PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34913811-5 2021 Meanwhile, Occludin, ZO-1, and RAGE protein levels were measured by western blotting; Results: Uric acid reduced the negative effects of Abeta on the vascular endothelium and smooth muscle cells and protected the vascular wall in vitro. Uric Acid 95-104 occludin Mus musculus 11-19 34913811-8 2021 After uric acid concentration was lowered in APP23 mice, ZO-1 and occludin expression levels were significantly lower than those in untreated animals; Conclusions: Uric acid in the blood protects the blood vessels from CAA damage to the blood vessel wall, and reduces the occurrence of cerebral hemorrhage. Uric Acid 164-173 occludin Mus musculus 66-74 33074353-14 2021 In vitro, we showed that soluble uric acid alone increased the expression of TSPO, depolarized mitochondrial membrane potential, increased ROS release and activated NLRP3 inflammasome, which further reduced the expression of occludin and claudin-1. Uric Acid 33-42 occludin Mus musculus 225-233