PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12543247-1	2003	We hypothesized that inhibitors of peroxide removal, such as BCNU, an indirect inhibitor of glutathione peroxidase (GPx), and 3-amino-1,2,4-triazole (AT), a direct inhibitor of catalase (CAT), should cause toxicity to cancer cells after manganese superoxide dismutase (MnSOD) overexpression due to elevated peroxide levels.	Peroxides	35-43	superoxide dismutase 2	Homo sapiens	237-267	
12543247-1	2003	We hypothesized that inhibitors of peroxide removal, such as BCNU, an indirect inhibitor of glutathione peroxidase (GPx), and 3-amino-1,2,4-triazole (AT), a direct inhibitor of catalase (CAT), should cause toxicity to cancer cells after manganese superoxide dismutase (MnSOD) overexpression due to elevated peroxide levels.	Peroxides	35-43	superoxide dismutase 2	Homo sapiens	269-274	
10401622-3	1999	Correlation of biochemical studies with cell cycle studies suggested that heteroploidy observed in the nonadapted MnSOD-overexpressing cell line may be due to increased intracellular peroxides with resultant disruption of the microtubule network, while a decreased mitotic rate was associated with decreased ATP levels in mitosis.	Peroxides	183-192	superoxide dismutase 2	Homo sapiens	114-119	
11912930-8	2002	During catalysis, MnSOD is inhibited by a peroxide complex of the metal in the active site, different from the inhibition of FeSOD and Cu,ZnSOD by Fenton chemistry.	Peroxides	42-50	superoxide dismutase 2	Homo sapiens	18-23	
11580280-1	2001	Manganese superoxide dismutase (MnSOD) cycles between the Mn(II) and Mn(III) states during the catalyzed disproportionation of O(2)(*-), a catalysis that is limited at micromolar levels of superoxide by a peroxide-inhibited complex with the metal.	Peroxides	12-20	superoxide dismutase 2	Homo sapiens	32-37	
11491657-6	2001	Our hypothesis for the mechanism of action of this combination is that overexpression of MnSOD leads to increased peroxide levels and that BCNU inhibits peroxide removal.	Peroxides	114-122	superoxide dismutase 2	Homo sapiens	89-94	
10919671-9	2000	This work suggests that manipulations that inhibit peroxide removal should enhance the tumor suppressive effect of MnSOD overexpression.	Peroxides	51-59	superoxide dismutase 2	Homo sapiens	115-120	
34981770-0	2022	Cryotrapping peroxide in the active site of human mitochondrial manganese superoxide dismutase crystals for neutron diffraction.	Peroxides	13-21	superoxide dismutase 2	Homo sapiens	64-94	
19401447-1	2009	Overexpression of manganese superoxide dismutase (MnSOD), when combined with certain chemicals that inhibit peroxide removal, increases cancer cell cytotoxicity.	Peroxides	30-38	superoxide dismutase 2	Homo sapiens	50-55	
20532186-2	2010	Recent work has shown that cancer cells can be sensitized to cell killing by raising peroxide levels through increased manganese superoxide dismutase (MnSOD) when combined with inhibition of peroxide removal.	Peroxides	85-93	superoxide dismutase 2	Homo sapiens	151-156	
20532186-2	2010	Recent work has shown that cancer cells can be sensitized to cell killing by raising peroxide levels through increased manganese superoxide dismutase (MnSOD) when combined with inhibition of peroxide removal.	Peroxides	131-139	superoxide dismutase 2	Homo sapiens	151-156	
18044968-6	2007	Moreover, the mechanism of this weakened product inhibition was similar to that in E. coli MnSOD, specifically a decrease in the rate constant for the oxidative addition of superoxide to Mn2+MnSOD leading to the formation of the peroxide-inhibited enzyme.	Peroxides	175-183	superoxide dismutase 2	Homo sapiens	91-96	
18044968-6	2007	Moreover, the mechanism of this weakened product inhibition was similar to that in E. coli MnSOD, specifically a decrease in the rate constant for the oxidative addition of superoxide to Mn2+MnSOD leading to the formation of the peroxide-inhibited enzyme.	Peroxides	175-183	superoxide dismutase 2	Homo sapiens	191-196