PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29292186-0 2018 Low serum uric acid concentration augments insulin effects on the prevalence of metabolic syndrome. Uric Acid 10-19 insulin Homo sapiens 43-50 29266345-12 2018 Hyperuricaemia was a strong independent predictor of new-onset T2DM, which suggests a substantial implication for a correlation between uric acid concentration and insulin resistance (or insulin sensitivity). Uric Acid 136-145 insulin Homo sapiens 164-171 29266345-12 2018 Hyperuricaemia was a strong independent predictor of new-onset T2DM, which suggests a substantial implication for a correlation between uric acid concentration and insulin resistance (or insulin sensitivity). Uric Acid 136-145 insulin Homo sapiens 187-194 29075989-5 2018 Women with UA level >= 4 mg/dL were characterized by larger body mass, triceps skinfold, waist circumference, body fat amount, and serum insulin, glucose, and triglyceride levels. Uric Acid 11-13 insulin Homo sapiens 140-147 29607709-11 2018 In contrast, obesity is associated with an increased risk of uric acid stone formation due to insulin resistance, impaired ammoniagenesis and low urinary pH. Uric Acid 61-70 insulin Homo sapiens 94-101 29496260-6 2018 Although several small clinical trials suggest benefits of urate-lowering therapies on kidney function, blood pressure, and insulin resistance, others have been negative, with many trials having design limitations and insufficient power. Uric Acid 59-64 insulin Homo sapiens 124-131 29292186-11 2018 The interaction between uric acid and insulin was associated with the number of MetS components (PROCESS Model 1, interaction coefficient = -0.009, 95%CI: -0.017 to -0.001, p = .036). Uric Acid 24-33 insulin Homo sapiens 38-45 29735453-0 2018 [Correlation between fasting C-peptide and serum uric acid in patients with type 2 diabetes mellitus]. Uric Acid 49-58 insulin Homo sapiens 29-38 29735453-1 2018 OBJECTIVE: To explore the relationship between fasting C-peptide (F-CP) and serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM). Uric Acid 82-91 insulin Homo sapiens 55-64 29393133-2 2018 For many years, hyperuricemia was attributed to the effects of insulin resistance to reduce urinary excretion of uric acid, and it was believed that uric acid may not have any causal role in the metabolic syndrome. Uric Acid 113-122 insulin Homo sapiens 63-70 29850377-10 2018 Mutations in these genes may prompt disturbances in UA reabsorption, and could lead to the development of hyperuricaemia, insulin resistance, endothelial dysfunction, diabetes and other metabolic diseases. Uric Acid 52-54 insulin Homo sapiens 122-129 29619007-0 2018 Uric Acid Impairs Insulin Signaling by Promoting Enpp1 Binding to Insulin Receptor in Human Umbilical Vein Endothelial Cells. Uric Acid 0-9 insulin Homo sapiens 18-25 29619007-9 2018 UA inhibited insulin-induced Akt/eNOS axis. Uric Acid 0-2 insulin Homo sapiens 13-20 29619007-12 2018 In endothelial cells, UA directly interferes with insulin signaling pathway at receptor level, through ENPP1 recruitment. Uric Acid 22-24 insulin Homo sapiens 50-57 29619007-13 2018 This evidence suggests a new molecular model of UA-induced insulin resistance and vascular damage. Uric Acid 48-50 insulin Homo sapiens 59-66 29568712-9 2018 Multivariable linear regression analysis showed serum UA exerted an independent impact on insulin secretion in females, but not on insulin resistance. Uric Acid 54-56 insulin Homo sapiens 90-97 29459295-0 2018 The link between insulin resistance parameters and serum uric acid is mediated by adiposity. Uric Acid 57-66 insulin Homo sapiens 17-24 29358459-9 2018 Subjects with insulin values >=15 U/L showed significant higher values of office systolic blood pressure, triglycerides, and uric acid and lower values of high-density lipoprotein than did those with normal insulin values. Uric Acid 128-137 insulin Homo sapiens 14-21 29393133-6 2018 Pilot studies in humans have reported a potential benefit of lowering serum uric acid on insulin resistance. Uric Acid 76-85 insulin Homo sapiens 89-96 29393133-5 2018 The mechanism for uric acid-induced insulin resistance appears to be mediated by the development of mitochondrial oxidative stress and impairment of insulin-dependent stimulation of nitric oxide in endothelial cells. Uric Acid 18-27 insulin Homo sapiens 36-43 28808071-8 2017 Insulin resistance partially mediated the effect of uric acid on subsequent hypertension, and the mediation effect of peripheral insulin resistance was significantly greater than that of hepatic insulin resistance (31.3% versus 13.2%; P<0.001, for the difference of mediation effects). Uric Acid 52-61 insulin Homo sapiens 0-7 29651957-1 2018 INTRODUCTION: Chronic serum uric acid elevation (SUA) is known to be induced by dyslipidemia, hypertension, inflammation, and insulin resistance. Uric Acid 28-37 insulin Homo sapiens 126-133 30763014-8 2018 Independent predictors of insulin resistance and premature carotid atherosclerosis in patients with multifocal fatty liver disease were: serum gamma-glutamyl transferase (odds ratio 1.69), high-sensitivity C-reactive protein (odds ratio 1.62), uric acid (odds ratio 1.55), very low-density lipoprotein (odds ratio 1.74), total cholesterol/high-density lipoprotein (odds ratio 1.58) and severity of liver stiffness measured by Fibroscan (odds ratio 1.9). Uric Acid 244-253 insulin Homo sapiens 26-33 30763014-17 2018 Independent predictors of insulin resistance and premature carotid atherosclerosis in patients with multifocal fatty liver disease were: serum gamma-glutamyl transferase (odds ratio 1.69), high-sensitivity C-reactive protein (odds ratio 1.62), uric acid (odds ratio 1.55), very low-density lipoprotein (odds ratio 1.74), total cholesterol/high-density lipoprotein (odds ratio 1.58) and severity of liver stiffness measured by Fibroscan (odds ratio 1.9). Uric Acid 244-253 insulin Homo sapiens 26-33 28808071-2 2017 This study assessed temporal relationship between uric acid and insulin resistance and its impact on future risk of hypertension by examining a longitudinal cohort including 8543 subjects aged 20 to 74 years from China, with an average follow-up of 5.3 years. Uric Acid 50-59 insulin Homo sapiens 64-71 28808071-5 2017 Cross-lagged panel and mediation analysis were used to examine the temporal relationship between uric acid and insulin resistance and its impact on follow-up hypertension. Uric Acid 97-106 insulin Homo sapiens 111-118 28808071-6 2017 After adjusting for covariates, the cross-lagged path coefficients (beta1 values) from baseline uric acid to follow-up insulin resistance indices were significantly greater than path coefficients (beta2 values) from baseline insulin resistance indices to follow-up uric acid (beta1=0.110 versus beta2=0.017; P<0.001, for hepatic insulin resistance; beta1=-0.208 versus beta2=-0.021; P<0.001, for peripheral insulin resistance). Uric Acid 96-105 insulin Homo sapiens 119-126 28152396-0 2017 Insulin resistance, atherogenicity, and iron metabolism in multiple sclerosis with and without depression: Associations with inflammatory and oxidative stress biomarkers and uric acid. Uric Acid 174-183 insulin Homo sapiens 0-7 28885369-7 2017 Otherwise, serum levels of C-peptide, premixed insulin injection, history of cardiovascular disease, and serum concentration of uric acid were inversely associated with GV parameters.Dysfunction of pancreatic beta-cell and better insulin sensitivity were independent contributors to the fluctuation of blood glucose. Uric Acid 128-137 insulin Homo sapiens 230-237 28248530-2 2017 We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their levels of uric acid with parameters of insulin resistance, lipid metabolism, C-reactive protein, anthropometric parameters. Uric Acid 109-118 insulin Homo sapiens 138-145 28248530-8 2017 Serum uric acid levels are even in low levels linearly correlated with parameters of metabolic syndrome (better with typical lipid characteristics than with parameters of insulin resistance) and could be associated with higher cardiovascular risk. Uric Acid 6-15 insulin Homo sapiens 171-178 28492722-8 2017 The levels of insulin, ultrasensitive C-reactive protein and uric acid were also associated with insulin resistance. Uric Acid 61-70 insulin Homo sapiens 97-104 26947600-2 2016 Increased serum uric acid levels are associated with the presence of cardiovascular risk factors such as hypertension, renal dysfunction, insulin resistance, and metabolic syndrome. Uric Acid 16-25 insulin Homo sapiens 138-145 26419665-1 2017 Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid, both mechanisms link elevated serum uric acid with metabolic syndrome. Uric Acid 99-108 insulin Homo sapiens 51-58 29059654-13 2017 A positive correlation between the serum uric acid concentration of serum insulin (r = 0.27, p <0.001), age (r = 0.21, p <0.002) and BMI patients (r = 0.26, p <0.002) has been shown. Uric Acid 41-50 insulin Homo sapiens 74-81 28105014-11 2016 Uric acid levels significantly rose with body mass index (BMI), waist circumference (WC), triglyceride (TG) levels, triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C), insulin levels, homeostatic model assessment index (HOMA-IR), high-sensitivity CRP (hs-CRP) levels, and leptin levels. Uric Acid 0-9 insulin Homo sapiens 188-195 26419665-1 2017 Hyperuricemia leads to insulin resistance, whereas insulin resistance decreases renal excretion of uric acid, both mechanisms link elevated serum uric acid with metabolic syndrome. Uric Acid 146-155 insulin Homo sapiens 51-58 26727147-0 2016 Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women. Uric Acid 44-53 insulin Homo sapiens 88-95 26727147-1 2016 INTRODUCTION: Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated. Uric Acid 20-29 insulin Homo sapiens 94-101 27143182-0 2016 [The correlation between serum uric acid level and early-phase insulin secretion in subjects with normal glucose regulation]. Uric Acid 31-40 insulin Homo sapiens 63-70 27143182-1 2016 OBJECTIVE: To investigate the correlation between serum uric acid (SUA) level and early-phase insulin secretion in subjects with normal glucose regulation (NGR). Uric Acid 56-65 insulin Homo sapiens 94-101 30234279-10 2016 Conclusions: Increased levels of serum uric acid are significantly associated with NAFLD and this association seemed to be mediated by insulin resistance among prediabetic subjects. Uric Acid 39-48 insulin Homo sapiens 135-142 26639394-0 2016 Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism. Uric Acid 0-9 insulin Homo sapiens 42-49 26639394-3 2016 This study aimed to investigate the effects and underlying mechanisms of uric acid on development of NAFLD and insulin resistance. Uric Acid 73-82 insulin Homo sapiens 111-118 26639394-6 2016 RESULTS: We found that uric acid directly induces hepatocyte fat accumulation, insulin resistance, and insulin signaling impairment both in vivo and in vitro. Uric Acid 23-32 insulin Homo sapiens 79-86 26639394-10 2016 CONCLUSIONS: Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome. Uric Acid 13-22 insulin Homo sapiens 55-62 26639394-11 2016 Uric acid may be a new therapeutic target for NAFLD and insulin resistance. Uric Acid 0-9 insulin Homo sapiens 56-63 26965771-6 2016 Insulin resistance correlated significantly with body fat and trunk fat percentages, age, liver enzymes, gammaGT, and uric acid in obese children. Uric Acid 118-127 insulin Homo sapiens 0-7 26645868-1 2016 Uric acid nephrolithiasis and unduly acidic urinary pH are both considered a renal manifestation of insulin resistance but the underlying mechanisms for the development of low urinary pH and the propensity for uric acid stone formation are not completely elucidated. Uric Acid 0-9 insulin Homo sapiens 100-107 27403443-10 2016 The concentration of uric acid was inversely correlated with HbA1c in the high insulin group, regardless of patient sex. Uric Acid 21-30 insulin Homo sapiens 79-86 26550697-1 2016 This study examined the relationship between serum levels of uric acid and insulin resistance and metabolic syndrome in nondiabetic patients with schizophrenia. Uric Acid 61-70 insulin Homo sapiens 75-82 26550697-5 2016 A significant positive relationship was found between serum levels of uric acid and the homeostasis model of assessing insulin resistance (log transformed, r=0.394, P<0.001), and a significant negative relationship was found between serum levels of uric acid and low-density lipoprotein particle size (log