PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31568823-19 2019 This CO-gastroprotection is mediated by the activity of sGC, NOS and K-ATP channels. Carbon Monoxide 5-7 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 56-59 27074170-1 2016 The heme oxygenase-carbon monoxide pathway has been shown to play an important role in many physiological processes and is capable of altering nociception modulation in the nervous system by stimulating soluble guanylate cyclase (sGC). Carbon Monoxide 19-34 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 203-228 28655348-0 2017 The Carbon monoxide releasing molecule ALF-186 mediates anti-inflammatory and neuroprotective effects via the soluble guanylate cyclase ss1 in rats" retinal ganglion cells after ischemia and reperfusion injury. Carbon Monoxide 4-19 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 110-135 27074170-1 2016 The heme oxygenase-carbon monoxide pathway has been shown to play an important role in many physiological processes and is capable of altering nociception modulation in the nervous system by stimulating soluble guanylate cyclase (sGC). Carbon Monoxide 19-34 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 230-233 17718419-1 2007 OBJECTIVE: To identify the role of soluble guanylyl cyclase-cyclic guanine monophosphate (sGC-cGMP) pathway in the carbon monoxide (CO) mediating regulation of respiratory rhythm from the medulla oblongata. Carbon Monoxide 115-130 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 90-93 18096151-1 2008 The aim of the present study was to investigate the role of the spinal cord heme oxygenase (HO)-carbon monoxide (CO)-soluble guanylate cyclase (sGC)-cGMP pathway in nociceptive response of rats to the formalin experimental nociceptive model. Carbon Monoxide 96-111 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 144-147 18096151-1 2008 The aim of the present study was to investigate the role of the spinal cord heme oxygenase (HO)-carbon monoxide (CO)-soluble guanylate cyclase (sGC)-cGMP pathway in nociceptive response of rats to the formalin experimental nociceptive model. Carbon Monoxide 113-115 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 144-147 23593279-3 2013 We hypothesized that delivery of CO via a novel releasing molecule (CORM) would impart neuroprotection in vivo against ischemia-reperfusion injury (IRI)-induced apoptosis of retinal ganglion cells (RGC) and in vitro of neuronal SH-SY5Y-cells via activation of soluble guanylate-cyclase (sGC). Carbon Monoxide 33-35 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 260-285 23593279-3 2013 We hypothesized that delivery of CO via a novel releasing molecule (CORM) would impart neuroprotection in vivo against ischemia-reperfusion injury (IRI)-induced apoptosis of retinal ganglion cells (RGC) and in vitro of neuronal SH-SY5Y-cells via activation of soluble guanylate-cyclase (sGC). Carbon Monoxide 33-35 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 287-290 21491957-6 2011 The rat-worm chimera containing the atypical sGC Gcy-33 H-NOX domain was weakly activated by NO, CO, and O(2), suggesting that atypical guanylate cyclases and NO-sensitive guanylate cyclases have a common molecular mechanism for enzyme activation. Carbon Monoxide 97-99 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 45-48 15167436-3 2004 By stimulating the soluble guanylyl cyclase (sGC)/cGMP pathway and activating K channels in vascular smooth muscle cells (SMCs), carbon monoxide relaxes vascular tissues under physiological conditions. Carbon Monoxide 129-144 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 19-43 16941138-1 2007 Carbon monoxide (CO) has been identified as a diffusible signaling messenger in the brain, capable of altering body temperature by stimulating soluble guanylate cyclase (sGC). Carbon Monoxide 0-15 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 143-168 16941138-1 2007 Carbon monoxide (CO) has been identified as a diffusible signaling messenger in the brain, capable of altering body temperature by stimulating soluble guanylate cyclase (sGC). Carbon Monoxide 0-15 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 170-173 16941138-1 2007 Carbon monoxide (CO) has been identified as a diffusible signaling messenger in the brain, capable of altering body temperature by stimulating soluble guanylate cyclase (sGC). Carbon Monoxide 17-19 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 143-168 16941138-1 2007 Carbon monoxide (CO) has been identified as a diffusible signaling messenger in the brain, capable of altering body temperature by stimulating soluble guanylate cyclase (sGC). Carbon Monoxide 17-19 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 170-173 18404501-5 2005 sGC may be activated either by nitric oxide (NO) or by carbon monoxide (CO). Carbon Monoxide 55-70 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 0-3 18404501-5 2005 sGC may be activated either by nitric oxide (NO) or by carbon monoxide (CO). Carbon Monoxide 72-74 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 