PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16874097-3 2006 Induction of autophagy by lithium led to enhanced clearance of autophagy substrates, like mutant huntingtin fragments and mutant alpha-synucleins, associated with Huntington"s disease (HD) and some autosomal dominant forms of Parkinson"s disease (PD), respectively. Lithium 26-33 huntingtin Homo sapiens 97-107 24165128-0 2013 Lithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin. Lithium 0-7 huntingtin Homo sapiens 87-97 24165128-6 2013 We also showed that depletion of HDAC1 is essential for the neuroprotective effects of lithium and for the lithium-mediated degradation of mutant huntingtin through the autophagic pathway. Lithium 107-114 huntingtin Homo sapiens 146-156 16186256-4 2005 We show that lithium induces autophagy, and thereby, enhances the clearance of autophagy substrates, like mutant huntingtin and alpha-synucleins. Lithium 13-20 huntingtin Homo sapiens 113-123