PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15097233-10 2004 CONCLUSIONS: The ACE I/D, alpha-adducin Gly460Trp and aldosterone synthase -344C/T polymorphisms interact to influence systolic blood pressure in Chinese, suggesting that these genes might indeed predispose to hypertension, especially in an ecogenetic context characterized by a high salt intake. Salts 284-288 adducin 1 Homo sapiens 26-39 15608390-1 2004 Previous studies have suggested that the Gly460Trp polymorphism of the alpha-adducin gene (ADD-1) is associated with salt sensitivity and primary hypertension. Salts 117-121 adducin 1 Homo sapiens 71-84 15608390-1 2004 Previous studies have suggested that the Gly460Trp polymorphism of the alpha-adducin gene (ADD-1) is associated with salt sensitivity and primary hypertension. Salts 117-121 adducin 1 Homo sapiens 91-96 15326084-1 2004 Previous studies have shown an association between the alpha-adducin Gly460Trp polymorphism and salt-sensitive hypertension. Salts 96-100 adducin 1 Homo sapiens 55-68 12195119-1 2002 BACKGROUND: The Gly460Trp polymorphism of the alpha-adducin gene (ADD-1 ) has been examined as a candidate gene for essential hypertension with salt sensitivity in the Caucasian population. Salts 144-148 adducin 1 Homo sapiens 46-59 14643575-2 2003 Mutations in the alpha-adducin gene may be associated with hypertension and salt-sensitive hypertension. Salts 76-80 adducin 1 Homo sapiens 17-30 14643575-3 2003 We investigated whether one alpha-adducin polymorphism, the Gly460Trp (G/T) variant, was associated with salt sensitivity, nitric oxide (NO) production; and cardiovascular risk factors in healthy adult normotensive Venezuelans. Salts 105-109 adducin 1 Homo sapiens 28-41 14643575-5 2003 The alpha-Adducin polymorphism was tested in salt-sensitive (SS) and salt-resistant (SR) subjects. Salts 45-49 adducin 1 Homo sapiens 4-17 12623934-2 2003 These genotypes where chosen because previous data showed their interaction in determining the BP response to salt probably was the result of their involvement in the activation of the renin-angiotensin system (ACE) and in the constitutive capacity of the kidney to reabsorb sodium (alpha-adducin) (treatment for 2 months). Salts 110-114 adducin 1 Homo sapiens 283-296 12195119-1 2002 BACKGROUND: The Gly460Trp polymorphism of the alpha-adducin gene (ADD-1 ) has been examined as a candidate gene for essential hypertension with salt sensitivity in the Caucasian population. Salts 144-148 adducin 1 Homo sapiens 66-71 11528213-1 2001 BACKGROUND: Previous studies have suggested that alpha-adducin (alpha-ADD) polymorphism may identify patients with a salt-sensitive form of hypertension. Salts 117-121 adducin 1 Homo sapiens 49-62 11847182-8 2002 Therefore, this study demonstrates a common genetic basis for altered cellular sodium homeostasis, impaired renal sodium handling, and salt-sensitivity of systolic blood pressure in individuals homozygous for the 460Trp polymorphism of the alpha-adducin gene. Salts 135-139 adducin 1 Homo sapiens 240-253 11926892-1 2002 CONTEXT: A genetic variant in alpha-adducin has been associated with renal sodium reabsorption and salt-sensitive hypertension. Salts 99-103 adducin 1 Homo sapiens 30-43 11775124-2 2001 In previous studies, an association has been found between the alpha-adducin Gly460Trp polymorphism and salt-sensitive hypertension. Salts 104-108 adducin 1 Homo sapiens 63-76 11528213-1 2001 BACKGROUND: Previous studies have suggested that alpha-adducin (alpha-ADD) polymorphism may identify patients with a salt-sensitive form of hypertension. Salts 117-121 adducin 1 Homo sapiens 64-73 11528213-2 2001 AIM: To investigate the association between Gly460Trp polymorphism of alpha-ADD and