PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34975483-0 2021 Low-Dose Fluvoxamine Modulates Endocytic Trafficking of SARS-CoV-2 Spike Protein: A Potential Mechanism for Anti-COVID-19 Protection by Antidepressants. Fluvoxamine 9-20 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 67-72 34975483-3 2021 Here, I investigated the effect of an antidepressant drug fluvoxamine on membrane trafficking of the SARS-CoV-2 spike protein and its cell host receptor ACE2 in HEK293T cells. Fluvoxamine 58-69 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 112-117 34975483-4 2021 A sub-therapeutic concentration (80 nM) of fluvoxamine rapidly upregulated fluid-phase endocytosis, resulting in enhanced accumulation of the spike-ACE2 complex in enlarged early endosomes. Fluvoxamine 43-54 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 142-147