PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22105559-6 2012 IL-1beta release induced by other well-characterized NLRP3-inflammasome activators, such as ATP and uric acid crystals, in addition to NLRC4 and AIM2 inflammasome activators was also blocked by these inhibitors. Uric Acid 100-109 NLR family pyrin domain containing 3 Homo sapiens 53-58 23295692-7 2012 With regard to recent findings identifying small particles such as asbestos and monosodium urate as NLRP3 activators, TiO(2) may be another potential target for inflammasome studies. Uric Acid 80-96 NLR family pyrin domain containing 3 Homo sapiens 100-105 23226314-1 2012 INTRODUCTION: Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung inflammation via activation of the NLRP3 inflammasome. Uric Acid 14-23 NLR family pyrin domain containing 3 Homo sapiens 199-204 23226314-1 2012 INTRODUCTION: Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung inflammation via activation of the NLRP3 inflammasome. Uric Acid 126-135 NLR family pyrin domain containing 3 Homo sapiens 199-204 21936977-2 2011 Endogenous and exogenous danger signals, e.g. DNA- and RNA-fragments, urate- and cholesterol crystals, silica and asbestos, ss-amyloid, UV-light and skin irritants, may induce NOD-like receptor protein (NLRP)3 inflammasomes. Uric Acid 70-75 NLR family pyrin domain containing 3 Homo sapiens 203-209 21428959-4 2011 The discovery that NLRP3 (NLR-related protein 3) can recognize host-derived particulate matter such as uric acid and cholesterol crystals has led to this inflammasome being implicated in a number of inflammatory diseases, including gout, atherosclerosis and Type 2 diabetes. Uric Acid 103-112 NLR family pyrin domain containing 3 Homo sapiens 19-24 21573893-6 2011 Besides ATP, uric acid or soluble extracellular matrix components are functional danger signals that activate the NLRP3 inflammasome when released from dying cells or from extracellular matrix. Uric Acid 13-22 NLR family pyrin domain containing 3 Homo sapiens 114-119 21352397-3 2011 Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1beta processing. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 71-76 21352397-3 2011 Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1beta processing. Uric Acid 14-30 NLR family pyrin domain containing 3 Homo sapiens 71-76 21352397-3 2011 Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1beta processing. Uric Acid 32-35 NLR family pyrin domain containing 3 Homo sapiens 71-76 21428959-4 2011 The discovery that NLRP3 (NLR-related protein 3) can recognize host-derived particulate matter such as uric acid and cholesterol crystals has led to this inflammasome being implicated in a number of inflammatory diseases, including gout, atherosclerosis and Type 2 diabetes. Uric Acid 103-112 NLR family pyrin domain containing 3 Homo sapiens 26-47 20502971-2 2010 Uric acid crystals, first sensed extracellularly by membrane lipid alterations, are internalized and subsequently activate the NLRP3 inflammasome. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 127-132 21234729-6 2011 Uric acid crystals also have been shown to trigger interleukin-1beta-mediated inflammation via activation of the NOD-like receptor protein (NLRP)3 inflammasome, a multimolecular complex whose activation appears to be central to many pathological inflammatory conditions. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 140-146 21245324-1 2011 Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 40-45 21245324-1 2011 Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome. Uric Acid 11-13 NLR family pyrin domain containing 3 Homo sapiens 40-45 20632067-4 2011 XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1beta into active IL-1beta. Uric Acid 13-22 NLR family pyrin domain containing 3 Homo sapiens 73-78 18390571-10 2009 The synergy between urate crystals and LPS was directed at the level of the NALP3 inflammasome, as it was present only when active IL1 beta was measured, but not at the level of IL1 mRNA or proIL1 beta. Uric Acid 20-25 NLR family pyrin domain containing 3 Homo sapiens 76-81 19439372-5 2009 Aluminum adjuvants activate NLRP3 by multiple mechanisms such as by causing damage and rupture of the phagolysosomes, generating reactive oxygen species, inducing K(+) efflux and via release from injured tissues of molecules that constitute danger-associated molecular patterns (DAMPs) such as uric acid and ATP. Uric Acid 294-303 NLR family pyrin domain containing 3 Homo sapiens 28-33 18638431-3 2008 At micromolar concentrations, it suppresses monosodium urate crystal-induced NACHT-LRR-PYD-containing protein-3 (NALP3) inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils. Uric Acid 44-60 NLR family pyrin domain containing 3 Homo sapiens 77-111 19057377-2 2009 More recently, it was shown that uric acid crystals stimulate dendritic cell maturation, activate the NALP3 inflammasome, and enhance antigen-specific immune responses. Uric Acid 33-42 NLR family pyrin domain containing 3 Homo sapiens 102-107 18715799-4 2008 The fact that several stimuli, including bacterial toxins and some viruses, but also sterile crystals made of uric acid, asbestos or aluminium hydroxide, can trigger the Nalp3 inflammasome illustrate the fascinating prospect that microbial infections and certain danger signals may be perceived similarly by host recognition systems. Uric Acid 110-119 NLR family pyrin domain containing 3 Homo sapiens 170-175 18638431-3 2008 At micromolar concentrations, it suppresses monosodium urate crystal-induced NACHT-LRR-PYD-containing protein-3 (NALP3) inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils. Uric Acid 44-60 NLR family pyrin domain containing 3 Homo sapiens 113-118 18281860-6 2008 Monosodium urate crystals stimulate IL-1beta secretion via cryopyrin, which led to the addition of gout to the spectrum of autoinflammatory diseases. Uric Acid 0-16 NLR family pyrin domain containing 3 Homo sapiens 59-68 17714972-11 2007 Urate monosodium crystals are specifically detected via the NALP3 inflammasome, which results in marked IL-1beta overproduction and initiation of an inflammatory response. