PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28876927-0 2017 Attenuation of Antioxidant Capacity in Human Breast Cancer Cells by Carbon Monoxide through Inhibition of Cystathionine beta-Synthase Activity: Implications in Chemotherapeutic Drug Sensitivity. Carbon Monoxide 68-83 cystathionine beta-synthase Homo sapiens 106-133 34573023-5 2021 While CBS is known to be inhibited by NO and CO, little is known about CSE regulation by gasotransmitters. Carbon Monoxide 45-47 cystathionine beta-synthase Homo sapiens 6-9 32031001-0 2020 Reaction of carbon monoxide with cystathionine beta-synthase: implications on drug efficacies in cancer chemotherapy. Carbon Monoxide 12-27 cystathionine beta-synthase Homo sapiens 33-60 32031001-3 2020 Findings from our group have shown CO to mitigate drug resistance in certain cancer cells by the inhibition of cystathionine beta-synthase (CBS), a key regulator of redox homeostasis in the cell. Carbon Monoxide 35-37 cystathionine beta-synthase Homo sapiens 111-138 32031001-3 2020 Findings from our group have shown CO to mitigate drug resistance in certain cancer cells by the inhibition of cystathionine beta-synthase (CBS), a key regulator of redox homeostasis in the cell. Carbon Monoxide 35-37 cystathionine beta-synthase Homo sapiens 140-143 30458366-5 2019 Treatment with exogenous carbon monoxide (CO), a known inhibitor of CBS, may mitigate cisplatin resistance in ovarian cancer cells by attenuation of GSH and MT levels. Carbon Monoxide 25-40 cystathionine beta-synthase Homo sapiens 68-71 30458366-5 2019 Treatment with exogenous carbon monoxide (CO), a known inhibitor of CBS, may mitigate cisplatin resistance in ovarian cancer cells by attenuation of GSH and MT levels. Carbon Monoxide 42-44 cystathionine beta-synthase Homo sapiens 68-71 28876927-6 2017 Carbon monoxide (CO) reduced GSH/GSSG in three breast cancer cell lines by inhibiting CBS. Carbon Monoxide 0-15 cystathionine beta-synthase Homo sapiens 86-89 28876927-6 2017 Carbon monoxide (CO) reduced GSH/GSSG in three breast cancer cell lines by inhibiting CBS. Carbon Monoxide 17-19 cystathionine beta-synthase Homo sapiens 86-89 23790103-3 2013 While Fe(III)-CBS is inert to exogenous ligands, Fe(II)-CBS can be reversibly inhibited by carbon monoxide (CO) and reoxidized by O2 to yield superoxide radical. Carbon Monoxide 91-106 cystathionine beta-synthase Homo sapiens 56-59 26582199-10 2016 These unprecedented observations demonstrate that CBS activation by AdoMet puzzlingly sensitizes the enzyme toward inhibition by exogenous ligands, like CO and NO( ). Carbon Monoxide 153-155 cystathionine beta-synthase Homo sapiens 50-53 28421128-4 2017 Here we found that the ferrous heme of the reportedly mild p.P49L CBS variant has altered spectral properties and markedly increased affinity for CO, making the protein much more prone than wild type (WT) CBS to inactivation at physiological CO levels. Carbon Monoxide 146-148 cystathionine beta-synthase Homo sapiens 66-69 28421128-4 2017 Here we found that the ferrous heme of the reportedly mild p.P49L CBS variant has altered spectral properties and markedly increased affinity for CO, making the protein much more prone than wild type (WT) CBS to inactivation at physiological CO levels. Carbon Monoxide 146-148 cystathionine beta-synthase Homo sapiens 205-208 24515102-7 2014 The novel findings reported here shed new light on CBS regulation by NO( ) and its possible (patho)physiological relevance, enforcing the growing evidence for an interplay among the gasotransmitters NO( ), CO, and H2S in cell signaling. Carbon Monoxide 206-208 cystathionine beta-synthase Homo sapiens 51-54 23790103-7 2013 The reaction of Fe(III)-CBS with the reduced form of the flavoprotein methionine synthase reductase in the presence of CO and NADPH resulted in its reduction and carbonylation to form Fe(II)CO-CBS. Carbon Monoxide 119-121 cystathionine beta-synthase Homo sapiens 24-27 23790103-7 2013 The reaction of Fe(III)-CBS with the reduced form of the flavoprotein methionine synthase reductase in the presence of CO and NADPH resulted in its reduction and carbonylation to form Fe(II)CO-CBS. Carbon Monoxide 119-121 cystathionine beta-synthase Homo sapiens 193-196 23790103-3 2013 While Fe(III)-CBS is inert to exogenous ligands, Fe(II)-CBS can be reversibly inhibited by carbon monoxide (CO) and reoxidized by O2 to yield superoxide radical. Carbon