PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31301771-7 2019 Furthermore, our results indicated that the NEDD8-conjugating E2 enzyme UBE2M was essential for E4orf6-mediated p53 degradation and that its dominant negative mutant UBE2M C111S dramatically blocked E4orf6 functions. e4orf6 96-102 tumor protein p53 Homo sapiens 112-115 31301771-8 2019 The Nedd8-activating enzyme inhibitor MLN4924 decreased E4orf6-induced neddylation of the cullin5 protein and subsequently suppressed p53 degradation. e4orf6 56-62 tumor protein p53 Homo sapiens 134-137 20861261-2 2010 During viral infection, E1B-55K and E4orf6 substitute for the substrate-binding subunits of the host cell cullin 5 class of ubiquitin ligases, resulting in p53 polyubiquitinylation and proteasomal degradation. e4orf6 36-42 tumor protein p53 Homo sapiens 156-159