transformed, r=-0.306, P=0.001) after controlling for potential confounding variables. Uric Acid 70-79 insulin Homo sapiens 119-126 26820798-9 2016 RESULTS: Variables predicted components of MetS in children: HOMA-IR (insulin resistance by HOMA index) was increased by 2.4 in hepatic steatosis, by 0.6 for each unit of SUA (serum uric acid), and by 0.009 for every mg/dL of triglycerides. Uric Acid 182-191 insulin Homo sapiens 70-77 26550697-6 2016 Hierarchical multiple regression suggested that serum uric acid level is a significant predictor of insulin resistance (P=0.001) and of low-density lipoprotein particle size (P<0.015). Uric Acid 54-63 insulin Homo sapiens 100-107 26300523-0 2015 [The role of uric acid in the insulin resistance in children and adolescents with obesity]. Uric Acid 13-22 insulin Homo sapiens 30-37 26571421-2 2015 Here we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance. Uric Acid 44-53 insulin Homo sapiens 106-113 26571421-6 2015 RESULTS: Allopurinol-treated subjects showed a reduction in serum uric acid in association with improvement in fasting blood glucose, fasting insulin, and HOMA-IR index, as well as a reduction in serum high-sensitivity C-reactive protein. Uric Acid 66-75 insulin Homo sapiens 142-149 26571421-0 2015 Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia. Uric Acid 9-18 insulin Homo sapiens 45-52 26300523-1 2015 OBJECTIVE: To investigate the association between serum uric acid levels and insulin resistance in children and adolescents with obesity. Uric Acid 56-65 insulin Homo sapiens 77-84 26300523-5 2015 To evaluate the association between uric acid levels and insulin resistance the Pearson"s test and logistic regression were applied. Uric Acid 36-45 insulin Homo sapiens 57-64 26300523-9 2015 The logistic regression model that included age, gender and obesity, showed an odds ratio of uric acid as a variable associated with insulin resistance of 1.91 (95%CI 1.40 to 2.62; p<-0.001). Uric Acid 93-102 insulin Homo sapiens 133-140 26300523-10 2015 CONCLUSIONS: The increase in serum uric acid showed a positive statistical correlation with insulin resistance and it is associated with and increased risk of insulin resistance in obese children and adolescents. Uric Acid 35-44 insulin Homo sapiens 92-99 26300523-10 2015 CONCLUSIONS: The increase in serum uric acid showed a positive statistical correlation with insulin resistance and it is associated with and increased risk of insulin resistance in obese children and adolescents. Uric Acid 35-44 insulin Homo sapiens 159-166 25361999-5 2015 Whereas nutrients that stimulate generation of uric acid (such as fructose and purine-rich food) cause insulin resistance and fat accumulation, other nutrients (such as antioxidants, plant food, probiotics, nuts, soy and omega-3) counteract the negative effects of a calorie-rich diet by salutary effects on mitochondrial biogenesis. Uric Acid 47-56 insulin Homo sapiens 103-110 25801748-9 2015 Association with weight, BMI, abdominal and waist circumferences, insulin levels and insulin resistance may support uric acid role as an important cardiovascular risk factor. Uric Acid 116-125 insulin Homo sapiens 66-73 25763991-0 2015 Renal clearance of uric acid is linked to insulin resistance and lower excretion of sodium in gout patients. Uric Acid 19-28 insulin Homo sapiens 42-49 25763991-5 2015 Clearance of uric acid was inversely correlated with insulin resistance and directly correlated with fractional excretion of sodium. Uric Acid 13-22 insulin Homo sapiens 53-60 25763991-6 2015 In multivariate analysis, hypertension and hyperlipidemia, in addition to insulin resistance and fractional excretion of sodium, were associated with renal clearance of uric acid. Uric Acid 169-178 insulin Homo sapiens 74-81 25763991-8 2015 The impact of insulin resistance and renal handling of sodium on renal clearance of uric acid may help to explain why hyperuricemia is more commonly associated with diabetes and hypertension. Uric Acid 84-93 insulin Homo sapiens 14-21 25801748-9 2015 Association with weight, BMI, abdominal and waist circumferences, insulin levels and insulin resistance may support uric acid role as an important cardiovascular risk factor. Uric Acid 116-125 insulin Homo sapiens 85-92 26328636-8 2015 CONCLUSION: The long-term effective control of serum uric acid by allopurinol may improve insulin resistance, decrease the serum levels of hs-CRP, reduce the carotid IMT, and may delay the development of atherosclerosis in patients with T2DM and asymptomatic HUA. Uric Acid 53-62 insulin Homo sapiens 90-97 26005873-1 2015 Recent studies have revealed an association between elevated levels of uric acid and conditions correlated to chronic kidney diseases such as hypertension, cardiovascular and cerebral disease, insulin resistance. Uric Acid 71-80 insulin Homo sapiens 193-200 25810959-0 2015 Mid-gestational serum uric acid concentration effect on neonate birth weight and insulin resistance in pregnant women. Uric Acid 22-31 insulin Homo sapiens 81-88 25810959-4 2015 Stratification analysis and independent t-test was used to assess the association between uric acid and birth weights regarding to insulin resistance. Uric Acid 90-99 insulin Homo sapiens 131-138 25810959-7 2015 CONCLUSIONS: Higher mid - gestation serum uric acid concentration, even if it does not exceed the normal range, is accompanied by lower birth weight only in non-insulin resistance women. Uric Acid 42-51 insulin Homo sapiens 161-168 25455681-0 2015 The effect of initiating pharmacologic insulin on serum uric acid levels in patients with diabetes: a matched cohort analysis. Uric Acid 56-65 insulin Homo sapiens 39-46 25455681-3 2015 Rising serum insulin levels correlate with an increase in serum uric acid (UA). Uric Acid 64-73 insulin Homo sapiens 13-20 25455681-3 2015 Rising serum insulin levels correlate with an increase in serum uric acid (UA). Uric Acid 75-77 insulin Homo sapiens 13-20 25455681-4 2015 The current study evaluated the effect of pharmacologic insulin on serum UA levels in patients with diabetes. Uric Acid 73-75 insulin Homo sapiens 56-63 25455681-11 2015 After controlling for baseline UA and time between UA measurements, regression modeling showed that insulin use was significantly associated with an increase in UA (beta = 1.25mg/dl, p = 0.02). Uric Acid 31-33 insulin Homo sapiens 100-107 25455681-11 2015 After controlling for baseline UA and time between UA measurements, regression modeling showed that insulin use was significantly associated with an increase in UA (beta = 1.25mg/dl, p = 0.02). Uric Acid 51-53 insulin Homo sapiens 100-107 25455681-11 2015 After controlling for baseline UA and time between UA measurements, regression modeling showed that insulin use was significantly associated with an increase in UA (beta = 1.25mg/dl, p = 0.02). Uric Acid 51-53 insulin Homo sapiens 100-107 25455681-12 2015 CONCLUSIONS: Initiation of insulin among patients with diabetes was associated with a statistically significant increase in serum UA levels. Uric Acid 130-132 insulin Homo sapiens 27-34 26005877-5 2015 Furthermore, uric acid has been shown to promote the development of insulin resistance, hypertrglyceridemia and haepatic steatosis through pro-oxidative mechanisms. Uric Acid 13-22 insulin Homo sapiens 68-75 25295417-9 2014 Serum UA levels significantly correlate with early-phase insulin secretion in nondiabetic Japanese women. Uric Acid 6-8 insulin Homo sapiens 57-64 25186106-7 2014 Uric acid levels were directly related with fasting and post-OGTT plasma insulin and with the HOMA index and inversely with 24-h creatinine clearance. Uric Acid 0-9 insulin Homo sapiens 73-80 25400699-8 2014 CONCLUSIONS: Our data indicate that in apparently healthy Chinese adults, there were synergistic effects of UA, TG and neck circumference on insulin resistance. Uric Acid 108-110 insulin Homo sapiens 141-148 25374817-0 2014 Role of insulin resistance in uric acid nephrolithiasis. Uric Acid 30-39 insulin Homo sapiens 8-15 25374817-3 2014 This review presents epidemiologic studies demonstrating the association between metabolic syndrome and nephrolithiasis in general as well as the relationship between insulin resistance and uric acid stone formation, in particular. Uric Acid 190-199 insulin Homo sapiens 167-174 25374817-4 2014 We also review studies that explore the pathophysiologic relationship between insulin resistance and uric acid nephrolithiasis. Uric Acid 101-110 insulin Homo sapiens 78-85 24418684-6 2014 Uric acid level was associated with diabetes even after adjustment for risk factors (per 1 mg/dL, hazard ratio = 1.18, 95% confidence interval: 1.13, 1.23), and the association remained significant after adjustment for fasting glucose and insulin levels. Uric Acid 0-9 insulin Homo sapiens 239-246 25146479-1 2014 Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Uric Acid 17-26 insulin Homo sapiens 74-81 25146480-1 2014 Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Uric Acid 17-26 insulin Homo sapiens 74-81 24769205-0 2014 High uric acid directly inhibits insulin signalling and induces insulin resistance. Uric Acid 5-14 insulin Homo sapiens 33-40 24769205-0 2014 High uric acid directly inhibits insulin signalling and induces insulin resistance. Uric Acid 5-14 insulin Homo sapiens 64-71 24769205-2 2014 However, how high uric acid (HUA) level causes insulin resistance remains unclear. Uric Acid 18-27 insulin Homo sapiens 47-54 24769205-10 2014 Increased uric acid level may inhibit IRS1 and Akt insulin signalling and induce insulin resistance. Uric Acid 10-19 insulin Homo sapiens 51-58 24769205-10 2014 Increased uric acid level may inhibit IRS1 and Akt insulin signalling and induce insulin resistance. Uric Acid 10-19 insulin Homo sapiens 81-88 25116356-1 2014 BACKGROUND/AIMS: Uric acid nephrolithiasis is prevalent among patients with type 2 diabetes and metabolic syndrome; it is correlated with an acidic urine and lower urinary ammonium excretion and is likely associated with insulin resistance. Uric Acid 17-26 insulin Homo sapiens 221-228 24353177-0 2014 Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Uric Acid 17-26 insulin Homo sapiens 74-81 24353177-2 2014 We evaluated whether alterations in levels of circulating uric acid (UA), a systemic antioxidant, affects the following: 1) systemic (plasma and saliva) nonenzymatic antioxidant capacity (NEAC); 2) markers of systemic (urinary 8-iso-prostaglandin-F2alpha) and muscle (carbonylated protein content) oxidative stress; and 3) whole-body insulin sensitivity (percentage increase in glucose uptake during a hyperinsulinemic-euglycemic clamp procedure). Uric Acid 58-67 insulin Homo sapiens 334-341 24353177-2 2014 We evaluated whether alterations in levels of circulating uric acid (UA), a systemic antioxidant, affects the following: 1) systemic (plasma and saliva) nonenzymatic antioxidant capacity (NEAC); 2) markers of systemic (urinary 8-iso-prostaglandin-F2alpha) and muscle (carbonylated protein content) oxidative stress; and 3) whole-body insulin sensitivity (percentage increase in glucose uptake during a hyperinsulinemic-euglycemic clamp procedure). Uric Acid 69-71 insulin Homo sapiens 334-341 24045866-1 2013 Plasma levels of uric acid, the final product of purine degradation in humans, are elevated in metabolic syndrome and are strongly associated with insulin resistance and nonalcoholic fatty liver disease (NAFLD). Uric Acid 17-26 insulin Homo sapiens 147-154 24309486-1 2014 OBJECTIVE: Serum uric acid (SUA) levels correlate with many recognized cardiovascular risk factors, including age, male sex, hypertension, diabetes mellitus, hypertriglyceridemia, obesity, and insulin resistance. Uric Acid 17-26 insulin Homo sapiens 193-200 23273711-0 2014 ESR1 gene and insulin resistance remission are associated with serum uric acid decline for severely obese patients undergoing bariatric surgery. Uric Acid 69-78 insulin Homo sapiens 14-21 23273711-12 2014 CONCLUSIONS: For severely obese Han Chinese patients, bariatric surgery appears to reduce serum uric acid levels, potentially mediated by synergic effects of surgery type, BMI reduction, rs712221 locus, insulin sensitivity, and changed dietary factors via an unknown mechanism. Uric Acid 96-105 insulin Homo sapiens 203-210 23266153-9 2013 A positive relation was also found between uric acid and insulin levels in the metabolic syndrome patients with morbid obesity. Uric Acid 43-52 insulin Homo sapiens 57-64 26064845-3 2013 In fact, insulin resistance, dyslipidemia, obesity