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 60-65 17977705-3 2007 Amongst the various inflammasomes, the NALP3 inflammasome is particularly qualified to sense a plethora of diverse molecules, ranging from bacterial muramyldipeptide to monosodium urate crystals. Uric Acid 169-185 NLR family pyrin domain containing 3 Homo sapiens 39-44 35309342-10 2022 Stimulation with uric acid in HK-2 cells also resulted in NLRP3 inflammasome activation and pyroptotic cell death, however treatment with 3-MA prevented all these responses. Uric Acid 17-26 NLR family pyrin domain containing 3 Homo sapiens 58-63 17442855-4 2007 Cryopyrin/NALP3 mediates caspase-1 activation in response to a wide variety of bacterial ligands, imidazoquinolines, dsRNA, and the endogenous danger signal uric acid. Uric Acid 157-166 NLR family pyrin domain containing 3 Homo sapiens 0-9 17442855-4 2007 Cryopyrin/NALP3 mediates caspase-1 activation in response to a wide variety of bacterial ligands, imidazoquinolines, dsRNA, and the endogenous danger signal uric acid. Uric Acid 157-166 NLR family pyrin domain containing 3 Homo sapiens 10-15 17352828-1 2007 Monosodium urate crystals stimulate monocytes and macrophages to release IL-1beta through the NALP3 component of the inflammasome. Uric Acid 0-16 NLR family pyrin domain containing 3 Homo sapiens 94-99 34875574-0 2022 Human fetal membrane IL-1beta production in response to bacterial components is mediated by uric-acid induced NLRP3 inflammasome activation. Uric Acid 92-101 NLR family pyrin domain containing 3 Homo sapiens 110-115 34925366-1 2021 Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1beta. Uric Acid 20-36 NLR family pyrin domain containing 3 Homo sapiens 59-64 34925366-1 2021 Gout flares require monosodium urate (MSU) to activate the NLRP3 inflammasome and secrete sufficient IL-1beta. Uric Acid 38-41 NLR family pyrin domain containing 3 Homo sapiens 59-64 34390315-1 2021 INTRODUCTION: The NLR family pyrin domain containing 3 (NLRP3) signaling pathway has an important role in inflammation mediated by monosodium urate crystals in gout, and the characterization of single nucleotide polymorphisms (SNPs) have helped to recognize disease susceptibility. Uric Acid 131-147 NLR family pyrin domain containing 3 Homo sapiens 18-54 34390315-1 2021 INTRODUCTION: The NLR family pyrin domain containing 3 (NLRP3) signaling pathway has an important role in inflammation mediated by monosodium urate crystals in gout, and the characterization of single nucleotide polymorphisms (SNPs) have helped to recognize disease susceptibility. Uric Acid 131-147 NLR family pyrin domain containing 3 Homo sapiens 56-61 35462936-0 2022 (-)-Epicatechin Ameliorates Monosodium Urate-Induced Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and the NF-kappaB Signaling Pathway. Uric Acid 28-44 NLR family pyrin domain containing 3 Homo sapiens 94-99 35462936-8 2022 Conclusion: These results indicated that EC could effectively improve MSU-induced acute gouty arthritis via inhibiting NLRP3 inflammasome and the NF-kappaB signaling pathway in vitro and in vivo, which suggested that EC might be a promising active ingredient for the prevention and treatment of gouty arthritis. Uric Acid 70-73 NLR family pyrin domain containing 3 Homo sapiens 119-124 11802744-10 2002 The inhibition was abolished by urate (a scavenger of ONOO(-) and *OH), but not by mannitol (a scavenger of *OH) or superoxide dismutase (a scavenger of O(2)(-)) and appeared to be specific to AII(t), since ONOO(-) only slightly influenced annexin I-mediated liposome aggregation. Uric Acid 32-37 NLR family pyrin domain containing 3 Homo sapiens 193-196 33798500-4 2021 Activation of the NLRP3 inflammasome by monosodium urate crystals with release of IL-1beta plays a major role in the initiation of the gout flare; aggregated neutrophil extracellular traps are important in the resolution phase. Uric Acid 40-56 NLR family pyrin domain containing 3 Homo sapiens 18-23 34831052-3 2021 One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Uric Acid 120-125 NLR family pyrin domain containing 3 Homo sapiens 38-43 35464445-2 2022 Acute gout symptoms are triggered by the inflammatory response to monosodium urate crystals, which is mediated by the innate immune system and immune cells (e.g., macrophages and neutrophils), the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation, and pro-inflammatory cytokine (e.g., IL-1beta) release. Uric Acid 66-82 NLR family pyrin domain containing 3 Homo sapiens 197-245 35464445-2 2022 Acute gout symptoms are triggered by the inflammatory response to monosodium urate crystals, which is mediated by the innate immune system and immune cells (e.g., macrophages and neutrophils), the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation, and pro-inflammatory cytokine (e.g., IL-1beta) release. Uric Acid 66-82 NLR family pyrin domain containing 3 Homo sapiens 247-252 33677310-0 2021 Total glucosides of paeony protects THP-1 macrophages against monosodium urate-induced inflammation via MALAT1/miR-876-5p/NLRP3 signaling cascade in gouty arthritis. Uric Acid 73-78 NLR family pyrin domain containing 3 Homo sapiens 122-127 33677310-8 2021 Overexpression of NLRP3 or MALAT1 reversed the protective effects of TGP in MSU-induced THP-1 macrophages. Uric Acid 76-79 NLR family pyrin domain containing 3 Homo sapiens 18-23 33677310-11 2021 TGP suppressed MSU-induced inflammation in THP-1 macrophages through regulating MALAT1/miR-876-5p/NLRP3 axis. Uric Acid 15-18 NLR family pyrin domain containing 3 Homo sapiens 98-103 33677310-12 2021 TGP suppressed MSU-induced activation of TLR4/MyD88/NF-kappaB pathway through regulating MALAT1/miR-876-5p/NLRP3 axis. Uric Acid 15-18 NLR family pyrin domain containing 3 Homo sapiens 107-112 34053376-4 2021 EXPERT OPINION: Advances in molecular biology reveal that at the base of the inflammatory cascade, stimulated by MSU or CPP crystals, there are many complex cellular mechanisms mainly involving the NLRP3 inflammasome, the hallmark of autoinflammatory syndromes. Uric Acid 113-116 NLR family pyrin domain containing 3 Homo sapiens 198-203 33902703-10 2021 This MSU-induced IL-1beta secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1beta (p17), which was inhibited by the pretreatment of MCC950, a specific inhibitor for NLRP3. Uric Acid 5-8 NLR family pyrin domain containing 3 Homo sapiens 201-206 33902703-13 2021 CONCLUSIONS: Our data indicate that CIRP, an endogenous stress molecule, triggers uric acid-induced mature IL-1beta induction as a priming stimulus for NLRP3 inflammasome in human neutrophils. Uric Acid 82-91 NLR family pyrin domain containing 3 Homo sapiens 152-157 33830232-4 2021 ACA inhibited Caspase-1 activation and IL-1beta production by NLRP3 agonists such as nigericin, monosodium urate (MSU) crystals, and ATP. Uric Acid 96-112 NLR family pyrin domain containing 3 Homo sapiens 62-67 33935726-9 2021 The abundance of the NLRP3 inflammasome and cytokines was significantly increased after RAW264.7 macrophages were treated with MSU (p < 0.01, respectively), while that of miR-223 was significantly reduced (p < 0.01). Uric Acid 127-130 NLR family pyrin domain containing 3 Homo sapiens 21-26 33830232-4 2021 ACA inhibited Caspase-1 activation and IL-1beta production by NLRP3 agonists such as nigericin, monosodium urate (MSU) crystals, and ATP. Uric Acid 114-117 NLR family pyrin domain containing 3 Homo sapiens 62-67 33746978-6 2021 In bone marrow-derived macrophages, THP-1 and U937 cells, we found that the MSU crystal-induced secretion of IL-1beta and activation of NLRP3 were suppressed by both DcR3.Fc and HBD.Fc. Uric Acid 76-79 NLR family pyrin domain containing 3 Homo sapiens 136-141 33746978-7 2021 The suppression of the MSU-induced NLRP3 inflammasome activation is accompanied by the inhibition of lysosomal rupture, mitochondrial production of the reactive oxygen species (ROS), expression of cathepsins, and activity of cathepsin B, without affecting the crystal uptake and the expression of NLRP3 or pro-IL-1beta. Uric