PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21615078-0 2011 Structure-based design of novel boronic acid-based inhibitors of autotaxin. Boronic Acids 32-44 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 65-74 21615078-3 2011 We recently described a boronic acid-based inhibitor of ATX, named HA155 (1). Boronic Acids 24-36 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 56-59 31547058-5 2019 In this work, we targeted new, improved inhibitors of ATX that mimic the important interactions of boronic acid using a benzoxaborole motif as the acidic warhead. Boronic Acids 99-111 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 54-57 20536182-0 2010 Discovery and optimization of boronic acid based inhibitors of autotaxin. Boronic Acids 30-42 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 63-72 20536182-5 2010 Interestingly, inhibitory potency was dramatically increased by introduction of a boronic acid moiety, designed to target the active site threonine in ATX. Boronic Acids 82-94 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 151-154 20536182-6 2010 Here we report on the discovery and further optimization of boronic acid based ATX inhibitors. Boronic Acids 60-72 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 79-82 20536182-8 2010 The finding that ATX can be targeted by boronic acids may aid the development of ATX inhibitors for therapeutic use. Boronic Acids 40-53 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 17-20 20536182-8 2010 The finding that ATX can be targeted by boronic acids may aid the development of ATX inhibitors for therapeutic use. Boronic Acids 40-53 ectonucleotide pyrophosphatase/phosphodiesterase 2 Homo sapiens 81-84