PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31109643-4	2019	METHODS: Here, we report on the purification of the human serum PON1 using simple methods and determine the interactions between some sulfonamides and the enzyme.	Sulfonamides	134-146	paraoxonase 1	Homo sapiens	64-68	
31109643-5	2019	RESULTS: We found that some sulfonamides exhibit potential inhibitor properties for the human serum PON1 with IC50 values in the range of 24.10-201.45 muM and Ki values in the range of 4.41 +- 0.52-150.23 +- 20.73 muM.	Sulfonamides	28-40	paraoxonase 1	Homo sapiens	100-104	
28665493-0	2017	Assessment of the inhibitory effects and molecular docking of some sulfonamides on human serum paraoxonase 1.	Sulfonamides	67-79	paraoxonase 1	Homo sapiens	95-108	
28665493-3	2017	In this study, we investigated the in vitro effects of some sulfonamides compounds on human serum PON1 (hPON1).	Sulfonamides	60-72	paraoxonase 1	Homo sapiens	98-102	
28665493-3	2017	In this study, we investigated the in vitro effects of some sulfonamides compounds on human serum PON1 (hPON1).	Sulfonamides	60-72	paraoxonase 1	Homo sapiens	104-109	
28665493-4	2017	For this aim, we purified the hPON1 from human serum with high specific activity by using simple chromatographic methods, and after the purification processes, we investigated in vitro interactions between the enzyme and some sulfonamides (2-amino-5-methyl-1,3-benzenedisulfonamide, 2-chloro-4-sulfamoilaniline, 4-amino-3-methylbenzenesulfanilamide, sulfisoxazole, sulfisomidine, and 5-amino-2-methylbenzenesulfonamide).	Sulfonamides	226-238	paraoxonase 1	Homo sapiens	30-35	
21040495-0	2010	An alternative purification method for human serum paraoxonase 1 and its interactions with sulfonamides.	Sulfonamides	91-103	paraoxonase 1	Homo sapiens	51-64	
21040495-6	2010	The six sulfonamides dose-dependently decreased the activity of hPON1 with inhibition constants in the millimolar-micromolar range.	Sulfonamides	8-20	paraoxonase 1	Homo sapiens	64-69	
31739032-4	2020	The various concentrations of early-synthesized sixteen sulfonamide derivatives were tested on the paraoxonase activity.	Sulfonamides	56-67	paraoxonase 1	Homo sapiens	99-110	
31109643-0	2019	The inhibition effects of some sulfonamides on human serum paraoxonase-1 (hPON1).	Sulfonamides	31-43	paraoxonase 1	Homo sapiens	74-79