Acid 23-26 NLR family pyrin domain containing 3 Homo sapiens 35-40 33746978-7 2021 The suppression of the MSU-induced NLRP3 inflammasome activation is accompanied by the inhibition of lysosomal rupture, mitochondrial production of the reactive oxygen species (ROS), expression of cathepsins, and activity of cathepsin B, without affecting the crystal uptake and the expression of NLRP3 or pro-IL-1beta. Uric Acid 23-26 NLR family pyrin domain containing 3 Homo sapiens 297-302 33131902-2 2020 Many triggers, including microbial pathogens (ie, bacteria and viruses) and other signals (ie, reactive oxygen species, adenosine triphosphate, urate, silicon, and asbestos), can stimulate the NLRP3 inflammasome. Uric Acid 144-149 NLR family pyrin domain containing 3 Homo sapiens 193-198 33505510-0 2021 Cichoric Acid Ameliorates Monosodium Urate-Induced Inflammatory Response by Reducing NLRP3 Inflammasome Activation via Inhibition of NF-kB Signaling Pathway. Uric Acid 26-42 NLR family pyrin domain containing 3 Homo sapiens 85-90 33505510-6 2021 Therefore, we infer that CA effectively alleviated MSU-induced inflammation by suppressing the degradation of IkappaBalpha, thereby reducing the activation of the NF-kappaB signaling pathway and the NLRP3 inflammasome. Uric Acid 51-54 NLR family pyrin domain containing 3 Homo sapiens 199-204 33389490-4 2021 NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of excessive uric acid and then it recruits apoptosis-related specular protein (ASC) as well as aspartic acid-specific cysteine protease (caspase)-1 precursor to form NLRP3 inflammasome. Uric Acid 89-98 NLR family pyrin domain containing 3 Homo sapiens 0-5 33389490-4 2021 NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) senses the stimuli signal of excessive uric acid and then it recruits apoptosis-related specular protein (ASC) as well as aspartic acid-specific cysteine protease (caspase)-1 precursor to form NLRP3 inflammasome. Uric Acid 89-98 NLR family pyrin domain containing 3 Homo sapiens 243-248 33547278-0 2021 Sensing soluble uric acid by Naip1-Nlrp3 platform. Uric Acid 16-25 NLR family pyrin domain containing 3 Homo sapiens 35-40 32452918-3 2020 Despite the controversy over the inflammatory role of uric acid in its soluble form, crystals of uric acid are able to activate the NLRP3 inflammasome in different tissues. Uric Acid 54-63 NLR family pyrin domain containing 3 Homo sapiens 132-137 32650532-4 2020 Although the mechanism is very complex and needs further explanation, it appears that high levels of cholesterol, urate, and glucose activates NLRP3 inflammasome, which produces IL-1beta, IL-18, and gasdermin D. Uric Acid 114-119 NLR family pyrin domain containing 3 Homo sapiens 143-148 32452918-3 2020 Despite the controversy over the inflammatory role of uric acid in its soluble form, crystals of uric acid are able to activate the NLRP3 inflammasome in different tissues. Uric Acid 97-106 NLR family pyrin domain containing 3 Homo sapiens 132-137 32452918-8 2020 Despite these conflicting views, several studies support the idea that hyperuricemia is indeed a cause of progression of kidney disease, with a putative role for soluble uric acid in activating renal NLRP3 inflammasome, in reprograming renal and immune cell metabolism and, therefore, in promoting kidney inflammation/injury. Uric Acid 170-179 NLR family pyrin domain containing 3 Homo sapiens 200-205 32452918-9 2020 SUMMARY: Therapies aiming to decrease uric acid levels prevent renal NLRP3 inflammasome activation and exert renoprotective effects in experimental kidney diseases. Uric Acid 38-47 NLR family pyrin domain containing 3 Homo sapiens 69-74 32695290-0 2020 Soluble uric acid induces inflammation via TLR4/NLRP3 pathway in intestinal epithelial cells. Uric Acid 8-17 NLR family pyrin domain containing 3 Homo sapiens 48-53 32536991-1 2020 Crystalized deposits of monosodium urate activate the Nod-like receptor protein 3 (NLRP3) inflammasome, resulting in kidney damage. Uric Acid 24-40 NLR family pyrin domain containing 3 Homo sapiens 54-81 32536991-1 2020 Crystalized deposits of monosodium urate activate the Nod-like receptor protein 3 (NLRP3) inflammasome, resulting in kidney damage. Uric Acid 24-40 NLR family pyrin domain containing 3 Homo sapiens 83-88 32695290-12 2020 Results: We found soluble uric acid alone increased the release of ROS, depolarized the mitochondrial membrane potential, up-regulated TSPO, increased the expression of TLR4 and NLRP3, and then activated NLRP3 inflammasome and NF-kappaB signaling, which further resulted in lower expression of tight junction protein and exerted adverse effects on intestinal epithelial cells. Uric Acid 26-35 NLR family pyrin domain containing 3 Homo sapiens 178-183 32695290-12 2020 Results: We found soluble uric acid alone increased the release of ROS, depolarized the mitochondrial membrane potential, up-regulated TSPO, increased the expression of TLR4 and NLRP3, and then activated NLRP3 inflammasome and NF-kappaB signaling, which further resulted in lower expression of tight junction protein and exerted adverse effects on intestinal epithelial cells. Uric Acid 26-35 NLR family pyrin domain containing 3 Homo sapiens 204-209 32695290-13 2020 Furthermore, the elevated IL-1beta could be restored by silencing of TLR4, indicating soluble uric acid induces inflammation via the TLR4/NLRP3 pathway. Uric Acid 94-103 NLR family pyrin domain containing 3 Homo sapiens 138-143 32695290-14 2020 Conclusion: Soluble uric acid exerted detrimental effect on intestinal epithelial cells through the TLR4/NLRP3 pathway. Uric Acid 20-29 NLR family pyrin domain containing 3 Homo sapiens 105-110 32469177-0 2020 Ethanol Augments Monosodium Urate-Induced NLRP3 Inflammasome Activation via Regulation of AhR and TXNIP in Human Macrophages. Uric Acid 17-33 NLR family pyrin domain containing 3 Homo sapiens 42-47 32469177-2 2020 The aim of this study was to identify the mechanism by which ethanol affects uric acid-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation by regulation of aryl hydrocarbon receptor (AhR) and thioredoxin-interacting protein (TXNIP). Uric Acid 77-86 NLR family pyrin domain containing 3 Homo sapiens 95-131 32469177-2 2020 The aim of this study was to identify the mechanism by which ethanol affects uric acid-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation by regulation of aryl hydrocarbon receptor (AhR) and thioredoxin-interacting protein (TXNIP). Uric Acid 77-86 NLR family pyrin domain containing 3 Homo sapiens 133-138 32469177-3 2020 MATERIALS AND METHODS: Human myeloid leukemia cells (U937 cells) were used to assess the role of ethanol in NLRP3 inflammasome activation induced by monosodium urate (MSU) crystals. Uric Acid 149-165 NLR family pyrin domain containing 3 Homo sapiens 108-113 32469177-3 2020 MATERIALS AND METHODS: Human myeloid leukemia cells (U937 cells) were used to assess the role of ethanol in NLRP3 inflammasome activation induced by monosodium urate (MSU) crystals. Uric Acid 167-170 NLR family pyrin domain containing 3 Homo sapiens 108-113 32469177-9 2020 