PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19052648-10 2008 There is a potential therapeutic advantage for beta-lactamase resistant cephalosporins with high activity against streptococci. Cephalosporins 72-86 beta-lactamase TEM-1 Haemophilus influenzae 47-61 18759995-9 2008 The third-generation cephalosporins cefixime and cefpodoxime, as well as amoxicillin plus clavulanic acid, continue to be very active against both BL-positive and BLNAR strains of H. influenzae, and thus remain useful treatment options for patients with respiratory tract infections. Cephalosporins 21-35 beta-lactamase TEM-1 Haemophilus influenzae 147-149 17428889-6 2007 Strains with alterations in penicillin binding proteins, particularly PBP3 (beta-lactamase negative ampicillin resistant and beta-lactamase positive amoxicillin-clavulanate resistant), are increasing in prevalence, particularly in Japan, with increasing resistance to ampicillin, amoxicillin, amoxicillin-clavulanate, and many cephalosporins, limiting the efficacy of expanded-spectrum cephalosporins against meningitis and of many oral cephalosporins against other diseases. Cephalosporins 327-341 beta-lactamase TEM-1 Haemophilus influenzae 76-90 17606681-0 2007 Can the Etest correctly determine the MICs of beta-lactam and cephalosporin antibiotics for beta-lactamase-negative ampicillin-resistant Haemophilus influenzae? Cephalosporins 62-75 beta-lactamase TEM-1 Haemophilus influenzae 92-106 17428889-6 2007 Strains with alterations in penicillin binding proteins, particularly PBP3 (beta-lactamase negative ampicillin resistant and beta-lactamase positive amoxicillin-clavulanate resistant), are increasing in prevalence, particularly in Japan, with increasing resistance to ampicillin, amoxicillin, amoxicillin-clavulanate, and many cephalosporins, limiting the efficacy of expanded-spectrum cephalosporins against meningitis and of many oral cephalosporins against other diseases. Cephalosporins 386-400 beta-lactamase TEM-1 Haemophilus influenzae 76-90 17428889-6 2007 Strains with alterations in penicillin binding proteins, particularly PBP3 (beta-lactamase negative ampicillin resistant and beta-lactamase positive amoxicillin-clavulanate resistant), are increasing in prevalence, particularly in Japan, with increasing resistance to ampicillin, amoxicillin, amoxicillin-clavulanate, and many cephalosporins, limiting the efficacy of expanded-spectrum cephalosporins against meningitis and of many oral cephalosporins against other diseases. Cephalosporins 386-400 beta-lactamase TEM-1 Haemophilus influenzae 76-90 9876205-5 1999 These beta-lactamase-negative ampicillin-resistant (BLNAR) organisms were resistant to other cephalosporins such as cefpodoxime and cefdinir, while beta-lactamase-producing strains were susceptible to them. Cephalosporins 93-107 beta-lactamase TEM-1 Haemophilus influenzae 6-20 16492720-4 2006 Although the prevalence of beta-lactamase-positive strains is high, TEM-derived extended-spectrum beta-lactamase (ESBL)-mediated cephalosporin resistance, which is common in Enterobacteriaceae, has not been reported in H. influenzae. Cephalosporins 129-142 beta-lactamase TEM-1 Haemophilus influenzae 98-112 1818798-2 1991 A total of 698 strains of bacteria were tested for beta-lactamase production by the rapid chromogenic cephalosporin method. Cephalosporins 102-115 beta-lactamase TEM-1 Haemophilus influenzae 51-65 1618002-0 1992 In vitro activity of a new broad-spectrum, beta-lactamase-stable oral cephalosporin, cefixime, in comparison with other drugs, against Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis and Streptococcus pneumoniae. Cephalosporins 70-83 beta-lactamase TEM-1 Haemophilus influenzae 43-57 8937842-7 1996 The prevalence of beta-lactamase-positive isolates of M. catarrhalis increased from 92.1% in 1992 to 93.8% in 1993 and to 96.5% in 1994; however, isolates of this species were highly susceptible to amoxicillin-clavulanic acid, the cephalosporins, the macrolides, the fluoroquinolones, chloramphenicol, doxycycline, and trimethoprim-sulfamethoxazole. Cephalosporins 231-245 beta-lactamase TEM-1 Haemophilus influenzae 18-32 3485505-9 1986 beta-Lactamase positive isolates of H. influenzae had higher rates of resistance to all of the cephalosporins than did strains that lacked beta-lactamase. Cephalosporins 95-109 beta-lactamase TEM-1 Haemophilus influenzae 0-14 2081716-8 1990 These results indicated that the mechanisms that confer non-beta-lactamase-mediated insusceptibility to penicillins, cephalosporins and aztreonam in H. influenzae have little or no effect on susceptibility to carbapenems. Cephalosporins 117-131 beta-lactamase TEM-1 Haemophilus influenzae 60-74 6967628-1 1980 Surveys carried out using a chromogenic cephalosporin test for beta-lactamase production (ampicillin resistance) among isolates of Haemophilus influenzae in Johannesburg have indicated an appreciable prevalence, especially among children seen at the new Johannesburg Hospital. Cephalosporins 40-53 beta-lactamase TEM-1 Haemophilus influenzae 63-77 6341936-2 1983 The rapid iodemetric, acidimetric, and chromogenic cephalosporin techniques are specific tests for the presence of beta-lactamase. Cephalosporins 51-64 beta-lactamase TEM-1 Haemophilus influenzae 115-129 3884304-3 1985 Cefuroxime, however, is the most active cephalosporin for beta-lactamase-producing Haemophilus influenzae. Cephalosporins 40-53 beta-lactamase TEM-1 Haemophilus influenzae 58-72 6606223-4 1983 Amoxycillin-sensitive and beta-lactamase-producing haemophili had similar MICs for all cephalosporins. Cephalosporins 87-101 beta-lactamase TEM-1 Haemophilus influenzae 26-40 6982024-0 1982 Pyridinium-2-azo-p-dimethylaniline chromophore, a new chromogenic cephalosporin for rapid beta-lactamase testing. Cephalosporins 66-79 beta-lactamase TEM-1 Haemophilus influenzae 90-104 1080656-5 1975 A rapid assay for beta-lactamase, utilizing a chromogenic cephalosporin substrate, detected enzyme production in all 17 ampicillin-resistant strains of H. influenzae. Cephalosporins 58-71 beta-lactamase TEM-1 Haemophilus influenzae 18-32