PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18230156-0	2008	Retinoic acid reduces human neuroblastoma cell migration and invasiveness: effects on DCX, LIS1, neurofilaments-68 and vimentin expression.	Tretinoin	0-13	doublecortin	Homo sapiens	86-89	
18230156-3	2008	The mechanism of action of retinoic acid is still unclear, and the development of resistance to this differentiating agent is a great therapy problem.Doublecortin, a microtubule-associated protein involved in neuronal migration, has recently been proposed as a molecular marker for the detection of minimal residual disease in human neuroblastoma.	Tretinoin	27-40	doublecortin	Homo sapiens	150-162	
18230156-9	2008	Treatment with retinoic acid reduces cell migration and invasiveness, down regulates doublecortin and lissencephaly-1 expression and up regulates neurofilament-68 expression.	Tretinoin	15-28	doublecortin	Homo sapiens	85-97	
18230156-10	2008	However, some cells that escape from retinoic acid action maintain migration capability and invasiveness and express doublecortin.	Tretinoin	37-50	doublecortin	Homo sapiens	117-129	
18230156-11	2008	CONCLUSION: a) Doublecortin is expressed in human neuroblastoma cells that show high motility and invasiveness;b) Retinoic acid treatment reduces migration and invasiveness of the more aggressive cell components of SK-N-SH cells;c) The cells that after retinoic acid exposure show migration and invasive capability may be identified on the basis of doublecortin expression.	Tretinoin	114-127	doublecortin	Homo sapiens	15-27	
18230156-11	2008	CONCLUSION: a) Doublecortin is expressed in human neuroblastoma cells that show high motility and invasiveness;b) Retinoic acid treatment reduces migration and invasiveness of the more aggressive cell components of SK-N-SH cells;c) The cells that after retinoic acid exposure show migration and invasive capability may be identified on the basis of doublecortin expression.	Tretinoin	114-127	doublecortin	Homo sapiens	349-361	
18230156-11	2008	CONCLUSION: a) Doublecortin is expressed in human neuroblastoma cells that show high motility and invasiveness;b) Retinoic acid treatment reduces migration and invasiveness of the more aggressive cell components of SK-N-SH cells;c) The cells that after retinoic acid exposure show migration and invasive capability may be identified on the basis of doublecortin expression.	Tretinoin	253-266	doublecortin	Homo sapiens	15-27	
19633294-9	2009	RA-induced repression of the Ca(2+)/calmodulin-dependent protein kinase kinase/CaMKIV/CREB pathway appears to be involved in regulating the timing of neuronal differentiation, as shown by the effect of RNA interference of CaMKIV to markedly accelerate RA-dependent up-regulation of p21/Cip1 and doublecortin expression and RA-promoted neurite outgrowth.	Tretinoin	0-2	doublecortin	Homo sapiens	295-307	
18312642-4	2008	Following induction of differentiation using retinoic acid treatment, we observed a 16-fold increase in doublecortin mRNA expression, as well as strong induction of doublecortin polypeptide expression.	Tretinoin	45-58	doublecortin	Homo sapiens	104-116	
18312642-4	2008	Following induction of differentiation using retinoic acid treatment, we observed a 16-fold increase in doublecortin mRNA expression, as well as strong induction of doublecortin polypeptide expression.	Tretinoin	45-58	doublecortin	Homo sapiens	165-177	
18312642-6	2008	Moreover, stable transfection in NTERA-2 cells of reporter constructs encoding fluorescent or luminescent genes under the control of the doublecortin promoter allowed us to directly detect induction of neuronal differentiation in cell culture, such as following retinoic acid treatment or mouse Ngn2 transient overexpression.	Tretinoin	262-275	doublecortin	Homo sapiens	137-149