PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35348612-0 2022 Exploring the mechanism of trehalose: dual functions of PI3K/Akt and VPS34/mTOR pathways in porcine oocytes and cumulus cells . Trehalose 27-36 mechanistic target of rapamycin kinase Homo sapiens 75-79 23997112-7 2013 Stimulation of mammalian target of rapamycin (mTOR)-dependent signaling protected against cell death induced by paraquat, whereas MPP+-induced toxicity was enhanced by wortmannin, a phosphoinositide 3-kinase class III inhibitor, rapamycin, and trehalose, an mTOR-independent autophagy activator. Trehalose 244-253 mechanistic target of rapamycin kinase Homo sapiens 15-44 23997112-7 2013 Stimulation of mammalian target of rapamycin (mTOR)-dependent signaling protected against cell death induced by paraquat, whereas MPP+-induced toxicity was enhanced by wortmannin, a phosphoinositide 3-kinase class III inhibitor, rapamycin, and trehalose, an mTOR-independent autophagy activator. Trehalose 244-253 mechanistic target of rapamycin kinase Homo sapiens 46-50 35455952-6 2022 Finally, mTOR-independent autophagy induction with trehalose resulted in a significant decrease in the lysosomes level sALS PBMCs. Trehalose 51-60 mechanistic target of rapamycin kinase Homo sapiens 9-13 35455952-8 2022 We also found that the induction of the mTOR-independent autophagy pathway leads to a decrease in lysosomes level, suggesting a more sensitivity of sALS PBMCs to trehalose. Trehalose 162-171 mechanistic target of rapamycin kinase Homo sapiens 40-44 35348612-4 2022 Trehalose has been reported as a novel mTOR-independent autophagy inducer in many cells. Trehalose 0-9 mechanistic target of rapamycin kinase Homo sapiens 39-43 35348612-7 2022 In this study, we found that trehalose plays a role as an autophagy activator by autophagic flux assay and determined that it promotes PI3K/Akt inhibition and VPS34/mTOR activation by immunoblotting, both in cumulus cells (CCs) and oocytes. Trehalose 29-38 mechanistic target of rapamycin kinase Homo sapiens 165-169 31481932-8 2019 Overexpression of two components of the chaperone assisted selective autophagy (CASA) complex (BAG3 and HSPB8), enhanced ARpolyQ clearance, while the treatment with the mTOR independent autophagy activator trehalose induced complete ARpolyQ degradation. Trehalose 206-215 mechanistic target of rapamycin kinase Homo sapiens 169-173 32554696-8 2020 Our data demonstrate that the naturally occurring sugar, trehalose, at doses safely achieved in humans inhibits HIV through two mechanisms: 1) decreased entry through the down-regulation of CCR5 in T-cells, and decreased CD4 expression in both T-cells and macrophages; and 2) degradation of intracellular HIV through the induction of MTOR independent autophagy. Trehalose 57-66 mechanistic target of rapamycin kinase Homo sapiens 334-338 32554696-11 2020 Here, we examined the HIV inhibitory effects of the MTOR independent inducer of autophagy, trehalose. Trehalose 91-100 mechanistic target of rapamycin kinase Homo sapiens 52-56 35199998-3 2022 Herein, a kind of nitric oxide (NO)-driven carrier-free nanomotor based on the reaction between trehalose (Tr, one of the mTOR-independent autophagy inducers), L-arginine (Arg), and phosphatidylserine (PS) is reported. Trehalose 96-105 mechanistic target of rapamycin kinase Homo sapiens 122-126 32554696-4 2020 Here, we examined the effect on HIV replication of trehalose, a non-toxic, non-reducing disaccharide that induces autophagy through an MTOR independent mechanism. Trehalose 51-60 mechanistic target of rapamycin kinase Homo sapiens 135-139 28981117-3 2017 In addition, we explored the potential protective effects of trehalose, a novel Mammalian Target of Rapamycin (mTOR)-independent autophagic inducer, in TBHP-treated mouse chondrocytes and a destabilized medial meniscus (DMM) mouse OA model. Trehalose 61-70 mechanistic target of rapamycin kinase Homo sapiens 111-115 31013754-4 2019 Considering these premises, in this study we have analyzed different mTOR-independent inducers, reporting that the disaccharide trehalose, a mTOR-independent autophagy activator, rescued the autophagy flux in Caco-2 cells treated with digested gliadin, as