Monoxide 108-110 cystathionine beta-synthase Homo sapiens 56-59 21480614-8 2011 Co(III) hCBS is slowly reduced to Co(II) hCBS, which contains a 5-coordinate, low-spin, S = 1/2 Co-porphyrin that does not retain the cysteine(thiolate) ligand; this form of Co(II) hCBS binds NO((g)) but not CO((g)). Carbon Monoxide 208-210 cystathionine beta-synthase Homo sapiens 8-12 21480614-8 2011 Co(III) hCBS is slowly reduced to Co(II) hCBS, which contains a 5-coordinate, low-spin, S = 1/2 Co-porphyrin that does not retain the cysteine(thiolate) ligand; this form of Co(II) hCBS binds NO((g)) but not CO((g)). Carbon Monoxide 208-210 cystathionine beta-synthase Homo sapiens 41-45 21480614-8 2011 Co(III) hCBS is slowly reduced to Co(II) hCBS, which contains a 5-coordinate, low-spin, S = 1/2 Co-porphyrin that does not retain the cysteine(thiolate) ligand; this form of Co(II) hCBS binds NO((g)) but not CO((g)). Carbon Monoxide 208-210 cystathionine beta-synthase Homo sapiens 41-45 21297920-0 2011 Carbon monoxide stimulates global protein methylation via its inhibitory action on cystathionine beta-synthase. Carbon Monoxide 0-15 cystathionine beta-synthase Homo sapiens 83-110 21297920-2 2011 Based on our previous results in vivo suggesting carbon monoxide serves as an inhibitor of cystathionine beta-synthase that rate-limits transsulfuration pathway for generation of hydrogen sulfide, we have herein hypothesized that the gas might serve as a regulator of protein methylation through accelerating turnover of remethylation cycle residing at the upstream of the enzyme. Carbon Monoxide 49-64 cystathionine beta-synthase Homo sapiens 91-118 21297920-3 2011 Metabolomic analysis in human monoblastic leukemia U937 cells in culture revealed that application of carbon monoxide-releasing molecules caused increases in methionine and S-adenosylmethionine and a decrease in cystathionine in the cells, suggesting the cystathionine beta-synthase inhibition by carbon monoxide. Carbon Monoxide 102-117 cystathionine beta-synthase Homo sapiens 255-282 21297920-5 2011 The protein arginine methylation elicited by carbon monoxide was attenuated by knocking down cystathionine beta-synthase with its small interfering RNA or by blocking S-adenosylhomocysteine hydrolase with adenosine dialdehyde, suggesting remethylation cycling is necessary to trigger the methylation processing. Carbon Monoxide 45-60 cystathionine beta-synthase Homo sapiens 93-120 21297920-7 2011 Collectively with our studies in vivo showing its inhibitory action on endogenous hydrogen sulfide production, the current results suggest that not only inhibition of transsulfuration pathway for H(2)S generation but also activation of protein methylation accounts for notable biological actions of carbon monoxide via the cystathionine beta-synthase inhibition. Carbon Monoxide 299-314 cystathionine beta-synthase Homo sapiens 323-350 16505479-0 2006 Dynamics of carbon monoxide binding to cystathionine beta-synthase. Carbon Monoxide 12-27 cystathionine beta-synthase Homo sapiens 39-66 11148040-7 2001 In addition, the CO adduct of ferrous CBS has vibrational frequencies characteristic of a histidine-heme-CO complex in a hydrophobic environment, and indicates that the Fe-S(Cys) bond is labile. Carbon Monoxide 17-19 cystathionine beta-synthase Homo sapiens 38-41 22331189-5 2012 Recent studies using metabolomics revealed that CO inhibits cystathionine beta-synthase (CBS), which generates H(2)S, another gaseous mediator. Carbon Monoxide 48-50 cystathionine beta-synthase Homo sapiens 60-87 22331189-5 2012 Recent studies using metabolomics revealed that CO inhibits cystathionine beta-synthase (CBS), which generates H(2)S, another gaseous mediator. Carbon Monoxide 48-50 cystathionine beta-synthase Homo sapiens 89-92 11744062-0 2001 Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme. Carbon Monoxide 109-111 cystathionine beta-synthase Homo sapiens 40-67 10052944-5 1999 Binding of carbon monooxide results in the displacement of a thiolate ligand to the ferrous heme, and is accompanied by complete loss of cystathionine beta-synthase activity. Carbon Monoxide 11-27 cystathionine beta-synthase Homo sapiens 137-164 10052944-7 1999 Binding of both CO and cyanide to ferrous cystathionine beta-synthase occurs in two distinct isotherms and indicates that the hemes are nonequivalent. Carbon Monoxide 16-18 cystathionine beta-synthase Homo sapiens 42-69