PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31412290-9	2019	Trehalose reduced the mRNA and secreted cytokines levels of IL-6, IL-8 and MCP-1 in corneal cells under TNF-alpha and desiccation stress mediated inflammation compared to controls.	Trehalose	0-9	tumor necrosis factor	Mus musculus	104-113	
19505677-7	2009	RESULTS: Treatment with trehalose suppressed LPS-induced IL-1beta and TNF-alpha production and downregulated transcription of these cytokines.	Trehalose	24-33	tumor necrosis factor	Mus musculus	70-79	
19505677-10	2009	CONCLUSION: These results may suggest that trehalose inhibits LPS-induced production of IL-1beta and TNF-alpha in mouse peritoneal macrophages by inhibiting degradation of IkappaB-alphavia the trehalose receptor T1R3.	Trehalose	43-52	tumor necrosis factor	Mus musculus	101-110	
11446983-5	2001	Trehalose significantly suppressed LPS-induced tumor necrosis factor (TNF)-alpha production after 90 min and decreased the number of osteoclasts in the bone marrow 48 hours after LPS injection.	Trehalose	0-9	tumor necrosis factor	Mus musculus	47-80	
11446983-6	2001	These results indicate that trehalose suppresses excessive osteoclastogenesis not only in OVX mice but also in a LPS-induced bone resorption mouse model and further suggest that the latter finding may be mediated at least in part through a decrease in TNF-alpha production.	Trehalose	28-37	tumor necrosis factor	Mus musculus	252-261	
1699114-0	1990	Induction of interferons (IFNs) and tumor necrosis factor (TNF) in mice by a novel glycolipid trehalose 2,3,6"-trimycolate from Rhodococcus aurantiacus (Gordona aurantiaca).	Trehalose	94-103	tumor necrosis factor	Mus musculus	36-57	
1699114-0	1990	Induction of interferons (IFNs) and tumor necrosis factor (TNF) in mice by a novel glycolipid trehalose 2,3,6"-trimycolate from Rhodococcus aurantiacus (Gordona aurantiaca).	Trehalose	94-103	tumor necrosis factor	Mus musculus	59-62	
35483619-3	2022	Here, we show that mixtures of the stabilizing excipients trehalose (Tre) and dextran (Dex), in combination with the shell-forming dispersion enhancer leucine (Leu), stabilize TNF-alpha siRNA-loaded LPNs during spray drying into nanocomposite microparticles, and result in DPI formulations with high aerosol performance.	Trehalose	58-67	tumor necrosis factor	Mus musculus	176-185	
35483619-3	2022	Here, we show that mixtures of the stabilizing excipients trehalose (Tre) and dextran (Dex), in combination with the shell-forming dispersion enhancer leucine (Leu), stabilize TNF-alpha siRNA-loaded LPNs during spray drying into nanocomposite microparticles, and result in DPI formulations with high aerosol performance.	Trehalose	69-72	tumor necrosis factor	Mus musculus	176-185	
35483619-10	2022	Our results demonstrate that at optimal ratios, ternary excipient mixtures of Leu, Tre and Dex protect TNF-alpha siRNA-loaded LPNs during spray drying.	Trehalose	83-86	tumor necrosis factor	Mus musculus	103-112