PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
235559-0	1975	Response of the kallikrein-kinin and renin-angiotensin systems to saline infusion and upright posture.	Sodium Chloride	66-72	renin	Homo sapiens	37-42	
1152349-0	1975	[Plasma aldosterone and plasma renin activity in patients with essential and renal hypertension under acute stimulation with saline depletion and acute suppression with saline infusion].	Sodium Chloride	125-131	renin	Homo sapiens	31-36	
1152349-5	1975	With infusion of saline all the groups showed suppression of the plasma aldosterone and the plasma renin activity.	Sodium Chloride	17-23	renin	Homo sapiens	99-104	
4360859-0	1974	A specific role for saline or the sodium ion in the regulation of renin and aldosterone secretion.	Sodium Chloride	20-26	renin	Homo sapiens	66-71	
4360859-12	1974	These results demonstrate that rate of response of the renin-angiotensin-aldosterone system to acute volume expansion with saline differed from that with dextran and glucose infusion in sodium-depleted man.	Sodium Chloride	123-129	renin	Homo sapiens	55-60	
4360859-13	1974	The data support a specific role for volume expansion with saline or the sodium ion per se in the regulation of renin and aldosterone.	Sodium Chloride	59-65	renin	Homo sapiens	112-117	
5056660-11	1972	As in the 2 day study, plasma aldosterone and renin activity had parallel decrements at 1, 2, 4, and 6 hr after the start of the saline infusion.	Sodium Chloride	129-135	renin	Homo sapiens	46-51	
22124804-6	2012	In addition, beta-adrenergic receptors are critical for the expression of high basal levels of renin and for its release response to lowering blood pressure or MD sodium chloride concentration.	Sodium Chloride	163-178	renin	Homo sapiens	95-100	
5572938-0	1971	Saline suppression of plasma aldosterone and plasma renin activity in hypertension.	Sodium Chloride	0-6	renin	Homo sapiens	52-57	
33382448-9	2021	Sodium chloride supplementation reduced plasma renin (166 to 122 ng/L), and increased the urinary excretions of angiotensinogen, albumin, and alpha1-microglobulin (all P < 0.05).	Sodium Chloride	0-15	renin	Homo sapiens	47-52	
25502115-4	2015	Acute NaCl loads or longer lasting high salt intakes suppress plasma renin activity, whereas reductions in NaCl intake stimulate it.	Sodium Chloride	6-10	renin	Homo sapiens	69-74	
22665048-2	2013	Experimental evidence, mostly from in vitro perfused preparations, indicates an inverse relation between luminal NaCl concentration and renin secretion.	Sodium Chloride	113-117	renin	Homo sapiens	136-141	
22665048-3	2013	The cellular transduction mechanism is initiated by concentration-dependent NaCl uptake through the Na-K-2Cl cotransporter (NKCC2) with activation of NKCC2 causing inhibition and deactivation of NKCC2 causing stimulation of renin release.	Sodium Chloride	76-80	renin	Homo sapiens	224-229	
22665048-6	2013	[NaCl] is a determinant of local PG release over an appropriate concentration range, and blockade of COX-2 activity interferes with the NaCl dependency of renin secretion.	Sodium Chloride	136-140	renin	Homo sapiens	155-160	
4341476-0	1972	Activation of renin in the single juxtaglomerular apparatus by sodium chloride in the tubular fluid at the macula densa.	Sodium Chloride	63-78	renin	Homo sapiens	14-19	
5488728-0	1970	Alterations in plasma renin activity of patients with essential hypertension induced by NaCl and by salt depletion.	Sodium Chloride	88-92	renin	Homo sapiens	22-27	
27600182-1	2016	Guidelines recommend suppression tests such as the saline infusion test (SIT) to ascertain the diagnosis of primary aldosteronism (PA) in patients with a high aldosterone:renin ratio.	Sodium Chloride	51-57	renin	Homo sapiens	171-176	
22071263-4	2012	Aldosterone to plasma renin activity ratio was also pathologic, confirmed by saline load.	Sodium Chloride	77-83	renin	Homo sapiens	22-27	
21424707-8	2011	Renin expression was upregulated by low-salt diet (0.03% NaCl, for 10 days) and downregulated by high-salt diet (4% NaCl, for 10 days).	Sodium Chloride	57-61	renin	Homo sapiens	0-5	
21424707-8	2011	Renin expression was upregulated by low-salt diet (0.03% NaCl, for 10 days) and downregulated by high-salt diet (4% NaCl, for 10 days).	Sodium Chloride	116-120	renin	Homo sapiens	0-5	
18250276-0	2008	Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio".	Sodium Chloride	96-100	renin	Homo sapiens	152-157	
