PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18636178-0 2008 Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes. Tretinoin 62-75 epidermal growth factor receptor Homo sapiens 98-102 18636178-7 2008 atRA treatment induces EGFR and ERK activation. Tretinoin 0-4 epidermal growth factor receptor Homo sapiens 23-27 18636178-8 2008 PD153035, an EGFR inhibitor, and U0126, an ERK inhibitor, inhibit atRA-induced upregulation of AQP3. Tretinoin 66-70 epidermal growth factor receptor Homo sapiens 13-17 18636178-9 2008 Nicotinamide also inhibits atRA-induced activation of EGFR/ERK signal transduction and decreases water permeability by downregulating AQP3 expression. Tretinoin 27-31 epidermal growth factor receptor Homo sapiens 54-58 18636178-10 2008 Collectively, our results indicate that the effect of atRA on AQP3 expression is at least partly mediated by EGFR/ERK signaling in cultured human skin keratinocytes. Tretinoin 54-58 epidermal growth factor receptor Homo sapiens 109-113 18636178-11 2008 Nicotinamide attenuates atRA-induced AQP3 expression through inhibition of EGFR/ERK signal transduction and eventually decreases water permeability and water loss. Tretinoin 24-28 epidermal growth factor receptor Homo sapiens 75-79 18064629-10 2008 We conclude that atRA protects against UV-induced down-regulation AQP3 and decrease in water permeability, reduction in cell migration and delayed in vitro wound healing via trans-activation of EGFR and inhibition on ROS-mediated MEK/ERK pathway. Tretinoin 17-21 epidermal growth factor receptor Homo sapiens 194-198 17286282-4 2007 The ErbB-1 inhibitor PD153035 cooperates with retinoic acid during growth inhibition and induces retinoic acid receptor-beta suggesting that ErbB-1 controls retinoic acid receptor-beta. Tretinoin 46-59 epidermal growth factor receptor Homo sapiens 4-10 17286282-4 2007 The ErbB-1 inhibitor PD153035 cooperates with retinoic acid during growth inhibition and induces retinoic acid receptor-beta suggesting that ErbB-1 controls retinoic acid receptor-beta. Tretinoin 46-59 epidermal growth factor receptor Homo sapiens 4-8 16470170-6 2006 Topical treatment of human skin with all-trans retinoic acid (tRA) induces EGFR ligands heparin-binding (HB)-EGF and amphiregulin (AR), and reduces betacellulin mRNA levels. Tretinoin 47-60 epidermal growth factor receptor Homo sapiens 75-79 16470170-6 2006 Topical treatment of human skin with all-trans retinoic acid (tRA) induces EGFR ligands heparin-binding (HB)-EGF and amphiregulin (AR), and reduces betacellulin mRNA levels. Tretinoin 62-65 epidermal growth factor receptor Homo sapiens 75-79 12392597-0 2002 A phosphorylation defective retinoic acid receptor mutant mimics the effects of retinoic acid on EGFR mediated AP-1 expression and cancer cell proliferation. Tretinoin 28-41 epidermal growth factor receptor Homo sapiens 97-101 15530851-10 2004 RA treatment increased steady-state levels of the protein tyrosine phosphatase PTP-1C and all measured effects of RA on EGF receptor function were reversed by the tyrosine phosphate inhibitor orthovanadate. Tretinoin 114-116 epidermal growth factor receptor Homo sapiens 120-132 12069693-2 2002 METHOD: In this study, we examined the interactions between T and retinoic acid (RA) in cell growth of human prostate carcinoma cells, LNCaP, and their relationship with the expression of RAR and epidermal growth factor receptor (EGF-R). Tretinoin 66-79 epidermal growth factor receptor Homo sapiens 196-228 12595744-2 2002 N-(4-hydroxyphenyl)-retinamide (4HPR), a synthetic analogue of ATRA, has been shown to repress the expression of HER2/neu and its family member, epidermal growth factor receptor (EGFR). Tretinoin 63-67 epidermal growth factor receptor Homo sapiens 145-177 12595744-2 2002 N-(4-hydroxyphenyl)-retinamide (4HPR), a synthetic analogue of ATRA, has been shown to repress the expression of HER2/neu and its family member, epidermal growth factor receptor (EGFR). Tretinoin 63-67 epidermal growth factor receptor Homo sapiens 179-183 12069693-0 2002 Androgen and retinoic acid interaction