and hypertension, each of these variables of metabolic syndrome gets influenced by the serum uric acid level. Uric Acid 144-153 insulin Homo sapiens 9-16 23981619-8 2013 The association between UA and baPWV was observed after adjustment for gender, age, blood pressure, BMI, serum creatinine and high density lipoprotein, and insulin resistance (r = 0.186, P < 0.0001). Uric Acid 24-26 insulin Homo sapiens 156-163 23981619-11 2013 CONCLUSIONS: The UA level is positively associated with baPWV and MS, but the association between UA and MS is dependent on insulin resistance. Uric Acid 98-100 insulin Homo sapiens 124-131 23935829-1 2013 Increased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) in men presenting with metabolic syndrome (MetS) and/or insulin resistance. Uric Acid 16-25 insulin Homo sapiens 175-182 23216460-6 2013 Insulin, homeostasis model assessment-R (HOMA-R), and body mass index (BMI) levels had a tendency to be in proportion to those of UA. Uric Acid 130-132 insulin Homo sapiens 0-7 23998049-11 2013 CONCLUSION: In the present study, it was concluded that the serum uric acid levels linearly increased with increasing serum insulin levels, in newly diagnosed diabetic patients. Uric Acid 66-75 insulin Homo sapiens 124-131 23360433-1 2013 BACKGROUND: Uric acid (UA) is known to be associated with excess adiposity and insulin resistance. Uric Acid 12-21 insulin Homo sapiens 79-86 23360433-1 2013 BACKGROUND: Uric acid (UA) is known to be associated with excess adiposity and insulin resistance. Uric Acid 23-25 insulin Homo sapiens 79-86 23360433-11 2013 UA is a potential target for preventing decreases in insulin sensitivity and rises in blood pressure and cholesterol. Uric Acid 0-2 insulin Homo sapiens 53-60 23439376-7 2013 Conversely, the most important urine variable in the causation of uric acid stones is low urine pH, linked to insulin resistance as a component of obesity and the metabolic syndrome. Uric Acid 66-75 insulin Homo sapiens 110-117 23020656-2 2012 AREAS COVERED: Insulin has a physiological action on renal tubules, causing a reduction in UA clearance, what could explain the hyperuricemia found in MS. On the other hand, it was also hypothesized a causal role of UA in fructose-induced MS. Uric Acid 91-93 insulin Homo sapiens 15-22 23762544-9 2013 Uric acid, a byproduct of this reaction, has been linked to endothelial dysfunction, insulin resistance, and hypertension. Uric Acid 0-9 insulin Homo sapiens 85-92 23020656-2 2012 AREAS COVERED: Insulin has a physiological action on renal tubules, causing a reduction in UA clearance, what could explain the hyperuricemia found in MS. On the other hand, it was also hypothesized a causal role of UA in fructose-induced MS. Uric Acid 216-218 insulin Homo sapiens 15-22 22753829-4 2012 During the follow-up period (through 2001), the incidence rates of diabetes and prediabetes (insulin resistance and impaired fasting glucose) were higher among persons with greater serum urate concentrations. Uric Acid 187-192 insulin Homo sapiens 93-100 23127592-10 2012 Serum uric acid levels in postmenopausal women correlated significantly with age, BMI, WC, TG, HDL-C, insulin, HOMA-IR, adiponectin and PWV. Uric Acid 6-15 insulin Homo sapiens 102-109 26558034-7 2012 (i) Abdominal obesity predisposes to insulin resistance, which at the renal level causes reduced urinary ammonium excretion and thus a low urinary pH; the consequence is a greater risk of uric acid stone formation. Uric Acid 188-197 insulin Homo sapiens 37-44 21842242-5 2012 Moreover, the elevation in uric acid levels observed after fructose ingestion, with a consequent reduction in nitric oxide, may lead to a reduced glucose uptake in the skeletal muscle, hyperinsulinemia, and insulin resistance. Uric Acid 27-36 insulin Homo sapiens 190-197 21992452-1 2012 There is an increased prevalence of nephrolithiasis and an increase in the incidence of renal colic in patients with diabetes, obesity, hypertension and insulin resistance because of an increased frequency of uric acid crystallization. Uric Acid 209-218 insulin Homo sapiens 153-160 21992452-3 2012 However, in the presence of insulin resistance, there is decreased renal tubular generation of ammonia and increased sodium absorption leading to acidification of the urine and uric acid crystallization. Uric Acid 177-186 insulin Homo sapiens 28-35 22000606-1 2012 Among adolescents, uric acid is associated with insulin resistance, hypertension, and the metabolic syndrome (MetS); and in adults, high uric acid levels are an independent risk factor for cardiovascular disease and diabetes. Uric Acid 19-28 insulin Homo sapiens 48-55 21866382-0 2012 Overweight, insulin resistance and blood pressure (parameters of the metabolic syndrome) in uric acid urolithiasis. Uric Acid 92-101 insulin Homo sapiens 12-19 21613382-9 2012 Serum uric acid was lowered non-significantly with low-fructose diet (7.1 +- 1.3 versus 6.6 +- 1.0 mg/dL, P < 0.1), whereas a significant decrease in fasting serum insulin was observed (11.2 +- 6.1 versus 8.2 +- 2.9 mIU/mL, P < 0.05) and the reduction persisted after return to the regular diet. Uric Acid 6-15 insulin Homo sapiens 167-174 21933003-0 2012 Optimal uric acid threshold to identify insulin resistance in healthy women. Uric Acid 8-17 insulin Homo sapiens 40-47 21933003-2 2012 Our aims were to determine the relationship between uric acid and insulin resistance and to define the optimal uric acid cutoff to identify insulin resistance in women. Uric Acid 111-120 insulin Homo sapiens 140-147 23013150-6 2012 Furthermore, insulin resistance is thought to alter renal acid-base metabolism, resulting in a lower urine pH and increased risk of uric acid stone disease. Uric Acid 132-141 insulin Homo sapiens 13-20 22303532-1 2012 A number of epidemiological studies have reported an association between serum uric acid levels and a wide variety of high-risk conditions including hypertension, insulin resistance, and kidney and cerebro-cardiovascular disease. Uric Acid 79-88 insulin Homo sapiens 163-170 22036135-10 2011 Using uric acid >= 5.0 mg/dL as a cutoff point, we could diagnose insulin resistance with 75.4% sensitivity and 73.1% specificity. Uric Acid 6-15 insulin Homo sapiens 69-76 22036135-13 2011 Among these, high serum uric acid levels seemed to be a useful marker identifying postmenopausal women with insulin resistance. Uric Acid 24-33 insulin Homo sapiens 108-115 20091036-6 2011 There were significant correlations between 24-h urinary uric acid excretion and waist circumference (r(2) = 0.225, P = 0.049), fasting insulin (r(2) = 0.241, P = 0.035), and insulin resistance (HOMA-IR) (r(2) = 0.271, P = 0.017). Uric Acid 57-66 insulin Homo sapiens 175-182 21684106-3 2011 In case of uric acid lithiasis, you must search a metabolic syndrome, an insulin resistance, a type 2 diabetes. Uric Acid 11-20 insulin Homo sapiens 73-80 22216028-0 2011 Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus. Uric Acid 44-53 insulin Homo sapiens 58-65 20048433-4 2010 They decrease the production of uric acid precursor in skeletal muscles under anaerobic condition induced by hypertension or insulin resistance. Uric Acid 32-41 insulin Homo sapiens 125-132 21063041-1 2010 AIM: to obtain prevalence of insulin resistance among siblings of subjects with type 2 DM and their metabolic abnormality profiles as measured by their BMI, waist circumference (WC), blood pressure, glucose intolerance, concentration of triglyceride, HDL cholesterol, and uric acid. Uric Acid 272-281 insulin Homo sapiens 29-36 20885365-6 2010 Associations with other systemic derangements, including endothelial dysfunction, low-level systemic inflammation, sympathetic overactivity and insulin resistance, render uric acid to a complex but potentially direct causal role in the pathogenesis of hypertension. Uric Acid 171-180 insulin Homo sapiens 144-151 20683957-1 2010 UNLABELLED: Elevated serum uric acid (UA) levels strongly reflect and may even cause oxidative stress, insulin resistance, and metabolic syndrome, which are risk factors for the progression of liver disease. Uric Acid 27-36 insulin Homo sapiens 103-110 20683957-1 2010 UNLABELLED: Elevated serum uric acid (UA) levels strongly reflect and may even cause oxidative stress, insulin resistance, and metabolic syndrome, which are risk factors for the progression of liver disease. Uric Acid 38-40 insulin Homo sapiens 103-110 20192932-3 2010 Recent data suggest that clearance of UA is being reduced with increase in insulin resistance and UA as a marker of prediabetes period. Uric Acid 38-40 insulin Homo sapiens 75-82 20199182-2 2010 In this study, we sought to research the relationship between the insulin resistance, which is one of the risk factors for CVD, and the inflammation markers, especially C-reactive protein, fibrinogen, uric acid, and homocysteine levels in our patients who were recently diagnosed with ESRD and started hemodialysis. Uric Acid 201-210 insulin Homo sapiens 66-73 21469322-0 2010 [Interrelations of uric acid metabolism indices with insulin and testosterone levels in men with type 2 diabetes]. Uric Acid 19-28 insulin Homo sapiens 53-60 21469322-8 2010 The results allow us to suggest a significance of insulin and testosterone influence on regulation of UA metabolism in aged men with type 2 diabetes and insulin resistance syndrome. Uric Acid 102-104 insulin Homo sapiens 50-57 19557736-1 2009 BACKGROUND: Elevated serum uric acid has been related to insulin resistance, but there are no studies regarding its association with beta-cell function. Uric Acid 27-36 insulin Homo sapiens 57-64 19729142-0 2009 Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women. Uric Acid 0-9 insulin Homo sapiens 45-52 19729142-1 2009 OBJECTIVE: We sought to investigate whether uric acid concentrations are increased in pregnant women with insulin resistance and to correlate both with fetal growth. Uric Acid 44-53 insulin Homo sapiens 106-113 19729142-3 2009 The association between uric acid and insulin resistance, as estimated using the homeostasis model assessment (HOMA), was analyzed and related to birthweights. Uric Acid 24-33 insulin Homo sapiens 38-45 19729142-6 2009 CONCLUSION: Increasing uric acid concentrations were associated with insulin resistance in midpregnancy. Uric Acid 23-32 insulin Homo sapiens 69-76 19534022-8 2009 In both groups, higher uric acid levels translated into an increase in metabolic syndrome components, in markers of insulin resistance, triglyceride / high-density lipoprotein levels, and Apo B/Apo A-I ratios, as well as in Framingham scores. Uric Acid 23-32 insulin Homo sapiens 116-123 19893872-1 2009 Elevated plasma uric acid levels are associated with obesity and could be an expression of insulin-resistant state. Uric Acid 16-25 insulin Homo sapiens 91-98 19258383-1 2009 BACKGROUND: Uric acid is heritable and associated with hypertension and insulin resistance. Uric Acid 12-21 insulin Homo sapiens 72-79 19258383-11 2009 Bivariate linkage analyses and pathway analysis were consistent with genes regulating insulin resistance and fructose metabolism contributing to the heritability of uric acid. Uric Acid 165-174 insulin Homo sapiens 86-93 18585721-2 2009 With the exception of specific genetic defects in purine metabolism, increased uric acid is generally associated with important risk factors for atherosclerosis like hypertension, abdominal obesity, insulin resistance, the metabolic syndrome and renal failure. Uric Acid 79-88 insulin Homo sapiens 199-206 19105055-10 2009 CONCLUSION: Our results suggest that menopause-related insulin resistance, obesity and ethanol ingestion as well as menopause may contribute to an increase in level of serum urate in postmenopausal Japanese women. Uric Acid 174-179 insulin Homo sapiens 55-62 19001525-1 2009 BACKGROUND: Elevated serum uric acid is associated with several cardiovascular disease (CVD) risk factors such as hypertension, inflammation, endothelial dysfunction, insulin resistance, dyslipidemia, and obesity. Uric Acid 27-36 insulin Homo sapiens 167-174 18702943-11 2008 In contrast, both GGT activity and uric acid concentrations correlated with insulin sensitivity and co-associated with insulin resistance-related risk factors and are therefore components of a true risk factor cluster. Uric Acid 35-44 insulin Homo sapiens 76-83 19526867-9 2009 The results suggest the significance of insulin resistance and abdominal obesity in UA metabolism in DM2. Uric Acid 84-86 insulin Homo sapiens 40-47 18973209-1 