Treatment with ethanol increased NLRP3 and IL-1beta mRNA and protein expression in U937 cells exposed to 1.0 mg/mL of MSU crystals for 24 h. TXNIP expression in U937 cells incubated with both 100 mM ethanol and 1.0 mg/mL of MSU crystals was significantly higher than in cells incubated with MSU crystals alone. Uric Acid 118-121 NLR family pyrin domain containing 3 Homo sapiens 33-38 32469177-11 2020 CONCLUSION: Ethanol stimulates uric acid-induced NLRP3 inflammasome activation through regression of AhR and upregulation of TXNIP. Uric Acid 31-40 NLR family pyrin domain containing 3 Homo sapiens 49-54 31705795-3 2020 The IL-1beta response to excess glucose was mediated by uric acid-induced activation of the NLRP3 inflammasome. Uric Acid 56-65 NLR family pyrin domain containing 3 Homo sapiens 92-97 32552358-2 2020 The urate monosodium crystals deposit initiates an inflammatory response; mediated by NLRP3 inflammasome, with the release of interleukin 1beta. Uric Acid 4-20 NLR family pyrin domain containing 3 Homo sapiens 86-91 31996020-5 2020 Approach and Results: The secretion of IL-1beta from human peripheral blood mononuclear cells mediated by NLRP3 (NACHT, LRR, and PYD domain-containing protein 3) inflammasome was promoted by physiological levels in serum uric acid. Uric Acid 221-230 NLR family pyrin domain containing 3 Homo sapiens 106-111 31924495-3 2020 Studies have shown that NOD-like receptor protein 3 (NLRP3) inflammasome as pattern recognition receptors can be activated by uric acid crystallization, triggering immune inflammation and causing acute gouty arthritis symptoms. Uric Acid 126-135 NLR family pyrin domain containing 3 Homo sapiens 24-51 31924495-3 2020 Studies have shown that NOD-like receptor protein 3 (NLRP3) inflammasome as pattern recognition receptors can be activated by uric acid crystallization, triggering immune inflammation and causing acute gouty arthritis symptoms. Uric Acid 126-135 NLR family pyrin domain containing 3 Homo sapiens 53-58 31819864-11 2019 Conclusion: The stone components CPPD and MSU activate NLRP3 in an ROS and TXNIP-dependent manner in bladder urothelium. Uric Acid 42-45 NLR family pyrin domain containing 3 Homo sapiens 55-60 31819864-0 2019 Calcium Pyrophosphate And Monosodium Urate Activate The NLRP3 Inflammasome Within Bladder Urothelium Via Reactive Oxygen Species And TXNIP. Uric Acid 26-42 NLR family pyrin domain containing 3 Homo sapiens 56-61 31707403-0 2019 Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism. Uric Acid 9-18 NLR family pyrin domain containing 3 Homo sapiens 91-118 31707403-0 2019 Elevated Uric Acid Levels Promote Vascular Smooth Muscle Cells (VSMC) Proliferation via an Nod-Like Receptor Protein 3 (NLRP3)-Inflammasome-Dependent Mechanism. Uric Acid 9-18 NLR family pyrin domain containing 3 Homo sapiens 120-125 31707403-2 2019 Uric acid has been reported to activate Nod-like receptor protein 3 (NLRP3)-inflammasome and alter vascular smooth muscle cells (VSMC). Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 40-67 31707403-2 2019 Uric acid has been reported to activate Nod-like receptor protein 3 (NLRP3)-inflammasome and alter vascular smooth muscle cells (VSMC). Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 69-74 31707403-9 2019 We also found that uric acid increases the level of NLRP3 and induces NLRP3-inflammasome activation. Uric Acid 19-28 NLR family pyrin domain containing 3 Homo sapiens 52-57 31707403-9 2019 We also found that uric acid increases the level of NLRP3 and induces NLRP3-inflammasome activation. Uric Acid 19-28 NLR family pyrin domain containing 3 Homo sapiens 70-75 31707403-11 2019 CONCLUSIONS Our findings revealed that uric acid induces inflammation through NLRP3-inflammasome-mediated VSMC proliferation. Uric Acid 39-48 NLR family pyrin domain containing 3 Homo sapiens 78-83 33693087-7 2019 In macrophages, MSU activates the NLRP3 inflammasome and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1beta and IL-18 secretion. Uric Acid 16-19 NLR family pyrin domain containing 3 Homo sapiens 34-39 31358323-0 2019 Anti-inflammatory effect of artemisinin on uric acid-induced NLRP3 inflammasome activation through blocking interaction between NLRP3 and NEK7. Uric Acid 43-52 NLR family pyrin domain containing 3 Homo sapiens 61-66 31649546-9 2019 Allopurinol, an inhibitor of uric acid production, has been shown to decrease renal inflammation by limiting activation of the NLRP3 inflammasome. Uric Acid 29-38 NLR family pyrin domain containing 3 Homo sapiens 127-132 31358323-13 2019 CONCLUSION: This study revealed that artemisinin inhibited activation of NLRP3 inflammasome by suppressing interaction between NEK7 and NLRP3 in uric acid-induced inflammation. Uric Acid 145-154 NLR family pyrin domain containing 3 Homo sapiens 73-78 31358323-13 2019 CONCLUSION: This study revealed that artemisinin inhibited activation of NLRP3 inflammasome by suppressing interaction between NEK7 and NLRP3 in uric acid-induced inflammation. Uric Acid 145-154 NLR family pyrin domain containing 3 Homo sapiens 136-141 31358323-0 2019 Anti-inflammatory effect of artemisinin on uric acid-induced NLRP3 inflammasome activation through blocking interaction between NLRP3 and NEK7. Uric Acid 43-52 NLR family pyrin domain containing 3 Homo sapiens 128-133 31358323-3 2019 The aim of this study was to clarify the anti-inflammatory effect of artemisinin on activation of uric acid-induced NLRP3 inflammasome through regulation of NEK7. Uric Acid 98-107 NLR family pyrin domain containing 3 Homo sapiens 116-121 31358323-9 2019 Enhanced expression of NLRP3, caspase-1, and IL-1beta was noted in macrophages treated with LPS (10 ng/ml) and MSU crystals (0.1 mg/ml), which was markedly suppressed by treatment with artemisinin (1, 10, and 100 muM). Uric Acid 111-114 NLR family pyrin domain containing 3 Homo sapiens 23-28 30824640-0 2019 Precipitation of Soluble Uric Acid Is Necessary for In Vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes. Uric Acid 25-34 NLR family pyrin domain containing 3 Homo sapiens 79-84 30824640-1 2019 OBJECTIVE: To investigate the effects of soluble uric acid (UA) on expression and activation of the NOD-like receptor (NLR) pyrin domain containing protein 3 (NLRP3) inflammasome in human monocytes to elucidate the role of hyperuricemia in the pathogenesis of gout. Uric Acid 49-58 NLR family pyrin domain containing 3 Homo sapiens 159-164 30824640-1 2019 OBJECTIVE: To investigate the effects of soluble uric acid (UA) on expression and activation of the NOD-like receptor (NLR) pyrin domain containing protein 3 (NLRP3) inflammasome in human monocytes to elucidate the role of hyperuricemia in the pathogenesis of gout. Uric Acid 60-62 NLR family pyrin domain containing 3 Homo sapiens 159-164 30824640-2 2019 METHODS: Primary human monocytes and the THP-1 human monocyte cell line were used to determine the effects of short- and longterm exposure to UA on activation of the NLRP3 inflammasome and subsequent interleukin 1beta (IL-1beta) secretion by ELISA and cell-based assays. Uric Acid 142-144 NLR family pyrin domain