in LNCaP cells, effects on cell proliferation and expression of retinoic acid receptors and epidermal growth factor receptor. Tretinoin 13-26 epidermal growth factor receptor Homo sapiens 131-163 11927016-8 2002 The YCU-H891 cells, in which the epidermal growth factor receptor (EGFR)-signal transducer and activator of transcription 3 (Stat3) pathway is constitutively activated, were more resistant to treatments with ATRA, 5-FU and the combination of both agents than YCU-N861 cells. Tretinoin 208-212 epidermal growth factor receptor Homo sapiens 33-65 11927016-8 2002 The YCU-H891 cells, in which the epidermal growth factor receptor (EGFR)-signal transducer and activator of transcription 3 (Stat3) pathway is constitutively activated, were more resistant to treatments with ATRA, 5-FU and the combination of both agents than YCU-N861 cells. Tretinoin 208-212 epidermal growth factor receptor Homo sapiens 67-71 12069693-2 2002 METHOD: In this study, we examined the interactions between T and retinoic acid (RA) in cell growth of human prostate carcinoma cells, LNCaP, and their relationship with the expression of RAR and epidermal growth factor receptor (EGF-R). Tretinoin 81-83 epidermal growth factor receptor Homo sapiens 196-228 12069693-10 2002 The opposite effects of T and RA on the expression of RAR and EGF-R suggest that signal events of these receptors might be involved in the interaction between T and RA in the control of LNCaP cell growth. Tretinoin 30-32 epidermal growth factor receptor Homo sapiens 62-67 11801540-6 2002 RA effects on epidermal growth factor (EGF) induction of EGFR-phosphotyrosine levels, cyclin D1 expression and mitogenesis were examined in BEAS-2B cells. Tretinoin 0-2 epidermal growth factor receptor Homo sapiens 57-61 11801540-11 2002 Notably, RA treatment prevented transformation as well as outgrowth of EGFR overexpressing bronchial epithelial cells, despite NNK exposure. Tretinoin 9-11 epidermal growth factor receptor Homo sapiens 71-75 11801540-8 2002 RA treatment repressed EGFR expression and reporter plasmid activity in these cells. Tretinoin 0-2 epidermal growth factor receptor Homo sapiens 23-27 10816385-7 2000 We evaluated the possibility that the differentiating effects of retinoids are due to retinoic-acid-induced decreases in phosphorylation of EGF-R and changes in downstream effector proteins. Tretinoin 86-99 epidermal growth factor receptor Homo sapiens 140-145 11746830-0 2001 Decreased mitogenic response to epidermal growth factor in human squamous cell carcinoma lines overexpressing epidermal growth factor receptor owing to limiting amounts of the adaptor protein Grb2: rescue by retinoic acid treatment. Tretinoin 208-221 epidermal growth factor receptor Homo sapiens 110-142 11746830-9 2001 RA inhibited expression of EGFR and proteins in the MAPK signaling pathway. Tretinoin 0-2 epidermal growth factor receptor Homo sapiens 27-31 11479234-10 2001 These results suggest that an RXR-selective retinoic acid decreases SCCHN proliferation in part by interfering with TGF-alpha/EGFR autocrine signaling. Tretinoin 44-57 epidermal growth factor receptor Homo sapiens 126-130 10816385-8 2000 Retinoic acid caused a decrease in tyrosine phosphorylation of EGF-R. Tretinoin 0-13 epidermal growth factor receptor Homo sapiens 63-68 10816385-11 2000 Retinoic acid induced a relocalization and decrease in the amount of Shc protein, another actin-binding protein which is an adaptor protein for EGF-R signaling. Tretinoin 0-13 epidermal growth factor receptor Homo sapiens 144-149 10816385-14 2000 These results are consistent with the idea that retinoic acid induces differentiation of RL95-2 cells by interfering with the EGF-R signaling pathway. Tretinoin 48-61 epidermal growth factor receptor Homo sapiens 126-131 9609098-6 1998 Pretreatment of both control and experimental groups with RA enhanced epidermal growth factor-induced proliferation despite RA-dependent downregulation of epidermal growth factor receptor expression. Tretinoin 124-126 epidermal growth factor receptor Homo sapiens 155-187 9770378-7 