19073901-1	2009	Saline administration may change renin-angiotensin-aldosterone system (RAAS) activity and sodium excretion at constant mean arterial pressure (MAP).	Sodium Chloride	0-6	renin	Homo sapiens	33-38	
18250276-0	2008	Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio".	Sodium Chloride	96-100	renin	Homo sapiens	196-201	
15970491-4	2005	In experimental NaCl sensitive hypertension brain endogenous ouabain, via activation of renin-angiotensin system and of sympathetic nervous system, stimulates adrenocortical production of marinobufagenin, a natriuretic and a vasoconstrictor.	Sodium Chloride	16-20	renin	Homo sapiens	88-93	
17275579-2	2006	Body volume and renin-angiotensin-aldosterone system status are determined by NaCl reabsorption in the distal nephron.	Sodium Chloride	78-82	renin	Homo sapiens	16-21	
11421643-3	2001	Decreased afferent glomerular arteriolar blood flow, increased renal sympathetic nerve discharge and a resultant decreased sodium chloride delivery around macula densa stimulates the Juxta-glomerular apparatus (JGA) and triggers renin-angiotensin-aldosterone mechanism.	Sodium Chloride	123-138	renin	Homo sapiens	229-234	
15486051-11	2005	Compared with GnRH antagonist alone treatments, preisotonic saline infusion plasma renin activity was greater only with P(4)-E(2) treatment, whereas the plasma atrial natriuretic peptide concentration was lower only with P(4) treatment.	Sodium Chloride	60-66	renin	Homo sapiens	83-88	
15486051-12	2005	Isotonic saline infusion suppressed plasma Ald under all conditions, but decreased plasma renin activity only with P(4)-E(2) treatment (average decrease, 1.3 +/- 0.5 ng/ml angiotensin I.h; P &lt; 0.05).	Sodium Chloride	9-15	renin	Homo sapiens	90-95	
15283759-5	2004	Upon moderate increases in luminal sodium chloride concentration macula densa cells release increasing amounts of ATP and decreasing amounts of prostaglandin E(2), thereby increasing afferent arteriolar tone and decreasing the release of renin from granular cells.	Sodium Chloride	35-50	renin	Homo sapiens	238-243	
12717396-7	2003	Significant increases in plasma renin activity (PRA) were found 24 hours and 6 days after paracentesis when saline was used (baseline, 5.6 +/- 5.7; 24 hours, 7.6 +/- 6.9; 6 days, 8.5 +/- 8.0 ng x mL(-1).	Sodium Chloride	108-114	renin	Homo sapiens	32-37	
11509520-6	2001	Saline loading reduced plasma renin activity and plasma arginine vasopressin levels in C and Ex, although the magnitude of decrease was greater in C (P &lt; 0.05).	Sodium Chloride	0-6	renin	Homo sapiens	30-35	
10564233-1	1999	Previous results from our laboratory have shown that in the isolated perfused juxtaglomerular apparatus, nonselective inhibitors of cyclooxygenase (COX) activity prevent the stimulation of renin secretion by a reduction in luminal NaCl concentration at the macula densa.	Sodium Chloride	231-235	renin	Homo sapiens	189-194	
11208568-11	2001	Also, compared with the saline-infused animals, mRNA expression levels of renin, the AT(1) receptor, and AT(2) receptor were elevated in kidneys of fetuses that received infusions of ANG-(1-7).	Sodium Chloride	24-30	renin	Homo sapiens	74-79	
10601119-7	1999	Saline at 150 mL produced qualitatively similar results regarding DL(CO) (-5%, P&lt;0.01 versus baseline), D(M) (-7%, P&lt;0.01 versus baseline), V(C) (9%, P&lt;0.01 versus baseline), rap, wpp, aldosterone (-9%, P&lt;0.05 versus baseline), and renin (-14%, P&lt;0.05 versus baseline).	Sodium Chloride	0-6	renin	Homo sapiens	244-249	
10564233-2	1999	The present studies were performed to examine which COX isoform is involved in NaCl-dependent renin secretion.	Sodium Chloride	79-83	renin	Homo sapiens	94-99	
10564233-3	1999	In the absence of COX inhibitors, a reduction in luminal NaCl (from Na 141/Cl 120 mM to Na 26/Cl 7 mM) caused an increase in renin secretion rate from 4.5 +/- 1.8 to 26.1 +/- 7.4 nGU/min (P &lt; 0.01, n = 19).	Sodium Chloride	57-61	renin	Homo sapiens	125-130	
10516741-5	1999	In both the normal and hypertensive patients saline and dextran suppressed plasma renin activity and aldosterone release, induced renal vasodilation and enhanced the renal vascular response to angiotensin II, similar to that observed during high salt balance.	Sodium Chloride	45-51	renin	Homo sapiens	82-87	