2008 BACKGROUND: While some studies have reported that retinol-binding protein 4 (RBP4) might induce insulin resistance, other studies have demonstrated that the presence of albuminuria in diabetic patients and increased uric acid are related to insulin resistance. Uric Acid 216-225 insulin Homo sapiens 241-248 18060751-0 2008 Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. Uric Acid 89-98 insulin Homo sapiens 5-12 18060751-2 2008 BACKGROUND AND AIMS: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. Uric Acid 134-143 insulin Homo sapiens 47-54 18702943-11 2008 In contrast, both GGT activity and uric acid concentrations correlated with insulin sensitivity and co-associated with insulin resistance-related risk factors and are therefore components of a true risk factor cluster. Uric Acid 35-44 insulin Homo sapiens 119-126 18349066-10 2008 In MFTs, a correlation was found after 2 yr of therapy between the homeostasis model assessment of insulin resistance and the serum uric acid (r = 0.59; P = 0.01). Uric Acid 132-141 insulin Homo sapiens 99-106 18480647-6 2008 RESULTS: For males, after multivariate adjustment, the odds ratios (95% confidence interval) of elevated serum uric acid associated with high blood pressure, low HDL-cholesterol, high triglycerides, insulin resistance, and high body mass index were 2.61 (1.13, 6.03), 1.47 (0.57, 3.80), 1.30 (0.55, 3.08), 2.87 (1.23, 6.71), and 3.25 (1.36, 7.74), respectively. Uric Acid 111-120 insulin Homo sapiens 199-206 18219300-6 2008 Higher body mass index and insulin resistance (i.e., the metabolic syndrome) may be etiologic in uric acid nephrolithiasis as increasing body weight is associated with decreasing urinary pH. Uric Acid 97-106 insulin Homo sapiens 27-34 18390895-0 2008 Haemoglobin A1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels--the Third National Health and Nutrition Examination Survey. Uric Acid 94-103 insulin Homo sapiens 54-61 18390895-8 2008 Serum uric acid levels increased linearly with increasing fasting serum C-peptide levels, serum insulin levels or insulin resistance (multivariate P-values for trend, <0.001). Uric Acid 6-15 insulin Homo sapiens 96-103 18390895-8 2008 Serum uric acid levels increased linearly with increasing fasting serum C-peptide levels, serum insulin levels or insulin resistance (multivariate P-values for trend, <0.001). Uric Acid 6-15 insulin Homo sapiens 114-121 18227000-5 2008 The defect of renal ammoniogenesis armature by the resistance of the renal cells to insulin involves a urinary hyperacidity which supports the crystallization of the uric acid responsible for the formation of uric or mixed uric acid/oxalate stones. Uric Acid 166-175 insulin Homo sapiens 84-91 18082342-0 2008 Uric acid: a surrogate of insulin resistance in older women. Uric Acid 0-9 insulin Homo sapiens 26-33 18082342-15 2008 CONCLUSION: A positive association was identified between serum UA and insulin resistance in older women but not in men. Uric Acid 64-66 insulin Homo sapiens 71-78 18227000-5 2008 The defect of renal ammoniogenesis armature by the resistance of the renal cells to insulin involves a urinary hyperacidity which supports the crystallization of the uric acid responsible for the formation of uric or mixed uric acid/oxalate stones. Uric Acid 223-232 insulin Homo sapiens 84-91 17761018-0 2008 Decreased levels of uric acid after oral glucose challenge is associated with triacylglycerol levels and degree of insulin resistance. Uric Acid 20-29 insulin Homo sapiens 115-122 17761018-9 2008 Subjects with a drop in UA concentrations >40.86 micromol/l (>75th percentile) had higher plasma TAG levels (P = 0.0001), baseline insulin (P = 0.02) and greater insulin resistance (P = 0.034). Uric Acid 24-26 insulin Homo sapiens 137-144 17761018-9 2008 Subjects with a drop in UA concentrations >40.86 micromol/l (>75th percentile) had higher plasma TAG levels (P = 0.0001), baseline insulin (P = 0.02) and greater insulin resistance (P = 0.034). Uric Acid 24-26 insulin Homo sapiens 168-175 17761018-10 2008 Women with a difference in plasma concentrations of UA above the 75th percentile had higher baseline insulin levels (P = 0.019), concentration of plasma TAG (P = 0.0001) and a greater insulin resistance index (P = 0.029), whereas the only significant difference in men was the level of TAG. Uric Acid 52-54 insulin Homo sapiens 101-108 17761018-10 2008 Women with a difference in plasma concentrations of UA above the 75th percentile had higher baseline insulin levels (P = 0.019), concentration of plasma TAG (P = 0.0001) and a greater insulin resistance index (P = 0.029), whereas the only significant difference in men was the level of TAG. Uric Acid 52-54 insulin Homo sapiens 184-191 17761018-12 2008 Levels of UA were significantly lower after the OGTT and the individuals with the greatest decrease in UA levels are those who have greater insulin resistance and higher TAG levels. Uric Acid 10-12 insulin Homo sapiens 140-147 17761018-12 2008 Levels of UA were significantly lower after the OGTT and the individuals with the greatest decrease in UA levels are those who have greater insulin resistance and higher TAG levels. Uric Acid 103-105 insulin Homo sapiens 140-147 18396620-0 2007 [Correlation between serum uric acid and insulin resistance]. Uric Acid 27-36 insulin Homo sapiens 41-48 18396620-1 2007 OBJECTIVE: To assess the correlation between serum uric acid and insulin resistance in natural population of Beijing. Uric Acid 51-60 insulin Homo sapiens 65-72 18396620-6 2007 The prevalence of insulin resistance increased with the elevation of uric acid level, from 13.8% in quartile 1 to 33.9% in quartile 4. Uric Acid 69-78 insulin Homo sapiens 18-25 18396620-9 2007 Uric acid was independently correlated with insulin resistance after adjustment for sex, age and main components of metabolic syndrome (MS). Uric Acid 0-9 insulin Homo sapiens 44-51 18396620-10 2007 CONCLUSION: Serum uric acid is correlated with insulin resistance in Beijing natural population after adjustment of sex, age, and the main components of MS. Uric Acid 18-27 insulin Homo sapiens 47-54 16775030-2 2006 Because insulin resistance, characteristic of the metabolic syndrome and type 2 diabetes, results in lower urine pH through impaired kidney ammoniagenesis and because a low urine pH is the main factor of uric acid (UA) stone formation, it was hypothesized that type 2 diabetes should favor the formation of UA stones. Uric Acid 204-213 insulin Homo sapiens 8-15 17978310-1 2007 Elevated serum uric acid level is associated with obesity, insulin resistance, diabetes, nephropathy, and hypertension. Uric Acid 15-24 insulin Homo sapiens 59-66 18218233-0 2007 [A prospective study on relationship between blood uric acid levels, insulin sensitivity and insulin resistance]. Uric Acid 51-60 insulin Homo sapiens 69-76 18218233-0 2007 [A prospective study on relationship between blood uric acid levels, insulin sensitivity and insulin resistance]. Uric Acid 51-60 insulin Homo sapiens 93-100 18218233-1 2007 OBJECTIVE: To assess the effect of the serum uric acid (UA) on insulin resistance (IR). Uric Acid 45-54 insulin Homo sapiens 63-70 18218233-1 2007 OBJECTIVE: To assess the effect of the serum uric acid (UA) on insulin resistance (IR). Uric Acid 56-58 insulin Homo sapiens 63-70 17552288-6 2007 Multiple logistic regression analysis showed that insulin resistance as evaluated by fasting insulin, sigma insulin during OGTT, HOMA-IR, insulin sensitivity index, the levels of uric acid, fasting glucose, systolic blood pressure and maximal oxygen uptake were independently associated with ST segment depression. Uric Acid 179-188 insulin Homo sapiens 50-57 17721747-0 2007 Serum uric acid shows a J-shaped trend with coronary mortality in non-insulin-dependent diabetic elderly people. Uric Acid 6-15 insulin Homo sapiens 70-77 17512306-2 2007 In addition, this study explores the relationship between UA and insulin resistance and serum leptin levels in metabolic syndrome. Uric Acid 58-60 insulin Homo sapiens 65-72 17512306-12 2007 Uric acid appeared to be better correlated with Tg, blood pressure (both systolic and diastolic), obesity, immunoreactive insulin, and HOMA-IR. Uric Acid 0-9 insulin Homo sapiens 122-129 16775030-2 2006 Because insulin resistance, characteristic of the metabolic syndrome and type 2 diabetes, results in lower urine pH through impaired kidney ammoniagenesis and because a low urine pH is the main factor of uric acid (UA) stone formation, it was hypothesized that type 2 diabetes should favor the formation of UA stones. Uric Acid 215-217 insulin Homo sapiens 8-15 16775030-2 2006 Because insulin resistance, characteristic of the metabolic syndrome and type 2 diabetes, results in lower urine pH through impaired kidney ammoniagenesis and because a low urine pH is the main factor of uric acid (UA) stone formation, it was hypothesized that type 2 diabetes should favor the formation of UA stones. Uric Acid 307-309 insulin Homo sapiens 8-15 16831320-1 2006 OBJECTIVE: To study the islet beta-cell function in patients with simple hyperuricemia (HUA) and to explore the relationship between the level of serum uric acid and insulin resistance. Uric Acid 152-161 insulin Homo sapiens 166-173 16831320-7 2006 CONCLUSION: The islet beta-cell function in hyperuricemic patients increases compensatively and the serum uric acid level is positively correlated with insulin resistance. Uric Acid 106-115 insulin Homo sapiens 152-159 16505518-6 2006 RESULTS: Significant genetic correlations were detected among BMI, waist circumference, HDL cholesterol, triglycerides, insulin, and plasminogen activator inhibitor-1 antigen and between uric acid and all of the above variables except insulin. Uric Acid 187-196 insulin Homo sapiens 120-127 16785612-7 2006 However, the high insulin response group was associated with higher BMI, subcutanesous fat area, uric acid levels, HOMA-beta cell values, and delta insulin/delta glucose (30 min) than the low insulin response group. Uric Acid 97-106 insulin Homo sapiens 18-25 16932373-3 2005 We recently reported that uric acid reduces levels of endothelial nitric oxide (NO), a key mediator of insulin action. Uric Acid 26-35 insulin Homo sapiens 103-110 16202255-7 2005 CONCLUSIONS: Serum uric acid level was strongly associated with triglyceride independent of age, genders, smoking, alcohol consumption, obesity and insulin resistance. Uric Acid 19-28 insulin Homo sapiens 148-155 16140208-0 2005 Insulin neuroprotection against oxidative stress in cortical neurons--involvement of uric acid and glutathione antioxidant defenses. Uric Acid 85-94 insulin Homo sapiens 0-7 16140208-6 2005 Oxidative stress-induced decreases in intracellular uric acid and GSH/GSSG levels were largely prevented upon treatment with insulin. Uric Acid 52-61 insulin Homo sapiens 125-132 16140208-7 2005 Inhibition of phosphatidylinositol-3-kinase (PI-3K) or mitogen-induced extracellular kinase (MEK) reversed the effect of insulin on uric acid and GSH/GSSG, suggesting the activation of insulin-mediated signaling pathways. Uric Acid 132-141 insulin Homo sapiens 121-128 16041161-7 2005 CONCLUSIONS: Serum uric acid concentration was found to be independently correlated with hypertension, insulin resistance and the risk factors of metabolic syndrome. Uric Acid 19-28 insulin Homo sapiens 103-110 15838747-0 2005 Elevated serum uric acid levels in gestational hypertension are correlated with insulin resistance. Uric Acid 15-24 insulin Homo sapiens 80-87 15781018-3 2005 Mean serum levels of uric acid were higher in those who had an abnormal ratio of >/=3 for triglyceride to high-density lipoprotein (suggesting insulin resistance) than in those who had a normal ratio (6.6 +/- 1.2 vs 5.87 +/- 1 mg/dl, p <0.001). Uric Acid 21-30 insulin Homo sapiens 146-153 16041161-0 2005 Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. Uric Acid 27-36 insulin Homo sapiens 55-62 15838747-1 2005 The purpose of this study was to assess a possible correlation between insulin resistance and uric acid levels in gestational hypertension (GH) and preeclampsia. Uric Acid 94-103 insulin Homo sapiens 71-78 15838747-9 2005 The elevated serum uric acid levels were highly correlated to insulin resistance in patients with GH. Uric Acid 19-28 insulin Homo sapiens 62-69 15838747-11 2005 Insulin resistance is associated with the elevated uric acid levels found in nonproteinuric gestational hypertensive disease. Uric Acid 51-60 insulin Homo sapiens 0-7 15562214-4 2004 Levels of