PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35526478-4 2022 Mono-fluorinated oximes showed comparable reactivation to non-halogenated (except asoxime) and mono-chlorinated oximes in case of AChE inhibited by sarin, cyclosarin, VX, and tabun, but were less efficient than di-chlorinated ones. tabun 175-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 15379785-1 2004 The efficacy of various oximes to reactivate acetylcholinesterase phosphorylated by tabun (O-ethyl-N,N-dimethyl phosphoramidocyanidate) was tested by in vitro and in vivo methods. tabun 84-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 33538594-5 2021 To gain insight into this issue, the structures of hAChE inhibited by tabun, sarin, cyclosarin, soman, and GP were obtained along with the inhibition kinetics for these agents. tabun 70-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-56 5576158-2 1971 Tabun is a more potent inhibitor of acetylcholinesterase than is DFP, is both lipid-and water-soluble, and penetrates readily into the squid giant axon in its inhibitory form. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 33538594-8 2021 To identify the structural underpinnings of this phenomenon, the structures of tabun, sarin, and soman-inhibited hAChE in complex with HI-6 were determined. tabun 79-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-118 32454005-5 2020 All compounds were assessed for their ability to reactivate human acetylcholinesterase inhibited by the nerve agents VX, tabun, sarin, cyclosarin and paraoxon in vitro. tabun 121-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 30978400-7 2019 Indeed, after initial screening of the triazole oxime library and its precursors for the reactivation efficacy on Y337A and Y337A/F338A human AChE mutants, we found potentially active oxime-mutant enzyme pairs capable of degrading tabun in cycles of inhibition and reactivation. tabun 231-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 30978400-9 2019 Hence, although the use of mutant enzyme bio-scavengers in humans may be limited in practicality, bioscavenging and efficient neutralization of tabun itself or phosphoramidate mixtures of organophosphates might be achieved efficiently in vitro or ex vivo with these mutant AChE combinations. tabun 144-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 273-277 30205495-5 2018 The novel compounds were prepared, evaluated in vitro on human AChE (HssAChE) inhibited by tabun, paraoxon, methylparaoxon or DFP and compared to commercial HssAChE reactivators (pralidoxime, methoxime, trimedoxime, obidoxime, asoxime) or previously prepared compounds (K048, K074, K075, K203). tabun 91-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 30458057-0 2019 Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase. tabun 12-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 30458057-5 2019 We identified several oximes with significantly improved in vitro reactivating potential for tabun-inhibited human AChE, and in vivo antidotal efficacies in tabun-exposed mice. tabun 93-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 29772260-7 2018 Therefore, it seems that aromatic amino acids at the peripheral binding site presented a limitation in bispyridinium oxime reactivation efficiency of tabun-phosphorylated AChE. tabun 150-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 22808117-1 2012 Oxime drugs translocate through the 20 A active-site gorge of acetylcholinesterase in order to liberate the enzyme from organophosphorus compounds" (such as tabun) conjugation. tabun 157-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 23148598-2 2012 Herein, we described a series of nine nonquaternary phenyltetrahydroisoquinoline-pyridinaldoxime conjugates more efficient than or as efficient as pyridinium oximes to reactivate VX-, tabun- and ethyl paraoxon-inhibited human AChE. tabun 184-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 28446076-1 2018 Tabun is one of the most dangerous nerve agents because it has deleterious effects like inhibition of the essential enzymes acetylcholinesterase (AChE) and butyrylcholinesterase. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 28446076-1 2018 Tabun is one of the most dangerous nerve agents because it has deleterious effects like inhibition of the essential enzymes acetylcholinesterase (AChE) and butyrylcholinesterase. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 26368669-1 2015 Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 26368669-1 2015 Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 24443939-8 2014 The reactivation of AChE inactivated with either cyclosarin or tabun requires the oxime therapeutic to possess an overall polar-positive surface area. tabun 63-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 23527625-0 2014 Reactivation steps by 2-PAM of tabun-inhibited human acetylcholinesterase: reducing the computational cost in hybrid QM/MM methods. tabun 31-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 23376121-1 2013 Nerve agents such as tabun, cyclosarin and Russian VX inhibit the essential enzyme acetylcholinesterase (AChE) by organophosphorylating the catalytic serine residue. tabun 21-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 23376121-1 2013 Nerve agents such as tabun, cyclosarin and Russian VX inhibit the essential enzyme acetylcholinesterase (AChE) by organophosphorylating the catalytic serine residue. tabun 21-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 22975155-1 2013 A library of more than 200 novel uncharged oxime reactivators was used to select and refine lead reactivators of human acetylcholinesterase (hAChE) covalently conjugated with sarin, cyclosarin, VX, paraoxon and tabun. tabun 211-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-146 22343626-2 2012 Starting with the initial lead oxime RS41A identified in our earlier study and extending to the azepine analog RS194B, reactivation rates for OP-hAChE conjugates formed by sarin, cyclosarin, VX, paraoxon, and tabun are enhanced severalfold in vitro. tabun 209-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-150 18501341-0 2008 Oximes: Reactivators of phosphorylated acetylcholinesterase and antidotes in therapy against tabun poisoning. tabun 93-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 20408548-1 2010 Tabun is a warfare agent that inhibits human acetylcholinesterase (hAChE) by rapid phosphylation of the catalytic serine. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-72 17370251-5 2007 In order to investigate the feasibility of combining obidoxime and HI 6, human AChE inhibited by sarin, cyclosarin, VX, tabun and paraoxon was reactivated by these oximes either alone or in combination. tabun 120-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 17924614-0 2007 Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). tabun 34-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 17562604-3 2007 Tabun-inhibited human erythrocyte acetylcholinesterase was completely reactivated only by the most flexible bispyridinium aldoxime - TMB-4 with a propylene chain between two rings. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 17194020-1 2006 Nerve agents such as sarin, cyclosarin and tabun are organophosphorus substances able to inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7). tabun 43-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 17194020-1 2006 Nerve agents such as sarin, cyclosarin and tabun are organophosphorus substances able to inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7). tabun 43-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134