0-3 15312976-1 2004 Soluble guanylyl cylase (sGC) has been identified for being a receptor for the gaseous transmitters nitric oxide and carbon monoxide. Carbon Monoxide 117-132 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 0-23 15312976-1 2004 Soluble guanylyl cylase (sGC) has been identified for being a receptor for the gaseous transmitters nitric oxide and carbon monoxide. Carbon Monoxide 117-132 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 25-28 15520526-1 2004 Carbon monoxide (CO), an activator of soluble guanylate cyclase (SGC) and generated enzymatically by heme oxygenases (HO), is considered to function as an intra- and intercellular neuromodulator or neurotransmitter in the central and peripheral nervous systems. Carbon Monoxide 0-15 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 38-63 15520526-1 2004 Carbon monoxide (CO), an activator of soluble guanylate cyclase (SGC) and generated enzymatically by heme oxygenases (HO), is considered to function as an intra- and intercellular neuromodulator or neurotransmitter in the central and peripheral nervous systems. Carbon Monoxide 0-15 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 65-68 15520526-1 2004 Carbon monoxide (CO), an activator of soluble guanylate cyclase (SGC) and generated enzymatically by heme oxygenases (HO), is considered to function as an intra- and intercellular neuromodulator or neurotransmitter in the central and peripheral nervous systems. Carbon Monoxide 17-19 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 38-63 15520526-1 2004 Carbon monoxide (CO), an activator of soluble guanylate cyclase (SGC) and generated enzymatically by heme oxygenases (HO), is considered to function as an intra- and intercellular neuromodulator or neurotransmitter in the central and peripheral nervous systems. Carbon Monoxide 17-19 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 65-68 14749300-1 2004 Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and carbon monoxide, resulting in cGMP production. Carbon Monoxide 69-84 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 0-24 14749300-1 2004 Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and carbon monoxide, resulting in cGMP production. Carbon Monoxide 69-84 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 26-29 15167436-3 2004 By stimulating the soluble guanylyl cyclase (sGC)/cGMP pathway and activating K channels in vascular smooth muscle cells (SMCs), carbon monoxide relaxes vascular tissues under physiological conditions. Carbon Monoxide 129-144 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 45-48 9930922-0 1999 Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide. Carbon Monoxide 112-127 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 9-33 12551840-0 2003 Visualization of gaseous monoxide reception by soluble guanylate cyclase in the rat retina. Carbon Monoxide 25-33 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 47-72 11309238-1 2001 The cleavage of haeme by haeme oxygenase (HO) yields carbon monoxide (CO), a biologically active molecule which exerts most of its effects via activation of soluble guanylate cyclase (sGC). Carbon Monoxide 53-68 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 157-182 11309238-1 2001 The cleavage of haeme by haeme oxygenase (HO) yields carbon monoxide (CO), a biologically active molecule which exerts most of its effects via activation of soluble guanylate cyclase (sGC). Carbon Monoxide 53-68 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 184-187 11309238-1 2001 The cleavage of haeme by haeme oxygenase (HO) yields carbon monoxide (CO), a biologically active molecule which exerts most of its effects via activation of soluble guanylate cyclase (sGC). Carbon Monoxide 70-72 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 157-182 11309238-1 2001 The cleavage of haeme by haeme oxygenase (HO) yields carbon monoxide (CO), a biologically active molecule which exerts most of its effects via activation of soluble guanylate cyclase (sGC). Carbon Monoxide 70-72 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 184-187 10772062-1 2000 The hypothesis that endogenous carbon monoxide (CO), produced during the oxidation of heme catalyzed by heme oxygenase (HO), plays a role similar to that of nitric oxide (NO) in the regulation of cardiovascular tone has been criticized because of the low potency of CO compared with NO in relaxing blood vessels and stimulating soluble guanylyl cyclase (sGC). Carbon Monoxide 31-46 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 328-352 10772062-1 2000 The hypothesis that endogenous carbon monoxide (CO), produced during the oxidation of heme catalyzed by heme oxygenase (HO), plays a role similar to that of nitric oxide (NO) in the regulation of cardiovascular tone has been criticized because of the low potency of CO compared with NO in relaxing blood vessels and stimulating soluble guanylyl cyclase (sGC). Carbon Monoxide 31-46 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 354-357 10772062-1 2000 The hypothesis that endogenous