PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25966970-0	2016	Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice.	Agmatine	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	60-64	
27685463-7	2016	We further demonstrated that the agmatine-induced activation of Nrf2 is likely through the PI3K/Akt pathway.	Agmatine	33-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	64-68	
27685463-11	2016	Taken together, our findings revealed that agmatine has antioxidant activity against LPS-induced ROS accumulation in RAW 264.7 cells involving HO-1 expression induced by Nrf2 via PI3K/Akt pathway activation.	Agmatine	43-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	170-174	
25966970-13	2016	Agmatine"s ability to produce an antidepressant-like effect was abolished in Nrf2 (-/-) mice.	Agmatine	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	77-81	
25966970-14	2016	The present results reinforce the participation of Nrf2 in the antidepressant-like effect produced by agmatine and expand literature data concerning its mechanisms of action.	Agmatine	102-110	nuclear factor, erythroid derived 2, like 2	Mus musculus	51-55	
27685463-0	2016	Agmatine Reduces Lipopolysaccharide-Mediated Oxidant Response via Activating PI3K/Akt Pathway and Up-Regulating Nrf2 and HO-1 Expression in Macrophages.	Agmatine	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	112-116	
27685463-6	2016	Our data demonstrate that agmatine is an activator of Nrf2 signaling that markedly enhances Nrf2 nuclear translocation, increases nuclear Nrf2 protein level, up-regulates the expression of the Nrf2 downstream effector HO-1, and attenuates ROS generation induced by Lipopolysaccharide (LPS).	Agmatine	26-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58	
27685463-6	2016	Our data demonstrate that agmatine is an activator of Nrf2 signaling that markedly enhances Nrf2 nuclear translocation, increases nuclear Nrf2 protein level, up-regulates the expression of the Nrf2 downstream effector HO-1, and attenuates ROS generation induced by Lipopolysaccharide (LPS).	Agmatine	26-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96	
27685463-6	2016	Our data demonstrate that agmatine is an activator of Nrf2 signaling that markedly enhances Nrf2 nuclear translocation, increases nuclear Nrf2 protein level, up-regulates the expression of the Nrf2 downstream effector HO-1, and attenuates ROS generation induced by Lipopolysaccharide (LPS).	Agmatine	26-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96	
27685463-6	2016	Our data demonstrate that agmatine is an activator of Nrf2 signaling that markedly enhances Nrf2 nuclear translocation, increases nuclear Nrf2 protein level, up-regulates the expression of the Nrf2 downstream effector HO-1, and attenuates ROS generation induced by Lipopolysaccharide (LPS).	Agmatine	26-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96	
25966970-2	2016	A recent study by our group demonstrated that agmatine induces Nrf2 and protects against corticosterone effects in a hippocampal neuronal cell line.	Agmatine	46-54	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67	
25966970-7	2016	Wild-type C57BL/6 mice (Nrf2 (+/+)) and Nrf2 KO (Nrf2 (-/-)) were treated during 21 days with agmatine (0.1 mg/kg/day, p.o.)	Agmatine	94-102	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44	
25966970-7	2016	Wild-type C57BL/6 mice (Nrf2 (+/+)) and Nrf2 KO (Nrf2 (-/-)) were treated during 21 days with agmatine (0.1 mg/kg/day, p.o.)	Agmatine	94-102	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44	
35408922-6	2022	Interestingly, we also discovered that agmatine alone increases lipid peroxidation end product levels, induces Nrf2 activation, increases total glutathione content, and GPx activity.	Agmatine	39-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115	
35408922-4	2022	In accordance with these results, agmatine suppresses inflammatory NF-kB, and stimulates antioxidant Nrf2 pathway, resulting in decreased TNF, IL-1 beta, and IL-6 release, and reduced iNOS and COX-2 levels.	Agmatine	34-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-105