9559415-3	1998	Although saline loading reduced plasma renin activity and plasma angiotensin II to a similar extent in both groups, it increased cardiac output, renal blood flow, and the ratio of renal blood flow to cardiac output in the mild CHF group but not in the control group.	Sodium Chloride	9-15	renin	Homo sapiens	39-44	
9486281-1	1998	Luminal NaCl concentration at the macula densa (MD) has the two established effects of regulating glomerular arteriolar resistance and renin secretion.	Sodium Chloride	8-12	renin	Homo sapiens	135-140	
9486281-4	1998	During long-lasting perturbations of MD NaCl concentration, control of renin secretion becomes the dominant function of the MD.	Sodium Chloride	40-44	renin	Homo sapiens	71-76	
8770169-8	1996	There was a rise in plasma renin concentration in response to adenosine, reaching levels of statistical significance on study day 1 (15.0 +/- 2.02 to 22.2 +/- 2.00 microU/ml, 1 h postcommencement of adenosine; P &lt; 0.05 vs. saline).	Sodium Chloride	226-232	renin	Homo sapiens	27-32	
9492109-5	1997	Plasma renin aldosterone levels responded appropriately to postural changes, salt restriction and saline infusion.	Sodium Chloride	98-104	renin	Homo sapiens	7-12	
9292244-10	1997	However, those CFS patients who again developed an abnormal response to tilt-test had a significantly reduced plasma renin activity (0.79 pmol/ml per h) compared both with healthy controls (1.29 pmol/ml per h) and with those 11 chronic fatigue patients (1.0 pmol/ml per h) who improved after sodium chloride therapy (p = 0.04).	Sodium Chloride	292-307	renin	Homo sapiens	117-122	
9292244-11	1997	In conclusion, in our study CFS patients who did not respond to sodium chloride therapy were found to have low plasma renin activity.	Sodium Chloride	64-79	renin	Homo sapiens	118-123	
9222944-4	1997	RESULTS: Studies on control subjects after placebo showed that natriuresis occurred during the 6 h after commencement of the saline infusion, with falls in plasma albumin concentration, plasma renin activity and plasma aldosterone concentration; in comparison with results of mock infusion (6 mmol Na+) there was no change in the urinary excretion of dopamine and noradrenaline (In their free or conjugated forms).	Sodium Chloride	125-131	renin	Homo sapiens	193-198	
9435952-3	1997	The tubuloglomerular feed-back (TGF) mechanism refers to a series of events whereby changes in the NaCl concentration in the tubular fluid at the end of the thick ascending limb of Henle"s loop are sensed by the macula densa which then elicits a twofold response in the juxtaglomerular apparatus: a change in the afferent arteriolar tone and GFR and an alteration in renin secretion from granular cells.	Sodium Chloride	99-103	renin	Homo sapiens	367-372	
9435952-8	1997	The TGF-mediated vasoconstriction and reduction in renin release following an elevation of the NaCl concentration at the macula densa can be blocked by theophylline and other adenosine-A1-receptor-specific antagonists.	Sodium Chloride	95-99	renin	Homo sapiens	51-56	
7599693-3	1995	Oral administration of furosemide, 40 mg for 2 days, under mild salt restriction (50 mEq NaCl/day) for 6 days stimulated the renin-angiotensin system resulting in significant increases in plasma renin activity (PRA) (1.84 +/- 0.12 vs. 1.05 +/- 0.17 ng/l/s; P &lt; 0.01), plasma angiotensin II concentration, and plasma aldosterone concentration (PAC).	Sodium Chloride	89-93	renin	Homo sapiens	125-130	
8762729-12	1996	Plasma renin increased during GH administration (saline 16.2 +/- 1.9 vs acute 19.0 +/- 1.9; vs 3 days GH 30.8 +/- 3.0; vs 3 weeks GH 27.0 +/- 3.0 mU/l, P = 0.03), whereas aldosterone and atrial natriuretic factor (ANF) levels remained unaffected by GH.	Sodium Chloride	49-55	renin	Homo sapiens	7-12	
8557909-8	1996	Saline infusion suppressed vasopressin, renin activity, angiotensin II and aldosterone in the two control groups (p &lt; or = 0.05) but not in the heart transplant recipients.	Sodium Chloride	0-6	renin	Homo sapiens	40-45	
7485606-10	1995	The plasma renin activity response to hypertonic saline infusion in both conditions was similar.	Sodium Chloride	49-55	renin	Homo sapiens	11-16	
7882601-0	1994	Effects of age and sex on sodium chloride sensitivity: association with plasma renin activity.	Sodium Chloride	26-41	renin	Homo sapiens	79-84	
