PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21505995-0 2011 Retinoic acid diminished the expression of MMP-2 in hyperoxia-exposed premature rat lung fibroblasts through regulating mitogen-activated protein kinases. Tretinoin 0-13 matrix metallopeptidase 2 Rattus norvegicus 43-48 29377254-7 2018 Retinoic acid, an agonist of GnT-V, further increased glycosylated CD147, and activated matrix metalloproteinase-2/-9 (MMP-2 and MMP-9) in the hypertrophied left ventricle of 2K1C rat. Tretinoin 0-13 matrix metallopeptidase 2 Rattus norvegicus 88-117 29377254-7 2018 Retinoic acid, an agonist of GnT-V, further increased glycosylated CD147, and activated matrix metalloproteinase-2/-9 (MMP-2 and MMP-9) in the hypertrophied left ventricle of 2K1C rat. Tretinoin 0-13 matrix metallopeptidase 2 Rattus norvegicus 119-124 28648614-3 2017 In this study the effects of RA on MMP-2 production in cells of rat uterus were investigated. Tretinoin 29-31 matrix metallopeptidase 2 Rattus norvegicus 35-40 28648614-11 2017 CONCLUSION: RA had negative effects on cell proliferation and cell morphology and inhibited MMP-2 expression. Tretinoin 12-14 matrix metallopeptidase 2 Rattus norvegicus 92-97 28488074-0 2017 All-trans retinoic acid enhances in vitro mesenchymal stem cells migration by targeting matrix metalloproteinases 2 and 9. Tretinoin 10-23 matrix metallopeptidase 2 Rattus norvegicus 88-121 28488074-2 2017 RESULTS: The expression of the MMP-2/-9 was at least five times higher in ATRA-treated MSCs (P < 0.001), and MMP-2/-9 activity was enhanced with increasing doses compared to the control MSCs. Tretinoin 74-78 matrix metallopeptidase 2 Rattus norvegicus 31-39 28488074-2 2017 RESULTS: The expression of the MMP-2/-9 was at least five times higher in ATRA-treated MSCs (P < 0.001), and MMP-2/-9 activity was enhanced with increasing doses compared to the control MSCs. Tretinoin 74-78 matrix metallopeptidase 2 Rattus norvegicus 31-36 28488074-5 2017 CONCLUSION: ATRA increases the in vitro migration capacity of the MSCs through stimulating the expression and activity of MMP-2/-9 and inhibiting caspase three enzyme activity. Tretinoin 12-16 matrix metallopeptidase 2 Rattus norvegicus 122-127 17164434-1 2007 Retinoic acid (RA) is a signaling molecule in the morphogenesis of the mammary gland, modulating the expression of matrix metalloproteinases (MMPs). Tretinoin 0-13 matrix metallopeptidase 2 Rattus norvegicus 142-146 12553043-3 2002 ATRA significantly and dose-dependently inhibited matrigel membrane invasion of the cells by 53%, inhibited MMP-2 activity by 71%, MMP-9(80%), alpha-(59%) and beta-(65%) catenin expression at 10 microM (p < 0.01). Tretinoin 0-4 matrix metallopeptidase 2 Rattus norvegicus 108-113 21273387-13 2011 ATRA reduced both MMP-2 and TIMP-1 activity in BAL fluid of emphysematous lungs. Tretinoin 0-4 matrix metallopeptidase 2 Rattus norvegicus 18-23 21505995-1 2011 This study examined the effects of retinoic acid (RA), PD98059, SP600125 and SB203580 on the hyperoxia-induced expression and regulation of matrix metalloproteinase-2 (MMP-2) and metalloproteinase-2 (TIMP-2) in premature rat lung fibroblasts (LFs). Tretinoin 35-48 matrix metallopeptidase 2 Rattus norvegicus 140-166 18846337-12 2008 ATRA treatment increased the protein levels of MMP2 and MMP13. Tretinoin 0-4 matrix metallopeptidase 2 Rattus norvegicus 47-51 21181362-7 2010 The results showed that ATRA inhibited HSCs proliferation and diminished the mRNA expression of collagen genes [procollagen alpha1 (I), procollagen alpha1 (III)] and profibrogenic genes (TGF-beta(1), CTGF, MMP-2, TIMP-1, TIMP-2, PAI-1), and significantly stimulated the mRNA expression of MMP-3 and MMP-13 in HSCs by suppressing the mRNA expression of JNK and AP-1. Tretinoin 24-28 matrix metallopeptidase 2 Rattus norvegicus 206-211 21181362-8 2010 These findings suggested that ATRA could inhibit proliferation and collagen production of HSCs via the suppression of active protein-1 and c-Jun N-terminal