PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 55-58 C-C motif chemokine ligand 2 Homo sapiens 100-134 20149224-0 2010 High-density lipoproteins downregulate CCL2 production in human fibroblast-like synoviocytes stimulated by urate crystals. Uric Acid 107-112 C-C motif chemokine ligand 2 Homo sapiens 39-43 20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 37-53 C-C motif chemokine ligand 2 Homo sapiens 94-98 20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 37-53 C-C motif chemokine ligand 2 Homo sapiens 100-134 20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 37-53 C-C motif chemokine ligand 2 Homo sapiens 136-141 20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 55-58 C-C motif chemokine ligand 2 Homo sapiens 94-98 20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 55-58 C-C motif chemokine ligand 2 Homo sapiens 136-141 19158351-8 2009 Fructose increased intracellular uric acid, and uric acid induced production of MCP-1 as well. Uric Acid 48-57 C-C motif chemokine ligand 2 Homo sapiens 80-85 15235923-13 2004 Renal epithelial cells exposed to uric acid crystals synthesize MCP-1 as well as PGE2. Uric Acid 34-43 C-C motif chemokine ligand 2 Homo sapiens 64-69 17322498-5 2007 RESULTS: The MCP-1 SNP c.-3813C>T exhibited trends for differences between the genotype groups in triglycerides, 2-h glucose and uric acid (P = 0.0084, 0.014, 0.027). Uric Acid 129-138 C-C motif chemokine ligand 2 Homo sapiens 13-18 16340663-4 2006 Experimental studies suggest that uric acid induce its detrimental effects at the cellular level entering to vascular smooth muscle cells (VSMC) via an organic anion transport system, and followed by the activation of specific MAP kinases, nuclear transcription factors, with stimulation of COX-2, PDGF A and C chain, PDGF alpha receptor, and various inflammatory mediators, including C-reactive protein and monocyte chemoattractant protein-1. Uric Acid 34-43 C-C motif chemokine ligand 2 Homo sapiens 408-442 17221363-10 2007 Moreover, plasma IL-1 beta, TNF-alpha and MCP-1 levels were positively correlated with clinical and well-establish biochemical parameters of pregnancy toxaemia, serum uric acid and proteinuria (p<0.01). Uric Acid 167-176 C-C motif chemokine ligand 2 Homo sapiens 42-47 33285354-6 2021 The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased. Uric Acid 71-74 C-C motif chemokine ligand 2 Homo sapiens 38-42 12743010-0 2003 Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Uric Acid 0-9 C-C motif chemokine ligand 2 Homo sapiens 21-55 12743010-3 2003 Crystal- and endotoxin-free uric acid was found to increase VSMC monocyte chemoattractant protein-1 (MCP-1) expression in a time- and dose-dependent manner, peaking at 24 hours. Uric Acid 28-37 C-C motif chemokine ligand 2 Homo sapiens 65-99 12743010-3 2003 Crystal- and endotoxin-free uric acid was found to increase VSMC monocyte chemoattractant protein-1 (MCP-1) expression in a time- and dose-dependent manner, peaking at 24 hours. Uric Acid 28-37 C-C motif chemokine ligand 2 Homo sapiens 101-106 12743010-4 2003 Increased mRNA and protein expression occurred as early as 3 hours after uric acid incubation and was partially dependent on posttranscriptional modification of MCP-1 mRNA. Uric Acid 73-82 C-C motif chemokine ligand 2 Homo sapiens 161-166 12743010-6 2003 Inhibition of p38 (with SB 203580), ERK 44/42 (with UO126 or PD 98059), or COX-2 (with NS398) each significantly suppressed uric acid-induced MCP-1 expression at 24 hours, implicating these pathways in the response to uric acid. Uric Acid 124-133 C-C motif chemokine ligand 2 Homo sapiens 142-147 12743010-6 2003 Inhibition of p38 (with SB 203580), ERK 44/42 (with UO126 or PD 98059), or COX-2 (with NS398) each significantly suppressed uric acid-induced MCP-1 expression at 24 hours, implicating these pathways in the response to uric acid. Uric Acid 218-227 C-C motif chemokine ligand 2 Homo sapiens 142-147 12743010-7 2003 The ability of both n-acetyl-cysteine and diphenyleneionium (antioxidants) to inhibit uric acid-induced MCP-1 production suggested involvement of intracellular redox pathways. Uric Acid 86-95 C-C motif chemokine ligand 2 Homo sapiens 104-109 26539255-6 2015 RESULTS: UA significantly increased the expressions of IL-6, ICAM-1, TNF-alpha, and MCP-1 and the production of ROS in HUVEC. Uric Acid 9-11 C-C motif chemokine ligand 2 Homo sapiens 84-89 23204548-5 2013 CONCLUSION: Hyperuricaemia causes elevated serum CCL2 levels and increased monocyte recruitment that may be driven by soluble uric acid-induced CCL2 production. Uric Acid 126-135 C-C motif chemokine ligand 2 Homo sapiens 49-53 24813355-8 2014 There was a positive relationship between serum MCP-1 and uric acid concentrations (r = 0.27, p < 0.05). Uric Acid 58-67 C-C motif chemokine ligand 2 Homo sapiens 48-53 23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Uric Acid 34-43 C-C motif chemokine ligand 2 Homo sapiens 116-120 23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Uric Acid 34-43 C-C motif chemokine ligand 2 Homo sapiens 122-127 23204548-5 2013 CONCLUSION: Hyperuricaemia causes elevated serum CCL2 levels and increased monocyte recruitment that may be driven by soluble uric acid-induced CCL2 production. Uric Acid 126-135 C-C motif chemokine ligand 2 Homo sapiens 144-148