PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20861261-2	2010	During viral infection, E1B-55K and E4orf6 substitute for the substrate-binding subunits of the host cell cullin 5 class of ubiquitin ligases, resulting in p53 polyubiquitinylation and proteasomal degradation.	e4orf6	36-42	tumor protein p53	Homo sapiens	156-159	
31301771-7	2019	Furthermore, our results indicated that the NEDD8-conjugating E2 enzyme UBE2M was essential for E4orf6-mediated p53 degradation and that its dominant negative mutant UBE2M C111S dramatically blocked E4orf6 functions.	e4orf6	96-102	tumor protein p53	Homo sapiens	112-115	
31301771-8	2019	The Nedd8-activating enzyme inhibitor MLN4924 decreased E4orf6-induced neddylation of the cullin5 protein and subsequently suppressed p53 degradation.	e4orf6	56-62	tumor protein p53	Homo sapiens	134-137