PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32058104-0 2020 Synthesis, structure elucidation, and in vitro pharmacological evaluation of novel polyfluoro substituted pyrazoline type sulfonamides as multi-target agents for inhibition of acetylcholinesterase and carbonic anhydrase I and II enzymes. Sulfonamides 122-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 33488256-6 2020 Secondary sulfonamides showed promising enzyme inhibitory effects on AChE while primary sulfonamide derivative was generally effective on hCA I and hCA II isoenzymes. Sulfonamides 10-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 33488256-6 2020 Secondary sulfonamides showed promising enzyme inhibitory effects on AChE while primary sulfonamide derivative was generally effective on hCA I and hCA II isoenzymes. Sulfonamides 10-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 31899985-0 2020 Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile. Sulfonamides 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 32401067-5 2020 The new sulphonamides showed low to moderate inhibition against hCAs, AChE, BChE, and tyrosinase enzymes. Sulfonamides 8-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 32285537-0 2020 Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors. Sulfonamides 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 32058104-1 2020 A novel series of 4-(3-(difluorophenyl)-5-(dimethoxyphenyl)-4,5-dihydropyrazol-1-yl)benzenesulfonamides 1-8 were designed since sulfonamide and pyrazoline pharmacophores draw great attention in novel drug design due to their wide range of bioactivities including acetylcholinesterase (AChE) and human carbonic anhydrase I and II (hCA I and hCA II) inhibitory potencies. Sulfonamides 91-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 263-283 32058104-1 2020 A novel series of 4-(3-(difluorophenyl)-5-(dimethoxyphenyl)-4,5-dihydropyrazol-1-yl)benzenesulfonamides 1-8 were designed since sulfonamide and pyrazoline pharmacophores draw great attention in novel drug design due to their wide range of bioactivities including acetylcholinesterase (AChE) and human carbonic anhydrase I and II (hCA I and hCA II) inhibitory potencies. Sulfonamides 91-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 285-289 30811749-0 2019 Investigation of the effects of some sulfonamides on acetylcholinesterase and carbonic anhydrase enzymes. Sulfonamides 37-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 30811749-2 2019 In this study, we investigated the inhibition effects of some sulfonamides on hCA I, hCA II, and AChE enzymes. Sulfonamides 62-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 30605787-3 2019 Inhibition potency of the sulfonamides were evaluated against human CA isoenzymes (hCA IandhCA II) and acetylcholinesterase (AChE) enzyme and also their cytotoxicities were investigated towards oral squamous cancer cell carcinoma (OSCC) cell lines (Ca9-22, HSC-2, HSC-3, and HSC-4) and non-tumor cells (HGF, HPLF, and HPC). Sulfonamides 26-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-137 30605787-5 2019 AChE enzyme was strongly inhibited by the sulfonamide derivatives with Ki values in the range of 37.7 +- 14.4-89.2 +- 30.2 nM The CC50 values of the compounds were found between 15 and 200 microM towards OSCC malign cell lines. Sulfonamides 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 30605787-8 2019 All sulfonamide derivatives studied here can be considered as good candidates to develop novel CAs or AChE inhibitor candidates based on the enzyme inhibition potencies with their low cytotoxicity and tumor selectivity. Sulfonamides 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106