PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11306979-2 2001 We could previously show that retinoic acid (RA) strongly inhibits CD40 + IL-4-mediated IgE production in vitro. Tretinoin 30-43 interleukin 4 Mus musculus 74-78 15606616-10 2005 A single administration of ATRA reduced the Th1 [interleukin (IL)-2, interferon (IFN)-gamma and IL-12], and a Th2 (IL-4) cytokine level, as effectively as administration of PSL. Tretinoin 27-31 interleukin 4 Mus musculus 115-119 18029491-6 2007 In vitro incubation of mouse splenocytes or purified spleen cluster of differentiation (CD) 4-positive T lymphocytes, with ATRA, increased, respectively, OVA- and anti-CD 3 antibody-induced IL-4 and IL-5 production and inhibited IFNgamma release. Tretinoin 123-127 interleukin 4 Mus musculus 190-194 18082674-0 2007 Retinoic acid promotes mouse splenic B cell surface IgG expression and maturation stimulated by CD40 and IL-4. Tretinoin 0-13 interleukin 4 Mus musculus 105-109 15580810-4 2004 Phorbol-myristate-acetate (PMA)/ionomycin-stimulated SMC (splenic mononuclear cells) from mice fed with ATRA and the vitamin A-deficient diet group showed increased interleukin-4 (IL-4) responses in non-sensitized mice. Tretinoin 104-108 interleukin 4 Mus musculus 165-178 15580810-4 2004 Phorbol-myristate-acetate (PMA)/ionomycin-stimulated SMC (splenic mononuclear cells) from mice fed with ATRA and the vitamin A-deficient diet group showed increased interleukin-4 (IL-4) responses in non-sensitized mice. Tretinoin 104-108 interleukin 4 Mus musculus 180-184 11306979-2 2001 We could previously show that retinoic acid (RA) strongly inhibits CD40 + IL-4-mediated IgE production in vitro. Tretinoin 45-47 interleukin 4 Mus musculus 74-78 10821786-6 2000 The in vivo administration of 9-cis-RA resulted in the inhibition of IL-12 production by macrophages stimulated in vitro with either LPS or HKL, leading to the inhibition of Th1 cytokine profile (decreased IFN-gamma and increased IL-4 production) in CD4(+) T cells. Tretinoin 30-38 interleukin 4 Mus musculus 230-234 10066345-4 1999 RA has another effect on isotype switching; RA strongly inhibits IL-4-dependent IgG1 and IgE production. Tretinoin 0-2 interleukin 4 Mus musculus 65-69 10066345-4 1999 RA has another effect on isotype switching; RA strongly inhibits IL-4-dependent IgG1 and IgE production. Tretinoin 44-46 interleukin 4 Mus musculus 65-69 10066345-5 1999 To analyze the mechanism of IgG1 inhibition, we tested whether RA can inhibit IL-4-dependent Smu-Sgamma1 switch rearrangement. Tretinoin 63-65 interleukin 4 Mus musculus 78-82 32865844-0 2020 The effect of calcitriol and all-trans retinoic acid on T-bet, IFN-gamma, GATA3 and IL-4 genes expression in experimental autoimmune encephalomyelitis. Tretinoin 29-52 interleukin 4 Mus musculus 84-88 9070313-5 1997 On the other hand, RA completely inhibited IL-4-induced I gamma 1C gamma 1 expression. Tretinoin 19-21 interleukin 4 Mus musculus 43-47 7704904-1 1995 The effects of retinoids (all-trans-retinoic acid (RA) and vitamin A) and hydrocortisone (HC) on the IL-4-dependent IgE and IgG1 response by mouse whole spleen cells and splenic B cells were studied. Tretinoin 26-49 interleukin 4 Mus musculus 101-105 7704904-1 1995 The effects of retinoids (all-trans-retinoic acid (RA) and vitamin A) and hydrocortisone (HC) on the IL-4-dependent IgE and IgG1 response by mouse whole spleen cells and splenic B cells were studied. Tretinoin 51-53 