1998 Treatment of ECE16-1 and ECE16-D1 cells with retinoic acid suppresses proliferation, EGFR level, EGFR mRNA level, and EGFR promoter activity. Tretinoin 45-58 epidermal growth factor receptor Homo sapiens 85-89 9770378-7 1998 Treatment of ECE16-1 and ECE16-D1 cells with retinoic acid suppresses proliferation, EGFR level, EGFR mRNA level, and EGFR promoter activity. Tretinoin 45-58 epidermal growth factor receptor Homo sapiens 97-101 9770378-7 1998 Treatment of ECE16-1 and ECE16-D1 cells with retinoic acid suppresses proliferation, EGFR level, EGFR mRNA level, and EGFR promoter activity. Tretinoin 45-58 epidermal growth factor receptor Homo sapiens 97-101 9770378-12 1998 Nevertheless expression of E6/E7 proteins did not confer retinoic acid regulation, as EGFR promoter activity remained elevated in normal cells cotransfected with pHPVE6/E7 and treated with retinoic acid. Tretinoin 189-202 epidermal growth factor receptor Homo sapiens 86-90 9770378-13 1998 These results suggest that human papillomavirus and retinoic acid regulate EGFR levels by independent effects on the EGFR promoter. Tretinoin 52-65 epidermal growth factor receptor Homo sapiens 75-79 9770378-13 1998 These results suggest that human papillomavirus and retinoic acid regulate EGFR levels by independent effects on the EGFR promoter. Tretinoin 52-65 epidermal growth factor receptor Homo sapiens 117-121 10816385-0 2000 Retinoic acid affects the EGF-R signaling pathway during differentiation induction of human endometrial adenocarcinoma cells. Tretinoin 0-13 epidermal growth factor receptor Homo sapiens 26-31 7859922-7 1994 Furthermore, RA treatment led to a concentration-dependent decrease in the amount of EGFR protein expression. Tretinoin 13-15 epidermal growth factor receptor Homo sapiens 85-89 8898244-2 1996 We previously reported that, in P19 embryonal carcinoma cells, the expression of kinase-negative EGFR inhibits retinoic acid (RA)-induced differentiation to nervous tissue, suggesting that EGFR plays a role in differentiation (J.-X. Tretinoin 111-124 epidermal growth factor receptor Homo sapiens 97-101 8898244-2 1996 We previously reported that, in P19 embryonal carcinoma cells, the expression of kinase-negative EGFR inhibits retinoic acid (RA)-induced differentiation to nervous tissue, suggesting that EGFR plays a role in differentiation (J.-X. Tretinoin 111-124 epidermal growth factor receptor Homo sapiens 189-193 8898244-2 1996 We previously reported that, in P19 embryonal carcinoma cells, the expression of kinase-negative EGFR inhibits retinoic acid (RA)-induced differentiation to nervous tissue, suggesting that EGFR plays a role in differentiation (J.-X. Tretinoin 126-128 epidermal growth factor receptor Homo sapiens 97-101 8898244-2 1996 We previously reported that, in P19 embryonal carcinoma cells, the expression of kinase-negative EGFR inhibits retinoic acid (RA)-induced differentiation to nervous tissue, suggesting that EGFR plays a role in differentiation (J.-X. Tretinoin 126-128 epidermal growth factor receptor Homo sapiens 189-193 11725062-0 1995 Retinoic Acid Modulates Epidermal Growth Factor Receptor Expression in Human Lung Epithelial Cancer Cells. Tretinoin 0-13 epidermal growth factor receptor Homo sapiens 24-56 11725062-1 1995 In human lung epithelial cancer cell line H460, an accumulation of epidermal growth factor receptors (EGF-R) was observed following treatment with 1 &mgr;M retinoic acid. Tretinoin 160-173 epidermal growth factor receptor Homo sapiens 67-100 11725062-1 1995 In human lung epithelial cancer cell line H460, an accumulation of epidermal growth factor receptors (EGF-R) was observed following treatment with 1 &mgr;M retinoic acid. Tretinoin 160-173 epidermal growth factor receptor Homo sapiens 102-107 11725062-3 1995 Transiently increased autophosphorylation of EGF-R after 48 h of retinoic acid treatment correlated with enhancement of EGF binding capacity on the H460 cell surface. Tretinoin 65-78 epidermal growth factor receptor Homo sapiens 45-50 11725062-4 1995 Nuclear run-on analysis indicated that retinoic