial and neuronal nitric oxide synthase activation and nitric oxide production.	Fluvoxamine	73-84	AKT serine/threonine kinase 1	Rattus norvegicus	99-102	
21044620-0	2011	Sigma-1 receptor stimulation with fluvoxamine activates Akt-eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding.	Fluvoxamine	34-45	AKT serine/threonine kinase 1	Rattus norvegicus	56-59	
21044620-6	2011	Fluvoxamine treatment also significantly restored pressure overload-induced impaired Akt phosphorylation and stimulated eNOS protein expression as well as Akt-mediated eNOS phosphorylation (Ser1177).	Fluvoxamine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	85-88	
21044620-6	2011	Fluvoxamine treatment also significantly restored pressure overload-induced impaired Akt phosphorylation and stimulated eNOS protein expression as well as Akt-mediated eNOS phosphorylation (Ser1177).	Fluvoxamine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	155-158	
19995565-13	2010	SIGNIFICANCE: This study demonstrates that fluvoxamine treatment rapidly increased phosphorylation of Akt-1.	Fluvoxamine	43-54	AKT serine/threonine kinase 1	Rattus norvegicus	102-107	
20722474-8	2010	Fluvoxamine treatment significantly restored PO-induced impaired eNOS and Akt activity in the LV.	Fluvoxamine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	74-77	
20722474-10	2010	Fluvoxamine treatment protects PO-induced cardiac injury via upregulation of Sig-1R and stimulation of Sig-1R-mediated Akt-eNOS signaling in ovariectomized rats.	Fluvoxamine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	119-122	
19995565-0	2010	Fluvoxamine and sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate induces the Ser473-phosphorylation of Akt-1 in PC12 cells.	Fluvoxamine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	118-123	
19995565-7	2010	Here, we examined whether fluvoxamine (FLV) activated Akt-1 and increased phosphorylation of Akt-1 via sigma-1 receptor in PC12 cells.	Fluvoxamine	26-37	AKT serine/threonine kinase 1	Rattus norvegicus	54-59	
19995565-7	2010	Here, we examined whether fluvoxamine (FLV) activated Akt-1 and increased phosphorylation of Akt-1 via sigma-1 receptor in PC12 cells.	Fluvoxamine	26-37	AKT serine/threonine kinase 1	Rattus norvegicus	93-98	
19995565-7	2010	Here, we examined whether fluvoxamine (FLV) activated Akt-1 and increased phosphorylation of Akt-1 via sigma-1 receptor in PC12 cells.	Fluvoxamine	39-42	AKT serine/threonine kinase 1	Rattus norvegicus	54-59	
19995565-7	2010	Here, we examined whether fluvoxamine (FLV) activated Akt-1 and increased phosphorylation of Akt-1 via sigma-1 receptor in PC12 cells.	Fluvoxamine	39-42	AKT serine/threonine kinase 1	Rattus norvegicus	93-98