interleukin 4 Mus musculus 101-105 32865844-11 2020 The expression of GATA3 and IL-4 genes was significantly increased in the ATRA-, calcitriol-, and combination-treated mice when compared with the control group (p < 0.05). Tretinoin 74-78 interleukin 4 Mus musculus 28-32 28515123-4 2017 ATRA suppressed IL13- or IL4-induced M2-type macrophages, and then inhibited migration of osteosarcoma cells as promoted by M2-type macrophages in vitro ATRA reduced the number of pulmonary metastatic nodes of osteosarcoma and decreased expression of M2-type macrophages in metastatic nodes both in intravenous injection and orthotopic transplantation models. Tretinoin 0-4 interleukin 4 Mus musculus 25-28 31419710-0 2019 Retinoic acid modulates IL-4, IL-10 and MCP-1 pathways in immune mediated hepatitis and interrupts CD4+ T cells infiltration. Tretinoin 0-13 interleukin 4 Mus musculus 24-28 31419710-10 2019 A significant decrease in the measured cytokines TNF-alpha and IL-4 was observed in ConA + RA group in addition to a decrease in MCP-1 level. Tretinoin 91-93 interleukin 4 Mus musculus 63-67 31419710-12 2019 SIGNIFICANCE: RA can protect against ConA-induced hepatitis through: interrupting early inflammatory response as neutrophils, monocytes and CD4+ T cells infiltration, modulating IL-4 level and subsequent production of TNF-alpha and NF-kappab activation, mitigating second inflammatory responses through increasing IL-10 liver production. Tretinoin 14-16 interleukin 4 Mus musculus 178-182 29042055-0 2017 Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication. Tretinoin 48-61 interleukin 4 Mus musculus 65-68 25899567-5 2015 Antagonism of RA receptors reduced production of resistin-like molecule alpha by DCs responding to IL-4, while addition of exogenous RA enhanced production of this marker of alternative activation. Tretinoin 14-16 interleukin 4 Mus musculus 99-103 27050967-6 2016 Meanwhile, ATRA was shown to decrease the levels of IFN-gamma and increase the levels of IL-4 as well as the IFN-gamma/IL-4 ratio in STZ-treated animals (P < 0.05). Tretinoin 11-15 interleukin 4 Mus musculus 89-93 27050967-6 2016 Meanwhile, ATRA was shown to decrease the levels of IFN-gamma and increase the levels of IL-4 as well as the IFN-gamma/IL-4 ratio in STZ-treated animals (P < 0.05). Tretinoin 11-15 interleukin 4 Mus musculus 119-123 27050967-8 2016 This study demonstrated that ATRA effectively prevents the progression of T1DM in a murine model of the disease by reducing IFN-gamma levels and increasing IL-4 levels. Tretinoin 29-33 interleukin 4 Mus musculus 156-160 27977740-5 2016 Studies to identify the factor(s) in MP responsible for promoting IL-4-induced M2 skewing suggests that all-trans retinoic acid (ATRA), TGFbeta and prostaglandin E2 (PGE2) all play a role. Tretinoin 114-127 interleukin 4 Mus musculus 66-70 27977740-5 2016 Studies to identify the factor(s) in MP responsible for promoting IL-4-induced M2 skewing suggests that all-trans retinoic acid (ATRA), TGFbeta and prostaglandin E2 (PGE2) all play a role. Tretinoin 129-133 interleukin 4 Mus musculus 66-70 27050967-0 2016 All-trans retinoic acid prevents the development of type 1 diabetes by affecting the levels of interferon gamma and interleukin 4 in streptozotocin-induced murine diabetes model. Tretinoin 10-23 interleukin 4 Mus musculus 116-129 25899567-6 2015 Functionally, RA increased DC induction of CD4(+) T-cell IL-10, while reducing CD4(+) T-cell IL-4 and