acid upregulates transcription of the EGF-R gene, reaching a maximum at 48 h and decreasing after 72 h of treatment. Tretinoin 39-52 epidermal growth factor receptor Homo sapiens 86-91 11725062-5 1995 When retinoic acid-treated cells were chased in drug-free medium, the increased EGF-R transcript level remained unchanged. Tretinoin 5-18 epidermal growth factor receptor Homo sapiens 80-85 11725062-7 1995 The results demonstrate that retinoic acid induces EGF-R synthesis in human lung cancer cells. Tretinoin 29-42 epidermal growth factor receptor Homo sapiens 51-56 7714611-6 1995 In addition, cell lines with the highest EGFR levels were also more resistant to the growth-suppressive effects of retinoic acid when maintained in soft agar. Tretinoin 115-128 epidermal growth factor receptor Homo sapiens 41-45 7714611-7 1995 These observations suggest that even though the overexpression of the EGFR did not confer a distinct growth advantage to glioma cells cultured on flat culture dishes, the ability of these cells to maintain anchorage-independent growth in soft agar especially in response to EGF and retinoic acid is facilitated. Tretinoin 282-295 epidermal growth factor receptor Homo sapiens 70-74 21597757-1 1995 Retinoic acid transiently induced expression of high levels of epidermal growth factor receptor (EGFR) in the human non-small cell lung carcinoma cell line H460a. Tretinoin 0-13 epidermal growth factor receptor Homo sapiens 63-95 21597757-1 1995 Retinoic acid transiently induced expression of high levels of epidermal growth factor receptor (EGFR) in the human non-small cell lung carcinoma cell line H460a. Tretinoin 0-13 epidermal growth factor receptor Homo sapiens 97-101 21597757-2 1995 Scatchard analysis revealed a 40-fold increase in the expression of EGFR on the cell surface of H460a cells within 48 h of treatment with 5 mu M concentrations of retinoic acid. Tretinoin 163-176 epidermal growth factor receptor Homo sapiens 68-72 21597757-3 1995 RNase protection and nuclear run-off assays established that increases in EGFR expression in retinoic acid-treated cells were not the result of increased promoter activity of EGFR gene, but were more likely the result of a posttranscriptional mechanism. Tretinoin 93-106 epidermal growth factor receptor Homo sapiens 74-78 21597757-4 1995 Immune complex kinase assays demonstrated that the EGFR induced by retinoic acid was functionally active. Tretinoin 67-80 epidermal growth factor receptor Homo sapiens 51-55 21597757-5 1995 We conclude that retinoic acid exerts its control over expression of the EGFR in H460a cells through a posttranscriptional mechanism. Tretinoin 17-30 epidermal growth factor receptor Homo sapiens 73-77 21597757-6 1995 Moreover, elevated EGFR might play a role in the increased tumorigenic potential exhibited by retinoic acid-treated H460a cells. Tretinoin 94-107 epidermal growth factor receptor Homo sapiens 19-23 7905817-0 1994 Modulation of EGF receptor and CD15 (Lewisx) antigen on the cell surface of breast carcinoma cell lines induced by cytokines, retinoic acid, 12-O-tetradecanoylphorbol 13-acetate and 1,25(OH)2-vitamin D3. Tretinoin 126-139 epidermal growth factor receptor Homo sapiens 14-26 8402622-0 1993 Human papillomavirus 16 immortalization of normal human ectocervical epithelial cells alters retinoic acid regulation of cell growth and epidermal growth factor receptor expression. Tretinoin 93-106 epidermal growth factor receptor Homo sapiens 137-169 8241025-0 1993 Retroviral gene transfer of epidermal growth factor receptor into HL60 cells results in a partial block of retinoic acid-induced granulocytic differentiation. Tretinoin 107-120 epidermal growth factor receptor Homo sapiens 28-60 8241025-12 1993 We found that these HL60-EGFR cells responded to retinoic acid differently from the HL60-control cells. Tretinoin 49-62 epidermal growth factor receptor Homo sapiens 25-29 1515368-0 1992 Transcriptional control of epidermal growth factor receptor by retinoic acid. Tretinoin 63-76 epidermal growth factor receptor Homo sapiens 27-59 1515368-5 