PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31515484-5 2019 In primary cultured SMCs, TFEB activator trehalose induced nuclear translocation of TFEB and upregulation of TFEB-controlled autophagy genes leading to enhanced autophagy signaling. Trehalose 41-50 transcription factor EB Mus musculus 26-30 32275682-8 2020 AKT inhibitors MK-2206 and trehalose significantly inhibited AKT phosphorylation and stimulated nuclear translocation of TFEB. Trehalose 27-36 transcription factor EB Mus musculus 121-125 32483422-0 2020 Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury. Trehalose 41-50 transcription factor EB Mus musculus 14-18 32483422-5 2020 Based on the transcriptional regulation role of transcription factor EB (TFEB) in autophagy and lysosome, we characterized trehalose-induced nuclear translocation of TFEB. Trehalose 123-132 transcription factor EB Mus musculus 48-71 32483422-5 2020 Based on the transcriptional regulation role of transcription factor EB (TFEB) in autophagy and lysosome, we characterized trehalose-induced nuclear translocation of TFEB. Trehalose 123-132 transcription factor EB Mus musculus 73-77 32483422-5 2020 Based on the transcriptional regulation role of transcription factor EB (TFEB) in autophagy and lysosome, we characterized trehalose-induced nuclear translocation of TFEB. Trehalose 123-132 transcription factor EB Mus musculus 166-170 32483422-6 2020 Furthermore, consistent with trehalose treatment, overexpression of TFEB inhibited cell injury induced by cisplatin. Trehalose 29-38 transcription factor EB Mus musculus 68-72 32483422-7 2020 However, the protective effects of trehalose were largely abrogated in tfeb-knockdown cells. Trehalose 35-44 transcription factor EB Mus musculus 71-75 32483422-9 2020 Trehalose administration activated TFEB-mediated autophagy, alleviated mitochondrial dysfunction and kidney injury in AKI mice. Trehalose 0-9 transcription factor EB Mus musculus 35-39 32483422-10 2020 Innovation and conclusion: Our data suggest that trehalose treatment preserves mitochondria function via activation of TFEB-mediated autophagy and attenuates cisplatin-induced kidney injury. Trehalose 49-58 transcription factor EB Mus musculus 119-123 31515484-5 2019 In primary cultured SMCs, TFEB activator trehalose induced nuclear translocation of TFEB and upregulation of TFEB-controlled autophagy genes leading to enhanced autophagy signaling. Trehalose 41-50 transcription factor EB Mus musculus 84-88 31515484-5 2019 In primary cultured SMCs, TFEB activator trehalose induced nuclear translocation of TFEB and upregulation of TFEB-controlled autophagy genes leading to enhanced autophagy signaling. Trehalose 41-50 transcription factor EB Mus musculus 84-88 31515484-7 2019 These effects of trehalose were mimicked by ectopic upregulation of TFEB and inhibited by TFEB gene silencing. Trehalose 17-26 transcription factor EB Mus musculus 68-72 31515484-7 2019 These effects of trehalose were mimicked by ectopic upregulation of TFEB and inhibited by TFEB gene silencing. Trehalose 17-26 transcription factor EB Mus musculus 90-94 31515484-10 2019 Treatment of mice with trehalose reversed this TFEB pathway suppression, and prevented SMC dedifferentiation and HFD-induced neointima formation. Trehalose 23-32 transcription factor EB Mus musculus 47-51 28165011-4 2017 The autophagy enhancer trehalose activates TFEB by diminishing Akt activity. Trehalose 23-32 transcription factor EB Mus musculus 43-47 29996716-0 2018 TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose. Trehalose 76-85 transcription factor EB Mus musculus 0-4 29996716-4 2018 Here, we demonstrate that trehalose induces hepatocyte TFEB (transcription factor EB)-dependent thermogenesis in vivo, concomitant with upregulation of hepatic and white adipose expression of UCP1 (uncoupling protein 1 [mitochondrial, protein carrier]). Trehalose 26-35 transcription factor EB Mus musculus 55-59 29996716-4 2018 Here, we demonstrate that trehalose induces hepatocyte TFEB (transcription factor EB)-dependent thermogenesis in vivo, concomitant with upregulation of hepatic and white adipose expression of UCP1 (uncoupling protein 1 [mitochondrial, protein carrier]). Trehalose 26-35 