ferritin, uric acid, white cell counts, fibrinogen, and C-reactive protein were significantly higher in individuals with a higher HOMA of insulin resistance (HOMA-IR). Uric Acid 20-29 insulin Homo sapiens 148-155 15571230-1 2004 We have examined whether hyperuricemia in essential hypertension may be related to an increased insulin secretion thereby enhancing the tubular reabsorption of sodium and thus uric acid. Uric Acid 176-185 insulin Homo sapiens 96-103 15459594-6 2004 RESULTS: Baseline serum uric acid levels correlated positively with the body mass index, serum insulin, creatinine, and triglyceride levels and inversely with serum HDL cholesterol levels. Uric Acid 24-33 insulin Homo sapiens 95-102 15571230-5 2004 These results suggest that insulin may mediate uric acid underexcretion due to its tubular sodium retaining effect in essential hypertensive patients. Uric Acid 47-56 insulin Homo sapiens 27-34 15206151-3 2004 Hyperinsulinemia induced by insulin resistance reduces uric acid clearance, leading to hyperuricemia. Uric Acid 55-64 insulin Homo sapiens 5-12 15202612-5 2004 RECENT FINDINGS: Epidemiological and metabolic studies have indicated an association between uric acid nephrolithiasis and insulin resistance. Uric Acid 93-102 insulin Homo sapiens 123-130 15086484-2 2004 Uric acid nephrolithiasis, a condition associated with a low urinary pH, has been linked to obesity and insulin resistance. Uric Acid 0-9 insulin Homo sapiens 104-111 15086484-11 2004 The results confirm the previously proposed scheme that obesity may sometimes cause uric acid nephrolithiasis by producing excessively acid urine due to insulin resistance. Uric Acid 84-93 insulin Homo sapiens 153-160 12629726-0 2003 [Effect of hyperglycemia and insulin resistance on serum uric acid]. Uric Acid 57-66 insulin Homo sapiens 29-36 14717908-3 2004 This study was designed to evaluate if insulin resistance is associated with excessively low urinary pH in overtly healthy volunteers (non-stone formers) and if insulin resistance may explain the excessively low urinary pH in patients with uric acid nephrolithiasis. Uric Acid 240-249 insulin Homo sapiens 161-168 14717908-8 2004 In addition to the previously described acidic urine pH and hypouricosuria, patients with recurrent uric acid nephrolithiasis were found to be severely insulin resistant (glucose disposal rate: uric acid stone-formers vs. normals; 4.1 +/- 1.3 vs. 6.9 +/- 2.1 mg/min/kg of lean body mass, P= 0.008). Uric Acid 100-109 insulin Homo sapiens 152-159 14717908-8 2004 In addition to the previously described acidic urine pH and hypouricosuria, patients with recurrent uric acid nephrolithiasis were found to be severely insulin resistant (glucose disposal rate: uric acid stone-formers vs. normals; 4.1 +/- 1.3 vs. 6.9 +/- 2.1 mg/min/kg of lean body mass, P= 0.008). Uric Acid 194-203 insulin Homo sapiens 152-159 14871461-1 2004 BACKGROUND: In some western populations, increased serum uric acid has been positively associated with cardiovascular disease, possibly because hyperuricaemia could be an untoward part of the insulin-resistant metabolic syndrome. Uric Acid 57-66 insulin Homo sapiens 192-199 12732400-7 2003 Serum uric acid concentrations were higher in hypertensives with PAD (404+/-101 vs. 347+/-80 micromol/l, P<0.001) independent of components of the metabolic syndrome (body mass index, triglycerides, insulin) and of age, gender, diabetes mellitus, pulse pressure, cholesterol, C-reactive protein, and treatment. Uric Acid 6-15 insulin Homo sapiens 202-209 12238635-1 2002 The serum uric acid level has been said to be an independent predictor of cardiovascular disease death, mainly for women, and to be linked with the metabolic Syndrome X of insulin resistance, obesity, hypertension, and dyslipidemia. Uric Acid 10-19 insulin Homo sapiens 172-179 12474637-5 2002 A novel renal manifestation of insulin resistance is a mild defect in ammonium excretion, which is not severe enough to disturb acid-base homeostasis, but is sufficient to set up the chemical milieu for uric acid nephrolithiasis. Uric Acid 203-212 insulin Homo sapiens 31-38 12160192-0 2002 Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. Uric Acid 19-28 insulin Homo sapiens 48-55 12160192-8 2002 CONCLUSIONS: The amelioration of insulin resistance by either a low-energy diet or troglitazone decreased the serum UA level in overweight hypertensive patients. Uric Acid 116-118 insulin Homo sapiens 33-40 12160192-9 2002 Insulin resistance or hyperinsulinemia, independent of body weight and BP, may play an important role in UA metabolism in multiple risk factor syndrome. Uric Acid 105-107 insulin Homo sapiens 0-7 12081231-5 2002 From these results, we speculated that octreotide acetate decreases the urinary excretion of uric acid by decreasing the concentration of glucagon and/or urinary excretion of sodium, and increases the plasma concentration of uridine via decreased concentrations of glucagon and insulin. Uric Acid 93-102 insulin Homo sapiens 278-285 11990393-10 2002 05) with increasing body mass index, fasting insulin, alanine transaminase, uric acid, triglycerides and gammaglutamyltranspeptidase; it decreased with increasing transferrin and quantitative insulin sensitivity check index. Uric Acid 76-85 insulin Homo sapiens 192-199 11990393-12 2002 CONCLUSIONS: Fasting insulin and serum uric acid levels indicating insulin resistance, but not indices of iron overload, are independent predictors of non-alcoholic fatty liver disease. Uric Acid 39-48 insulin Homo sapiens 67-74 11887176-3 2002 Our study aimed to establish the relationship between uric acid (avoiding the interference of high triglyceride levels), insulin sensitivity, and components of the metabolic syndrome in a group of subjects at high risk of developing DM. Uric Acid 54-63 insulin Homo sapiens 121-128 10189006-4 1999 Insulin was positively associated with the female sex, height, body mass index, waist-to-hip ratio, serum triglyceride, total cholesterol, uric acid, and fasting plasma glucose, and was negatively associated with age, smoking, and high-density lipoprotein cholesterol. Uric Acid 139-148 insulin Homo sapiens 0-7 11296961-0 2001 Gender differences in the relationships of serum uric acid with fasting serum insulin and plasma glucose in patients without diabetes. Uric Acid 49-58 insulin Homo sapiens 78-85 11296961-1 2001 OBJECTIVE: To explore gender differences in the relationship of serum uric acid levels with fasting serum insulin and fasting plasma glucose concentrations among an adult Chinese nondiabetic population in Kinmen, Taiwan. Uric Acid 70-79 insulin Homo sapiens 106-113 11296961-8 2001 Elevated levels of uric acid should alert physicians to the possibility of insulin resistance. Uric Acid 19-28 insulin Homo sapiens 75-82 11296961-9 2001 The serum uric acid level was associated with insulin resistance and plasma glucose levels more strongly in females than in males in our study population. Uric Acid 10-19 insulin Homo sapiens 46-53 11079811-5 2000 This 8-year longitudinal study demonstrates that dyslipidemia, high blood pressure, and uric acid are associated with insulin resistance, whereas high systolic blood pressure and VLDL cholesterol are associated with impaired first-phase insulin secretion. Uric Acid 88-97 insulin Homo sapiens 118-125 10707571-4 2000 It is of interest to examine the effects of insulin sensitizer which was developed recently on serum urate concentration because it may provide a new idea as to the mechanism of the association between IR, hyperuricemia and vascular disorders. Uric Acid 101-106 insulin Homo sapiens 44-51 10583426-10 1999 In the kidney, insulin spares sodium and uric acid from excretion; in chronic hyperinsulinaemic states, these effects may contribute to high blood pressure and hyperuricaemia. Uric Acid 41-50 insulin Homo sapiens 15-22 10419058-6 1999 Selective insulin resistance and hyperinsulinism estimulates the tubular sodium-hydrogen exchanger and facilitates the active reabsorption of urate. Uric Acid 142-147 insulin Homo sapiens 10-17 10075379-6 1999 In normotensive subjects, serum uric acid, which is known to be related to sodium handling at renal tubules of microalbuminuria-positive subjects, was significantly higher than those of microalbuminuria negative subjects as well as triglycerides and area of insulin, without the differences of the levels of blood pressure and BMI. Uric Acid 32-41 insulin Homo sapiens 258-265 9539195-6 1998 In the whole dataset, insulin resistance was directly related to BMI, the waist-to-hip ratio (WHR), endogenous glucose production, insulin secretion, and fasting serum triglycerides and uric acid concentrations. Uric Acid 186-195 insulin Homo sapiens 22-29 9627362-9 1998 Diversion of glycolytic intermediates toward R-5-P, PPRP, and uric acid will follow if there is diminished activity of glyceraldehyde-3-phosphate dehydrogenase (GA3PDH), which is regulated by insulin. Uric Acid 62-71 insulin Homo sapiens 192-199 9886724-9 1998 In stepwise regression analyses, serum uric acid emerged as the strongest predictor of ICAM-1, interleukin-6, TNF, sTNFR1 and sTNFR2, independent of diuretic dose, age, body mass index, alcohol intake, serum creatinine, plasma insulin and glucose, and insulin sensitivity. Uric Acid 39-48 insulin Homo sapiens 227-234 9886724-9 1998 In stepwise regression analyses, serum uric acid emerged as the strongest predictor of ICAM-1, interleukin-6, TNF, sTNFR1 and sTNFR2, independent of diuretic dose, age, body mass index, alcohol intake, serum creatinine, plasma insulin and glucose, and insulin sensitivity. Uric Acid 39-48 insulin Homo sapiens 252-259 9461318-4 1998 RESULTS: In univariate analyses the concentration of fasting serum uric acid was negatively correlated to the insulin sensitivity index in both men (r2 = -0.25, P = 0.001) and women (r2 = -0.25, P < 0.001). Uric Acid 67-76 insulin Homo sapiens 110-117 9152657-10 1997 In multivariate regression analysis, serum uric acid concentrations emerged as a significant predictor of MVO2, exercise time (both P < 0.001,) VE-VCO2 slope and NYHA functional class (both P < 0.02), independent of diuretic dose, age, body mass index, serum creatinine, alcohol intake, plasma insulin levels, and insulin sensitivity index. Uric Acid 43-52 insulin Homo sapiens 300-307 9398143-5 1997 More specifically, there is evidence to support the hypothesis that elevated plasma insulin concentrations may enhance renal sodium retention and decrease urinary uric acid clearance. Uric Acid 163-172 insulin Homo sapiens 84-91 9290400-9 1997 In stepwise regression analysis, uric acid emerged as the only predictor of maximum blood flow (standardised coefficient = -0.83 (P < 0.001), R2 = 0.68 (P < 0.001)), independently of diuretic dose, age, body mass index, plasma creatinine, fasting and IVGTT glucose and insulin, insulin sensitivity, maximum oxygen uptake and exercise time during the treadmill exercise test, and alcohol intake. Uric Acid 33-42 insulin Homo sapiens 275-282 9377725-8 1997 Insulin antinatriuresis is accompanied by a reduction in the urinary excretion of uric acid. Uric Acid 82-91 insulin Homo sapiens 0-7 9237784-4 1997 C-peptide levels were significantly (P < 0.05) correlated with systolic (r = 0.21) and diastolic blood pressure (r = 0.19), BMI (r = 0.21), high density lipoprotein (HDL) (r = -0.22), non-HDL-cholesterol (r = 0.23), apolipoprotein B (r = 0.29), log of triglycerides (r = 0.39) and uric acid (r = 0.35). Uric Acid 284-293 insulin Homo sapiens 0-9 9237784-5 1997 The C-peptide/bloodsugar ratio had statistically significant correlations with known duration of diabetes (r = -0.23), diastolic blood pressure (r = 0.21), body mass index (BMI) (r = 0.22), log of triglycerides (r = 0.23) and uric acid (r = 0.36). Uric Acid 226-235 insulin Homo sapiens 4-13 9472456-6 1997 RESULTS: There was a significant correlation between elevated "true" fasting serum insulin level and various constituents of the insulin resistance syndrome, such as obesity, dyslipidemia (hypertriglyceridemia, increased apolipoprotein B and decreased high-density lipoprotein cholesterol and apolipoprotein A1 concentrations), increased serum glucose, uric acid levels, and plasminogen activator inhibitor type I concentration, as well as increased frequency of diabetes. Uric Acid 353-362 insulin Homo sapiens 83-90 9152657-10 1997 In multivariate regression analysis, serum uric acid concentrations emerged as a significant predictor of MVO2, exercise time (both P < 0.001,) VE-VCO2 slope and