1992 There is evidence for functional interactions between RA and the EGF receptor (EGFR). Tretinoin 54-56 epidermal growth factor receptor Homo sapiens 65-77 1515368-5 1992 There is evidence for functional interactions between RA and the EGF receptor (EGFR). Tretinoin 54-56 epidermal growth factor receptor Homo sapiens 79-83 1515368-6 1992 RA enhances the proliferative response of cultured keratinocytes to EGF, increases the number of EGFRs on the surface of some cells, and induces EGFR promoter activity in most cells. Tretinoin 0-2 epidermal growth factor receptor Homo sapiens 97-101 1515368-7 1992 In contrast, immunoprecipitation, Northern blot, and nuclear run-on analysis described in this paper show that RA suppresses EGFR synthesis at the transcriptional level in human epidermoid carcinoma ME180 cells. Tretinoin 111-113 epidermal growth factor receptor Homo sapiens 125-129 1584225-1 1992 The epidermal growth factor (EGF) receptor (EGFR) promoter is negatively regulated by thyroid hormone and retinoic acid. Tretinoin 106-119 epidermal growth factor receptor Homo sapiens 4-42 1584225-1 1992 The epidermal growth factor (EGF) receptor (EGFR) promoter is negatively regulated by thyroid hormone and retinoic acid. Tretinoin 106-119 epidermal growth factor receptor Homo sapiens 44-48 2340496-0 1990 Epidermal growth factor receptor expression in a retinoic acid-treated human melanoma cell line. Tretinoin 49-62 epidermal growth factor receptor Homo sapiens 0-32 1389683-0 1992 Suppression by retinoic acid of epidermal growth factor receptor autophosphorylation and glycosylation in cultured human head and neck squamous carcinoma cells. Tretinoin 15-28 epidermal growth factor receptor Homo sapiens 32-64 1389683-3 1992 Here we examined the effects of RA on the expression and function of EGF-R in two HNSCC cell lines, 1483 and 183, which exhibit distinct states of squamous cell differentiation, EGF-R mRNA levels, and responses to the growth inhibitory effects of RA. Tretinoin 32-34 epidermal growth factor receptor Homo sapiens 69-74 1389683-4 1992 Treatment with RA (1 microM, 7 days) of the RA-sensitive 1483 cells decreased the level of EGF-R mRNA two- to four-fold and the binding of 125I-EGF to the cell surface by 30%-35%. Tretinoin 15-17 epidermal growth factor receptor Homo sapiens 91-96 1389683-6 1992 Other effects of RA on EGF-R structure and function were similar in both cell lines. Tretinoin 17-19 epidermal growth factor receptor Homo sapiens 23-28 1389683-8 1992 More important, RA treatment of both cell lines decreased EGF-R autophosphorylation activity detected in immune-complex-kinase assay by about three- and five-fold in the 1483 and 183 cells, respectively. Tretinoin 16-18 epidermal growth factor receptor Homo sapiens 58-63 1389683-9 1992 Likewise, RA decreased the glycosylation of EGF-R in both cell lines. Tretinoin 10-12 epidermal growth factor receptor Homo sapiens 44-49 1389683-11 1992 These results demonstrate that RA can modify the structure of the EGF-R by decreasing its glycosylation and suggest that these changes may suppress the autophosphorylation activity of the receptor kinase. Tretinoin 31-33 epidermal growth factor receptor Homo sapiens 66-71 1389683-12 1992 The RA-induced changes in EGF-R do not correlate with the effect of RA on the growth of the cells but may be related to the suppression of squamous cell differentiation in the 1483 cells. Tretinoin 4-6 epidermal growth factor receptor Homo sapiens 26-31 34650910-10 2021 In vitro, treatment with the EGFR inhibitor gefitinib (ZD1839) reduced cell proliferation and survival of NB4 (ATRA-sensitive) and NB4-R2 (ATRA-resistant) cells. Tretinoin 111-115 epidermal growth factor receptor Homo sapiens 29-33 2307713-0 1990 Inhibition of epidermal growth factor receptor activity by retinoic acid in glioma cells. Tretinoin 59-72 epidermal growth factor receptor Homo sapiens 14-46 2307713-2 1990 The protein tyrosine kinase activity of epidermal growth factor receptor (EGF-receptor) appeared to parallel the cell"s growth responsiveness to RA. Tretinoin 145-147 