PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32401067-5	2020	The new sulphonamides showed low to moderate inhibition against hCAs, AChE, BChE, and tyrosinase enzymes.	Sulfonamides	8-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74	
33488256-6	2020	Secondary sulfonamides showed promising enzyme inhibitory effects on AChE while primary sulfonamide derivative was generally effective on hCA I and hCA II isoenzymes.	Sulfonamides	10-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-73	
33488256-6	2020	Secondary sulfonamides showed promising enzyme inhibitory effects on AChE while primary sulfonamide derivative was generally effective on hCA I and hCA II isoenzymes.	Sulfonamides	10-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-73	
31899985-0	2020	Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile.	Sulfonamides	0-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-99	
30605787-3	2019	Inhibition potency of the sulfonamides were evaluated against human CA isoenzymes (hCA IandhCA II) and acetylcholinesterase (AChE) enzyme and also their cytotoxicities were investigated towards oral squamous cancer cell carcinoma (OSCC) cell lines (Ca9-22, HSC-2, HSC-3, and HSC-4) and non-tumor cells (HGF, HPLF, and HPC).	Sulfonamides	26-38	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-137	
32285537-0	2020	Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors.	Sulfonamides	0-12	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-111	
32058104-0	2020	Synthesis, structure elucidation, and in vitro pharmacological evaluation of novel polyfluoro substituted pyrazoline type sulfonamides as multi-target agents for inhibition of acetylcholinesterase and carbonic anhydrase I and II enzymes.	Sulfonamides	122-134	acetylcholinesterase (Cartwright blood group)	Homo sapiens	176-196	
32058104-1	2020	A novel series of 4-(3-(difluorophenyl)-5-(dimethoxyphenyl)-4,5-dihydropyrazol-1-yl)benzenesulfonamides 1-8 were designed since sulfonamide and pyrazoline pharmacophores draw great attention in novel drug design due to their wide range of bioactivities including acetylcholinesterase (AChE) and human carbonic anhydrase I and II (hCA I and hCA II) inhibitory potencies.	Sulfonamides	91-102	acetylcholinesterase (Cartwright blood group)	Homo sapiens	263-283	
32058104-1	2020	A novel series of 4-(3-(difluorophenyl)-5-(dimethoxyphenyl)-4,5-dihydropyrazol-1-yl)benzenesulfonamides 1-8 were designed since sulfonamide and pyrazoline pharmacophores draw great attention in novel drug design due to their wide range of bioactivities including acetylcholinesterase (AChE) and human carbonic anhydrase I and II (hCA I and hCA II) inhibitory potencies.	Sulfonamides	91-102	acetylcholinesterase (Cartwright blood group)	Homo sapiens	285-289	
30811749-0	2019	Investigation of the effects of some sulfonamides on acetylcholinesterase and carbonic anhydrase enzymes.	Sulfonamides	37-49	acetylcholinesterase (Cartwright blood group)	Homo sapiens	53-73	
30811749-2	2019	In this study, we investigated the inhibition effects of some sulfonamides on hCA I, hCA II, and AChE enzymes.	Sulfonamides	62-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	97-101	
30605787-5	2019	AChE enzyme was strongly inhibited by the sulfonamide derivatives with Ki values in the range of 37.7 +- 14.4-89.2 +- 30.2 nM The CC50 values of the compounds were found between 15 and 200 microM towards OSCC malign cell lines.	Sulfonamides	42-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4	
30605787-8	2019	All sulfonamide derivatives studied here can be considered as good candidates to develop novel CAs or AChE inhibitor candidates based on the enzyme inhibition potencies with their low cytotoxicity and tumor selectivity.	Sulfonamides	4-15	acetylcholinesterase (Cartwright blood group)	Homo sapiens	102-106