kinase signal, then decrease the mRNAs expression of profibrogenic genes (TGF-beta(1), CTGF, MMP-2, TIMP-1, TIMP-2, PAI-1), and significantly induce the mRNA expression of MMP-3 and MMP-13. Tretinoin 30-34 matrix metallopeptidase 2 Rattus norvegicus 249-254 19357873-3 2009 Therefore, a rat model of GS was established to investigate the effect of all-trans retinoic acid (ATRA) on the renal expressions of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1). Tretinoin 74-97 matrix metallopeptidase 2 Rattus norvegicus 161-166 19357873-3 2009 Therefore, a rat model of GS was established to investigate the effect of all-trans retinoic acid (ATRA) on the renal expressions of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1). Tretinoin 99-103 matrix metallopeptidase 2 Rattus norvegicus 133-159 19357873-3 2009 Therefore, a rat model of GS was established to investigate the effect of all-trans retinoic acid (ATRA) on the renal expressions of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1). Tretinoin 99-103 matrix metallopeptidase 2 Rattus norvegicus 161-166 19357873-15 2009 In conclusion, ATRA may protect renal function and step down the progression of GS by reducing the expression of TIMP-1, enhancing the expression and activity of MMP-2 and MMP-9, and regulating the ratio of MMPs/TIMPs to dynamic balance, so as to reduce the accumulation of ECM. Tretinoin 15-19 matrix metallopeptidase 2 Rattus norvegicus 162-167 19357873-15 2009 In conclusion, ATRA may protect renal function and step down the progression of GS by reducing the expression of TIMP-1, enhancing the expression and activity of MMP-2 and MMP-9, and regulating the ratio of MMPs/TIMPs to dynamic balance, so as to reduce the accumulation of ECM. Tretinoin 15-19 matrix metallopeptidase 2 Rattus norvegicus 207-211 19357873-0 2009 Effect of all-trans retinoic acid on renal expressions of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rats with glomerulosclerosis. Tretinoin 10-33 matrix metallopeptidase 2 Rattus norvegicus 58-84 19357873-3 2009 Therefore, a rat model of GS was established to investigate the effect of all-trans retinoic acid (ATRA) on the renal expressions of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1). Tretinoin 74-97 matrix metallopeptidase 2 Rattus norvegicus 133-159 18846337-15 2008 It was concluded that ATRA could inhibit CBDL-induced liver fibrosis in rats by suppressing the expression of TGF-beta1 and CTGF so as to diminish the inhibition of TIMP-1 on MMP2 and MMP13 and increase the activity of MMP2 and MMP13. Tretinoin 22-26 matrix metallopeptidase 2 Rattus norvegicus 175-179 18846337-15 2008 It was concluded that ATRA could inhibit CBDL-induced liver fibrosis in rats by suppressing the expression of TGF-beta1 and CTGF so as to diminish the inhibition of TIMP-1 on MMP2 and MMP13 and increase the activity of MMP2 and MMP13. Tretinoin 22-26 matrix metallopeptidase 2 Rattus norvegicus 219-223 19099751-0 2008 [Retinoic acid diminished the expression of lung tissue matrix metalloproteinase-2 and matrix metalloproteinase-9 in hyperoxia-exposed premature rats through regulating mitogen-activated protein kinases]. Tretinoin 1-14 matrix metallopeptidase 2 Rattus norvegicus 56-113 19099751-12 2008 The pups treated with RA in the hyperoxic environment expressed significantly lower mRNA levels of MMP-2 and MMP-9 than the hyperoxic control pups on each experimental day (P < 0.05 for all). Tretinoin 22-24 matrix metallopeptidase 2 Rattus norvegicus 99-104 19099751-13 2008 The levels of active MMP-2 and pro/active MMP-9 decreased to a different degree after RA treatment in hyperoxia exposure rat pups. Tretinoin 86-88 matrix metallopeptidase 2 Rattus norvegicus 21-26 19099751-16 2008 RA could have a protective effect on hyperoxia induced lung injury by decreasing active levels of JNK and p38, which subsequently reduce the expression and activation of MMP-2 and MMP-9. Tretinoin 0-2 matrix metallopeptidase 2 Rattus norvegicus 170-175