containing 3 Homo sapiens 166-171 30824640-4 2019 RESULTS: Precipitation of UA was required for activation of the NLRP3 inflammasome and subsequent release of IL-1beta in human monocytes. Uric Acid 26-28 NLR family pyrin domain containing 3 Homo sapiens 64-69 30824640-9 2019 CONCLUSION: Despite reports indicating that soluble UA can prime and activate the NLRP3 inflammasome in human peripheral blood mononuclear cells, precipitation of soluble UA into MSU crystals is essential for in vitro NLRP3 signaling in primary human monocytes. Uric Acid 52-54 NLR family pyrin domain containing 3 Homo sapiens 82-87 30824640-9 2019 CONCLUSION: Despite reports indicating that soluble UA can prime and activate the NLRP3 inflammasome in human peripheral blood mononuclear cells, precipitation of soluble UA into MSU crystals is essential for in vitro NLRP3 signaling in primary human monocytes. Uric Acid 171-173 NLR family pyrin domain containing 3 Homo sapiens 218-223 30833078-0 2019 TXNIP-mediated nuclear factor-kappaB signaling pathway and intracellular shifting of TXNIP in uric acid-induced NLRP3 inflammasome. Uric Acid 94-103 NLR family pyrin domain containing 3 Homo sapiens 112-117 31412804-0 2019 Uric acid regulates NLRP3/IL-1beta signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 20-25 31412804-9 2019 RESULTS: The expression of IL-1beta, ICAM-1, NLRP3 complexes, and activation of NLRP3 inflammasome could be induced by UA, but the changes induced by UA were partially reversed by siRNA NLRP3 or caspase 1 inhibitor. Uric Acid 119-121 NLR family pyrin domain containing 3 Homo sapiens 45-50 31412804-9 2019 RESULTS: The expression of IL-1beta, ICAM-1, NLRP3 complexes, and activation of NLRP3 inflammasome could be induced by UA, but the changes induced by UA were partially reversed by siRNA NLRP3 or caspase 1 inhibitor. Uric Acid 119-121 NLR family pyrin domain containing 3 Homo sapiens 80-85 31412804-9 2019 RESULTS: The expression of IL-1beta, ICAM-1, NLRP3 complexes, and activation of NLRP3 inflammasome could be induced by UA, but the changes induced by UA were partially reversed by siRNA NLRP3 or caspase 1 inhibitor. Uric Acid 119-121 NLR family pyrin domain containing 3 Homo sapiens 80-85 31412804-11 2019 In vivo results showed that UA caused the vascular endothelial injury by activating NLRP3/IL-1beta pathway. Uric Acid 28-30 NLR family pyrin domain containing 3 Homo sapiens 84-89 30807742-3 2019 The cathepsins B, C, L, S and Z have been implicated in NLRP3 inflammasome activation following their activation with ATP, monosodium urate, silica crystals, or bacterial components, among others. Uric Acid 123-139 NLR family pyrin domain containing 3 Homo sapiens 56-61 30807742-8 2019 Cathepsin Z is non-redundantly required for NLRP3 inflammasome activation following nigericin, ATP and monosodium urate activation. Uric Acid 103-119 NLR family pyrin domain containing 3 Homo sapiens 44-49 31357788-3 2019 Under the influence of ethanol, the damaged hepatocyte release uric acid, and adenosine triphosphate and induces NLRP3 inflammasome assembly and functional activation in Kupffer cells to promote the release of inflammatory mediators, such as interleukin-1beta and interleukin-18, that cascade mediates inflammation and drive alcoholic liver disease from steatosis to inflammation and fibrosis. Uric Acid 63-72 NLR family pyrin domain containing 3 Homo sapiens 113-118 29385859-1 2019 OBJECTIVE: Previous studies have indicated that the nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3) inflammasome is activated by monosodium urate in the trophoblast of preeclampsia (PE) patients, leading to augmented placental IL-1beta levels. Uric Acid 157-173 NLR family pyrin domain containing 3 Homo sapiens 121-126 31189953-1 2019 The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid crystals, amyloid-beta fibrils and extracellular ATP. Uric Acid 75-84 NLR family pyrin domain containing 3 Homo sapiens 4-9 30833078-1 2019 OBJECTIVE: The aim of this study was to assess the role of thioredoxin-interacting protein (TXNIP) in nuclear factor-kappaB (NF-kappaB) signaling and the interaction between TXNIP and NOD-like receptor protein 3 (NLRP3) in activation of the NLRP3 inflammasome in monosodium urate (MSU)-induced inflammation. Uric Acid 263-279 NLR family pyrin domain containing 3 Homo sapiens 184-211 30833078-1 2019 OBJECTIVE: The aim of this study was to assess the role of thioredoxin-interacting protein (TXNIP) in nuclear factor-kappaB (NF-kappaB) signaling and the interaction between TXNIP and NOD-like receptor protein 3 (NLRP3) in activation of the NLRP3 inflammasome in monosodium urate (MSU)-induced inflammation. Uric Acid 281-284 NLR family pyrin domain containing 3 Homo sapiens 184-211 30833078-7 2019 Binding between TXNIP and NLRP3 under oxidative stress caused by MSU crystals was observed and was blocked by quercetin or ascorbic acid. Uric Acid 65-68 NLR family pyrin domain containing 3 Homo sapiens 26-31 30833078-8 2019 CONCLUSION: This study showed that activation of MSU-induced NLRP3 inflammasome requires TXNIP-mediated NF-kappaB signaling pathway and intracellular TXNIP shifting. Uric Acid 49-52 NLR family pyrin domain containing 3 Homo sapiens 61-66 30637441-2 2019 In humans, the induction of IL-1beta production through MSU-induced NLRP3 inflammasome activation in monocytes/macrophages is responsible for pathogenesis of gouty arthritis. Uric Acid 56-59 NLR family pyrin domain containing 3 Homo sapiens 68-73 30637441-7 2019 Resveratrol also inhibited NLRP3 inflammasome activation in MSU-stimulated monocytes by suppressing oligomerization of ASC. Uric Acid 60-63 NLR family pyrin domain containing 3 Homo sapiens 27-32 30728075-5 2019 METHODS: Peripheral blood mononuclear cells (PBMCs) were cultured with a combination of monosodium urate crystals (MSU) and palmitic acid (C16.0) in order to activate the NLRP3 inflammasome and induce IL-1beta production. Uric Acid 88-104 NLR family pyrin domain containing 3 Homo sapiens 171-176 30612459-3 2019 Gouty arthritis is an inflammatory disease characterized by urate crystal-induced NLRP3 inflammasome activation with up-regulated caspase-1 protease and IL-1 beta in macrophages. Uric Acid 60-65 NLR family pyrin domain containing 3 Homo sapiens 82-87 30347231-0 2019 LncRNA ANRIL promotes NLRP3 inflammasome activation in uric acid nephropathy through miR-122-5p/BRCC3 axis. Uric Acid 55-64 NLR family pyrin domain containing 3 Homo sapiens 22-27 30591286-11 2019 Recent demonstration that cholesterol crystals trigger the NLRP3 (nucleotide oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3) inflammasome and the release of inflammatory cytokines that also drive uric acid crystal-induced inflammation indicates that the multiple actions of colchicine that make it effective in gout may be relevant to preventing inflammation and limiting inflammatory injury in atherosclerosis. Uric Acid 234-243 NLR family pyrin domain containing 3 Homo sapiens 59-64 29780394-2 2018 Uric acid was shown to be one of the "danger" signals involved in the activation of NLRP3 inflammasome; notably, the concentration of uric acid is increased in the serum and in the cerebrospinal fluid of MS individuals. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 84-89 29683202-2 2018 Crystalline cholesterol and uric acid activate the PRR Nod-like receptor protein (NLRP)3 inflammasome to release interleukin (IL)-1beta and result in vigorous inflammation. Uric Acid 28-37 NLR family pyrin domain containing 3 Homo sapiens 51-88 29960001-3 2018 To elucidate the effects on NLRP3 inflammasome pathway and to determine the structure-activity relationships, NLRP3 inflammasome in differentiated THP-1 cells was activated via treatment with monosodium urate (MSU) crystals. Uric Acid 192-208 NLR family pyrin domain containing 3 Homo sapiens 28-33 29960001-3 2018 To elucidate the effects on NLRP3 inflammasome pathway and to determine the structure-activity relationships, NLRP3 inflammasome in differentiated THP-1 cells was activated via treatment with monosodium urate (MSU) crystals. Uric Acid 192-208 NLR family pyrin domain containing 3 Homo sapiens 110-115 29960001-3 2018 To elucidate the effects on NLRP3 inflammasome pathway and to determine the structure-activity relationships, NLRP3 inflammasome in differentiated THP-1 cells was activated via treatment with monosodium urate (MSU) crystals. Uric Acid 210-213 NLR family pyrin domain containing 3 Homo sapiens 28-33 29960001-3 2018 To elucidate the effects on NLRP3 inflammasome pathway and to determine the structure-activity relationships, NLRP3 inflammasome in differentiated THP-1 cells was activated via treatment with monosodium urate (MSU) crystals. Uric Acid 210-213 NLR family pyrin domain containing 3 Homo sapiens 110-115 29780394-2 2018 Uric acid was shown to be one of the "danger" signals involved in the activation of NLRP3 inflammasome; notably, the concentration of uric acid is increased in the serum and in the cerebrospinal fluid of MS individuals. Uric Acid 134-143 NLR family pyrin domain containing 3 Homo sapiens 84-89 29780394-7 2018 Results showed that uric acid serum concentration was significantly increased in PPMS; in these and in AMS patients, mRNA for NLRP3, ASC, and IL-18 was upregulated as well, but caspase-8 mRNA was upregulated only in PPMS. Uric Acid 20-29 NLR family pyrin domain containing 3 Homo sapiens 126-131 28084571-16 2017 Uric acid formed from xanthine-xanthine oxidase interaction stimulates CD36 expression and triggers foam cell formation independent of NLRP3 activation. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 135-140 29415757-0 2018 Soluble uric acid increases PDZK1 and ABCG2 expression in human intestinal cell lines via the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway. Uric Acid 8-17 NLR family pyrin domain containing 3 Homo sapiens 99-104 29415757-12 2018 Moreover, the upregulation of PDZK1 and ABCG2 by soluble uric acid was partially decreased by either TLR4-NLRP3 inflammasome inhibitors or PI3K/Akt signaling inhibitors. Uric Acid 57-66 NLR family pyrin domain containing 3 Homo sapiens 106-111 29415757-14 2018 CONCLUSIONS: These findings suggest that urate upregulates the expression of PDZK1 and ABCG2 for excretion in intestinal cells via activating the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway. Uric Acid 41-46 NLR family pyrin domain containing 3 Homo sapiens 151-156 29247992-3 2018 The NLRP3 inflammasome has been shown to sense metabolites such as palmitate, uric acid, and cholesterol crystals and is inhibited by ketone bodies produced during metabolic flux. Uric Acid 78-87 NLR family pyrin domain containing 3 Homo sapiens 4-9 28569730-5 2017 This is followed by signal two, which involves recognition of PAMPs or damage-associated molecular patterns (DAMPs), such as uric acid or ATP, via NLRP3, which leads to caspase-1-dependent cleavage of pro-IL-1beta to active IL-1beta and pyroptosis. Uric Acid 125-134 NLR family pyrin domain containing 3 Homo sapiens 147-152 28394398-9 2017 Expression of PPARGC1B and NLRP3 was induced in urate crystal-activated THP-1, peripheral blood mononuclear cells and synovial cells from gout patients in acute stage. Uric Acid 48-53 NLR family pyrin domain containing 3 Homo sapiens 27-32 28394398-10 2017 siRNA knockdown of PPARGC1B upregulated NLRP3 in urate crystal-activated macrophages. Uric Acid 49-54 NLR family pyrin domain containing 3 Homo sapiens 40-45 28880687-1 2018 OBJECTIVE: Monosodium urate (MSU) has been shown to promote interleukin-1beta (IL-1beta) secretion in human monocytes, but the priming signals for NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway remains elusive. Uric Acid 11-27 NLR family pyrin domain containing 3 Homo sapiens 199-204 29214547-1 2018 The NLRP3-interleukin1beta (IL1beta) signaling pathway is involved in monosodium urate (MSU)-mediated inflammation. Uric Acid 70-86 NLR family pyrin domain containing 3 Homo sapiens 4-9 29214547-1 2018 The NLRP3-interleukin1beta (IL1beta) signaling pathway is involved in monosodium urate (MSU)-mediated inflammation. Uric Acid 88-91 NLR family pyrin domain containing 3 Homo sapiens 4-9 29263464-12 2017 We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator. Uric Acid 110-115 NLR family pyrin domain containing 3 Homo sapiens 160-165 29263464-12 2017 We also found that downregulation of ATG5 and Beclin1 sensitized cells for the release of IL-1beta induced by MSU (monosodium urate) or nigericin which was the NLRP3 inflammasome activator. Uric Acid 115-131 NLR family pyrin domain containing 3 Homo sapiens 160-165 28084571-4 2017 This study was designed to study the role of various scavenger receptors and NLRP3 inflammasome in xanthine oxidase and uric acid-induced foam cell formation. Uric Acid 120-129 NLR family pyrin domain containing 3 Homo sapiens 77-82 26639394-0 2016 Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 73-78 27903743-4 2017 One of these damage-associated molecular patterns, uric acid, is increased in the maternal circulation in pathological pregnancies and is a known agonist of the Nlrp3 inflammasome and inducer of inflammation. Uric Acid 51-60 NLR family pyrin domain containing 3 Homo sapiens 161-166 25829326-3 2016 Urate-induced inflammasome pathway is comprised of urate crystal uptake into intracellular lysosomes and subsequent lysosomal rupture with mitochondrial reactive oxygen species (ROS) production, which activates the NLRP3 inflammasome. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 215-220 25829326-3 2016 Urate-induced inflammasome pathway is comprised of urate crystal uptake into intracellular lysosomes and subsequent lysosomal rupture with mitochondrial reactive oxygen species (ROS) production, which activates the NLRP3 inflammasome. Uric Acid 51-56 NLR family pyrin domain containing 3 Homo sapiens 215-220 26639394-5 2016 Subsequently, we studied the role of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome in uric acid-induced fat accumulation and insulin signaling impairment. Uric Acid 116-125 NLR family pyrin domain containing 3 Homo sapiens 93-98 26639394-8 2016 Moreover, knocking down NLRP3 expression significantly attenuated uric acid-induced fat accumulation both in HepG2 cells and L02 cells. Uric Acid 66-75 NLR family pyrin domain containing 3 Homo sapiens 24-29 26639394-9 2016 Knocking down NLRP3 expression also rescued uric acid-induced insulin signaling impairment in both cell types. Uric Acid 44-53 NLR family pyrin domain containing 3 Homo sapiens 14-19 26639394-10 2016 CONCLUSIONS: Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome. Uric Acid 13-22 NLR family pyrin domain containing 3 Homo sapiens 86-91 27689075-13 2016 Therefore, berberine alleviates monosodium urate crystals-induced inflammation by downregulating NLRP3 and IL-1beta expressions. Uric Acid 32-48 NLR family pyrin domain containing 3 Homo sapiens 97-102 25589513-1 2016 OBJECTIVES: Acute gouty arthritis is caused by endogenously formed monosodium urate (MSU) crystals, which are potent activators of the NLRP3 inflammasome. Uric Acid 67-83 NLR family pyrin domain containing 3 Homo sapiens 135-140 25589513-1 2016 OBJECTIVES: Acute gouty arthritis is caused by endogenously formed monosodium urate (MSU) crystals, which are potent activators of the NLRP3 inflammasome. Uric Acid 85-88 NLR family pyrin domain containing 3 Homo sapiens 135-140 26546608-4 2015 Additionally, the NLRP3 activators nigericin and monosodium urate crystals lowered iATP through K(+)- and Ca(2+)-mediated mitochondrial dysfunction, suggesting a feedback loop between iATP loss and lowering of mitochondrial membrane potential. Uric Acid 49-65 NLR family pyrin domain containing 3 Homo sapiens 18-23 26234731-0 2015 Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation. Uric Acid 39-55 NLR family pyrin domain containing 3 Homo sapiens 103-108 26116704-1 2015 The Nod-like receptor family protein 3 (NLRP3)-inflammasome pathway is known to be activated by danger signals such as monosodium urate (MSU). Uric Acid 119-135 NLR family pyrin domain containing 3 Homo sapiens 4-38 26116704-1 2015 The Nod-like receptor family protein 3 (NLRP3)-inflammasome pathway is known to be activated by danger signals such as monosodium urate (MSU). Uric Acid 119-135 NLR family pyrin domain containing 3 Homo sapiens 40-45 26116704-1 2015 The Nod-like receptor family protein 3 (NLRP3)-inflammasome pathway is known to be activated by danger signals such as monosodium urate (MSU). Uric Acid 137-140 NLR family pyrin domain containing 3 Homo sapiens 4-38 26116704-1 2015 The Nod-like receptor family protein 3 (NLRP3)-inflammasome pathway is known to be activated by danger signals such as monosodium urate (MSU). Uric Acid 137-140 NLR family pyrin domain containing 3 Homo sapiens 40-45 26116704-2 2015 We investigated the role of P2 purinergic receptors in the activation of NLRP3-inflammasome pathway after MSU treatment of primary human monocyte-derived macrophages (MDMs). Uric Acid 106-109 NLR family pyrin domain containing 3 Homo sapiens 73-78 26238426-2 2015 The present study aimed to investigate the role of PPARgamma in regulating NOD-like receptor family, pyrin domain containing 3 (NALP3) inflammasome and interleukin (IL)-1beta levels during monosodium urate (MSU) crystal-induced inflammation. Uric Acid 189-205 NLR family pyrin domain containing 3 Homo sapiens 128-133 26212544-3 2015 The NLRP3 inflammasome could be activated by lipopolysaccharide (LPS) plus ATP or monosodium urate (MSU) in PMA-pretreated THP-1 macrophages. Uric Acid 82-98 NLR family pyrin domain containing 3 Homo sapiens 4-9 26212544-3 2015 The NLRP3 inflammasome could be activated by lipopolysaccharide (LPS) plus ATP or monosodium urate (MSU) in PMA-pretreated THP-1 macrophages. Uric Acid 100-103 NLR family pyrin domain containing 3 Homo sapiens 4-9 26282945-8 2015 Multivariate analysis demonstrated that body mass index and serum level of uric acid were predictors of NLRP3 expression in SAT. Uric Acid 75-84 NLR family pyrin domain containing 3 Homo sapiens 104-109 26053021-0 2015 Endogenous and Uric Acid-Induced Activation of NLRP3 Inflammasome in Pregnant Women with Preeclampsia. Uric Acid 15-24 NLR family pyrin domain containing 3 Homo sapiens 47-52 26053021-12 2015 These cells stimulation with MSU demonstrates that uric acid plays a role in NLRP3 inflammasome activation, suggesting the participation of this inflammatory complex in the pathogenesis of preeclampsia. Uric Acid 51-60 NLR family pyrin domain containing 3 Homo sapiens 77-82 25651569-2 2015 We investigated the role of soluble uric acid in NLRP3 inflammasome activation in macrophages to demonstrate the effect of systemic hyperuricemia on progressive kidney damage in type 2 diabetes. Uric Acid 36-45 NLR family pyrin domain containing 3 Homo sapiens 49-54 25651569-5 2015 Soluble uric acid stimulated NLRP3 inflammasomes to produce IL-1beta in macrophages. Uric Acid 8-17 NLR family pyrin domain containing 3 Homo sapiens 29-34 25651569-6 2015 Uric acid-induced MitoSOX mediates NLRP3 activation and IL-1beta secretion. Uric Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 35-40 25879284-6 2015 The NLRP3 inflammasome is especially relevant to aging as it can get activated in response to structurally diverse damage-associated molecular patterns (DAMPs) such as extracellular ATP, excess glucose, ceramides, amyloids, urate, and cholesterol crystals, all of which increase with age. Uric Acid 224-229 NLR family pyrin domain containing 3 Homo sapiens 4-9 25813103-0 2015 Soluble uric acid increases NALP3 inflammasome and interleukin-1beta expression in human primary renal proximal tubule epithelial cells through the Toll-like receptor 4-mediated pathway. Uric Acid 8-17 NLR family pyrin domain containing 3 Homo sapiens 28-33 25813103-1 2015 Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also known as NOD-like receptor family, pyrin domain containing 3 (NALP3) and cryopyrin] inflammasome, caspase-1 activation and interleukin (IL)-1beta expression in gout. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 120-167 25813103-1 2015 Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also known as NOD-like receptor family, pyrin domain containing 3 (NALP3) and cryopyrin] inflammasome, caspase-1 activation and interleukin (IL)-1beta expression in gout. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 169-174 25813103-1 2015 Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also known as NOD-like receptor family, pyrin domain containing 3 (NALP3) and cryopyrin] inflammasome, caspase-1 activation and interleukin (IL)-1beta expression in gout. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 243-248 25813103-1 2015 Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also known as NOD-like receptor family, pyrin domain containing 3 (NALP3) and cryopyrin] inflammasome, caspase-1 activation and interleukin (IL)-1beta expression in gout. