PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17305412-4 2007 Although both groups of drugs lower blood pressure, studies of the ACE inhibitor perindopril have revealed preservation of beneficial vascular and endothelial effects mediated by bradykinin and nitric oxide. Perindopril 81-92 kininogen 1 Homo sapiens 179-189 24117346-1 2014 The efficacy of the ACE (angiotensin-converting enzyme) inhibitor perindopril in coronary artery disease [EUROPA (European trial on reduction of cardiac events with perindopril in stable coronary artery disease) study] is associated with the rs12050217 A/G single nucleotide polymorphism in the B1 receptor (bradykinin type 1 receptor) gene. Perindopril 66-77 kininogen 1 Homo sapiens 308-318 23933903-2 2013 Among the ACE inhibitor class, the agent perindopril, in particular, has pleiotropic effects that are not equally shared by other ACE inhibitors, including bradykinin site selectivity and subsequent enhancement of nitric oxide and inhibition of endothelial cell apoptosis. Perindopril 41-52 kininogen 1 Homo sapiens 156-166 19275271-13 2009 We therefore have clinical results showing that perindopril normalizes the angiotensin II/bradykinin balance, reduces inflammation and prevents endothelial apoptosis. Perindopril 48-59 kininogen 1 Homo sapiens 90-100 19804327-1 2008 Perindopril, a prodrug ester of perindoprilat, is an angiotensin-converting enzyme inhibitor that lowers angiotensin II and potentiates bradykinin. Perindopril 0-11 kininogen 1 Homo sapiens 136-146 20631409-12 2010 The thrombolytic actions of lipophilic ACE-Is (e.g., quinapril and perindopril) were prevented by pretreatment with either bradykinin B(2) receptor antagonists (e.g., icatibant) or with endothelial COX-2 inhibitors (e.g., rofecoxib, celecoxib and high dose aspirin). Perindopril 67-78 kininogen 1 Homo sapiens 123-133 19379059-2 2009 ACE inhibition by perindopril has two main effects: it inhibits the angiotensin II formation and potentiates bradykinin. Perindopril 18-29 kininogen 1 Homo sapiens 109-119 18221093-4 2006 Perindopril is a third-generation long acting, once-daily lipophilic angiotensin-converting enzyme inhibitor with high tissue angiotensin-converting enzyme affinity, lowering angiotensin II and potentiating bradykinin. Perindopril 0-11 kininogen 1 Homo sapiens 207-217 18219959-10 2007 The most prominent therapeutic effect of perindopril is a result of its high affinity to endothelial ACE and the inhibition of bradykinin degradation. Perindopril 41-52 kininogen 1 Homo sapiens 127-137 15723572-1 2005 Perindopril is a long-acting, once-daily lipophilic angiotensin-converting enzyme inhibitor with high tissue angiotensin-converting enzyme affinity, lowering angiotensin II and potentiating bradykinin. Perindopril 0-11 kininogen 1 Homo sapiens 190-200 16485516-1 2005 Perindopril is a long-acting, once-daily lipophilic angiotensin-converting enzyme inhibitor with high tissue angiotensin-converting enzyme affinity, lowering angiotensin II and potentiating bradykinin. Perindopril 0-11 kininogen 1 Homo sapiens 190-200 16125051-1 2005 Perindopril is a long-acting, once-daily lipophilic angiotensin-converting enzyme inhibitor with high tissue angiotensin-converting enzyme affinity, lowering angiotensin II and potentiating bradykinin. Perindopril 0-11 kininogen 1 Homo sapiens 190-200 11208485-12 2001 "Tissue type" ACE-Is, e.g. quinapril or perindopril acted through accumulation of endogenous Bk. Perindopril 40-51 kininogen 1 Homo sapiens 93-95 12706934-8 2003 The increases in CBF induced by BK in the perindopril and losartan groups were significantly greater than those in the control group. Perindopril 42-53 kininogen 1 Homo sapiens 32-34 12706934-11 2003 CONCLUSIONS: Perindopril and losartan similarly augment BK-induced coronary vasodilation. Perindopril 13-24 kininogen 1 Homo sapiens 56-58 12706934-12 2003 Perindopril may have a greater potential to enhance the BK-induced coronary release of t-PA than losartan. Perindopril 0-11 kininogen 1 Homo sapiens 56-58 11855668-7 2002 The extent of reduction of left ventricular wall motion score by perindopril was closely correlated with that of inhibition of serum ACE activities (P<0.01) and with that of increase in plasma bradykinin concentrations (P<0.05). Perindopril 65-76 kininogen 1 Homo sapiens 196-206 11230284-9 2001 In addition, vasodilator response of balloon-injured coronary arteries to bradykinin was restored by perindopril treatment, whereas no vasodilator response was observed in balloon-injured vessels treated with vehicle. Perindopril 101-112 kininogen 1 Homo sapiens 74-84 29676873-8 2018 In the pharmacological class of ACE-Is, perindopril likely produces the strongest effects on bradykinin, which may explain, at least in part, the documented superiority of this drug in the prevention and treatment of cardiovascular disease. Perindopril 40-51 kininogen 1 Homo sapiens 93-103 32157838-3 2020 This report describes a patient with a bradykinin-mediated angioedema soon after the initiation of perindopril, with laryngeal involvement requiring orotracheal intubation in emergency. Perindopril 99-110 kininogen 1 Homo sapiens 39-49 9634724-6 1998 The hyperinsulinemic euglycaemic clamping of 7 patients with NIDDM and essential hypertension showed that ACE-inhibitor (Perindopril, 4 mg) prevented bradykinin from destruction and increased the glucose consumption by tissues. Perindopril 121-132 kininogen 1 Homo sapiens 150-160