PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17640491-5	2007	RESULTS: Docking studies showed that compound 4 bind into the primary binding site of COX-2 with the sulfonamide SO2NH2 moiety interacting with the secondary pocket amino acid residues.	Sulfonamides	101-112	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	86-91	
8627608-1	1996	A novel series of terphenyl methyl sulfones and sulfonamides have been shown to be highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.	Sulfonamides	48-60	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	111-127	
10649977-4	2000	In the sulfonamide series, the introduction of a methyl group at the 5-position of the oxazolone ring gave rise to very COX-2-selective compounds but with decreased in vivo activity.	Sulfonamides	7-18	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	120-125	
8627608-1	1996	A novel series of terphenyl methyl sulfones and sulfonamides have been shown to be highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.	Sulfonamides	48-60	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	129-134	
8627608-2	1996	The sulfonamide analogs 17 and 21 were found to be much more potent COX-2 inhibitors and orally active anti-inflammatory agents than the corresponding methyl sulfone analogs 16 and 20, respectively, albeit with some decrease in COX-2 selectivity.	Sulfonamides	4-15	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	68-73	
8627608-2	1996	The sulfonamide analogs 17 and 21 were found to be much more potent COX-2 inhibitors and orally active anti-inflammatory agents than the corresponding methyl sulfone analogs 16 and 20, respectively, albeit with some decrease in COX-2 selectivity.	Sulfonamides	4-15	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	228-233	
7473585-1	1995	A series of 1,2-diarylcyclopentene methyl sulfones and sulfonamides have been shown to be remarkably potent and selective cyclooxygenase-2 (COX-2) inhibitors.	Sulfonamides	55-67	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	122-138	
7473585-1	1995	A series of 1,2-diarylcyclopentene methyl sulfones and sulfonamides have been shown to be remarkably potent and selective cyclooxygenase-2 (COX-2) inhibitors.	Sulfonamides	55-67	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	140-145	
7473585-4	1995	Replacement of the methyl sulfone moiety with a sulfonamide group gave a slightly more potent (typically 2-5-fold) but less selective COX-2 inhibitor, mainly due to an increase (20- > 100-fold) in COX-1 activity.	Sulfonamides	48-59	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	134-139	
7473585-5	1995	However, in vitro COX-1/COX-2 selectivity for the sulfonamides 8 could be increased in many cases by simply incorporating a substituent at the 3-position of the phenyl group.	Sulfonamides	50-62	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	24-29	
7473585-7	1995	More importantly, the sulfonamide COX-2 inhibitors showed greatly enhanced oral activity in the rat model of established adjuvant-induced arthritis, with inhibition values of 79.0% (8a), 81.5% (8c), and 83.0% (8g) at 1 mg/kg.	Sulfonamides	22-33	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	34-39