PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34954711-9	2022	Moreover, the memory-improving doses of agmatine augmented Akt/GSK-3beta pathway.	Agmatine	40-48	thymoma viral proto-oncogene 1	Mus musculus	59-62	
23154244-7	2013	Western blotting revealed that agmatine treatment significantly induced vascular endothelial growth factor (VEGF), VEGF receptor 2 (Flk-1/KDR or VEGFR2), phosphatidylinositol 3-kinase (PI3K), Akt/protein kinase B (also known as PKB, PI3K downstream effector protein), endothelial nitric oxide synthase (eNOS) nitric oxide (NO; product by eNOS) and intercellular adhesion molecule 1 (ICAM-1) expressions during bEnd.3 cells migration.	Agmatine	31-39	thymoma viral proto-oncogene 1	Mus musculus	192-195	
23154244-7	2013	Western blotting revealed that agmatine treatment significantly induced vascular endothelial growth factor (VEGF), VEGF receptor 2 (Flk-1/KDR or VEGFR2), phosphatidylinositol 3-kinase (PI3K), Akt/protein kinase B (also known as PKB, PI3K downstream effector protein), endothelial nitric oxide synthase (eNOS) nitric oxide (NO; product by eNOS) and intercellular adhesion molecule 1 (ICAM-1) expressions during bEnd.3 cells migration.	Agmatine	31-39	thymoma viral proto-oncogene 1	Mus musculus	228-231	
23154244-9	2013	SIGNIFICANCE: Taken together, we provide the first evidence that activation of VEGF/VEGFR2 and the consequential PI3K/Akt/eNOS/NO/ICAM-1 signaling pathways are serial events, through which the treatment of agmatine could lead to bEnd.3 cells migration.	Agmatine	206-214	thymoma viral proto-oncogene 1	Mus musculus	118-121	
29763645-9	2018	A 24 h co-incubation with subthreshold concentrations of ketamine (0.01 muM) and agmatine (0.001 muM) was able to cause a significant increase in the phosphorylation levels of Akt (Ser473) and p70S6 kinase (Thr389) as well as PSD95 immunocontent.	Agmatine	81-89	thymoma viral proto-oncogene 1	Mus musculus	176-179	
27685463-0	2016	Agmatine Reduces Lipopolysaccharide-Mediated Oxidant Response via Activating PI3K/Akt Pathway and Up-Regulating Nrf2 and HO-1 Expression in Macrophages.	Agmatine	0-8	thymoma viral proto-oncogene 1	Mus musculus	82-85	
27685463-7	2016	We further demonstrated that the agmatine-induced activation of Nrf2 is likely through the PI3K/Akt pathway.	Agmatine	33-41	thymoma viral proto-oncogene 1	Mus musculus	96-99	
27685463-8	2016	LY294002, a specific PI3K/Akt inhibitor, abolished agmatine-induced HO-1 up-regulation and ROS suppression significantly.	Agmatine	51-59	thymoma viral proto-oncogene 1	Mus musculus	26-29	
27685463-11	2016	Taken together, our findings revealed that agmatine has antioxidant activity against LPS-induced ROS accumulation in RAW 264.7 cells involving HO-1 expression induced by Nrf2 via PI3K/Akt pathway activation.	Agmatine	43-51	thymoma viral proto-oncogene 1	Mus musculus	184-187