PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26397393-5	2015	Notably, the restricted sulfonamide analog 38 with 6,7-dimethoxy groups exhibited the most potent antimalarial activity (IC50 = 2.8 muM).	Sulfonamides	24-35	latexin	Homo sapiens	132-135	
30580515-3	2019	To illustrate the structural information on class-specific monoclonal antibodies (mAbs) and dihydropteroate synthase (DHPS) against sulfonamides (SAs) we have previously prepared, we initially measured the kinetic parameters of mAb 4C7, 4D11, and DHPS, which showed that the affinities of 4C7 and 4D11 were in the pM to muM range, while DHPS was uniformly in the muM range.	Sulfonamides	146-149	latexin	Homo sapiens	320-323	
30580515-3	2019	To illustrate the structural information on class-specific monoclonal antibodies (mAbs) and dihydropteroate synthase (DHPS) against sulfonamides (SAs) we have previously prepared, we initially measured the kinetic parameters of mAb 4C7, 4D11, and DHPS, which showed that the affinities of 4C7 and 4D11 were in the pM to muM range, while DHPS was uniformly in the muM range.	Sulfonamides	146-149	latexin	Homo sapiens	363-366	
29689093-6	2018	Both inhibitors were based on NS-1502 (IC50: 315 muM), but the deliberate placement of a sulfonamide group significantly improved the potency of JN-01 (IC50: 73.8 muM) and JN-02 (IC50: 112.8 muM) in comparison to the parent compound.	Sulfonamides	89-100	latexin	Homo sapiens	49-52	
29689093-6	2018	Both inhibitors were based on NS-1502 (IC50: 315 muM), but the deliberate placement of a sulfonamide group significantly improved the potency of JN-01 (IC50: 73.8 muM) and JN-02 (IC50: 112.8 muM) in comparison to the parent compound.	Sulfonamides	89-100	latexin	Homo sapiens	163-166	
29689093-6	2018	Both inhibitors were based on NS-1502 (IC50: 315 muM), but the deliberate placement of a sulfonamide group significantly improved the potency of JN-01 (IC50: 73.8 muM) and JN-02 (IC50: 112.8 muM) in comparison to the parent compound.	Sulfonamides	89-100	latexin	Homo sapiens	163-166	
28319782-3	2017	Among all the indoleamides, compounds 22, 24, 26 and 30 with sulfonamide pharmacophore showed promising activity with IC50 of 1.87, 1.93, 2.00, 2.17 muM against CQ sensitive Pf3D7 strain and 1.69, 2.12, 1.60, 2.19 muM against CQ resistant PfK1 strain, respectively.	Sulfonamides	61-72	latexin	Homo sapiens	149-152	
26325575-2	2015	All cytotoxic complexes showed complete inhibition of cell growth at active concentration, two complexes based on pyrrolidine and azepane substituted sulfonamides displayed IC50 values below 1.7 muM and are more cytotoxic than cisplatin in both tested cell lines.	Sulfonamides	150-162	latexin	Homo sapiens	195-198	
25934226-2	2015	Most triazoles with open-chain sulfonamide showed significant aromatase inhibitory activity (IC50=1.3-9.4muM).	Sulfonamides	31-42	latexin	Homo sapiens	105-108	
24090422-5	2014	Biological screening results showed that sulfonamides 6, 9, 11, 16 and 17 with IC50 values 21.81, 25.50, 20.60, 25.83 and 31.20 muM, respectively, possessed higher antiproliferative activity compared to doxorubicin, IC50 value 32.00 muM, as position control.	Sulfonamides	41-53	latexin	Homo sapiens	128-131	
24090422-5	2014	Biological screening results showed that sulfonamides 6, 9, 11, 16 and 17 with IC50 values 21.81, 25.50, 20.60, 25.83 and 31.20 muM, respectively, possessed higher antiproliferative activity compared to doxorubicin, IC50 value 32.00 muM, as position control.	Sulfonamides	41-53	latexin	Homo sapiens	233-236	
24735442-5	2014	Three sulfonamide compounds with EC50 values <12 muM were further characterized for their point of intervention in the viral replication cycle and for broad antiviral efficacy.	Sulfonamides	6-17	latexin	Homo sapiens	52-55	
24694543-2	2014	These sulfonamides showed promising activity with IC50 values ranging from 49.5 to 70.2 muM.	Sulfonamides	6-18	latexin	Homo sapiens	88-91	
23072738-4	2012	The results indicated that sulfonamides 2c, 3c, 6d, 8, 13, 3b and 16 were endowed with a pharmacologically interesting antiproliferative activity with compounds 2c and 3c showing the lower IC(50) (from 0.50 +- 0.09 to 1.83 +- 0.52 muM and from 0.58 +- 0.17 to 5.83 +- 1.83 muM, respectively).	Sulfonamides	27-39	latexin	Homo sapiens	231-234	
23072738-4	2012	The results indicated that sulfonamides 2c, 3c, 6d, 8, 13, 3b and 16 were endowed with a pharmacologically interesting antiproliferative activity with compounds 2c and 3c showing the lower IC(50) (from 0.50 +- 0.09 to 1.83 +- 0.52 muM and from 0.58 +- 0.17 to 5.83 +- 1.83 muM, respectively).	Sulfonamides	27-39	latexin	Homo sapiens	273-276	
22162242-2	2012	In this study, a fast analytical method based on HPLC-UV was developed using a sub-2 mum column at elevated temperature for the simultaneous determination of nine sulphonamides.	Sulfonamides	163-176	latexin	Homo sapiens	85-88	
21190426-4	2011	The sulfonamides torsemide, sulfathiazole, and sulfadiazine were found to inhibit the ATPase activity of Hsp90 with IC(50) values of 1.0, 2.6, and 1.5 muM, respectively.	Sulfonamides	4-16	latexin	Homo sapiens	151-154