7882601-2	1994	The present study was undertaken in 87 Japanese inpatients with essential hypertension to investigate the interrelation among effects of age, sex and the renin-angiotensin system on NaCl sensitivity.	Sodium Chloride	182-186	renin	Homo sapiens	154-159	
7994831-7	1994	The intravenous saline load (0.25 mL.kg-1.min-1 for 2 hours) performed on a low-Na+ diet increased plasma ANP levels in low-renin (from 14.30 +/- 4.68 to 23.30 +/- 7.52 fmol/mL at 120 minutes, P &lt; .05) and modulating patients (from 10.95 +/- 3.55 to 18.21 +/- 5.42 fmol/mL at 120 minutes, P &lt; .05), whereas it did not change the hormone levels in nonmodulators (from 10.77 +/- 3.25 to 13.83 +/- 5.70 fmol/mL at 120 minutes, P = NS).	Sodium Chloride	16-22	renin	Homo sapiens	124-129	
7994831-9	1994	However, when the saline load was repeated on a high-NaCl intake, ANP levels increased in both low-renin and modulating patients (P &lt; .05), whereas it failed to increase in nonmodulators.	Sodium Chloride	18-24	renin	Homo sapiens	99-104	
7882601-9	1994	In conclusion, NaCl sensitivity of blood pressure is independently associated with age and the inadequate suppression of the renin-angiotensin system.	Sodium Chloride	15-19	renin	Homo sapiens	125-130	
7917153-0	1994	Effect of atrial natriuretic hormone on hypertonic saline-induced suppression of the renin-aldosterone system.	Sodium Chloride	51-57	renin	Homo sapiens	85-90	
7917153-1	1994	To evaluate the effect of physiologic doses of atrial natriuretic hormone (ANH) on hypertonic saline-induced renin-aldosterone system suppression, nine healthy subjects were studied three times: 1) on a low-salt (LS) diet with a 2 h placebo infusion; 2) on LS with 2 h infusion of human Ser-Tyr28 ANH (0.6 pmol/kg/min)(LS+ANH); and 3) on a high-salt (HS) diet with a 2 h placebo infusion.	Sodium Chloride	94-100	renin	Homo sapiens	109-114	
8107485-2	1993	We reviewed the main mechanisms leading to stimulation of the renin-angiotensin-aldosterone axis during physical stress, i.e. the decrease in renal perfusion and in the NaCl load to the macula densa, the enhancement of sympathetic activity, and the reduction in hormone clearance rate.	Sodium Chloride	169-173	renin	Homo sapiens	62-67	
8110432-2	1993	While sodium chloride is well known to suppress the activity of the renin-angiotensin-aldosterone and the sympathetic nervous system, the effects of nonchloride sodium salts on the response of these systems to physiological stimuli have not been previously studied.	Sodium Chloride	6-21	renin	Homo sapiens	68-73	
8110432-3	1993	We therefore examined the effect of dietary intake of sodium chloride or sodium citrate on the activity of the renin-angiotensin-aldosterone and the sympathetic nervous system during rest and following stimulation by active orthostasis in normotensive salt-sensitive (n = 7) and salt-resistant (n = 8) subjects.	Sodium Chloride	54-69	renin	Homo sapiens	111-116	
1328369-6	1992	RESULTS: Plasma renin activity on a low-NaCl diet was lower, and the erythrocyte Na+ concentration on both diets higher, in hypertensive patients with than in those without a family history.	Sodium Chloride	40-44	renin	Homo sapiens	16-21	
8324915-5	1993	On the placebo day, saline infusion caused significant decreases in plasma albumin concentration, plasma renin activity (PRA), plasma aldosterone concentration and urinary aldosterone excretion, with 2 to 3-fold increases in plasma atrial natriuretic peptide (ANP) concentration and urinary dopamine: noradrenaline ratio (DA:NA), whereas mean urinary kallikrein and prostaglandin E2 (PGE2) excretion rates were unchanged.	Sodium Chloride	20-26	renin	Homo sapiens	105-110	
8104577-2	1993	Following an infusion of 2 L of isotonic saline at a rate of 500 mL/h, plasma renin activity (PRA) and the plasma aldosterone concentration (PAC) were similarly suppressed, while sodium excretion appreciably increased in hypertensive as well as normotensive subjects.	Sodium Chloride	41-47	renin	Homo sapiens	78-83	
1291335-3	1992	(1) Microdissection of an isolated afferent artery with or without macula densa (MD) has revealed that renin release is regulated by NaCl exposure to MD.	Sodium Chloride	133-137	renin	Homo sapiens	103-108	
