PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34593422-0 2021 Inhibition of CYP27B1 and CYP24 Increases the Anti-proliferative Effects of 25-Hydroxyvitamin D3 in LNCaP Cells. Calcifediol 76-96 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 26-31 11686044-7 2001 These results strongly suggest that CYP24 is highly responsible for the metabolism of both 25-hydroxyvitamin D3 and 1 alpha,25-dihydroxyvitamin D3. Calcifediol 91-111 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 36-41 34534339-4 2021 Uptake of 25(OH)D3 led to a significant upregulation of vitamin D metabolizing CYP24A1 mRNA levels, indicating that kidney organoids possess a feedback mechanism to control active vitamin D (1,25(OH)2D3) levels. Calcifediol 10-18 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 79-86 34593422-6 2021 The inhibitory effect of 25(OH)D3 on cell proliferation was potentiated after inhibition of CYP17B1 and CYP24 by genistein, preventing further metabolism of 25(OH)D3 to 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3). Calcifediol 25-33 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-109 34593422-8 2021 CONCLUSION: 25(OH)D3 has a direct inhibitory effect on cell proliferation, which is enhanced and accelerated when the metabolism of 25(OH)D3 to 1,25(OH)2D3 and 24,25(OH)2D3 was inhibited by the CYP17B1 and CYP24 inhibitor genistein. Calcifediol 12-20 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 206-211 34593422-8 2021 CONCLUSION: 25(OH)D3 has a direct inhibitory effect on cell proliferation, which is enhanced and accelerated when the metabolism of 25(OH)D3 to 1,25(OH)2D3 and 24,25(OH)2D3 was inhibited by the CYP17B1 and CYP24 inhibitor genistein. Calcifediol 132-140 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 206-211 34337279-1 2021 Context: CYP24A1 encodes 24-hydroxylase, which converts 25(OH)D3 and 1,25(OH)2D3 to inactive metabolites. Calcifediol 56-64 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 9-16 34298790-3 2021 GBM incidence has been negatively correlated with the serum levels of 25-hydroxy-vitamin D3, while the low pH within tumors has been shown to promote the expression of the vitamin D3-degrading enzyme 24-hydroxylase, encoded by the CYP24A1 gene. Calcifediol 70-91 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 231-238 34337279-1 2021 Context: CYP24A1 encodes 24-hydroxylase, which converts 25(OH)D3 and 1,25(OH)2D3 to inactive metabolites. Calcifediol 56-64 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 25-39 34320495-6 2021 The serum was evaluated by liquid chromatography tandem-mass spectrometry for the ratio of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3, (25-OH-D3:24,25-(OH)2D3), an elevation pathognomonic for the loss of function of the CYP24A1 enzyme. Calcifediol 91-111 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 227-234 34320495-6 2021 The serum was evaluated by liquid chromatography tandem-mass spectrometry for the ratio of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3, (25-OH-D3:24,25-(OH)2D3), an elevation pathognomonic for the loss of function of the CYP24A1 enzyme. Calcifediol 143-151 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 227-234 34320495-15 2021 The 25-OH-D3:24,25-(OH)2D3 ratio is an excellent tool for screening for biallelic pathogenic variants in CYP24A1. Calcifediol 4-12 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 105-112 31891001-2 2019 CYP24A1-mediated vitamin D clearance, calculated as the ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 (the vitamin D metabolic ratio, VDMR), is induced by 1,25-dihydroxyvitamin D and may assess tissue-level activity. Calcifediol 100-120 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 30367940-1 2019 Three 23-hydroxylated vitamin D3 derivatives, which are metabolites of 25-hydroxyvitamin D3 produced by CYP24A1 and a related diastereomer, were efficiently synthesized. Calcifediol 71-91 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-111 25446887-14 2015 Taken together, these studies indicate that rapid increases in 25-hydroxyvitamin D3 trigger CYP24A1 and FGF23 induction, limiting effective exposure to calcitriol and iPTH reduction in SHPT. Calcifediol 63-83 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 92-99 28548312-9 2017 Lastly, in patients who received calcifediol (25-OH-D3 ), we documented normal 24-hydroxylase activity (CYP24A1). Calcifediol 33-44 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 104-111 28304097-2 2017 A rapid liquid-chromatography tandem mass spectrometry (LC-MS/MS)-based blood test enabling measurement of the 25-OH-D3 :24,25-(OH)2 D3 ratio (R) can identify IIH patients on the basis of reduced C24-hydroxylation of 25-OH-D3 by CYP24A1 in vivo. Calcifediol 111-119 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 229-236 22940288-2 2013 Calcitriol and its precursor calcidiol (25(OH)D3) are degraded by the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1). Calcifediol 29-38 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 70-109 22940288-2 2013 Calcitriol and its precursor calcidiol (25(OH)D3) are degraded by the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1). Calcifediol 