PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15993055-3 2005 SAR trends were elucidated for sulfonamide derivatives with generality across different scaffolds. Sulfonamides 31-42 sarcosine dehydrogenase Homo sapiens 0-3 26463131-3 2015 The results of the SAR developed highlight the relationship between the sulfonamide and quinoline nitrogen, while also suggesting that an aryl substituent at the 5-position of the quinoline ring contributes to the potency in the interaction assay. Sulfonamides 72-83 sarcosine dehydrogenase Homo sapiens 19-22 22506561-3 2012 The SAR for steroid inhibition of G6PD has been substantially developed; the 3beta-alcohol can be replaced with 3beta-H-bond donors such as sulfamide, sulfonamide, urea, and carbamate. Sulfonamides 151-162 sarcosine dehydrogenase Homo sapiens 4-7 20493690-2 2010 Extensive SAR shows that a large number of sulfonamides at position 7 of the tricycle are very well tolerated. Sulfonamides 43-55 sarcosine dehydrogenase Homo sapiens 10-13 18554753-0 2009 Synthesis, biological evaluation and SAR of sulfonamide 4-methoxychalcone derivatives with potential antileishmanial activity. Sulfonamides 44-55 sarcosine dehydrogenase Homo sapiens 37-40 18816537-6 2008 SAR for aromatase inhibition shows that compounds containing an alkylene- and thioether-based linker system are more potent than those that are ether-, sulfone-, or sulfonamide-based, and that the length of the linker has a limited effect on aromatase inhibition beyond two methylene units. Sulfonamides 165-176 sarcosine dehydrogenase Homo sapiens 0-3 12941345-2 2003 A study of the SAR around sulfonamide 31 (IC(50)=5 nM, EC(50)=1400 nM) is discussed. Sulfonamides 26-37 sarcosine dehydrogenase Homo sapiens 15-18