PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17047095-4 2007 In HepG2 cells, silencing of ODC-antizyme-1, but not of antizyme inhibitor, by RNA interference resulted in an increase of agmatine"s antiproliferative effect. Agmatine 123-131 ornithine decarboxylase 1 Homo sapiens 29-32 10691775-6 2000 In addition, both NO and agmatine exert inhibitory effects on ornithine decarboxylase (ODC) and the putrescine transporter by significantly different mechanisms. Agmatine 25-33 ornithine decarboxylase 1 Homo sapiens 62-85 10691775-6 2000 In addition, both NO and agmatine exert inhibitory effects on ornithine decarboxylase (ODC) and the putrescine transporter by significantly different mechanisms. Agmatine 25-33 ornithine decarboxylase 1 Homo sapiens 87-90 34560100-2 2021 The polyamines putrescine, agmatine and cadaverine, are produced by pyridoxal 5"-phosphate-dependent L-ornithine, L-arginine and L-lysine decarboxylases (ODC, ADC, LDC), respectively, from both the alanine racemase (AR) and aspartate aminotransferase (AAT) folds. Agmatine 27-35 ornithine decarboxylase 1 Homo sapiens 154-157 35454090-6 2022 (4) The present review provides a novel and complete scheme for the biosynthesis of Pas, including glycine, glutamate, proline and others as PA precursors, and provides a hypothesis that the agmatine pathway may rescue putrescine production when ODC knockout seems to be lethal (solving the apparent contradiction in the literature). Agmatine 191-199 ornithine decarboxylase 1 Homo sapiens 246-249 3145970-4 1988 Inhibition is specific, as a number of substrates and end products of ODC and ADC activities antagonize DFMA and DFMO (i.e. ornithine greater than putrescine = spermidine greater than agmatine). Agmatine 184-192 ornithine decarboxylase 1 Homo sapiens 70-73 27102990-2 2016 Here we aim to develop a pH-responsive cationic poly(agmatine) based on a polyamine analogue-agmatine that can dually function as a gene delivery vector as well as an anticancer agent by inhibiting ODC after intracellular degradation. Agmatine 53-62 ornithine decarboxylase 1 Homo sapiens 198-201 27102990-2 2016 Here we aim to develop a pH-responsive cationic poly(agmatine) based on a polyamine analogue-agmatine that can dually function as a gene delivery vector as well as an anticancer agent by inhibiting ODC after intracellular degradation. Agmatine 53-61 ornithine decarboxylase 1 Homo sapiens 198-201 11160620-1 2001 Agmatine, a product of arginine decarboxylation in mammalian cells, is believed to govern cell polyamines by inducing antizyme, which in turn suppresses ornithine decarboxylase (ODC) activity and polyamine uptake. Agmatine 0-8 ornithine decarboxylase 1 Homo sapiens 153-176 11160620-1 2001 Agmatine, a product of arginine decarboxylation in mammalian cells, is believed to govern cell polyamines by inducing antizyme, which in turn suppresses ornithine decarboxylase (ODC) activity and polyamine uptake. Agmatine 0-8 ornithine decarboxylase 1 Homo sapiens 178-181 25655388-0 2015 Influence of ornithine decarboxylase antizymes and antizyme inhibitors on agmatine uptake by mammalian cells. Agmatine 74-82 ornithine decarboxylase 1 Homo sapiens 13-36 25655388-5 2015 In cells transfected with any of the three ornithine decarboxylase antizymes (AZ1, AZ2 and AZ3), agmatine uptake was dramatically reduced. Agmatine 97-105 ornithine decarboxylase 1 Homo sapiens 43-66 25655388-7 2015 Furthermore, whereas putrescine uptake was significantly decreased in cells transfected with ornithine decarboxylase (ODC), the accumulation of agmatine was stimulated, suggesting a trans-activating effect of intracellular putrescine on agmatine uptake. Agmatine 144-152 ornithine decarboxylase 1 Homo sapiens 93-116 25655388-7 2015 Furthermore, whereas putrescine uptake was significantly decreased in cells transfected with ornithine decarboxylase (ODC), the accumulation of agmatine was stimulated, suggesting a trans-activating effect of intracellular putrescine on agmatine uptake. Agmatine 144-152 ornithine decarboxylase 1 Homo sapiens 118-121 25655388-7 2015 Furthermore, whereas putrescine uptake was significantly decreased in cells transfected with ornithine decarboxylase (ODC), the accumulation of agmatine was stimulated, suggesting a trans-activating effect of intracellular putrescine on agmatine uptake. Agmatine 237-245 ornithine decarboxylase 1 Homo sapiens 93-116 25655388-7 2015 Furthermore, whereas putrescine uptake was significantly decreased in cells transfected with ornithine decarboxylase (ODC), the accumulation of agmatine was stimulated, suggesting a trans-activating effect of intracellular putrescine on agmatine uptake. Agmatine 237-245 ornithine decarboxylase 1 Homo sapiens 118-121 25655388-8 2015 All these results indicate that ODC and its regulatory proteins (antizymes and antizyme inhibitors) may influence agmatine homeostasis in mammalian tissues. Agmatine 114-122 ornithine decarboxylase 1 Homo sapiens 32-35 17047095-5 2007 Thus, the distinct decrease in intracellular polyamine content by agmatine was due to a reduced translation of the synthesizing protein ODC but was not essentially mediated by induction of ODC-antizyme or blockade of antizyme inhibitor. Agmatine 66-74 ornithine decarboxylase 1 Homo sapiens 136-139 15028568-6 2003 We propose that the catabolism of agmatine to its aldehyde metabolite may act as a gating mechanism at the transition from the iNOS/NO axis to the arginase/ODC/polyamine axis. Agmatine 34-42 ornithine decarboxylase 1 Homo sapiens 156-159 16085059-4 2005 Agmatine decreased the rate of L-ornithine decarboxylation and induced a 70% down-regulation of ornithine decarboxylase (ODC) expression. Agmatine 0-8 ornithine decarboxylase 1 Homo sapiens 96-119 16085059-4 2005 Agmatine decreased the rate of L-ornithine decarboxylation and induced a 70% down-regulation of ornithine decarboxylase (ODC) expression. Agmatine 0-8 ornithine decarboxylase 1 Homo sapiens 121-124 15290337-6 2004 Here we describe the capacity of these three arginine pathways to interregulate, and propose a model whereby agmatine has the potential to serve in the coordination of the early and repair phase pathways of arginine in the inflammatory response by acting as a gating mechanism at the transition from the iNOS/NO axis to the arginase/ODC/polyamine axis. Agmatine 109-117 ornithine decarboxylase 1 Homo sapiens 333-336 11804860-2 2002 Agmatinase, which hydrolyzes agmatine to putrescine and urea, not only represents a potentially important mechanism for regulating the biological effects of agmatine in mammalian cells but also represents an alternative to ornithine decarboxylase for polyamine biosynthesis. Agmatine 29-37 ornithine decarboxylase 1 Homo sapiens 223-246