PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9621288-8	1998	In the BEA animals treated with enalapril, ED-1-positive cells, alpha-smooth muscle actin, and transforming growth factor-beta1 were decreased compared with BEA alone.	Enalapril	32-41	actin gamma 2, smooth muscle	Rattus norvegicus	64-127	
26881856-5	2016	We detected lower levels of transforming growth factor beta (TGF-beta) and alpha-smooth muscle actin (alpha-SMA, a fibroblast activation marker) in the kidney tissue of Enalapril-treated UUO rats relative to the control UUO rats.	Enalapril	169-178	actin gamma 2, smooth muscle	Rattus norvegicus	75-100	
26881856-5	2016	We detected lower levels of transforming growth factor beta (TGF-beta) and alpha-smooth muscle actin (alpha-SMA, a fibroblast activation marker) in the kidney tissue of Enalapril-treated UUO rats relative to the control UUO rats.	Enalapril	169-178	actin gamma 2, smooth muscle	Rattus norvegicus	102-111	
22129820-9	2011	High dose of enalapril decreased the serum and dialysate TGF-beta1 levels, decreased the thickness of the liver peritoneum, and decreased the expression of TGF-beta1, alpha-SMA, fibronectin, collagen and VEGF-positive cells in the liver peritoneum.	Enalapril	13-22	actin gamma 2, smooth muscle	Rattus norvegicus	167-176	
19349682-12	2009	CONCLUSION: Enalapril significantly alleviates renal interstitial fibrosis by suppressing the expression of TGF-beta1, CTGF and alpha-SMA, upregulating the expression of Smad7, and has better effect at early stage (within 14 days after the UUO).	Enalapril	12-21	actin gamma 2, smooth muscle	Rattus norvegicus	128-137	
11435885-12	2001	Group 3 rats treated with enalapril showed fewer tubulointerstitial lesions than nontreated group 2 rats, as indicated by the mean scores plus or minus standard error of mean for inflammatory infiltrate (2.16 +/- 0.2 versus 0.83 +/- 0.16), tubular atrophy (2 +/- 0.27 versus 0.66 +/- 0.14), interstitial fibrosis (2.5 +/- 0.15 versus 0.5 +/- 0.1), glomerular ED1 (1.75 +/- 0.25 versus 0.16 +/- 0.11), interstitial ED1 (2.33 +/- 0.18 versus 0.58 +/- 0.10) tubular transforming growth factor-beta1 (2.09 +/- 0.08 versus 0.91 +/- 0.14), interstitial transforming growth factor-beta 1 (2.33 +/- 0.22 versus 0.66 +/- 0.12), tubulointerstitial alpha-smooth muscle actin (2.91 +/- 0.22 versus 0.83 +/- 0.16), lower urinary albumin excretion (35.5 +/- 2.7 mg. daily versus 10.9 +/- 1) and higher creatinine clearance (2.29 +/- 0.04 ml.	Enalapril	26-35	actin gamma 2, smooth muscle	Rattus norvegicus	638-663	
19349682-0	2009	[Dynamic observation of enalapril on the expression of TGF-beta1, CTGF, Smad7 and alpha-SMA in rats with unilateral ureteral obstruction].	Enalapril	24-33	actin gamma 2, smooth muscle	Rattus norvegicus	82-91	
19349682-1	2009	OBJECTIVE: To dynamically observe the effect of enalapril on the expression of transforming growth factor beta1 (TGF-beta1), connective tissue growth factor (CTGF), alpha-smooth muscle actin (alpha-SMA), and Smad7 in the obstructed kidney after unilateral ureteral obstruction (UUO) in rats, and to investigate the effect of enalapril on transdifferentiation of renal tubular epithelial cells.	Enalapril	48-57	actin gamma 2, smooth muscle	Rattus norvegicus	165-190	
19349682-1	2009	OBJECTIVE: To dynamically observe the effect of enalapril on the expression of transforming growth factor beta1 (TGF-beta1), connective tissue growth factor (CTGF), alpha-smooth muscle actin (alpha-SMA), and Smad7 in the obstructed kidney after unilateral ureteral obstruction (UUO) in rats, and to investigate the effect of enalapril on transdifferentiation of renal tubular epithelial cells.	Enalapril	48-57	actin gamma 2, smooth muscle	Rattus norvegicus	192-201	
19349682-11	2009	Enalapril could significantly affect the expression of CTGF mRNA,alpha-SMA,CTGF and Smad7 on day 3, 7, 14 after UUO initiation.	Enalapril	0-9	actin gamma 2, smooth muscle	Rattus norvegicus	65-74	
8691732-10	1996	Histological studies showed augmented Vv, monocyte/macrophage infiltration, interstitial alpha-smooth muscle actin expression, and collagen IV protein deposition on days 3, 5, 8, or 10 of UUO; enalapril treatment from day 4 to 8 or from day 6 to 10 halted and to an extent reversed these increases.	Enalapril	193-202	actin gamma 2, smooth muscle	Rattus norvegicus	89-114	
8915981-8	1996	In the enalapril- plus-L-NAME-treated animals, there were modest but significant increases in monocyte/macrophage infiltration of the interstitium and glomerulus, and collagen IV and alpha-smooth muscle actin expression in the interstitium of the contralateral unobstructed kidney.	Enalapril	7-16	actin gamma 2, smooth muscle	Rattus norvegicus	183-208	
30700837-11	2019	Enalapril-treated kidneys exhibited profibrogenic properties with increased expression of alpha-SMA and FSP-1 and enhanced deposition of interstitial collagen.	Enalapril	0-9	actin gamma 2, smooth muscle	Rattus norvegicus	90-99