transcription factor EB Mus musculus 61-84 29996716-6 2018 Strikingly, hepatocyte-selective TFEB knockdown abrogated trehalose induction of thermogenesis and white adipose tissue UCP1 upregulation in vivo. Trehalose 58-67 transcription factor EB Mus musculus 33-37 34669246-2 2021 Trehalose might antagonize dAGEs induced neurotoxicity via GSK3beta-TFEB signaling. Trehalose 0-9 transcription factor EB Mus musculus 68-72 34971589-0 2022 Trehalose protects against cisplatin-induced cochlear hair cell damage by activating TFEB-mediated autophagy. Trehalose 0-9 transcription factor EB Mus musculus 85-89 34971589-9 2022 Mechanistically, we showed that the effect of trehalose was attributed to increased nuclear translocation of transcription factor EB (TFEB), and this effect could be mimicked by TFEB overexpression and inhibited by TFEB gene silencing or treatment with cyclosporin A (CsA), a calcineurin inhibitor. Trehalose 46-55 transcription factor EB Mus musculus 134-138 34971589-9 2022 Mechanistically, we showed that the effect of trehalose was attributed to increased nuclear translocation of transcription factor EB (TFEB), and this effect could be mimicked by TFEB overexpression and inhibited by TFEB gene silencing or treatment with cyclosporin A (CsA), a calcineurin inhibitor. Trehalose 46-55 transcription factor EB Mus musculus 178-182 34971589-9 2022 Mechanistically, we showed that the effect of trehalose was attributed to increased nuclear translocation of transcription factor EB (TFEB), and this effect could be mimicked by TFEB overexpression and inhibited by TFEB gene silencing or treatment with cyclosporin A (CsA), a calcineurin inhibitor. Trehalose 46-55 transcription factor EB Mus musculus 215-219 34669246-8 2021 Trehalose elevated p-GSK3beta ser9, induced TFEB nuclear translocation, consequently reversed AGE-BSA induced tau phosphorylation in vitro. Trehalose 0-9 transcription factor EB Mus musculus 44-48 34669246-10 2021 Trehalose could strongly reverse dAGEs-induced tau phosphorylation by potentiating TFEB nuclear translocation via inhibiting GSK-3beta. Trehalose 0-9 transcription factor EB Mus musculus 83-87 34669246-7 2021 Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus. Trehalose 0-9 transcription factor EB Mus musculus 39-43 34669246-7 2021 Trehalose upregulated p-GSK3beta ser9, TFEB and TRPML1, ADAM10, OST48, ERalpha and induced TFEB nuclear translocation in hippocampus, elevated IDE and ERbeta in cortex, while reduced p-tau ser396&404, CDK5, cathepsin B and GFAP in hippocampus. Trehalose 0-9 transcription factor EB Mus musculus 91-95 33227703-8 2021 Moreover, a pathogenic role of TFEB in adenine-induced CKD was speculated because the pharmacological activation of TFEB by trehalose failed to protect mice from tubulointerstitial injuries. Trehalose 124-133 transcription factor EB Mus musculus 116-120 34486131-0 2021 Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice. Trehalose 0-9 transcription factor EB Mus musculus 53-57 34486131-2 2021 Trehalose, a disaccharide, activates TFEB and protects against diet-induced nonalcoholic fatty liver disease in mice. Trehalose 0-9 transcription factor EB Mus musculus 37-41 34486131-3 2021 The aim of the present study was to investigate whether trehalose would reverse the impairment of TFEB induced by alcohol and protect against alcohol-induced liver injury. Trehalose 56-65 transcription factor EB Mus musculus 98-102 34486131-7 2021 Trehalose increased TFEB nuclear translocation, elevated levels of LC3-II and lysosomal proteins in mouse livers and cultured AML12 cells, confirming the activation of TFEB by trehalose. Trehalose 0-9 transcription factor EB Mus musculus 20-24 34486131-7 2021 Trehalose increased TFEB nuclear translocation, elevated levels of LC3-II and lysosomal proteins in mouse livers and cultured AML12 cells, confirming the activation of TFEB by trehalose. Trehalose 176-185 transcription factor EB Mus musculus 20-24 34486131-7 2021 Trehalose increased TFEB nuclear translocation, elevated levels of LC3-II and lysosomal proteins in mouse livers and cultured AML12 cells, confirming the activation of TFEB by trehalose. Trehalose 176-185 transcription factor EB Mus musculus 168-172