PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15968885-1	2005	OBJECTIVE: A novel sulfonamide derivative, S-3304, was discovered as a potent matrix metalloproteinase (MMP) inhibitor.	Sulfonamides	19-30	matrix metallopeptidase 1	Homo sapiens	104-107	
15080939-2	2004	The combination of a biphenylsulfonamide group with oxyamino oxygen in the pharmacophoric central skeleton of sulfonamide-based MMPi obtained in the new sulfonamides 10 seems to be able to give selectivity for MMP-2 over MMP-1.	Sulfonamides	29-40	matrix metallopeptidase 1	Homo sapiens	221-226	
15080939-2	2004	The combination of a biphenylsulfonamide group with oxyamino oxygen in the pharmacophoric central skeleton of sulfonamide-based MMPi obtained in the new sulfonamides 10 seems to be able to give selectivity for MMP-2 over MMP-1.	Sulfonamides	153-165	matrix metallopeptidase 1	Homo sapiens	221-226	
11605653-4	2001	Some of the prepared carboxylate derivatives, such as carbamate compounds (12c,d, 22) and sulfonamide compounds (14b,c), proved to be effective MMP-1 inhibitors (with IC50 values of a 10(-6) M order), depending on the substituent at the N(alpha)-position of 2,3-diaminopropionic acid.	Sulfonamides	90-101	matrix metallopeptidase 1	Homo sapiens	144-149	
15553924-3	2003	Replacement of the sulfonamide functionality with an isosteric sulfonate ester has resulted in a series of sulfonate ester hydroxamates, 2a-e, with excellent activity against TACE and excellent selectivity over MMP-1 and MMP-13.	Sulfonamides	19-30	matrix metallopeptidase 1	Homo sapiens	211-216	
10353819-1	1999	The solution structure of the catalytic fragment of human fibroblast collagenase (MMP-1) complexed with a sulfonamide derivative of a hydroxamic acid compound (CGS-27023A) has been determined using two-dimensional and three-dimensional heteronuclear NMR spectroscopy.	Sulfonamides	106-117	matrix metallopeptidase 1	Homo sapiens	82-87