1531279-2	1992	After saline infusion, increases in urinary sodium excretion, glomerular filtration rate, atrial natriuretic hormone, and urinary dopamine excretion along with suppression of plasma renin activity and aldosterone were compared in the three groups.	Sodium Chloride	6-12	renin	Homo sapiens	182-187	
1590419-12	1992	The data also suggest that urodilatin and the renin-aldosterone system might participate in the long-term renal response to an acute saline infusion and also in the mediation of circadian urinary excretion rhythms.	Sodium Chloride	133-139	renin	Homo sapiens	46-51	
1959849-0	1991	Large-volume paracentesis and intravenous saline: effects on the renin-angiotensin system.	Sodium Chloride	42-48	renin	Homo sapiens	65-70	
1959037-5	1991	In 24 h, renin and sodium deprivation both induced about 14 ml of NaCl consumption, but the time course of the fluid intake differed for the two regimens.	Sodium Chloride	66-70	renin	Homo sapiens	9-14	
2144096-4	1990	Normal VV30 showed a sudden increase in plasma Na+/K+ ATPase inhibitor in response to saline associated with an increase in blood pressure, a forearm arterial and venous constriction, and a sluggish suppression in plasma renin activity, whereas low VV30 exhibited a completely opposite pattern.	Sodium Chloride	86-92	renin	Homo sapiens	221-226	
2268141-5	1990	Plasma renin activity (PRA) after insulin administration was higher than under basal conditions or after saline injection.	Sodium Chloride	105-111	renin	Homo sapiens	7-12	
1851063-9	1991	Urinary sodium excretion, lithium clearance and plasma atrial natriuretic peptide increased and plasma renin activity decreased after saline infusion, whether or not aldosterone was infused.	Sodium Chloride	134-140	renin	Homo sapiens	103-108	
2160342-4	1990	Renin was responsive to posture, low sodium diet, saline infusion and frusemide, but relatively unresponsive to raising or lowering circulating levels of angiotensin II.	Sodium Chloride	50-56	renin	Homo sapiens	0-5	
2196064-3	1990	Suppressions of plasma norepinephrine, renin activity and aldosterone concentration were significantly smaller with NaCit than with NaCl supplement.	Sodium Chloride	132-136	renin	Homo sapiens	39-44	
2147304-6	1990	The explanation of this finding may be the persistence of high activity of the renin-angiotensin-aldosterone system despite its partial inhibition by infusion of saline in cirrhosis of the liver (PRA 1.69 +/- 0.66 nmols/l/hr., PAC 1.12 nmol/l).	Sodium Chloride	162-168	renin	Homo sapiens	79-84	
1705619-1	1990	Renin secretion from renal juxtaglomerular cells is controlled by the intrarenal blood pressure, sodium chloride load of the organism, sympathetic nerve activity, and a number of hormones.	Sodium Chloride	97-112	renin	Homo sapiens	0-5	
2155004-0	1990	Short-term plasma renin activity suppression by saline and release of a plasma endogenous Na/K ATPase inhibitor in essential hypertension.	Sodium Chloride	48-54	renin	Homo sapiens	18-23	
2155004-1	1990	The present study was conducted in 15 essential hypertensives to evaluate the modifications of plasma levels of an endogenous Na/K ATPase inhibitor, blood pressure, forearm hemodynamics and plasma renin activity (PRA) elicited by an intravenous saline infusion (0.9% NaCl at the mean rate of 0.22 mL/min/kg body weight for 2 h).	Sodium Chloride	245-251	renin	Homo sapiens	197-202	
2155004-6	1990	Our results support the hypothesis that acute volume expansion with saline causes an increase in plasma levels of an endogenous sodium pump inhibitor with hemodynamic effects and whose release is related to the individual handling of infused fluids and to the degree of renin-angiotensin-aldosterone suppression.	Sodium Chloride	68-74	renin	Homo sapiens	270-275	
2405885-5	1990	The cellular mechanisms by which changes in tubular fluid NaCl produce vasoconstriction and inhibition of renin secretion are unknown, but the anatomy of the juxtaglomerular apparatus strongly suggests that such responses may be mediated by the extraglomerular mesangial cells located in the polar cushion underlying the macula densa.	Sodium Chloride	58-62	renin	Homo sapiens	106-111	
1705619-5	1990	Moreover, current concepts about the mechanisms by which the blood pressure and the sodium chloride load could influence renin secretion are discussed.	Sodium Chloride	84-99	renin	Homo sapiens	121-126	