the pattern of blood pressure response to subacute (1 week) salt loading and depletion in young adult thin Polish hypertensives. Salts 144-148 adducin 1 Homo sapiens 70-79 9495254-1 1998 Significant linkage and association of alpha-adducin, a cytoskeleton protein involved in transmembrane ion transport, with essential hypertension were recently shown in Caucasian populations, especially in relation to salt sensitivity. Salts 218-222 adducin 1 Homo sapiens 39-52 10912756-2 2000 Additional studies have suggested that a polymorphism within exon 10 of the human alpha-adducin gene (Gly-460-Trp) may be associated with hypertension and salt sensitivity. Salts 155-159 adducin 1 Homo sapiens 82-95 10673730-1 2000 Previous studies have suggested that the Trp460 allele of the Gly460Trp polymorphism in the alpha-adducin gene is associated with salt sensitivity and primary hypertension. Salts 130-134 adducin 1 Homo sapiens 92-105 9678591-4 1998 Also in humans, a polymorphism of alpha-adducin gene (Gly460Trp) has been found to be significantly associated both to hypertension and salt sensitivity. Salts 136-140 adducin 1 Homo sapiens 34-47 9377722-8 1997 Recently, alpha-adducin variants have been associated to both human primary hypertension and salt sensitive hypertension. Salts 93-97 adducin 1 Homo sapiens 10-23 9149697-12 1997 INTERPRETATION: Our findings of significant linkage of the alpha-adducin locus to essential hypertension and greater sensitivity to changes in sodium balance among patients with the mutant allele suggest that alpha-adducin is associated with a salt-sensitive form of essential hypertension. Salts 244-248 adducin 1 Homo sapiens 209-222 30621146-5 2019 With SIK-2 and Na+/K+-ATPase activation, salt increased the metabolites involved in the renin-angiotensin-aldosterone system (RAAS) such as ADD1, CYP11beta2, and MCR. Salts 41-45 adducin 1 Homo sapiens 140-144 2197289-3 1990 Subcellular distribution studies reveal that fibroblast alpha-adducin is largely associated with the particulate fraction and is most effectively solubilized from that fraction by a combination of nonionic detergent and high salt. Salts 225-229 adducin 1 Homo sapiens 56-69 34055401-2 2021 It is suggested that one of the salt-sensitive arterial hypertension potential markers may be the alpha-adducin gene because its protein product is involved in the ion transport regulation in the renal epithelium. Salts 32-36 adducin 1 Homo sapiens 98-111 19574959-1 2009 BACKGROUND: We examined the association between 12 single-nucleotide polymorphisms (SNPs) in the alpha-adducin (ADD1) and guanine nucleotide binding protein (G protein) beta-polypeptide 3 (GNB3) genes and systolic (SBP), diastolic (DBP), and mean arterial (MAP) pressure responses to salt intake. Salts 284-288 adducin 1 Homo sapiens 97-110 21364877-1 2011 BACKGROUND: Mounting evidence has suggested that alpha-adducin and G-protein beta3 (GNB3) genes are logical candidates for salt-sensitive hypertension. Salts 123-127 adducin 1 Homo sapiens 49-62 30062972-2 2019 alpha-adducin-1 (ADD1) gene is salt sensitive gene which has its role in etiology of hypertension via salt sensitivity. Salts 31-35 adducin 1 Homo sapiens 17-21 30062972-2 2019 alpha-adducin-1 (ADD1) gene is salt sensitive gene which has its role in etiology of hypertension via salt sensitivity. Salts 102-106 adducin 1 Homo sapiens 17-21 30387422-19 2018 CONCLUSION: In our study, the hypertension-associated polymorphisms are linked to the renin-angiotensin-aldosterone axis (ACE I/D, ACE A2350G), as well as to salt and water management (ADD1 G460W, GNB3 C825T). Salts 158-162 adducin 1 Homo sapiens 185-189 28648322-4 2017 Polymorphism of the alpha adducin gene, angiotensin-converting enzyme