PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1388592-1	1992	The influence of bioisosteric replacement of catechol moiety of L-Dopa and alpha-Methyldopa with benzimidazole and benzotriazole ring has been examined on dopamine beta-hydroxylase and tyrosinase, in order to evidentiate an inhibitory activity on the synthesis of catecholamines and a possible antihypertensive action.	Methyldopa	75-91	tyrosinase	Homo sapiens	185-195	
8131222-5	1994	Tyrosinase was used to generate ortho-quinones from dopamine and alpha-methyldopa which may bind covalently to GST and thereupon irreversibly inhibit GST.	Methyldopa	65-81	tyrosinase	Homo sapiens	0-10	
8131222-7	1994	The inhibition (expressed as a % of control) after incubating 0.5 microM GST in the presence of 100 units/ml tyrosinase with 5 microM of the catecholamines for 10 min at 25 degrees, was 99% and 67% for dopamine and alpha-methyldopa, respectively.	Methyldopa	215-231	tyrosinase	Homo sapiens	109-119	
2125208-0	1990	Effect of pH on the oxidation pathway of alpha-methyldopa catalysed by tyrosinase.	Methyldopa	41-57	tyrosinase	Homo sapiens	71-81	
2125208-2	1990	Tyrosinase catalyses the oxidation by molecular oxygen of alpha-methyldopa to o-alpha-methyldopaquinone, which evolves non-enzymically through a branched pathway with cyclization or hydroxylation reactions.	Methyldopa	58-74	tyrosinase	Homo sapiens	0-10	
30149701-4	2018	Inspired by such a simple and convenient fluorogenic reaction, a novel polymethyldopa nanoparticles-based fluorescent sensor for detection of tyrosinase activity was developed by using the commercially available metyrosine as a substrate, accompanied by the tyrosinase-catalyzed specific conversion of metyrosine into methyldopa.	Methyldopa	75-85	tyrosinase	Homo sapiens	142-152	
32198661-3	2020	Metyrosine was employed as a TYR substrate because its enzyme catalytic product (methyldopa) was able to function as a monomer molecule to form fluorescent polymethyldopa (PMeDP) with the assistance of BSA/Gly-Gly CuNCs.	Methyldopa	81-91	tyrosinase	Homo sapiens	29-32	
30149701-4	2018	Inspired by such a simple and convenient fluorogenic reaction, a novel polymethyldopa nanoparticles-based fluorescent sensor for detection of tyrosinase activity was developed by using the commercially available metyrosine as a substrate, accompanied by the tyrosinase-catalyzed specific conversion of metyrosine into methyldopa.	Methyldopa	75-85	tyrosinase	Homo sapiens	258-268