PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10094816-6 1999 Olomoucine, a potent p34(cdc2) and Cdk2 inhibitor, effectively blocked RA-mediated p34(cdc2) kinase activation and prevented RA-induced apoptosis. Tretinoin 71-73 cyclin dependent kinase 1 Homo sapiens 25-29 17420990-2 2008 In evaluating the mechanisms by which retinoic acid (RA) or nerve growth factor (NGF) decrease cell number in MYCN amplified NB cells, we have identified a number of proteins whose expression either decreases (E2F, CDC2, CDK6, cyclin dependent kinase activity) or increases (p27) in association with a decrease in MYCN expression. Tretinoin 38-51 cyclin dependent kinase 1 Homo sapiens 215-219 16888198-0 2006 Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1. Tretinoin 0-13 cyclin dependent kinase 1 Homo sapiens 86-111 11384110-6 2001 ATRA also inhibited docetaxel-induced activation of MAPK indicating that the effects of docetaxel and ATRA on cdc2 phosphorylation are dependent on MAPK. Tretinoin 102-106 cyclin dependent kinase 1 Homo sapiens 110-114 11384110-7 2001 We conclude that ATRA synergistically enhances docetaxel toxicity by down-regulating Bcl-2 expression and partially reverses the docetaxel-induced G2/M arrest by inhibiting docetaxel-induced cdc2 phosphorylation in a pathway that is dependent on MAPK. Tretinoin 17-21 cyclin dependent kinase 1 Homo sapiens 191-195 11384110-5 2001 ATRA inhibited docetaxel-induced phosphorylation of cdc2 resulting in activation of cdc2 kinase and partial reversal of the G2/M arrest. Tretinoin 0-4 cyclin dependent kinase 1 Homo sapiens 52-56 11384110-5 2001 ATRA inhibited docetaxel-induced phosphorylation of cdc2 resulting in activation of cdc2 kinase and partial reversal of the G2/M arrest. Tretinoin 0-4 cyclin dependent kinase 1 Homo sapiens 84-88 11384110-6 2001 ATRA also inhibited docetaxel-induced activation of MAPK indicating that the effects of docetaxel and ATRA on cdc2 phosphorylation are dependent on MAPK. Tretinoin 0-4 cyclin dependent kinase 1 Homo sapiens 110-114 10094816-0 1999 Induction of p21(CIP1/Waf1) and activation of p34(cdc2) involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells. Tretinoin 68-81 cyclin dependent kinase 1 Homo sapiens 50-54 10094816-3 1999 This RA-induced apoptosis was accompanied by p53-independent up-regulation of endogenous p21(CIPI/Waf1) and Bax proteins, as well as activation of p34(cdc2) kinase, and increase of Rb2 protein level and phosphorylation pattern. Tretinoin 5-7 cyclin dependent kinase 1 Homo sapiens 151-155 10094816-6 1999 Olomoucine, a potent p34(cdc2) and Cdk2 inhibitor, effectively blocked RA-mediated p34(cdc2) kinase activation and prevented RA-induced apoptosis. Tretinoin 71-73 cyclin dependent kinase 1 Homo sapiens 87-91 10094816-7 1999 Furthermore, antisense oligonucleotide complementary to p21(CIP2/Waf1) and p34(cdc2) mRNA significantly rescued RA-induced apoptosis. Tretinoin 112-114 cyclin dependent kinase 1 Homo sapiens 79-83 10094816-11 1999 These findings suggest that inappropriate regulation of the cell cycle regulators p21(CIP2/Waf1) and p34(cdc2) is coupled with induction of Bax and involved in cell death with apoptosis when Hep3B cells are exposed to RA. Tretinoin 218-220 cyclin dependent kinase 1 Homo sapiens 105-109 1751405-0 1991 Retinoic acid negatively regulates p34cdc2 expression during human neuroblastoma differentiation. Tretinoin 0-13 cyclin dependent kinase 1 Homo sapiens 35-42 9260897-2 1997 RA did not affect cyclins D1, A, and E and cyclin-dependent kinase 