2685330-1	1989	Single crystals of glycosylated recombinant human renin have been obtained using the hanging-drop vapor diffusion method with polyethylene glycol and sodium chloride as coprecipitants.	Sodium Chloride	150-165	renin	Homo sapiens	50-55	
2978286-5	1988	Saline loading and ANF infusions initially induced similar natriuresis and suppression of renin-angiotensin-aldosterone system activity in association with markedly disparate values of plasma ANF.	Sodium Chloride	0-6	renin	Homo sapiens	90-95	
2708819-2	1989	The sodium chloride sensitivity was independently correlated with the change in erythrocyte sodium concentration (r = 0.47) and with the change in plasma renin activity (r = 0.29); but it was not related to basal blood pressure, the change in plasma volume of the change in plasma norepinephrine concentration.	Sodium Chloride	4-19	renin	Homo sapiens	154-159	
2708819-3	1989	These data suggest that both intracellular sodium accumulation and inadequate suppression of the renin-angiotensin system may be independently involved in the elevation of blood pressure after sodium chloride loading.	Sodium Chloride	193-208	renin	Homo sapiens	97-102	
2654438-6	1989	These results suggest that an increase in sodium chloride sensitivity of blood pressure in patients with low renin hypertension may be due to the inhibition of Na+-K+ pump in vascular smooth muscle cell membrane.	Sodium Chloride	42-57	renin	Homo sapiens	109-114	
2970806-2	1988	Head-up tilt at 45 degrees for 2 h during placebo saline infusion caused a 7% fall in blood volume accompanied by increases in plasma renin activity (PRA) and plasma arginine vasopressin (AVP) of 112 and 175%, respectively.	Sodium Chloride	50-56	renin	Homo sapiens	134-139	
2968804-2	1988	We studied two groups of borderline hypertensives (BHTs) with different capacities to suppress plasma renin activity in response to saline infusion (0.20 mL/kg/per minute for 2 hours).	Sodium Chloride	132-138	renin	Homo sapiens	102-107	
3411123-5	1988	Saline loading evoked proportionately similar falls in basal plasma renin (PRC) and plasma aldosterone (PAC) concentrations in pregnant and non-pregnant women.	Sodium Chloride	0-6	renin	Homo sapiens	68-73	
2973615-2	1988	Plasma renin activity and plasma aldosterone concentration exhibited opposite changes during saline infusion.	Sodium Chloride	93-99	renin	Homo sapiens	7-12	
3326859-6	1987	Our results support the idea that sodium chloride reabsorption at the macula densa region is negatively correlated to the plasma renin activity in man.	Sodium Chloride	34-49	renin	Homo sapiens	129-134	
3308701-0	1987	Renin suppression by saline is blunted in nonmodulating essential hypertension.	Sodium Chloride	21-27	renin	Homo sapiens	0-5	
2839625-4	1987	By increasing dietary sodium chloride from 2 g/day for 5 days to 20 g/day for 6 days, systolic blood pressure increased significantly from 122 +/- 3.9 to 138 +/- 3.8 mmHg (p less than 0.005), whereas plasma renin activity decreased significantly from 3.9 +/- 0.8 to 0.8 +/- 0.3 ng/ml/hr (p less than 0.002).	Sodium Chloride	22-37	renin	Homo sapiens	207-212	
3328783-19	1987	In the 24 h after renin injection pigeons took 16.58 +/- 2.89 ml of 3% NaCl.	Sodium Chloride	71-75	renin	Homo sapiens	18-23	
3312441-2	1987	Renin release is inhibited by increased sodium chloride transport and stimulated by interrupted sodium chloride transport.	Sodium Chloride	40-55	renin	Homo sapiens	0-5	
3312441-2	1987	Renin release is inhibited by increased sodium chloride transport and stimulated by interrupted sodium chloride transport.	Sodium Chloride	96-111	renin	Homo sapiens	0-5	
3312441-8	1987	The intermediate steps between alterations of sodium chloride transport in the TALH and renin release remain to be defined.	Sodium Chloride	46-61	renin	Homo sapiens	88-93	
3308701-3	1987	To evaluate whether the abnormalities described in these different groups of patients actually occur in the same patient, we assessed the renin-angiotensin-aldosterone axis response to short-term saline loading in 38 hypertensive patients.	Sodium Chloride	196-202	renin	Homo sapiens	138-143	
3308701-5	1987	In response to a 3-hour infusion of saline, 75 mEq/hr, the reduction in plasma renin activity at both 60 and 120 minutes was significantly greater (p less than 0.008) in patients with normal modulation than in the nonmodulators.	Sodium Chloride	36-42	renin	Homo sapiens	79-84	