IL-13, revealing a previously unidentified role for RA in regulating the ability of alternatively activated DCs to influence Th2 polarization. Tretinoin 14-16 interleukin 4 Mus musculus 93-97 25834349-0 2015 Retinoic Acid promotes interleukin-4 plasmid-dimethylsulfoxide topical transdermal delivery for treatment of psoriasis. Tretinoin 0-13 interleukin 4 Mus musculus 23-36 25834349-4 2015 OBJECTIVE: We investigated whether RA could improve anti-psoriasis efficiency using IL-4 expression plasmid pORF-mIL-4 (pIL-4) via transdermal delivery system in K14-vascular endothelial growth (K14-VEGF) factor transgenic mice. Tretinoin 35-37 interleukin 4 Mus musculus 84-88 23885329-5 2013 We demonstrate that although ATRA alone has no effect on the expression or activities of arginase 1, ATRA can dramatically potentiate the induction of arginase 1 by IL-4. Tretinoin 101-105 interleukin 4 Mus musculus 165-169 24316973-5 2014 T helper cell rerouting in EAE was dependent on IL-4, which enhanced retinoic acid (RA) production by dendritic cells, which further induced expression of gut-homing receptors CCR9 and alpha4beta7 on Bcl11b-deficient CD4+ T cells. Tretinoin 69-82 interleukin 4 Mus musculus 48-52 24316973-5 2014 T helper cell rerouting in EAE was dependent on IL-4, which enhanced retinoic acid (RA) production by dendritic cells, which further induced expression of gut-homing receptors CCR9 and alpha4beta7 on Bcl11b-deficient CD4+ T cells. Tretinoin 84-86 interleukin 4 Mus musculus 48-52 23885329-3 2013 In this report, we focus on the combinatorial effects of IL-4 with all-trans retinoic acid (ATRA) and lipopolysaccharide (LPS). Tretinoin 67-90 interleukin 4 Mus musculus 57-61 22806070-8 2012 42: 1685-1694] show that RA ameliorates Con A-induced murine hepatitis by selectively downmodulating IFN-gamma and IL-4 production in disease-causing NKT cells in the liver. Tretinoin 25-27 interleukin 4 Mus musculus 115-119 23885329-3 2013 In this report, we focus on the combinatorial effects of IL-4 with all-trans retinoic acid (ATRA) and lipopolysaccharide (LPS). Tretinoin 92-96 interleukin 4 Mus musculus 57-61 19190084-0 2009 GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity. Tretinoin 67-80 interleukin 4 Mus musculus 11-15 18453568-6 2008 Consistent with the finding that the vitamin A metabolite retinoic acid (RA) induces gut-homing molecules on T cells, we further demonstrate that IL-4 up-regulated retinaldehyde dehydrogenase 2 mRNA on MLN-DC, a critical enzyme involved in the synthesis of RA. Tretinoin 58-71 interleukin 4 Mus musculus 146-150 18400747-8 2008 Retinoic acid in the presence of TGF-beta1 reduced STAT6 binding to the Foxp3 promoter and enhanced histone acetylation, thereby reverting the effect of IL-4. Tretinoin 0-13 interleukin 4 Mus musculus 153-157 18453568-6 2008 Consistent with the finding that the vitamin A metabolite retinoic acid (RA) induces gut-homing molecules on T cells, we further demonstrate that IL-4 up-regulated retinaldehyde dehydrogenase 2 mRNA on MLN-DC, a critical enzyme involved in the synthesis of RA. Tretinoin 73-75 interleukin 4 Mus musculus 146-150 18453568-6 2008 Consistent with the finding that the vitamin A metabolite retinoic acid (RA) induces gut-homing molecules on T cells, we further demonstrate that IL-4 up-regulated retinaldehyde dehydrogenase 2 mRNA on MLN-DC, a critical enzyme involved in the synthesis of RA. Tretinoin 257-259 interleukin 4 Mus musculus 146-150