epidermal growth factor receptor Homo sapiens 40-72 2307713-2 1990 The protein tyrosine kinase activity of epidermal growth factor receptor (EGF-receptor) appeared to parallel the cell"s growth responsiveness to RA. Tretinoin 145-147 epidermal growth factor receptor Homo sapiens 74-86 2307713-3 1990 Cells sensitive to RA-induced growth inhibition exhibited a dose-dependent decrease in EGF-receptor activity, whereas RA-resistant cells showed no alterations in EGF-receptor protein tyrosine kinase activity or expression. Tretinoin 19-21 epidermal growth factor receptor Homo sapiens 87-99 2307713-4 1990 The modulation of EGF-receptor by RA was further examined with RA-sensitive (LG) and -resistant (NG-1) cell lines. Tretinoin 34-36 epidermal growth factor receptor Homo sapiens 18-30 2307713-8 1990 These results suggest RA-induced growth inhibition in sensitive cells may arise, at least in part, through alterations in EGF-receptor and structure. Tretinoin 22-24 epidermal growth factor receptor Homo sapiens 122-134 2575317-1 1989 The effects of 13-cis retinoic acid (RA) and dexamethasone on the levels of epidermal growth factor (EGF) receptor and fibroblast derived proteoglycan core protein (PG40) mRNAs were studied in human skin fibroblasts. Tretinoin 37-39 epidermal growth factor receptor Homo sapiens 76-114 35078784-0 2022 Targeting S100A9-ALDH1A1-retinoic acid signaling to suppress brain relapse in EGFR-mutant lung cancer. Tretinoin 25-38 epidermal growth factor receptor Homo sapiens 78-82 2912547-0 1989 Modulation of growth and epidermal growth factor receptor activity by retinoic acid in human glioma cells. Tretinoin 70-83 epidermal growth factor receptor Homo sapiens 25-57 2613750-0 1989 Modulation of transforming growth factor alpha-dependent expression of epidermal growth factor receptor gene by transforming growth factor beta, triiodothyronine, and retinoic acid. Tretinoin 167-180 epidermal growth factor receptor Homo sapiens 71-103 2613750-6 1989 Similarly, retinoic acid treatment also enhanced in a time- and dose-dependent manner the TGF alpha-dependent response of EGF receptor mRNA and acted synergistically with TGF beta 1. Tretinoin 11-24 epidermal growth factor receptor Homo sapiens 122-134 31810919-6 2019 Importantly, PLX4032, when used in combination with ATRA, an inhibitor of PIN1, reduced EGFR expression, and consequently reduced cell viability and anchorage-independent growth of A375R cells compared to PLX4032 alone. Tretinoin 52-56 epidermal growth factor receptor Homo sapiens 88-92 3021829-5 1986 Many studies have indicated that retinoic acid can markedly increase the number of cellular receptors for epidermal growth factor, which is partially encoded by another oncogene, erb-B. Tretinoin 33-46 epidermal growth factor receptor Homo sapiens 179-184 21705183-1 2011 In the present report, we investigated the action of retinoic acid (RA) on the transactivation of the epidermal growth factor receptor (EGFR) gene promoter. Tretinoin 53-66 epidermal growth factor receptor Homo sapiens 102-134 28684780-0 2017 Retinoic Acid affects Lung Adenocarcinoma growth by inducing differentiation via GATA6 activation and EGFR and Wnt inhibition. Tretinoin 0-13 epidermal growth factor receptor Homo sapiens 102-106 28684780-5 2017 In addition, our results demonstrate that RA inhibits EGFR and Wnt signaling activation, two pathways involved in NSCLC progression. Tretinoin 42-44 epidermal growth factor receptor Homo sapiens 54-58 28684780-6 2017 Furthermore, we uncovered a novel mechanism in NSCLC that shows how RA exerts its function; we found that RA-mediated GATA6 activation is necessary for EGFR and Wnt inhibition, thus leading to 1) increased differentiation and 2) loss of proliferation. Tretinoin 68-70 epidermal growth factor receptor Homo sapiens 152-156 28684780-6 2017 Furthermore, we uncovered a novel mechanism in NSCLC that shows how RA exerts its function; we found that RA-mediated GATA6 activation is necessary for EGFR and Wnt inhibition, thus leading to 1) increased differentiation and 2) loss of proliferation. Tretinoin 