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 254-263 25813103-5 2015 Soluble UA significantly enhanced TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 8-10 NLR family pyrin domain containing 3 Homo sapiens 40-45 25813103-6 2015 The TLR4 inhibitor, TAK242 effectively blocked the soluble UA-induced upregulation of TLR4, NALP3, caspase-1, IL-1beta and ICAM-1 expression in the human primary renal proximal tubule epithelial cells. Uric Acid 59-61 NLR family pyrin domain containing 3 Homo sapiens 92-97 25813103-7 2015 Our findings indicate that soluble UA enhances NALP3 expression, caspase-1 activation, IL-1beta and ICAM-1 production in renal proximal tubule epithelial cells in a TLR4-dependent manner, suggesting the activation of innate immunity in human primary renal proximal tubule epithelial cells by soluble UA. Uric Acid 35-37 NLR family pyrin domain containing 3 Homo sapiens 47-52 25897296-0 2015 Role of the NLRP3 inflammasome in the transient release of IL-1beta induced by monosodium urate crystals in human fibroblast-like synoviocytes. Uric Acid 79-95 NLR family pyrin domain containing 3 Homo sapiens 12-17 25897296-6 2015 Simultaneously, intercellular pro-IL-1beta was detected at 6 h. Furthermore, MSU crystals also induced NLRP3 mRNA and protein expression at 6 h to 48 h after MSU treatment. Uric Acid 77-80 NLR family pyrin domain containing 3 Homo sapiens 103-108 24703401-4 2014 Activation of the NLRP3-inflammasome by microcrystals, such as monosodium urate (MSU) and basic calcium phosphate (BCP) crystals, leads to IL1beta release, which in turn triggers local inflammation. Uric Acid 63-79 NLR family pyrin domain containing 3 Homo sapiens 18-23 25594175-5 2015 Importantly, in vivo data show that DA and DRD1 signaling prevent NLRP3 inflammasome-dependent inflammation, including neurotoxin-induced neuroinflammation, LPS-induced systemic inflammation, and monosodium urate crystal (MSU)-induced peritoneal inflammation. Uric Acid 196-212 NLR family pyrin domain containing 3 Homo sapiens 66-71 26435646-0 2015 Urate crystals induce NLRP3 inflammasome-dependent IL-1beta secretion and proliferation in isolated primary human T-cells. Uric Acid 0-5 NLR family pyrin domain containing 3 Homo sapiens 22-27 26435646-11 2015 CONCLUSIONS: Urate, a well defined danger signal, stimulates directly human T-cells in a NLRP3 infmmasomela-dependent way. Uric Acid 13-18 NLR family pyrin domain containing 3 Homo sapiens 89-94 25445147-4 2014 Silica and monosodium urate crystal-treated macrophages with undisturbed lysosomes demonstrated strong co-localization of ASC and Caspase-1, indicative of NLRP3 inflammasome activation. Uric Acid 11-27 NLR family pyrin domain containing 3 Homo sapiens 155-160 25761061-6 2015 We also demonstrated that NLRP3 could activate NF-kappaB and induce cytokines in response to sterile signals, monosodium urate crystals and aluminum adjuvant. Uric Acid 110-126 NLR family pyrin domain containing 3 Homo sapiens 26-31 25686106-4 2015 We report that BHB, but neither AcAc nor the structurally related short-chain fatty acids butyrate and acetate, suppresses activation of the NLRP3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids. Uric Acid 175-180 NLR family pyrin domain containing 3 Homo sapiens 141-146 24703401-4 2014 Activation of the NLRP3-inflammasome by microcrystals, such as monosodium urate (MSU) and basic calcium phosphate (BCP) crystals, leads to IL1beta release, which in turn triggers local inflammation. Uric Acid 81-84 NLR family pyrin domain containing 3 Homo sapiens 18-23 23344781-2 2013 The identification of the role of NLRP3 inflammasome in the recognition of monosodium urate crystals and the subsequent release of IL-1beta was a milestone in the elucidation of the pathogenesis of this disorder. Uric Acid 75-91 NLR family pyrin domain containing 3 Homo sapiens 34-39 24422572-6 2014 The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. Uric Acid 63-79 NLR family pyrin domain containing 3 Homo sapiens 132-137 24456929-0 2013 NLRP3 promotes autophagy of urate crystals phagocytized by human osteoblasts. Uric Acid 28-33 NLR family pyrin domain containing 3 Homo sapiens 0-5 24456929-1 2013 INTRODUCTION: Monosodium urate (MSU) microcrystals present in bone tissues of chronic gout can be ingested by nonprofessional phagocytes like osteoblasts (OBs) that express NLRP3 (nucleotide-binding domain and leucine-rich repeat region containing family of receptor protein 3). Uric Acid 14-30 NLR family pyrin domain containing 3 Homo sapiens 173-178 24127597-4 2013 Recent studies indicate that the reactive oxygen species produced by mitochondrial respiration is critical for the activation of the NLRP3 inflammasome by monosodium urate, alum, and ATP. Uric Acid 155-171 NLR family pyrin domain containing 3 Homo sapiens 133-138 23798679-6 2013 In addition, the extracellular overproduction of metabolites such as uric acid and cholesterol crystals acts as a signal sensed by NLRP3, leading to the production of IL-1beta. Uric Acid 69-78 NLR family pyrin domain containing 3 Homo sapiens 131-136 23430110-10 2013 In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases. Uric Acid 66-82 NLR family pyrin domain containing 3 Homo sapiens 174-179 23762324-9 2013 These findings demonstrate that aPL, via TLR4 activation, induce a uric acid response in human trophoblast, which in turn activates the Nalp3/ASC inflammasome leading to IL-1beta processing and secretion. Uric Acid 67-76 NLR family pyrin domain containing 3 Homo sapiens 136-141 23430110-10 2013 In addition, downregulation of PML by arsenic trioxide suppressed monosodium urate (MSU)-induced IL-1beta production, suggesting that targeting to PML could be used to treat NLRP3 inflammasome-associated diseases. Uric Acid 84-87 NLR family pyrin domain containing 3 Homo sapiens 174-179 23253918-10 2013 Indeed, NLRP3 inflammasome agonists such as uric acid crystal or nigericin induce IL-1alpha cleavage and secretion, leading to the cosecretion of both IL-1beta and IL-1alpha. Uric Acid 44-53 NLR family pyrin domain containing 3 Homo sapiens 8-13 24376319-1 2013 BACKGROUND: Urate through Nacht Domain, Leucine-Rich Repeat, and pyrin domain-containing protein 3 (NALP3) dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1beta (IL-1beta). Uric Acid 12-17 NLR family pyrin domain containing 3 Homo sapiens 100-105 24376319-2 2013 Purinergic receptor P2X7 plays a role in the urate induced NALP3 activation. Uric Acid 45-50 NLR family pyrin domain containing 3 Homo sapiens 59-64 22726397-0 2012 Monosodium urate (MSU) crystals increase gout associated coronary heart disease (CHD) risk through the activation of NLRP3 inflammasome. Uric Acid 0-16 NLR family pyrin domain containing 3 Homo sapiens 117-122 22726397-0 2012 Monosodium urate (MSU) crystals increase gout associated coronary heart disease (CHD) risk through the activation of NLRP3 inflammasome. Uric Acid 18-21 NLR family pyrin domain containing 3 Homo sapiens 117-122 22608202-1 2012 BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1beta (IL-1beta) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive. Uric Acid 12-28 NLR family pyrin domain containing 3 Homo sapiens 235-240 22608202-1 2012 BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1beta (IL-1beta) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive. Uric Acid 30-33 NLR family pyrin domain containing 3 Homo sapiens 235-240