PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30077642-3	2018	In our study, two purine analogues, purvalanol A and roscovitine, were identified as effective inhibitors of aldo-keto reductase 1C3 (AKR1C3), an enzyme that is overexpressed in many cancer types and is also a key player in tumour cell resistance to anthracyclines.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	36-48	aldo-keto reductase family 1 member C3	Homo sapiens	109-132	
30077642-3	2018	In our study, two purine analogues, purvalanol A and roscovitine, were identified as effective inhibitors of aldo-keto reductase 1C3 (AKR1C3), an enzyme that is overexpressed in many cancer types and is also a key player in tumour cell resistance to anthracyclines.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	36-48	aldo-keto reductase family 1 member C3	Homo sapiens	134-140	
30077642-4	2018	Purvalanol A and roscovitine potently inhibited human recombinant AKR1C3 (Ki = 5.5 muM and 1.4 muM, respectively) and displayed similar activity in experiments with intact cells.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	0-12	aldo-keto reductase family 1 member C3	Homo sapiens	66-72	
30077642-6	2018	Furthermore, we demonstrated that the combination of daunorubicin with purvalanol A or roscovitine exhibited a synergistic effect in AKR1C3 overexpressing cells.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	71-83	aldo-keto reductase family 1 member C3	Homo sapiens	133-139	
30077642-7	2018	Based on these findings, it is possible to presume that purvalanol A and roscovitine may have the potential to enhance the therapeutic effectiveness and safety of anthracyclines via inhibition of AKR1C3.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	56-68	aldo-keto reductase family 1 member C3	Homo sapiens	196-202