PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12941322-3	2003	Target acylsulfonamides were prepared in two steps from commercially available primary sulfonamides, which were selected based on in silico screening for their potential ability to interact with one of three binding surfaces proximal to the PTP1B catalytic site.	Sulfonamides	11-23	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	241-246	
20410637-0	2010	Sulphonamides as inhibitors of protein tyrosine phosphatase 1B: a three-dimensional quantitative structure-activity relationship study using self-organizing molecular field analysis approach.	Sulfonamides	0-13	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	31-62	
20410637-3	2010	A three-dimensional quantitative structure-activity relationship (3D-QSAR) study has been performed on a novel class of sulphonamides using self-organizing molecular field analysis (SOMFA) to correlate their chemical structures with their observed PTP 1B inhibitory activities.	Sulfonamides	120-133	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	248-254	
18372175-0	2008	PTP1B inhibitors: synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold.	Sulfonamides	94-105	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	0-5	
16789735-2	2006	An X-ray cocrystal structure of inhibitor 46/PTP1B at 1.8 A resolution demonstrated that the benzimidazole sulfonamides form a bidentate H bond to Asp48 as designed, although the aryl group of the sulfonamide unexpectedly interacts intramolecularly in a pi-stacking manner with the benzimidazole.	Sulfonamides	107-118	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	45-50	
30743173-0	2019	Toward a treatment of diabesity: Rational design, synthesis and biological evaluation of benzene-sulfonamide derivatives as a new class of PTP-1B inhibitors.	Sulfonamides	97-108	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	139-145	
16046123-0	2005	Discovery and structure-activity relationships of novel sulfonamides as potent PTP1B inhibitors.	Sulfonamides	56-68	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	79-84