PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22033923-7	2011	A positive feedback loop was described in which VEGF activated Nrf2 in an ERK1/2-dependent manner; the up-regulation of HO-1 expression by Nrf2 augmented the production of carbon monoxide, which in turn up-regulated VEGF expression.	Carbon Monoxide	172-187	mitogen-activated protein kinase 3	Homo sapiens	74-80	
29524413-0	2018	Heme oxygenase-1/carbon monoxide axis suppresses transforming growth factor-beta1-induced growth inhibition by increasing ERK1/2-mediated phosphorylation of Smad3 at Thr-179 in human hepatocellular carcinoma cell lines.	Carbon Monoxide	17-32	mitogen-activated protein kinase 3	Homo sapiens	122-128	
17967787-5	2008	Inhibiting hemin-induced ERK-1/2 activation by U0126 (MAPK-inhibitor), the antioxidant N-acetyl cysteine, the NADPH oxidase inhibitors apocynin and diphenyleneiodonium chloride, the superoxide scavenger tiron, or tricarbonyldichlororuthenium(II)-dimer (carbon-monoxide donor; CORM-2) blocked hemin-induced Egr-1 expression.	Carbon Monoxide	253-268	mitogen-activated protein kinase 3	Homo sapiens	25-32	
16003000-0	2005	Carbon monoxide inhibits IL-17-induced IL-6 production through the MAPK pathway in human pulmonary epithelial cells.	Carbon Monoxide	0-15	mitogen-activated protein kinase 3	Homo sapiens	67-71	
15863496-1	2005	Carbon monoxide (CO), one of the end products of heme oxygenase activity, inhibits smooth muscle proliferation by decreasing ERK1/2 phosphorylation and cyclin D1 expression, a signaling pathway that is known to be modulated by reactive oxygen species (ROS) in airway smooth muscle cells (ASMCs).	Carbon Monoxide	0-15	mitogen-activated protein kinase 3	Homo sapiens	125-131	
15863496-1	2005	Carbon monoxide (CO), one of the end products of heme oxygenase activity, inhibits smooth muscle proliferation by decreasing ERK1/2 phosphorylation and cyclin D1 expression, a signaling pathway that is known to be modulated by reactive oxygen species (ROS) in airway smooth muscle cells (ASMCs).	Carbon Monoxide	17-19	mitogen-activated protein kinase 3	Homo sapiens	125-131	
15863496-4	2005	Here we show that a recently identified carbon monoxide-releasing molecule, [Ru(CO)3Cl2]2 (or CORM-2) 1) inhibits NAD(P)H oxidase cytochrome b558 activity, 2) increases oxidant production by the mitochondria, and 3) inhibits ASMC proliferation and phosphorylation of the ERK1/2 mitogen-activated protein kinase and expression of cyclin D1, two critical pathways involved in muscle proliferation.	Carbon Monoxide	40-55	mitogen-activated protein kinase 3	Homo sapiens	271-277