NYHA functional class (both P < 0.02), independent of diuretic dose, age, body mass index, serum creatinine, alcohol intake, plasma insulin levels, and insulin sensitivity index. Uric Acid 43-52 insulin Homo sapiens 320-327 10374288-8 1997 The insulin resistance was positively correlated with serum uric acid in women (P < 0.05), but not in men (P > 0.05). Uric Acid 60-69 insulin Homo sapiens 4-11 8923153-10 1996 In multivariate regression analysis, serum triglycerides, BMI and WHR (at borderline significance) were independent positive predictors of uric acid (R2 of the model 0.122, P < 0.001), while fasting insulin concentration did not give any independent contribution to explain the variability uric acid levels. Uric Acid 139-148 insulin Homo sapiens 202-209 9088862-6 1997 Multiple linear regression analysis confirmed that plasma insulin was independently correlated with plasma triglycerides and, to a lesser extent, with blood pressure and uric acid concentration. Uric Acid 170-179 insulin Homo sapiens 58-65 8981120-1 1996 Recently, an inverse correlation between serum uric acid concentrations and insulin sensitivity has been described in subjects with varying degrees of metabolic syndrome, suggesting that measurement of serum uric acid may provide a simple marker of insulin resistance. Uric Acid 47-56 insulin Homo sapiens 76-83 8981120-1 1996 Recently, an inverse correlation between serum uric acid concentrations and insulin sensitivity has been described in subjects with varying degrees of metabolic syndrome, suggesting that measurement of serum uric acid may provide a simple marker of insulin resistance. Uric Acid 208-217 insulin Homo sapiens 76-83 8986933-15 1996 The changes in the lipid profile and in uric acid levels paralleled the changes in insulin sensitivity. Uric Acid 40-49 insulin Homo sapiens 83-90 8976106-2 1996 Several clinical studies revealed that insulin resistance and/or hyperinsulinaemia is associated with hypertension and higher plasma concentrations of uric acid, triglyceride and plasminogen activator inhibitor 1 and with lower HDL cholesterol concentrations. Uric Acid 151-160 insulin Homo sapiens 39-46 8976108-2 1996 Our data showed a low, but significant correlation between serum uric acid concentration and the degree of insulin resistance (GIR) estimated by euglycemic hyperinsulinemic clamp method in 67 subjects with combined normal glucose tolerance and IGT(r = -0.278, p < 0.05). Uric Acid 65-74 insulin Homo sapiens 107-114 8981120-1 1996 Recently, an inverse correlation between serum uric acid concentrations and insulin sensitivity has been described in subjects with varying degrees of metabolic syndrome, suggesting that measurement of serum uric acid may provide a simple marker of insulin resistance. Uric Acid 208-217 insulin Homo sapiens 249-256 8981120-7 1996 Serum uric acid concentrations were inversely related to serum hormone-binding globulin (SHBG) concentrations, and positively with body mass index (BMI), insulin concentrations and testosterone:SHBG ratio in the PCOS group. Uric Acid 6-15 insulin Homo sapiens 154-161 8862220-0 1996 Effect of insulin on renal sodium and uric acid handling in essential hypertension. Uric Acid 38-47 insulin Homo sapiens 10-17 8923162-4 1996 In conclusion, in this group of subjects the serum uric acid values were directly related to insulin resistance independently of age, sex, excess body weight, fat distribution and blood pressure. Uric Acid 51-60 insulin Homo sapiens 93-100 8959528-0 1996 The relationship between insulin, glucose and serum uric acid and their contribution to the progression of renal damage in patients with primary glomerulonephritis. Uric Acid 52-61 insulin Homo sapiens 25-32 8862220-9 1996 Insulin-induced changes in urate excretion were coupled (r = 0.55, P < .0001) to the respective changes in sodium excretion. Uric Acid 27-32 insulin Homo sapiens 0-7 8862220-10 1996 In hypertensive patients, higher uric acid levels and lower renal urate clearance rates cluster with insulin resistance and dyslipidemia. Uric Acid 33-42 insulin Homo sapiens 101-108 8862220-10 1996 In hypertensive patients, higher uric acid levels and lower renal urate clearance rates cluster with insulin resistance and dyslipidemia. Uric Acid 66-71 insulin Homo sapiens 101-108 8876844-7 1996 The uric acid level was positively correlated in both sexes with a variety of health-related factors, most notably body mass index, creatinine, triglycerides, diuretic use, alcohol intake, hypertension, diabetes, and insulin levels. Uric Acid 4-13 insulin Homo sapiens 217-224 7484901-3 1995 After we classified patients according to the quartiles of serum insulin level, we noted in the top quartile the presence of practically all manifestations of insulin resistance syndrome in persons of both sexes (e.g., increased waist/hip ratio, body mass index, glucose, uric acid, triglycerides, apolipoprotein B and decreased high-density lipoprotein cholesterol levels as well as apolipoprotein A-I/B ratios, and so forth). Uric Acid 272-281 insulin Homo sapiens 65-72 7557840-8 1995 The levels of serum UA (p < 0.001) and serum triglycerides (TG) (p < 0.01) in the subgroup with hyperinsulinemia were significantly higher than in the subgroup with normal insulin levels. Uric Acid 20-22 insulin Homo sapiens 107-114 8866908-7 1995 In the insulin-resistant group, 50% showed elevated levels of serum triglycerides (> 2.0 mmol/l), 50% had abdominal obesity (waist:hip ratio > 0.95), 20% had elevated levels of serum uric acid (> 400 mumol/l) and 48% had low high-density lipid (HDL)-cholesterol levels (< 1.0 mmol/l). Uric Acid 189-198 insulin Homo sapiens 7-14 7557840-9 1995 By linear regression analyses, the serum UA concentration was positively correlated with peak plasma insulin level (r = 0.31, p < 0.001), and BMI (r = 0.20, p < 0.01), but not with age, DOI, or peak glucose. Uric Acid 41-43 insulin Homo sapiens 101-108 7918315-6 1994 Fasting insulin concentration was significantly associated with levels of glucose, triglycerides, uric acid, serum albumin, creatinine, and fibrinogen as well as resting heart rate. Uric Acid 98-107 insulin Homo sapiens 8-15 7723681-3 1995 However, data on the effects of nibbling on serum lipids throughout the day are not available, nor is it known how nibbling affects serum uric acid as a further insulin-related risk factor for cardiovascular disease. Uric Acid 138-147 insulin Homo sapiens 161-168 7840165-0 1995 Effect of insulin on uric acid excretion in humans. Uric Acid 21-30 insulin Homo sapiens 10-17 7840165-1 1995 Although hyperuricemia is a frequent finding in insulin-resistant states, insulin"s effect on renal uric acid (UA) handling is not known. Uric Acid 100-109 insulin Homo sapiens 74-81 7840165-1 1995 Although hyperuricemia is a frequent finding in insulin-resistant states, insulin"s effect on renal uric acid (UA) handling is not known. Uric Acid 111-113 insulin Homo sapiens 74-81 7840165-2 1995 In 20 healthy volunteers, diastolic blood pressure, body weight, and fasting plasma insulin were positively (and age was negatively) related to fasting plasma UA concentrations, together accounting for 53% of their variability. Uric Acid 159-161 insulin Homo sapiens 84-91 7840165-6 1995 Fractional UA excretion was related to Na fractional excretion under basal conditions (r = 0.59, P < 0.01) and during the insulin period (r = 0.53, P < 0.02). Uric Acid 11-13 insulin Homo sapiens 125-132 7840165-7 1995 Furthermore, the insulin-induced changes in fractional UA and Na excretion correlated with one another (r = 0.66, P < 0.001). Uric Acid 55-57 insulin Homo sapiens 17-24 8205270-6 1994 (Means for cases versus controls: 16.8 and 16.6 microU/mL), although serum insulin showed significant correlations with low-density-lipoprotein cholesterol, triglycerides, and uric acid. Uric Acid 176-185 insulin Homo sapiens 75-82 7937426-3 1994 Positive associations were found between serum uric acid concentration and body mass index, waist hip ratio, systolic and diastolic blood pressure, urea, creatinine, protein, glucose (fasting and 2 hours after 75 g oral glucose load), 2 hour insulin, triglycerides, and apolipoprotein B in men. Uric Acid 47-56 insulin Homo sapiens 242-249 1362115-5 1992 From simple linear regression analysis, female gender, high BMI and elevated triglyceride and uric acid levels were correlated with insulin levels (p < 0.05). Uric Acid 94-103 insulin Homo sapiens 132-139 8288709-4 1994 In simple linear regression analysis, the serum uric acid concentration (range, 182-568 mumol/L) was inversely correlated with insulin sensitivity (rate of glucose utilization; r = -0.61; P < 0.001) and positively with serum triglycerides (r = 0.68; P < 0.001), but not with body mass index, age, or the plasma glucose concentration. Uric Acid 48-57 insulin Homo sapiens 127-134 8288709-5 1994 In multiple linear regression analysis, both insulin sensitivity (P < 0.05) and serum triglycerides (P < 0.005) were independently associated with the serum uric acid concentration, and together explained 50% of its variation. Uric Acid 163-172 insulin Homo sapiens 45-52 34313822-4 2022 High UA concentrations decrease insulin-induced NO synthesis within the endothelial cells by interfering with insulin signaling at either the receptor or post-receptor levels (i.e., proximal and distal steps). Uric Acid 5-7 insulin Homo sapiens 32-39 1820474-0 1991 Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. Uric Acid 108-117 insulin Homo sapiens 35-42 1820474-1 1991 OBJECTIVE: To define the relationship, if any, between insulin-mediated glucose disposal and serum uric acid. Uric Acid 99-108 insulin Homo sapiens 55-62 1820474-6 1991 RESULTS: Magnitude of insulin resistance and serum uric acid concentration were significantly related (r = .69; P less than .001), and the relationship persisted when differences in age, sex, overall obesity, and abdominal obesity were taken into account (r = .57; P less than .001). Uric Acid 51-60 insulin Homo sapiens 22-29 1820474-7 1991 Insulin resistance was also inversely related to urinary uric acid clearance (r = -.49; P less than .002), and, in addition, urinary uric acid clearance was inversely related to serum uric acid concentration (r = -.61; P less than .001). Uric Acid 57-66 insulin Homo sapiens 0-7 1820474-8 1991 CONCLUSIONS: Urinary uric acid clearance appears to decrease in proportion to increases in insulin resistance in normal volunteers, leading to an increase in serum uric acid concentration. Uric Acid 21-30 insulin Homo sapiens 91-98 1820474-8 1991 CONCLUSIONS: Urinary uric acid clearance appears to decrease in proportion to increases in insulin resistance in normal volunteers, leading to an increase in serum uric acid concentration. Uric Acid 164-173 insulin Homo sapiens 91-98 1771807-9 1991 The higher blood pressure levels were associated also with other manifestations of insulin resistance, i.e. elevated triacylglycerols, low HDL cholesterol levels, raised uric acid levels. Uric Acid 170-179 insulin Homo sapiens 83-90 33770169-0 2021 Genetic Predisposition to Type 2 Diabetes and Insulin Levels is Positively Associated with Serum Urate Levels. Uric Acid 97-102 insulin Homo sapiens 46-53 33770169-7 2021 RESULTS: Genetic predisposition to higher risk of T2D (beta=0.042; 95% CI=0.016-0.068; p=0.002) and higher levels of fasting insulin (beta=0.756; 95% CI=0.408-1.102; p=1.96e-05) were significantly associated with increased serum urate concentrations. Uric Acid 229-234 insulin Homo sapiens 125-132 33770169-10 2021 CONCLUSIONS: This study provides supportive evidence on causal associations of T2D and fasting insulin with serum urate concentrations, and suggestive association of fasting insulin with risk of gout. Uric Acid 114-119 insulin Homo sapiens 95-102 34848368-0 2022 Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages. Uric Acid 33-42 insulin Homo sapiens 51-58 34313822-4 2022 High UA concentrations decrease insulin-induced NO synthesis within the endothelial cells by interfering with insulin signaling at either the receptor or post-receptor levels (i.e., proximal and distal steps). Uric Acid 5-7 insulin Homo sapiens 110-117 34313822-5 2022 At the proximal post-receptor level, UA impairs the function of the insulin receptor substrate (IRS) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) in the insulin signaling pathway. Uric Acid 37-39 insulin Homo sapiens 172-179 34313822-7 2022 Clinically, UA-induced endothelial insulin resistance is translated into impaired