106-108 epidermal growth factor receptor Homo sapiens 152-156 23974111-0 2013 EGFR inhibitors exacerbate differentiation and cell cycle arrest induced by retinoic acid and vitamin D3 in acute myeloid leukemia cells. Tretinoin 76-89 epidermal growth factor receptor Homo sapiens 0-4 23974111-1 2013 By means of an unbiased, automated fluorescence microscopy-based screen, we identified the epidermal growth factor receptor (EGFR) inhibitors erlotinib and gefitinib as potent enhancers of the differentiation of HL-60 acute myeloid leukemia (AML) cells exposed to suboptimal concentrations of vitamin A (all-trans retinoic acid, ATRA) or vitamin D (1alpha,25-hydroxycholecalciferol, VD). Tretinoin 314-327 epidermal growth factor receptor Homo sapiens 91-123 23974111-1 2013 By means of an unbiased, automated fluorescence microscopy-based screen, we identified the epidermal growth factor receptor (EGFR) inhibitors erlotinib and gefitinib as potent enhancers of the differentiation of HL-60 acute myeloid leukemia (AML) cells exposed to suboptimal concentrations of vitamin A (all-trans retinoic acid, ATRA) or vitamin D (1alpha,25-hydroxycholecalciferol, VD). Tretinoin 314-327 epidermal growth factor receptor Homo sapiens 125-129 23974111-1 2013 By means of an unbiased, automated fluorescence microscopy-based screen, we identified the epidermal growth factor receptor (EGFR) inhibitors erlotinib and gefitinib as potent enhancers of the differentiation of HL-60 acute myeloid leukemia (AML) cells exposed to suboptimal concentrations of vitamin A (all-trans retinoic acid, ATRA) or vitamin D (1alpha,25-hydroxycholecalciferol, VD). Tretinoin 329-333 epidermal growth factor receptor Homo sapiens 91-123 23974111-1 2013 By means of an unbiased, automated fluorescence microscopy-based screen, we identified the epidermal growth factor receptor (EGFR) inhibitors erlotinib and gefitinib as potent enhancers of the differentiation of HL-60 acute myeloid leukemia (AML) cells exposed to suboptimal concentrations of vitamin A (all-trans retinoic acid, ATRA) or vitamin D (1alpha,25-hydroxycholecalciferol, VD). Tretinoin 329-333 epidermal growth factor receptor Homo sapiens 125-129 23644172-7 2013 We found that EGFR inhibitor AG1478 prevented the increase in VEGF-A production induced by PGE2- and all-trans retinoic acid. Tretinoin 111-124 epidermal growth factor receptor Homo sapiens 14-18 23644172-9 2013 PGE2 and all-trans retinoic acid also increased EGFR phosphorylation and this effect was sensitive to antagonists of EP receptors. Tretinoin 9-32 epidermal growth factor receptor Homo sapiens 48-52 23644172-10 2013 The role of intracellular PGE2 was indicated by two facts; i) PGE2-induced EGFR phosphorylation was substantially prevented by inhibitor of prostaglandin uptake transporter bromocresol green and ii) all-trans retinoic acid treatment, which enhanced intracellular but not extracellular PGE2, had lower effect on EGFR phosphorylation upon pre-treatment with cyclooxygenase inhibitor diclofenac. Tretinoin 209-222 epidermal growth factor receptor Homo sapiens 75-79 21705183-1 2011 In the present report, we investigated the action of retinoic acid (RA) on the transactivation of the epidermal growth factor receptor (EGFR) gene promoter. Tretinoin 53-66 epidermal growth factor receptor Homo sapiens 136-140 21705183-1 2011 In the present report, we investigated the action of retinoic acid (RA) on the transactivation of the epidermal growth factor receptor (EGFR) gene promoter. Tretinoin 68-70 epidermal growth factor receptor Homo sapiens 102-134 21705183-1 2011 In the present report, we investigated the action of retinoic acid (RA) on the transactivation of the epidermal growth factor receptor (EGFR) gene promoter. Tretinoin 68-70 epidermal growth factor receptor Homo sapiens 136-140 21705183-7 2011 Our results suggest that the interference with the activity of Sp1 on the EGFR promoter could be related to the observed RA-mediated growth suppression of breast cancer cells. Tretinoin 121-123 epidermal growth factor receptor Homo sapiens 74-78