PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24090422-5 2014 Biological screening results showed that sulfonamides 6, 9, 11, 16 and 17 with IC50 values 21.81, 25.50, 20.60, 25.83 and 31.20 muM, respectively, possessed higher antiproliferative activity compared to doxorubicin, IC50 value 32.00 muM, as position control. Sulfonamides 41-53 latexin Homo sapiens 128-131 28319782-3 2017 Among all the indoleamides, compounds 22, 24, 26 and 30 with sulfonamide pharmacophore showed promising activity with IC50 of 1.87, 1.93, 2.00, 2.17 muM against CQ sensitive Pf3D7 strain and 1.69, 2.12, 1.60, 2.19 muM against CQ resistant PfK1 strain, respectively. Sulfonamides 61-72 latexin Homo sapiens 149-152 26397393-5 2015 Notably, the restricted sulfonamide analog 38 with 6,7-dimethoxy groups exhibited the most potent antimalarial activity (IC50 = 2.8 muM). Sulfonamides 24-35 latexin Homo sapiens 132-135 26325575-2 2015 All cytotoxic complexes showed complete inhibition of cell growth at active concentration, two complexes based on pyrrolidine and azepane substituted sulfonamides displayed IC50 values below 1.7 muM and are more cytotoxic than cisplatin in both tested cell lines. Sulfonamides 150-162 latexin Homo sapiens 195-198 25934226-2 2015 Most triazoles with open-chain sulfonamide showed significant aromatase inhibitory activity (IC50=1.3-9.4muM). Sulfonamides 31-42 latexin Homo sapiens 105-108 24090422-5 2014 Biological screening results showed that sulfonamides 6, 9, 11, 16 and 17 with IC50 values 21.81, 25.50, 20.60, 25.83 and 31.20 muM, respectively, possessed higher antiproliferative activity compared to doxorubicin, IC50 value 32.00 muM, as position control. Sulfonamides 41-53 latexin Homo sapiens 233-236 24735442-5 2014 Three sulfonamide compounds with EC50 values <12 muM were further characterized for their point of intervention in the viral replication cycle and for broad antiviral efficacy. Sulfonamides 6-17 latexin Homo sapiens 52-55 30580515-3 2019 To illustrate the structural information on class-specific monoclonal antibodies (mAbs) and dihydropteroate synthase (DHPS) against sulfonamides (SAs) we have previously prepared, we initially measured the kinetic parameters of mAb 4C7, 4D11, and DHPS, which showed that the affinities of 4C7 and 4D11 were in the pM to muM range, while DHPS was uniformly in the muM range. Sulfonamides 146-149 latexin Homo sapiens 320-323 24694543-2 2014 These sulfonamides showed promising activity with IC50 values ranging from 49.5 to 70.2 muM. Sulfonamides 6-18 latexin Homo sapiens 88-91 23072738-4 2012 The results indicated that sulfonamides 2c, 3c, 6d, 8, 13, 3b and 16 were endowed with a pharmacologically interesting antiproliferative activity with compounds 2c and 3c showing the lower IC(50) (from 0.50 +- 0.09 to 1.83 +- 0.52 muM and from 0.58 +- 0.17 to 5.83 +- 1.83 muM, respectively). Sulfonamides 27-39 latexin Homo sapiens 231-234 23072738-4 2012 The results indicated that sulfonamides 2c, 3c, 6d, 8, 13, 3b and 16 were endowed with a pharmacologically interesting antiproliferative activity with compounds 2c and 3c showing the lower IC(50) (from 0.50 +- 0.09 to 1.83 +- 0.52 muM and from 0.58 +- 0.17 to 5.83 +- 1.83 muM, respectively). Sulfonamides 27-39 latexin Homo sapiens 273-276 22162242-2 2012 In this study, a fast analytical method based on HPLC-UV was developed using a sub-2 mum column at elevated temperature for the simultaneous determination of nine sulphonamides. Sulfonamides 163-176 latexin Homo sapiens 85-88 21190426-4 2011 The sulfonamides torsemide, sulfathiazole, and sulfadiazine were found to inhibit the ATPase activity of Hsp90 with IC(50) values of 1.0, 2.6, and 1.5 muM, respectively. Sulfonamides 4-16 latexin Homo sapiens 151-154 30580515-3 2019 To illustrate the structural information on class-specific monoclonal antibodies (mAbs) and dihydropteroate synthase (DHPS) against sulfonamides (SAs) we have previously prepared, we initially measured the kinetic parameters of mAb 4C7, 4D11, and DHPS, which showed that the affinities of 4C7 and 4D11 were in the pM to muM range, while DHPS was uniformly in the muM range. Sulfonamides 146-149 latexin Homo sapiens 363-366 29689093-6 2018 Both inhibitors were based on NS-1502 (IC50: 315 muM), but the deliberate placement of a sulfonamide group significantly improved the potency of JN-01 (IC50: 73.8 muM) and JN-02 (IC50: 112.8 muM) in comparison to the parent compound. Sulfonamides 89-100 latexin Homo sapiens 49-52 29689093-6 2018 Both inhibitors were based on NS-1502 (IC50: 315 muM), but the deliberate placement of a sulfonamide group significantly improved the potency of JN-01 (IC50: 73.8 muM) and JN-02 (IC50: 112.8 muM) in comparison to the parent compound. Sulfonamides 89-100 latexin Homo sapiens 163-166 29689093-6 2018 Both inhibitors were based on NS-1502 (IC50: 315 muM), but the deliberate placement of a sulfonamide group significantly improved the potency of JN-01 (IC50: 73.8 muM) and JN-02 (IC50: 112.8 muM) in comparison to the parent compound. Sulfonamides 89-100 latexin Homo sapiens 163-166