well as improved cell viability. Trehalose 128-137 mechanistic target of rapamycin kinase Homo sapiens 69-73 31013754-4 2019 Considering these premises, in this study we have analyzed different mTOR-independent inducers, reporting that the disaccharide trehalose, a mTOR-independent autophagy activator, rescued the autophagy flux in Caco-2 cells treated with digested gliadin, as well as improved cell viability. Trehalose 128-137 mechanistic target of rapamycin kinase Homo sapiens 141-145 30166521-6 2018 We selected the mTOR-independent disaccharide trehalose and the mTOR-dependent macrolide lactone rapamycin autophagy inducers. Trehalose 46-55 mechanistic target of rapamycin kinase Homo sapiens 16-20 29241092-2 2018 Trehalose, a naturally occurring nontoxic disaccharide found in plants, insects, microorganisms and invertebrates, but not in mammals, was reported to function as a mechanistic target of the rapamycin (mTOR)-independent inducer of autophagy. Trehalose 0-9 mechanistic target of rapamycin kinase Homo sapiens 202-206 26409001-5 2015 In contrast, another mTOR-independent autophagy inducer trehalose has been found to induce autophagy without activating ERK1/2 signaling pathway. Trehalose 56-65 mechanistic target of rapamycin kinase Homo sapiens 21-25 26295831-1 2016 Trehalose, a chemical chaperone and mTOR-independent autophagy enhancer, has shown promise in models of Huntington"s disease, Parkinson"s disease and tauopathies. Trehalose 0-9 mechanistic target of rapamycin kinase Homo sapiens 36-40 27328819-0 2016 Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. Trehalose 0-9 mechanistic target of rapamycin kinase Homo sapiens 101-105 27328819-7 2016 mTOR signalling was not affected by trehalose treatment, suggesting that trehalose induced autophagy through an mTOR-independent pathway. Trehalose 73-82 mechanistic target of rapamycin kinase Homo sapiens 0-4 27328819-7 2016 mTOR signalling was not affected by trehalose treatment, suggesting that trehalose induced autophagy through an mTOR-independent pathway. Trehalose 73-82 mechanistic target of rapamycin kinase Homo sapiens 112-116 25412249-0 2014 Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment. Trehalose 0-9 mechanistic target of rapamycin kinase Homo sapiens 14-18 26559848-0 2016 Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types. Trehalose 0-9 mechanistic target of rapamycin kinase Homo sapiens 14-18 26559848-6 2016 We chose to use trehalose, a nontoxic naturally occurring disaccharide that is found in plants, insects, microorganisms, and invertebrates but not in mammals and that induces autophagy by an mTOR-independent mechanism. Trehalose 16-25 mechanistic target of rapamycin kinase Homo sapiens 191-195 25412249-5 2014 Trehalose, a natural disaccharide, is an mTOR independent autophagy inducer. Trehalose 0-9 mechanistic target of rapamycin kinase Homo sapiens 41-45 25412249-12 2014 It was shown that trehalose induced podocyte autophagy in an mTOR independent manner and without reactive oxygen species involvement. Trehalose 18-27 mechanistic target of rapamycin kinase Homo sapiens 61-65 24505621-7 2014 Additionally, while the autophagy inhibitor chloroquine had no effect, significant neuroprotection was seen instead with two drugs that enhance autophagy induction by different mechanisms, rapamycin (mTOR-dependent) and trehalose (mTOR-independent). Trehalose 220-229 mechanistic target of rapamycin kinase Homo sapiens 231-235 24568549-8 2014 Notably, trehalose is an mTOR-independent inducer of autophagy, and in animal models of neurodegenerative disorders including Alzheimer"s disease, Parkinson"s disease, and Huntington"s disease, has been shown to decrease the levels of toxic protein aggregates, increase autophagy, and improve clinical symptoms and survival. Trehalose 9-18 mechanistic target of rapamycin kinase Homo sapiens 25-29 17182613-0 2007 Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. Trehalose 0-9 mechanistic target of rapamycin kinase Homo sapiens 19-23 17182613-3 2007 Here we report a novel function of trehalose as an mTOR-independent autophagy activator. Trehalose 35-44 mechanistic target of rapamycin kinase Homo sapiens 51-55