endothelial function, impaired NO-dependent vasodilation, and the development of systemic insulin resistance. Uric Acid 12-14 insulin Homo sapiens 35-42 34313822-7 2022 Clinically, UA-induced endothelial insulin resistance is translated into impaired endothelial function, impaired NO-dependent vasodilation, and the development of systemic insulin resistance. Uric Acid 12-14 insulin Homo sapiens 172-179 34820139-0 2021 Serum Uric Acid Is Associated with Metabolic Syndrome and Insulin Resistance among Health Personnel from Peru. Uric Acid 6-15 insulin Homo sapiens 58-65 34925239-0 2021 Obesity-Induced Insulin Resistance Is Mediated by High Uric Acid in Obese Children and Adolescents. Uric Acid 55-64 insulin Homo sapiens 16-23 34925239-1 2021 Objective: This study aimed to evaluate whether serum uric acid (SUA) plays a mediating role in the development of insulin resistance (IR) in obese children and adolescents. Uric Acid 54-63 insulin Homo sapiens 115-122 34820139-1 2021 We explored the association between serum uric acid (SUA) and metabolic syndrome (MetS) and insulin resistance (IR) among health personnel from a public hospital in Peru in a cross-sectional study with data from the Plan for the Prevention and Surveillance of Communicable and Noncommunicable Diseases of Huaycan Hospital. Uric Acid 42-51 insulin Homo sapiens 92-99 34331525-8 2021 Uric acid levels were significantly correlated with BMI (r=0.527), waist circumference (r=0.580), SBP (r=0.497), DBP (r=0.362), TG (r=0.534), total cholesterol (r=0.416), LDLc (r=0.286), HDLc (r=-0.248), insulin (r=0.613), and HOMA-IR index (r=0.607). Uric Acid 0-9 insulin Homo sapiens 204-211 34408667-0 2021 Genetic and Physiological Effects of Insulin on Human Urate Homeostasis. Uric Acid 54-59 insulin Homo sapiens 37-44 34408667-1 2021 Insulin and hyperinsulinemia reduce renal fractional excretion of urate (FeU) and play a key role in the genesis of hyperuricemia and gout, via uncharacterized mechanisms. Uric Acid 66-71 insulin Homo sapiens 0-7 34408667-2 2021 To explore this association further we studied the effects of genetic variation in insulin-associated pathways on serum urate (SU) levels and the physiological effects of insulin on urate transporters. Uric Acid 182-187 insulin Homo sapiens 171-178 34408667-3 2021 We found that urate-associated variants in the human insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 (IRS1) loci associate with the expression of the insulin-like growth factor 2, IRS1, INSR, and ZNF358 genes; additionally, we found genetic interaction between SLC2A9 and the three loci, most evident in women. Uric Acid 14-19 insulin Homo sapiens 53-60 34408667-4 2021 We also found that insulin stimulates the expression of GLUT9 and increases (14C)-urate uptake in human proximal tubular cells (PTC-05) and HEK293T cells, transport activity that was effectively abrogated by uricosurics or inhibitors of protein tyrosine kinase (PTK), PI3 kinase, MEK/ERK, or p38 MAPK. Uric Acid 82-87 insulin Homo sapiens 19-26 34836102-11 2021 "Metabolically healthy" patients, but with insulin resistance, had higher blood pressure, glucose, uric acid and triglyceride levels than those without insulin resistance (all p < 0.05). Uric Acid 99-108 insulin Homo sapiens 43-50 34148058-0 2021 Mediating effects of insulin resistance on the development of hypertension associated with elevated serum uric acid: a prospective cohort study. Uric Acid 106-115 insulin Homo sapiens 21-28 34148058-2 2021 However, the role of insulin resistance in the relationship between serum uric acid and hypertension is still unelucidated. Uric Acid 74-83 insulin Homo sapiens 21-28 34148058-3 2021 Based on a prospective cohort study, we aimed to examine the longitudinal link between serum uric acid and hypertension and whether this relationship was mediated by insulin resistance. Uric Acid 93-102 insulin Homo sapiens 166-173 34148058-5 2021 Adjusted Cox-regression analyses and mediation analyses were performed to assess the risk of hypertension by serum uric acid quartile distribution and whether insulin resistance mediated the association between serum uric acid and hypertension. Uric Acid 217-226 insulin Homo sapiens 159-166 34148058-11 2021 Elevated serum uric acid levels are associated with an increased risk of incident hypertension, and insulin resistance may play a mediating role in the relationship between serum uric acid and hypertension. Uric Acid 179-188 insulin Homo sapiens 100-107 34163195-0 2021 The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study. Uric Acid 25-34 insulin Homo sapiens 63-70 34163195-3 2021 We aimed to investigate the association between SUA levels and insulin resistance and beta-cell dysfunction in individuals without diabetes, thus explicating the role of uric acid in the early stage of the natural history of type 2 diabetes. Uric Acid 170-179 insulin Homo sapiens 63-70 35185617-0 2022 The Association Between Physical Activity and Insulin Level Under Different Levels of Lipid Indices and Serum Uric Acid. Uric Acid 110-119 insulin Homo sapiens 46-53 34394285-0 2021 Uric acid lowering improves insulin sensitivity and lowers blood pressure: a meta-analysis of randomized parallel-controlled clinical trials. Uric Acid 0-9 insulin Homo sapiens 28-35 34394285-1 2021 Objectives: This meta-analysis aimed to investigate whether uric acid lowering treatment can improve beta-cell function and insulin sensitivity. Uric Acid 60-69 insulin Homo sapiens 124-131 34394285-8 2021 Conclusion: Uric acid-lowering therapies might improve insulin sensitivity and lower blood pressure, but had no significant effect on HOMA-beta and serum lipids. Uric Acid 12-21 insulin Homo sapiens 55-62 35591906-1 2022 Aim: The aim of this study was to investigate the association between serum uric acid (SUA) levels and four insulin resistance surrogates in patients with type 2 diabetes (T2DM). Uric Acid 76-85 insulin Homo sapiens 108-115 35001416-0 2022 Elevated serum uric acid is a facilitating mechanism for insulin resistance mediated accumulation of visceral adipose tissue. Uric Acid 15-24 insulin Homo sapiens 57-64 35001416-1 2022 OBJECTIVE: Serum uric acid (SUA) has been associated with cardiometabolic conditions such as insulin resistance (IR) and visceral adipose tissue (VAT) accumulation. Uric Acid 17-26 insulin Homo sapiens 93-100 35300582-12 2022 Triglyceride, uric acid, CRP, vitamin B12, and homeostatic model assessment of insulin resistance were found to be affected by high uric acid levels. Uric Acid 132-141 insulin Homo sapiens 79-86 35153251-0 2022 Correlation between serum C-peptide-releasing effects and the risk of elevated uric acid in type 2 diabetes mellitus. Uric Acid 79-88 insulin Homo sapiens 26-35 35153251-1 2022 Our study aimed to investigate the C-peptide-releasing effect associated with the risk of elevated serum uric acid (SUA) levels in patients with type 2 diabetes mellitus (T2DM). Uric Acid 105-114 insulin Homo sapiens 35-44 3548194-7 1987 As the insulin infusion progressed, the urea nitrogen, uric acid and bicarbonate levels fell as well. Uric Acid 55-64 insulin Homo sapiens 7-14 35001880-3 2022 RESULTS: serum uric acid, but not the serum uric acid/creatinine ratio, results strongly influenced by the number of cardiovascular risk factors and by the insulin resistance degree. Uric Acid 15-24 insulin Homo sapiens 156-163 3322912-1 1987 In a representative sample of the adult Jewish population in Israel (n = 1016) excluding known diabetic patients and individuals on antihypertensive medications, serum uric acid showed a positive association with plasma insulin response (sum of 1- and 2-hour post glucose load levels) in both males (r = 0.316, p less than 0.001) and females (r = 0.236, p less than 0.001). Uric Acid 168-177 insulin Homo sapiens 220-227 3322912-3 1987 The net portion of the variance of serum uric acid attributable to insulin response was 12% in males and 8% in females, the total variance accountable by all these variables being 17% and 19% respectively. Uric Acid 41-50 insulin Homo sapiens 67-74 35169393-4 2022 Results: Compared with the control group, the level values of serum c-peptide, sICAM-1, and IL-1beta were significantly higher in the case group (P < 0.001), with CSVD being the dependent variable, and age, smoking, uric acid, history of stroke, serum c-peptide, sICAM-1, and IL-1beta being the independent variables. Uric Acid 216-225 insulin Homo sapiens 68-77 2698352-0 1989 The insulin response to oral glucose, concentrations of total cholesterol, triglycerides and uric acid in women with idiopathic hirsutism. Uric Acid 93-102 insulin Homo sapiens 4-11 33986829-9 2021 The results demonstrated that UA treatment significantly reduced cell viability, increased cell apoptosis and reduced insulin secretion in Min6 cells compared with the control group. Uric Acid 30-32 insulin Homo sapiens 118-125 3899461-5 1985 The correlation of initial pressure with plasma insulin remained significant even when allowing for age, surface area, BMI, and plasma concentrations of glucose, urea, creatinine, sodium and urate. Uric Acid 191-196 insulin Homo sapiens 48-55 33986829-12 2021 In UA-treated pancreatic beta-cells, compared with the inhibitor control group, miR-770-5p knockdown regulated the expression of apoptosis-related genes, increased cell viability, inhibited cell apoptosis and increased insulin secretion by targeting BAG5. Uric Acid 3-5 insulin Homo sapiens 219-226 33886461-0 2022 The elevation of serum uric acid depends on insulin resistance but not fasting plasma glucose in hyperuricaemia. Uric Acid 23-32 insulin Homo sapiens 44-51 33218916-0 2021 Serum Uric Acid concentration is associated with insulin resistance and impaired insulin secretion in adults at risk for Type 2 Diabetes. Uric Acid 6-15 insulin Homo sapiens 49-56 33487257-3 2021 Furthermore, the association between uric acid levels and insulin resistance indexes was assessed. Uric Acid 37-46 insulin Homo sapiens 58-65 33487257-10 2021 A positive significant association between uric acid with insulin concentration and the homeostasis model assessment of insulin resistance (HOMA-IR) and an inverse significant relationship with insulin sensitivity (Quicki) were also found (p < 0.05). Uric Acid 43-52 insulin Homo sapiens 58-65 33487257-10 2021 A positive significant association between uric acid with insulin concentration and the homeostasis model assessment of insulin resistance (HOMA-IR) and an inverse significant relationship with insulin sensitivity (Quicki) were also found (p < 0.05). Uric Acid 43-52 insulin Homo sapiens 120-127 33487257-10 2021 A positive significant association between uric acid with insulin concentration and the homeostasis model assessment of insulin resistance (HOMA-IR) and an inverse significant relationship with insulin sensitivity (Quicki) were also found (p < 0.05). Uric Acid 43-52 insulin Homo sapiens 120-127 33487257-11 2021 CONCLUSION: Probiotic yogurt consumption through improvement in insulin sensitivity may exert positive effects on the oxidative stress and uric acid levels. Uric Acid 139-148 insulin Homo sapiens 64-71 33227361-0 2021 Association between Plasma Uric Acid and Insulin Resistance in Type 2 Diabetes: A Mendelian Randomization Analysis. Uric Acid 27-36 insulin Homo sapiens 41-48 32767109-1 2021 INTRODUCTION: This cross-sectional study investigates the association between insulin resistance (IR) and serum uric acid (sUA) and relative fat (RFM) and lean mass (RLM) profiles in children with chronic kidney disease (CKD). Uric Acid 112-121 insulin Homo sapiens 78-85 33551217-6 2021 RESULTS: HiFruD increased fasting uric acid (p < 0.05) and reduced fasting insulin sensitivity estimated by the homeostasis model assessment (HOMA) for insulin resistance (p < 0.05), in both groups. Uric Acid 34-43 insulin Homo sapiens 152-159 33545795-0 2021 Analysis of the correlation between plasma coagulation factor VII, PAI-1, and uric acid with insulin resistance and macrovascular complications in elderly patients with type 2 diabetes. Uric Acid 78-87 insulin Homo sapiens 93-100 33227361-1 2021 OBJECTIVE: Circulating uric acid levels were associated with insulin resistance, but the causality is unclear. Uric Acid 23-32 insulin Homo sapiens 61-68 33227361-2 2021 We aimed to investigate the association between plasma uric acid and insulin resistance in newly diagnosed type 2 diabetes (T2D). Uric Acid 55-64 insulin Homo sapiens 69-76 33227361-12 2021 CONCLUSIONS: Elevated plasma uric acid was associated with