3330878-0	1987	[Effects of brain ventricular injection of hypertonic/hypotonic NaCl solutions on plasma renin activity and renal sympathetic nerve activity].	Sodium Chloride	64-68	renin	Homo sapiens	89-94	
3326954-0	1987	[Plasma renin substrate in normal subjects and various diseases--influence of sodium chloride and various medicines].	Sodium Chloride	78-93	renin	Homo sapiens	8-13	
2958207-4	1987	During the saline infusion, there was a significant increase in plasma ANP and urinary sodium excretion and a significant decrease in plasma renin activity, aldosterone, albumin, creatinine and packed cell volume.	Sodium Chloride	11-17	renin	Homo sapiens	141-146	
6407871-7	1983	Inactive renin consists of a single polypeptide chain and is activated by proteolysis but not by dissociative reagents such as 4 M NaCl or detergent.	Sodium Chloride	131-135	renin	Homo sapiens	9-14	
3531301-6	1986	However, 3 days after the ewes returned to drinking water fetal plasma renin activity was significantly higher than it was prior to maternal ingestion of 0.17 M NaCl.	Sodium Chloride	161-165	renin	Homo sapiens	71-76	
3005169-4	1986	Natriuresis in hypertensive subjects with normal renin was either normal or blunted; delayed sodium excretion occurred in a subset, along with delayed suppression of the renin-angiotensin-aldosterone system by the saline load.	Sodium Chloride	214-220	renin	Homo sapiens	170-175	
3522420-8	1986	Expressed inactive renin bound to a cibacron-blue affinity column and could be eluted with 0.5M NaCl.	Sodium Chloride	96-100	renin	Homo sapiens	19-24	
3529267-3	1986	Increases in distal NaCl concentration are also believed to inhibit renin secretion.	Sodium Chloride	20-24	renin	Homo sapiens	68-73	
3932470-9	1985	In contrast to the exercise control group, the saline and dobutamine groups developed orthostatic hypotension, tachycardia, and accentuation of the renin-aldosterone response over the 3-wk treatment period; for the saline group, this is best explained by the observed fall in blood volume and for the dobutamine group, by the blunting of vascular vasoconstrictive responses.	Sodium Chloride	47-53	renin	Homo sapiens	148-153	
6392448-4	1984	The results suggested that the NaCl loading group successfully preserved negative feed back in the kallikrein-kinin system, prostaglandin system and renin-angiotensin-aldosterone system as the blood pressure regulation mechanism.	Sodium Chloride	31-35	renin	Homo sapiens	149-154	
6741563-2	1984	Effect of dietary sodium chloride intake on renal prostaglandins, vasopressin and renin-angiotensin-aldosterone system.	Sodium Chloride	18-33	renin	Homo sapiens	82-87	
6139122-4	1983	Plasma renin activity, however, tended to decrease in both the actively (-38%) and saline (-28%) treated subjects.	Sodium Chloride	83-89	renin	Homo sapiens	7-12	
6624788-6	1983	Plasma renin activity fell 45% after hypertonic saline solution.	Sodium Chloride	37-54	renin	Homo sapiens	7-12	
6337502-0	1983	Effects of NaCl on renin and aldosterone responses to potassium depletion.	Sodium Chloride	11-15	renin	Homo sapiens	19-24	
6303178-5	1983	Similarly, in humans, plasma renin activity was suppressed by sodium chloride but not by sodium bicarbonate infusion.	Sodium Chloride	62-77	renin	Homo sapiens	29-34	
6337502-4	1983	Potassium depletion prevented suppression of plasma renin activity (PRA) by dietary NaCl loading and augmented the PRA response to NaCl deprivation.	Sodium Chloride	84-88	renin	Homo sapiens	52-57	
6341193-3	1983	In 4 out of 7 patients with pheochromocytoma, plasma renin activity remained high after saline suppression and decreased into the normal range in all 4 patients after removal of pheochromocytoma.	Sodium Chloride	88-94	renin	Homo sapiens	53-58	
6752539-10	1982	The mediation by the renin-angiotensin system, which is influenced by the sodium chloride balance, allows the sensitivity of this control of GFR to be adjusted in a homeostatically appropriate manner.	Sodium Chloride	74-89	renin	Homo sapiens	21-26	
6346424-0	1983	Effects of light saline loading on renal renin and catecholamine release in hypertensive humans.	Sodium Chloride	17-23	renin	Homo sapiens	41-46	
6346424-2	1983	of isotonic saline over 20 min decreased plasma renin activity but did not affect plasma adrenaline or noradrenaline concentrations in suprarenal aortic, renal venous and caval blood.	Sodium Chloride	12-18	renin	Homo sapiens	48-53	
