PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15894465-7	2005	The older generation cephalosporins can be considered for the therapy of urinary tract infections caused by E. coli harbouring TEM-1, TEM-2 and SHV-1 beta-lactamases but a shorter dosing interval is needed.	Cephalosporins	21-35	hypothetical protein	Escherichia coli	127-132	
9174192-11	1997	In conclusion, this new type of complex mutant derived from TEM-1 (CMT-1) is able to confer resistance at a very low level to inhibitors and at a low level to extended-spectrum cephalosporins.	Cephalosporins	177-191	hypothetical protein	Escherichia coli	60-65	
15797820-9	2005	All isolates exhibiting resistance to third generation cephalosporins harbored the bla(CMY-2) and bla(TEM-1) genes.	Cephalosporins	55-69	hypothetical protein	Escherichia coli	102-107	
1769944-0	1991	An in-vitro and in-vivo comparison of the activity of beta-lactamase inhibitor combinations with imipenem and cephalosporins against Escherichia coli producing TEM-1 or TEM-2 beta-lactamase.	Cephalosporins	110-124	hypothetical protein	Escherichia coli	160-165	
8285630-2	1993	A comparative kinetic analysis of both the wild-type and the Ala-235 TEM-1 enzymes revealed little effect of this substitution of residue 235 on the turnover of penicillins but a greater effect on the turnover of cephalosporins.	Cephalosporins	213-227	hypothetical protein	Escherichia coli	69-74	
20444963-1	2010	Punctual mutations in the TEM-1 or TEM-2 gene may lead to inhibitor-resistant-TEM (IRT) beta-lactamases with resistance to beta-lactam-beta-lactamase inhibitor combinations and susceptibility to cephalosporins.	Cephalosporins	195-209	hypothetical protein	Escherichia coli	26-31	
22116024-3	2012	In addition, the German outbreak strain was found to possess several virulence factors of extra-intestinal pathogenic E. coli and to have acquired resistance to numerous antibiotics, including third-generation cephalosporins, owing to several plasmid-borne genes encoding TEM-1 and CTX-M-15 beta-lactamases.	Cephalosporins	210-224	hypothetical protein	Escherichia coli	272-277	
2197339-1	1990	A clinical Escherichia coli isolate (MG32) resistant to ceftazidime but susceptible to other third-generation cephalosporins was previously examined and found to harbor TEM-1 and exhibit alterations in outer membrane proteins.	Cephalosporins	110-124	hypothetical protein	Escherichia coli	169-174