higher risk of insulin resistance, along with observation of gender difference in such association. Uric Acid 29-38 insulin Homo sapiens 74-81 33082244-1 2020 OBJECTIVE: Weight loss diets may reduce serum urate (SU) by lowering insulin resistance while providing cardiometabolic benefits, something urate-lowering drugs have not shown in trials. Uric Acid 46-51 insulin Homo sapiens 69-76 33368618-2 2021 Metabolic syndrome conditions, such as obesity, hypercholesterolemia, and insulin resistance, are believed to regulate the expression of uric acid transporters and decrease the excretion of uric acid. Uric Acid 137-146 insulin Homo sapiens 74-81 33368618-2 2021 Metabolic syndrome conditions, such as obesity, hypercholesterolemia, and insulin resistance, are believed to regulate the expression of uric acid transporters and decrease the excretion of uric acid. Uric Acid 190-199 insulin Homo sapiens 74-81 32772309-1 2020 INTRODUCTION: Hyperuricemia is related to health issues among children and adolescents, once the uric acid concentration is associated with metabolic syndrome, hypertension, insulin resistance, obesity, and dyslipidemia. Uric Acid 97-106 insulin Homo sapiens 174-181 33553022-0 2020 Preserved C-peptide secretion in patients with type 1 diabetes and incipient chronic complications is associated with lower serum resistin and higher uric acid levels. Uric Acid 150-159 insulin Homo sapiens 10-19 32623939-6 2020 In parallel, uric acid in addition to its pro-inflammatory effects, aggravates insulin resistance and hyperglycaemia, which worsen the process. Uric Acid 13-22 insulin Homo sapiens 79-86 33553022-5 2020 Results: C-peptide secretors had shorter diabetes duration (5.1 vs. 16 years; p < 0,001), lower resistin (4.53 vs. 4.93 mg/mL p = 0.045), and higher uric acid (259 vs 238 mumol/L, p = 0.048) level than T1DM patients with no detectable C-peptide levels, while no differences in routine anthropometric and laboratory variables, including HbA1c, were observed. Uric Acid 149-158 insulin Homo sapiens 9-18 33553022-7 2020 Conclusion: The results of our study revealed that patients with detectable C-peptide had lower resistin and higher uric acid level compared to patients with undetectable C-peptide. Uric Acid 116-125 insulin Homo sapiens 76-85 32825165-0 2020 Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance. Uric Acid 0-9 insulin Homo sapiens 65-72 32825165-2 2020 Uric acid may adversely affect the insulin signalling pathway inducing insulin resistance (IR). Uric Acid 0-9 insulin Homo sapiens 35-42 32825165-2 2020 Uric acid may adversely affect the insulin signalling pathway inducing insulin resistance (IR). Uric Acid 0-9 insulin Homo sapiens 71-78 32599713-2 2020 In the present review, we summarize experimental data on the potential biological mechanisms linking fructose and uric acid in the development of insulin resistance, metabolic syndrome, obesity, diabetes, hypertension, non-alcoholic fatty liver disease and chronic renal disease, thereby contributing to an increase in cardiovascular risk at pediatric age. Uric Acid 114-123 insulin Homo sapiens 146-153 33511070-15 2020 In addition, insulin resistance was observed more frequently in these patients compared to the general population, and insulin resistance was found to be associated with high BMI, hepatosteatosis rate, VLDL, TG, GGT, total protein, uric acid, TG/HDL ratio, and low HDL. Uric Acid 232-241 insulin Homo sapiens 119-126 31691260-6 2020 RESULTS: Uric acid was significantly and positively associated with blood pressure, BMI, waist circumference, insulin resistance, C-reactive protein and leptin (p < 0.01), while inversely with renal function (p = 0.01). Uric Acid 9-18 insulin Homo sapiens 110-117 31720687-0 2020 Changes Over Time in Uric Acid in Relation to Changes in Insulin Sensitivity, Beta-Cell Function, and Glycemia. Uric Acid 21-30 insulin Homo sapiens 57-64 31720687-3 2020 OBJECTIVE: To evaluate the impact of changes in uric acid over 2 years on changes in insulin sensitivity, beta-cell function, and glycemia in women with and without recent gestational diabetes (GDM), a model of the early natural history of T2DM. Uric Acid 48-57 insulin Homo sapiens 85-92 30868444-0 2020 Thyroid hormones modulate uric acid metabolism in patients with recent onset subclinical hypothyroidism by improving insulin sensitivity. Uric Acid 26-35 insulin Homo sapiens 117-124 32082372-9 2019 Conclusions: Our results indicate that insulin resistance is associated with plasma XOR activity and that relationship is independent of visceral adiposity and adiponectin level, suggesting that the development of insulin resistance resulting from increased visceral adiposity and/or reduced serum adiponectin contributes to increased uric acid production by stimulating XOR activity. Uric Acid 335-344 insulin Homo sapiens 39-46 32082372-9 2019 Conclusions: Our results indicate that insulin resistance is associated with plasma XOR activity and that relationship is independent of visceral adiposity and adiponectin level, suggesting that the development of insulin resistance resulting from increased visceral adiposity and/or reduced serum adiponectin contributes to increased uric acid production by stimulating XOR activity. Uric Acid 335-344 insulin Homo sapiens 214-221 31235151-0 2019 Relationship between insulin resistance, metabolic syndrome components and serum uric acid. Uric Acid 81-90 insulin Homo sapiens 21-28 31028067-0 2019 The Association between Serum Uric Acid Levels and Insulin Resistance and Secretion in Prediabetes Mellitus: A Cross-Sectional Study. Uric Acid 30-39 insulin Homo sapiens 51-58 30576922-4 2019 The reactive oxygen and nitrogen species and the uric acid derived from XOR concur to the development of hypertension, dyslipidemia and insulin resistance and participate in both cell transformation and proliferation, as well as in the progression and metastasis process. Uric Acid 49-58 insulin Homo sapiens 136-143 31235151-3 2019 Some research have reported relation between metabolic syndrome mediated by insulin resistance with increasing of serum uric acid level. Uric Acid 120-129 insulin Homo sapiens 76-83 31235151-4 2019 OBJECTIVE: Assess relationship between insulin resistance and metabolic syndrome components with the level of serum uric acid. Uric Acid 116-125 insulin Homo sapiens 39-46 31235151-10 2019 CONCLUSION: Insulin resistance is related to the incidence of MetS and in both of these circumstances an independent tendency is found to increase uric acid levels. Uric Acid 147-156 insulin Homo sapiens 12-19 29803897-5 2018 Evidence available also suggests an association between elevated UA and traditional cardiovascular risk factors, metabolic syndrome, insulin resistance, obesity, non-alcoholic fatty liver disease and chronic kidney disease. Uric Acid 65-67 insulin Homo sapiens 133-140 30469427-6 2018 UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. Uric Acid 0-2 insulin Homo sapiens 119-126 30068899-8 2018 Eleven of the 12 female subjects with high plasma XOR activity and a low uric acid level had liver dysfunction and/or insulin resistance. Uric Acid 73-82 insulin Homo sapiens 118-125 29803897-6 2018 Experimental and clinical studies have evidenced several mechanisms through which elevated UA level exerts deleterious effects on cardiovascular health including increased oxidative stress, reduced availability of nitric oxide and endothelial dysfunction, promotion of local and systemic inflammation, vasoconstriction and proliferation of vascular smooth muscle cells, insulin resistance and metabolic dysregulation. Uric Acid 91-93 insulin Homo sapiens 370-377 29916994-6 2018 A positive significant association between uric acid, and office, daytime and night-time SBP, insulin and triglycerides was observed. Uric Acid 43-52 insulin Homo sapiens 94-101 29916994-7 2018 When boys and girls were grouped by sex-specific uric acid tertiles, a progressive increment was observed in BMI, BMI z-score and waist circumference as well as fasting insulin and HOMA index. Uric Acid 49-58 insulin Homo sapiens 169-176 29916994-11 2018 CONCLUSION: The present study found a positive association between uric acid and blood pressure, insulin and triglycerides. Uric Acid 67-76 insulin Homo sapiens 97-104 29796661-1 2018 Objective: Insulin resistance is inversely correlated with the clearance rate of uric acid, which may indicate that improvement in the clearance rate of uric acid could reduce insulin resistance. Uric Acid 81-90 insulin Homo sapiens 11-18 29796661-1 2018 Objective: Insulin resistance is inversely correlated with the clearance rate of uric acid, which may indicate that improvement in the clearance rate of uric acid could reduce insulin resistance. Uric Acid 81-90 insulin Homo sapiens 176-183 29796661-1 2018 Objective: Insulin resistance is inversely correlated with the clearance rate of uric acid, which may indicate that improvement in the clearance rate of uric acid could reduce insulin resistance. Uric Acid 153-162 insulin Homo sapiens 11-18 29796661-1 2018 Objective: Insulin resistance is inversely correlated with the clearance rate of uric acid, which may indicate that improvement in the clearance rate of uric acid could reduce insulin resistance. Uric Acid 153-162 insulin Homo sapiens 176-183 29856171-9 2018 Insulin resistance is thought to alter the renal acid-base metabolism, resulting in a lower urine pH, and increasing the risk of uric acid stone disease. Uric Acid 129-138 insulin Homo sapiens 0-7 29774469-0 2018 Higher serum levels of uric acid are associated with a reduced insulin clearance in non-diabetic individuals. Uric Acid 23-32 insulin Homo sapiens 63-70 29774469-2 2018 The aim of this study was to evaluate whether higher levels of uric acid (UA), a known risk factor of type 2 diabetes, are associated with a reduced insulin clearance. Uric Acid 63-72 insulin Homo sapiens 149-156 29774469-2 2018 The aim of this study was to evaluate whether higher levels of uric acid (UA), a known risk factor of type 2 diabetes, are associated with a reduced insulin clearance. Uric Acid 74-76 insulin Homo sapiens 149-156 29774469-6 2018 RESULTS: Subjects with higher levels of UA displayed an unfavorable metabolic phenotype with a worse lipid profile, increased levels of 2-h post-load glucose levels, fasting, and 2-h post-load insulin levels, hsCRP, liver IR index, and lower levels of eGFR and skeletal muscle insulin sensitivity, in comparison to individuals with lower UA levels. Uric Acid 40-42 insulin Homo sapiens 193-200 29774469-7 2018 Moreover, subjects with higher UA concentrations exhibited decreased levels of insulin clearance even after adjustment for age, gender, BMI, eGFR, and skeletal muscle insulin sensitivity. Uric Acid 31-33 insulin Homo sapiens 79-86 29774469-8 2018 In a multivariate regression analysis model including several confounding factors, UA concentration was an independent predictor of insulin clearance (beta = - 0.145; P = 0.03). Uric Acid 83-85 insulin Homo sapiens 132-139 29774469-9 2018 However, when liver IR index was included in the model, the independent association between UA levels and insulin clearance was not retained. Uric Acid 92-94 insulin Homo sapiens 106-113 29774469-10 2018 Accordingly, in a mediation analysis, liver IR index was a mediator of the negative effects of UA levels on insulin clearance (t = - 2.55, P = 0.01). Uric Acid 95-97 insulin Homo sapiens 108-115 29774469-11 2018 CONCLUSIONS: Higher serum levels of UA may affect insulin clearance by impairing hepatic insulin sensitivity. Uric Acid 36-38 insulin Homo sapiens 50-57 30349765-1 2018 Background Plasma uric acid has been shown to be associated with an increased risk of hypertension, cardiovascular disease, chronic kidney disease, insulin resistance, and metabolic syndrome. Uric Acid 18-27 insulin Homo sapiens 148-155 30349765-3 2018 The present study aimed to evaluate plasma uric acid levels in type 2 diabetic patients and to determine the effects of hypoglycemic drugs and pharmacologic insulin on plasma uric acid concentration. Uric Acid 175-184 insulin Homo sapiens 157-164 29955837-2 2018 Uric acid may contribute to insulin resistance and dyslipidemia in the general population. Uric Acid 0-9 insulin Homo sapiens 28-35 29570819-3 2018 (i) Insulin is considered to stimulate uric acid reabsorption via specific transporter and the effect of hyperuricaemia on the new-onset T2DM should be evaluated by considering insulin resistance. Uric Acid 39-48 insulin Homo sapiens 4-11