gene, and insulin receptor substrate 1 gene has been found to be associated with new incident diabetes in hypertensive patients via salt sensitivity and insulin resistance. Salts 202-206 adducin 1 Homo sapiens 20-33 20145305-0 2010 Association between alpha-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis. Salts 94-98 adducin 1 Homo sapiens 20-33 20145305-1 2010 Linkage and association studies suggested the relationship between alpha-adducin polymorphism (Gly460Trp; rs4961) and genetic susceptibility to salt-sensitivity. Salts 144-148 adducin 1 Homo sapiens 67-80 20145305-3 2010 This study aimed to define quantitatively the association between salt-sensitivity and alpha-adducin Gly460Trp polymorphism in all published case-control studies. Salts 66-70 adducin 1 Homo sapiens 87-100 20145305-11 2010 More studies based on a larger population are required to evaluate further the role of alpha-adducin Gly460Trp polymorphism in salt-sensitive hypertension. Salts 127-131 adducin 1 Homo sapiens 87-100 19574959-1 2009 BACKGROUND: We examined the association between 12 single-nucleotide polymorphisms (SNPs) in the alpha-adducin (ADD1) and guanine nucleotide binding protein (G protein) beta-polypeptide 3 (GNB3) genes and systolic (SBP), diastolic (DBP), and mean arterial (MAP) pressure responses to salt intake. Salts 284-288 adducin 1 Homo sapiens 112-116 16612256-1 2006 BACKGROUND: A single-nucleotide polymorphism (Gly460Trp) within the alpha-adducin gene (ADD1) may influence several renal phenotypes, including salt sensitivity, susceptibility to renal failure, the renal haemodynamics and confer a worse cardiovascular risks profile. Salts 144-148 adducin 1 Homo sapiens 68-81 18458162-1 2008 The Gly460Trp variant of the alpha-adducin gene has been associated with renal sodium retention and salt-sensitive hypertension. Salts 100-104 adducin 1 Homo sapiens 29-42 18393230-0 2008 [Association of alpha-adducin and angiotensin converting enzyme gene polymorphisms with salt-sensitive hypertension and early renal injury]. Salts 88-92 adducin 1 Homo sapiens 16-29 18393230-1 2008 OBJECTIVE: To investigate the association between the alpha-adducin gene G460T, angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphisms and salt-sensitive hypertension and early renal injury in Chinese people. Salts 159-163 adducin 1 Homo sapiens 54-67 19145769-1 2009 INTRODUCTION: The Gly460Trp variant of the alpha-adducin gene has been associated with the salt-sensitive and diuretic responsive form of hypertension. Salts 91-95 adducin 1 Homo sapiens 43-56 18667944-6 2008 ADD1 Gly460Trp polymorphism is associated with salt-sensitive hypertension and increased Na-K pump activity in transfected cells. Salts 47-51 adducin 1 Homo sapiens 0-4 18398333-9 2008 Thus, patients with ADD1 Trp alleles are sensitive to salt and tubular Na reabsorption remains elevated after volume expansion. Salts 54-58 adducin 1 Homo sapiens 20-24 16612256-1 2006 BACKGROUND: A single-nucleotide polymorphism (Gly460Trp) within the alpha-adducin gene (ADD1) may influence several renal phenotypes, including salt sensitivity, susceptibility to renal failure, the renal haemodynamics and confer a worse cardiovascular risks profile. Salts 144-148 adducin 1 Homo sapiens 88-92 16531798-1 2006 BACKGROUND: The 460Trp allele of the alpha-adducin gene (ADD1), which is involved in a form of salt-sensitive hypertension, has been associated with patterns of target organ damage. Salts 95-99 adducin 1 Homo sapiens 37-50 16531798-1 2006 BACKGROUND: The 460Trp allele of the alpha-adducin gene (ADD1), which is involved in a form of salt-sensitive hypertension, has been associated with patterns of target organ damage. Salts 95-99 adducin 1 Homo sapiens 57-61