2 (CDK2) expression, but significantly reduced cyclin D3 and CDK4 expression after 24 h. RA also inhibited cyclin B1 and CDC2 expression, possibly responsible for the reduction of the proportion of cells in G2 + M and S phases. Tretinoin 0-2 cyclin dependent kinase 1 Homo sapiens 188-192 17180006-6 1994 In this study we isolated RA-resistant 15N cell lines and analyzed their growth properties and changes in cell cycle related (cdc2, cdk2, cyclins A, B, D and E) and early response (fos and jun) gene expression to evaluate the role IGF2 may play in mediating RA resistance. Tretinoin 26-28 cyclin dependent kinase 1 Homo sapiens 126-130 1751405-2 1991 In this work, we show that the arrest of cell growth and induction of differentiation in a tumorigenic neuroblastoma cell line by retinoic acid (RA) is associated with a 75-fold decrease in the level of p34cdc2 protein. Tretinoin 130-143 cyclin dependent kinase 1 Homo sapiens 203-210 34910930-5 2022 These phenotypes resulted from the action of food-derived retinoic acid (ATRA), which enhanced actomyosin contractility and promoted LP cDC2 transmigration into the epithelium. Tretinoin 58-71 cyclin dependent kinase 1 Homo sapiens 136-140 34910930-5 2022 These phenotypes resulted from the action of food-derived retinoic acid (ATRA), which enhanced actomyosin contractility and promoted LP cDC2 transmigration into the epithelium. Tretinoin 73-77 cyclin dependent kinase 1 Homo sapiens 136-140 26129652-3 2016 Here we show that RA acts cell intrinsically in developing gut-tropic pre-mucosal dendritic cell (pre-muDC) to effect the differentiation and drive the specialization of intestinal CD103(+)CD11b(-) (cDC1) and of CD103(+)CD11b(+) (cDC2). Tretinoin 18-20 cyclin dependent kinase 1 Homo sapiens 230-234 26129652-4 2016 Systemic deficiency or DC-restricted antagonism of RA signaling resulted in altered phenotypes of intestinal cDC1 and cDC2, and reduced numbers of cDC2. Tretinoin 51-53 cyclin dependent kinase 1 Homo sapiens 118-122 26129652-4 2016 Systemic deficiency or DC-restricted antagonism of RA signaling resulted in altered phenotypes of intestinal cDC1 and cDC2, and reduced numbers of cDC2. Tretinoin 51-53 cyclin dependent kinase 1 Homo sapiens 147-151 23518499-5 2013 We showed that CDK1 function is required for all-trans retinoic acid (ATRA) to achieve the optimal effect in U-937 human leukemic cells. Tretinoin 45-68 cyclin dependent kinase 1 Homo sapiens 15-19 23518499-5 2013 We showed that CDK1 function is required for all-trans retinoic acid (ATRA) to achieve the optimal effect in U-937 human leukemic cells. Tretinoin 70-74 cyclin dependent kinase 1 Homo sapiens 15-19 23518499-6 2013 CDK1 modulates the levels of P27(kip) and AKT phosphorylation in response to ATRA treatment. Tretinoin 77-81 cyclin dependent kinase 1 Homo sapiens 0-4 23518499-8 2013 The regulation of the subcellular content of CDK1 and RARgamma by ATRA is an important process for achieving an effective response in treatment of leukemia. Tretinoin 66-70 cyclin dependent kinase 1 Homo sapiens 45-49 23518499-10 2013 In addition, expression of wee1 kinase and Cdc25A/C phosphatases also coincide with CDK1 expression and its subcellular localization in response to ATRA treatment. Tretinoin 148-152 cyclin dependent kinase 1 Homo sapiens 84-88 23518499-11 2013 Our study reveals a novel mechanism by which CDK1 and RARgamma coordinate with ATRA to influence cell cycle progression and cellular differentiation. Tretinoin 79-83 cyclin dependent kinase 1 Homo sapiens 45-49