PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27061450-0	2016	Agmatine Reverses Sub-chronic Stress induced Nod-like Receptor Protein 3 (NLRP3) Activation and Cytokine Response in Rats.	Agmatine	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	45-72	
31518574-2	2019	Furthermore, administration of agmatine (AGM), a nitric oxide synthase (NOS) inhibitor, reverses stress-induced NLRP3 inflammasome activation in rats.	Agmatine	31-39	NLR family, pyrin domain containing 3	Rattus norvegicus	112-117	
31518574-2	2019	Furthermore, administration of agmatine (AGM), a nitric oxide synthase (NOS) inhibitor, reverses stress-induced NLRP3 inflammasome activation in rats.	Agmatine	41-44	NLR family, pyrin domain containing 3	Rattus norvegicus	112-117	
31518574-9	2019	AGM and other NOS inhibitor treatments were found to be more effective in suppressing NLRP3 and NLRP1, respectively.	Agmatine	0-3	NLR family, pyrin domain containing 3	Rattus norvegicus	86-91	
27061450-0	2016	Agmatine Reverses Sub-chronic Stress induced Nod-like Receptor Protein 3 (NLRP3) Activation and Cytokine Response in Rats.	Agmatine	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	74-79	
27061450-3	2016	In this study, we examined the effect of exogenously administered agmatine on NLRP3 inflammasome pathway/cytokine responses in rats exposed to restraint stress for 7 days.	Agmatine	66-74	NLR family, pyrin domain containing 3	Rattus norvegicus	78-83	
27061450-6	2016	Agmatine significantly down-regulated the gene expressions of all stress-induced NLRP3 inflammasome components (NLRP3, NF-kappaB, PYCARD, caspase-1, IL-1beta and IL-18) in the hippocampus and prefrontal cortex (PFC) and reduced pro-inflammatory cytokine levels not only in both brain regions, but also in serum.	Agmatine	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	81-86	
27061450-6	2016	Agmatine significantly down-regulated the gene expressions of all stress-induced NLRP3 inflammasome components (NLRP3, NF-kappaB, PYCARD, caspase-1, IL-1beta and IL-18) in the hippocampus and prefrontal cortex (PFC) and reduced pro-inflammatory cytokine levels not only in both brain regions, but also in serum.	Agmatine	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	112-117	
27061450-8	2016	The findings of the present study suggest that stress-activated NLRP3 inflammasome and cytokine responses are reversed by an acute administration of agmatine.	Agmatine	149-157	NLR family, pyrin domain containing 3	Rattus norvegicus	64-69	
27061450-9	2016	Whether antidepressant-like effect of agmatine can somehow, at least partially, be mediated by the inhibition of NLRP3 inflammasome cascade and relevant inflammatory responses requires further studies in animal models of depression.	Agmatine	38-46	NLR family, pyrin domain containing 3	Rattus norvegicus	113-118