PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15369392-0 2004 Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal. Sulfonamides 105-116 prostaglandin-endoperoxide synthase 2 Homo sapiens 73-89 15702813-2 2005 Valdecoxib is a new sulfonamide-containing COX-2-specific inhibitor indicated for the treatment of acute pain, osteoarthritis, and rheumatoid arthritis. Sulfonamides 20-31 prostaglandin-endoperoxide synthase 2 Homo sapiens 43-48 15318279-2 2004 Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor containing a sulfonamide substitute, is now clinically widely used due to its advantage of lower rate of gastrointestinal irritation. Sulfonamides 71-82 prostaglandin-endoperoxide synthase 2 Homo sapiens 41-46 15324885-0 2004 Exploring QSAR with E-state index: selectivity requirements for COX-2 versus COX-1 binding of terphenyl methyl sulfones and sulfonamides. Sulfonamides 124-136 prostaglandin-endoperoxide synthase 2 Homo sapiens 64-69 15324885-1 2004 An attempt has been made to explore selectivity requirements for cyclooxygenase-2 (COX-2) versus cyclooxygenase-1 (COX-1) binding of terphenyl methyl sulfones and sulfonamides using electrotopological state (E-state) index and suitable indicator parameters. Sulfonamides 163-175 prostaglandin-endoperoxide synthase 2 Homo sapiens 65-81 15324885-1 2004 An attempt has been made to explore selectivity requirements for cyclooxygenase-2 (COX-2) versus cyclooxygenase-1 (COX-1) binding of terphenyl methyl sulfones and sulfonamides using electrotopological state (E-state) index and suitable indicator parameters. Sulfonamides 163-175 prostaglandin-endoperoxide synthase 2 Homo sapiens 83-88 14604691-0 2003 Design and synthesis of novel celecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the sulfonamide pharmacophore by a sulfonylazide bioisostere. Sulfonamides 119-130 prostaglandin-endoperoxide synthase 2 Homo sapiens 81-86 12013363-2 2002 Celecoxib, a cyclooxygenase-2 inhibitor, is a sulfonamide derivative commonly prescribed to treat arthritis in patients who cannot tolerate or who have a contraindication for taking traditional nonsteroidal antiinflammatory agents. Sulfonamides 46-57 prostaglandin-endoperoxide synthase 2 Homo sapiens 13-29 33511940-3 2021 Consequently, the antineoplastic activity of the sulfonamide coxibs may be justified by the contribution of hCA inhibition to such processes in addition to COX-2 inhibition. Sulfonamides 49-60 prostaglandin-endoperoxide synthase 2 Homo sapiens 156-161 11520213-0 2001 Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere. Sulfonamides 123-134 prostaglandin-endoperoxide synthase 2 Homo sapiens 71-87 9825305-0 1998 Novel inhibitors of cyclooxygenase-2: the sulfones and sulfonamides of 1,2-diaryl-4,5-difluorobenzene. Sulfonamides 55-67 prostaglandin-endoperoxide synthase 2 Homo sapiens 20-36 9351974-8 1997 The greatest loss of potency for inhibition of hPGHS-2(R106E) was observed with the hPGHS-2-selective sulfonamide-containing inhibitors NS-398 and flosulide. Sulfonamides 102-113 prostaglandin-endoperoxide synthase 2 Homo sapiens 47-54 9351974-8 1997 The greatest loss of potency for inhibition of hPGHS-2(R106E) was observed with the hPGHS-2-selective sulfonamide-containing inhibitors NS-398 and flosulide. Sulfonamides 102-113 prostaglandin-endoperoxide synthase 2 Homo sapiens 84-91 9171872-7 1997 Analog 20 containing a sulfonamide group is an excellent inhibitor of COX-2 with an IC50 of 14 nm. Sulfonamides 23-34 prostaglandin-endoperoxide synthase 2 Homo sapiens 70-75 9135032-1 1997 A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Sulfonamides 12-23 prostaglandin-endoperoxide synthase 2 Homo sapiens 121-137 9135032-1 1997 A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Sulfonamides 12-23 prostaglandin-endoperoxide synthase 2 Homo sapiens 139-144 11330653-2 2001 Celecoxib, a selective cyclo-oxygenase-2 inhibitor, is a diaryl-substituted pyrazole derivative containing a sulfonamide substituent. Sulfonamides 109-120 prostaglandin-endoperoxide synthase 2 Homo sapiens 23-40 33511940-2 2021 Interestingly, there is emerging evidence that the sulfonamide-type COX-2 selective inhibitors (coxibs) demonstrate inhibitory action against the cancer-related hCA isoforms, confirmed by X-ray crystal structures for celecoxib and valdecoxib complexes with the hCA active site. Sulfonamides 51-62 prostaglandin-endoperoxide synthase 2 Homo sapiens 68-73 33137555-0 2020 Discovery of novel sulfonamide-containing aminophosphonate derivatives as selective COX-2 inhibitors and anti-tumor candidates. Sulfonamides 19-30 prostaglandin-endoperoxide synthase 2 Homo sapiens 84-89 33137555-2 2020 In this work, a novel series of sulfonamide-containing aminophosphonate derivatives (A1-A25) were developed as selective COX-2 inhibitors and anti-cancer candidates. Sulfonamides 32-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 121-126 22341941-3 2012 Tetrazoles contained a methylsulfonyl or sulfonamide group as COX-2 pharmacophore displayed only low inhibitory potency towards COX-2. Sulfonamides 41-52 prostaglandin-endoperoxide synthase 2 Homo sapiens 62-67 22341941-3 2012 Tetrazoles contained a methylsulfonyl or sulfonamide group as COX-2 pharmacophore displayed only low inhibitory potency towards COX-2. Sulfonamides 41-52 prostaglandin-endoperoxide synthase 2 Homo sapiens 128-133 31052167-0 2019 Dihydropyrazole Derivatives Containing Benzo Oxygen Heterocycle and Sulfonamide Moieties Selectively and Potently Inhibit COX-2: Design, Synthesis, and Anti-Colon Cancer Activity Evaluation. Sulfonamides 68-79 prostaglandin-endoperoxide synthase 2 Homo sapiens 122-127 31052167-2 2019 In our research, a series of dihydropyrazole derivatives containing benzo oxygen heterocycle and sulfonamide moieties were designed as highly potent and selective COX-2 inhibitors by computer-aided drug analysis of known COX-2 inhibitors. Sulfonamides 97-108 prostaglandin-endoperoxide synthase 2 Homo sapiens 163-168 31052167-2 2019 In our research, a series of dihydropyrazole derivatives containing benzo oxygen heterocycle and sulfonamide moieties were designed as highly potent and selective COX-2 inhibitors by computer-aided drug analysis of known COX-2 inhibitors. Sulfonamides 97-108 prostaglandin-endoperoxide synthase 2 Homo sapiens 221-226 27272369-2 2016 A number of other drugs (for example diuretics, anti-diabetic drugs, cyclooxygenase-2 inhibitors and triptans) are also chemically speaking sulphonamides, and many of these are considered to be contraindicated in patients who have experienced an allergic reaction to sulfonamide antibiotics. Sulfonamides 140-153 prostaglandin-endoperoxide synthase 2 Homo sapiens 69-85