29-38 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 111-118 22940288-2 2013 Calcitriol and its precursor calcidiol (25(OH)D3) are degraded by the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1). Calcifediol 40-48 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 70-109 22940288-2 2013 Calcitriol and its precursor calcidiol (25(OH)D3) are degraded by the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1). Calcifediol 40-48 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 111-118 16289102-1 2005 25-Hydroxyvitamin D(3)-24-hydroxylase (24-hydroxylase) is an important inactivating enzyme and its expression is induced by 25-hydroxyvitamin D3 (25OHD3) and 1alpha,25-dihydroxyvitamin D3 (1alpha,25-(OH)2D3) through action of heterodimers of vitamin D receptor (VDR) and retinoid X receptor (RXR). Calcifediol 124-144 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 23-37 22213329-9 2012 In a recent study, our group demonstrated that calcidiol is an active hormone in CYP24 (24-hydroxylase) deficient cells. Calcifediol 47-56 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 81-86 19667160-1 2009 Tissue-specific expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase) and vitamin D-hydroxylase (24-OHase) may act as the pivotal link between 25-hydroxyvitamin D3 (25(OH)D3) serum levels and the anticancer effects of 1,25-dihydoxyvitamin D3 (1,25(OH)2D3) and alternative splicing of the enzymes may regulate their biological function. Calcifediol 157-177 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 111-119 16600026-5 2006 At least one positive SNP with a TDT of p < 0.05 for asthma or total IgE and calcidiol or calcitriol was seen in IL10, GC, IL12B, CYP2R1, IL4R, and CYP24A1. Calcifediol 80-89 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 151-158 16600026-7 2006 Haplotype association were found only for CYP24A1, the main calcidiol degrading enzyme, where a frequent 5-point-haplotype was associated with asthma (p = 0.00063), total IgE (p = 0.0014), calcidiol (p = 0.0043) and calcitriol (p = 0.0046). Calcifediol 60-69 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 42-49 16600026-7 2006 Haplotype association were found only for CYP24A1, the main calcidiol degrading enzyme, where a frequent 5-point-haplotype was associated with asthma (p = 0.00063), total IgE (p = 0.0014), calcidiol (p = 0.0043) and calcitriol (p = 0.0046). Calcifediol 189-198 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 42-49 16524720-1 2006 25-Hydroxyvitamin D3-24-hydroxylase (24-hydroxylase, CYP24) is an important inactivating enzyme controlling the concentrations of both active metabolites 25-hydroxyvitamin D3 and 1alpha,25-dihydroxyvitamin D3. Calcifediol 154-174 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 53-58 22862690-8 2012 Human CYP27B1 was also active on 25-hydroxyvitamin D(2) and on intermediates of the CYP24A1-mediated inactivation pathway, 24R,25-dihydroxyvitamin D3, 24-oxo-25-hydroxyvitamin D3 and 24-oxo-23,25-dihydroxyvitamin D3, with all these substrates showing comparable k(cat) values of 50-71 min(-1) , similar to 25-hydroxyvitamin D3. Calcifediol 159-179 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 85-92 21610497-4 2011 RECENT FINDINGS: CYP24A1 is the cytochrome P450 enzyme that catalyzes the conversion of 25-hydroxyvitamin D3 (25-OHD3) and its hormonal form, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], into 24-hydroxylated products targeted for excretion. Calcifediol 88-108 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 17-24 21610497-4 2011 RECENT FINDINGS: CYP24A1 is the cytochrome P450 enzyme that catalyzes the conversion of 25-hydroxyvitamin D3 (25-OHD3) and its hormonal form, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], into 24-hydroxylated products targeted for excretion. Calcifediol 110-117 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 17-24 16289102-1 2005 25-Hydroxyvitamin D(3)-24-hydroxylase (24-hydroxylase) is an important inactivating enzyme and its expression is induced by 25-hydroxyvitamin D3 (25OHD3) and 1alpha,25-dihydroxyvitamin D3 (1alpha,25-(OH)2D3) through action of heterodimers of vitamin D receptor (VDR) and retinoid X receptor (RXR). Calcifediol 124-144 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 39-53 15574355-9 2005 CYP24A1 expressed in E. coli showed a remarkable metabolic processes of 25(OH)D3 and 1alpha,25(OH)2D3. Calcifediol 72-80 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 0-7 15223133-8 2004 Equivalent activity in normal and cancer cells of Vitamin D 24-hydroxylase, a mitochondrial enzyme that also uses 25(OH)D(3) as a substrate, further ruled out lack of access to substrate as a basis for low activity of 1alpha(OH)ase in cancer cells. Calcifediol 114-124 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 50-74 14760115-4 2004 We induced CYP24 in seven esophageal cancer cell lines using 25-hydroxyvitamin D3 [25(OH)D3] and compared cell growth rate, measured using the 3-(4, 5-dimethylthiazol-2-y)-2, 5-diphenyltetrazolium bromide (MTT) assay system. Calcifediol 61-81 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 11-16