6346424-4	1983	These data suggest that inhibition of renin secretion after slight volume expansion with saline in hypertensive humans occurs without parallel inhibition of either renal neurosympathetic drive or humoral adrenergic tone to the kidney through circulating catecholamines.	Sodium Chloride	89-95	renin	Homo sapiens	38-43	
6752539-2	1982	Increasing the sodium chloride concentration at the macula densa by perfusion with Ringer"s solution or saline increased the JGA renin activity.	Sodium Chloride	15-30	renin	Homo sapiens	129-134	
6752539-2	1982	Increasing the sodium chloride concentration at the macula densa by perfusion with Ringer"s solution or saline increased the JGA renin activity.	Sodium Chloride	104-110	renin	Homo sapiens	129-134	
573464-3	1979	The juxtaglomerular renin activity and tubuloglomerular feedback response were inhibited acutely, by saline expansion, or chronically, by DOCA-treatment with saline drinking fluid or salt diet, by high salt diet alone, or by inducing two-kidney Goldblatt hypertension.	Sodium Chloride	101-107	renin	Homo sapiens	20-25	
7063287-7	1982	It is concluded that an unusual avidity for sodium chloride reabsorption by the renal tubules leading to extracellular volume expansion and renin-aldosterone suppression plays a significant pathogenic role in this syndrome and may explain the hypertension and biochemical abnormalities discussed.	Sodium Chloride	44-59	renin	Homo sapiens	140-145	
7033266-6	1982	After chromatography on affigel blue, active renin was not bound to the gel, and inactive renin eluted only with 1 M NaCl.	Sodium Chloride	117-121	renin	Homo sapiens	90-95	
6791458-0	1981	Relationship between the postnatal development of the renin-angiotensin-aldosterone system and the electrolyte and acid-base status in the sodium chloride supplemented premature infant.	Sodium Chloride	139-154	renin	Homo sapiens	54-59	
468969-0	1979	Comparison of the suppressive effects of water immersion and saline administration on renin-aldosterone in normal man.	Sodium Chloride	61-67	renin	Homo sapiens	86-91	
469152-5	1979	The fluctuation of plasma renin activity in response to an excess of sodium chloride or to thiazide treatment was reduced progressively with age.	Sodium Chloride	69-84	renin	Homo sapiens	26-31	
7047859-4	1982	The renin-angiotensin-aldosterone system cannot be fully inhibited even by intravascular volume expansion and this may account for the blunted natriuretic response of the developing animal and human to the acute infusion of saline or albumin solutions.	Sodium Chloride	224-230	renin	Homo sapiens	4-9	
589941-12	1977	The results indicate that the suppressibility of the renin-aldosterone system by hyperosmotic sodium chloride solution is normal in young patients with mild essential hypertension.	Sodium Chloride	94-109	renin	Homo sapiens	53-58	
690899-0	1978	Changes in urinary aldosterone excretion and plasma renin activity in response to dietary sodium chloride deprivation in man [proceedings].	Sodium Chloride	90-105	renin	Homo sapiens	52-57	
750669-7	1978	Plasma renin activity (PRA) did not differ in either group on either NaCl ingestion and was equally suppressed on a daily ingestion of 4 Gm of NaCl, while little changed on a high salt intake.	Sodium Chloride	143-147	renin	Homo sapiens	7-12	
833263-0	1977	The effect of posture and saline loading on plasma renin activity and aldosterone concentration in pregnant, non-pregnant and estrogen-treated women.	Sodium Chloride	26-32	renin	Homo sapiens	51-56	
1002819-4	1976	The infusion of 1/3 normal saline (25 mEq sodium/h for 2 h) produced a significant reduction (P less than 0.01) in plasma renin activity (from control levels of 5.2 +/- 0.8 to 3.1 +/- 0.6 ng/ml/h at 90 min).	Sodium Chloride	27-33	renin	Homo sapiens	122-127	
975459-0	1976	A delayed suppression of the renin-aldosterone axis following saline infusion in human hypertension.	Sodium Chloride	62-68	renin	Homo sapiens	29-34	
857177-0	1977	Effects of hemodialysis and saline loading on body fluid compartments, plasma renin activity and blood pressure in patients on chronic hemodialysis.	Sodium Chloride	28-34	renin	Homo sapiens	78-83	
1257693-0	1976	Unimpeded plasma renin increase after intravenous furosemide during saline replacement.	Sodium Chloride	68-74	renin	Homo sapiens	17-22