carbon monoxide (CO), produced during the oxidation of heme catalyzed by heme oxygenase (HO), plays a role similar to that of nitric oxide (NO) in the regulation of cardiovascular tone has been criticized because of the low potency of CO compared with NO in relaxing blood vessels and stimulating soluble guanylyl cyclase (sGC). Carbon Monoxide 48-50 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 328-352 10772062-1 2000 The hypothesis that endogenous carbon monoxide (CO), produced during the oxidation of heme catalyzed by heme oxygenase (HO), plays a role similar to that of nitric oxide (NO) in the regulation of cardiovascular tone has been criticized because of the low potency of CO compared with NO in relaxing blood vessels and stimulating soluble guanylyl cyclase (sGC). Carbon Monoxide 48-50 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 354-357 10714848-0 2000 Halogenated volatile anesthetics inhibit carbon monoxide-stimulated soluble guanylyl cyclase activity in rat brain. Carbon Monoxide 41-56 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 68-92 10714848-3 2000 Carbon monoxide (CO), a more stable gas than NO, activates sGC by the same mechanism as NO. Carbon Monoxide 0-15 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 59-62 10714848-3 2000 Carbon monoxide (CO), a more stable gas than NO, activates sGC by the same mechanism as NO. Carbon Monoxide 17-19 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 59-62 12777948-1 2003 BACKGROUND: Vascular contractility and blood pressure (BP) are regulated by soluble guanylyl cyclase (sGC) and cyclic guanosine monophosphate (cGMP) pathway, which can be influenced by heme oxygenase (HO)-derived carbon monoxide (CO). Carbon Monoxide 213-228 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 76-100 12777948-1 2003 BACKGROUND: Vascular contractility and blood pressure (BP) are regulated by soluble guanylyl cyclase (sGC) and cyclic guanosine monophosphate (cGMP) pathway, which can be influenced by heme oxygenase (HO)-derived carbon monoxide (CO). Carbon Monoxide 213-228 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 102-105 12777948-1 2003 BACKGROUND: Vascular contractility and blood pressure (BP) are regulated by soluble guanylyl cyclase (sGC) and cyclic guanosine monophosphate (cGMP) pathway, which can be influenced by heme oxygenase (HO)-derived carbon monoxide (CO). Carbon Monoxide 230-232 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 76-100 12777948-1 2003 BACKGROUND: Vascular contractility and blood pressure (BP) are regulated by soluble guanylyl cyclase (sGC) and cyclic guanosine monophosphate (cGMP) pathway, which can be influenced by heme oxygenase (HO)-derived carbon monoxide (CO). Carbon Monoxide 230-232 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 102-105 10910101-1 2000 Heme oxygenase-2 (HO-2) synthesizes carbon monoxide (CO), a modulator of soluble guanylate cyclase (sGC). Carbon Monoxide 36-51 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 73-98 10910101-1 2000 Heme oxygenase-2 (HO-2) synthesizes carbon monoxide (CO), a modulator of soluble guanylate cyclase (sGC). Carbon Monoxide 36-51 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 100-103 10910101-1 2000 Heme oxygenase-2 (HO-2) synthesizes carbon monoxide (CO), a modulator of soluble guanylate cyclase (sGC). Carbon Monoxide 53-55 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 73-98 10910101-1 2000 Heme oxygenase-2 (HO-2) synthesizes carbon monoxide (CO), a modulator of soluble guanylate cyclase (sGC). Carbon Monoxide 53-55 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 100-103 9930922-16 1999 The activator experiments show that in a synergistic stimulation with YC-1 sGC can be activated maximally both by nitric oxide and by carbon monoxide and that YC-1 does not directly act via heme. Carbon Monoxide 134-149 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 75-78 8861110-1 1996 Carbon monoxide (CO) is a gas that can permeate biological membranes and it has been suggested that the gas plays a signaling role in the brain by activating soluble guanylyl cyclase (sGC). Carbon Monoxide 0-15 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 158-182 8861110-1 1996 Carbon monoxide (CO) is a gas that can permeate biological membranes and it has been suggested that the gas plays a signaling role in the brain by activating soluble guanylyl cyclase (sGC). Carbon Monoxide 0-15 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 184-187 8861110-1 1996 Carbon monoxide (CO) is a gas that can permeate biological membranes and it has been suggested that the gas plays a signaling role in the brain by activating soluble guanylyl cyclase (sGC). Carbon Monoxide 17-19 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 158-182 8861110-1 1996 Carbon monoxide (CO) is a gas that can permeate biological membranes and it has been suggested that the gas plays a signaling role in the brain by activating soluble guanylyl cyclase (sGC). Carbon Monoxide 17-19 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 184-187