PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25531381-0 2014 [The anti-apoptotic effect of cytoplasmic alpha-fetoprotein in hepatoma cells induced by all-trans retinoic acid involves activation of the PI3K/AKT signaling pathway]. Tretinoin 99-112 AKT serine/threonine kinase 1 Homo sapiens 145-148 26295826-5 2015 RA increased the expression of p110alpha subunit of phosphoinositide 3-kinase (PI3K), Akt and beta1 subunit of Na(+)/K(+)-ATPase. Tretinoin 0-2 AKT serine/threonine kinase 1 Homo sapiens 86-89 25531381-6 2014 CONCLUSION: AFP can activate transduction of the PI3K/AKT signal, and expression of AFP in hepatoma cells is a pivotal event for resisting ATRA-induced apoptosis. Tretinoin 139-143 AKT serine/threonine kinase 1 Homo sapiens 54-57 24522204-0 2014 Prohibitin 2 represents a novel nuclear AKT substrate during all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells. Tretinoin 71-84 AKT serine/threonine kinase 1 Homo sapiens 40-43 24954410-10 2014 In this study, it was shown that the differentiation-inducing effect on human alveolar epithelial stem cells by ATRA was induced by increased expression of integrin, and that the induced integrin enhanced phosphorylation signaling of AKT, resulting in inducing differentiations. Tretinoin 112-116 AKT serine/threonine kinase 1 Homo sapiens 234-237 24522204-2 2014 In the human acute promyelocytic leukemia cell line NB4, nuclear AKT activity increases during all-trans retinoic acid (ATRA)-mediated differentiation. Tretinoin 105-118 AKT serine/threonine kinase 1 Homo sapiens 65-68 24522204-2 2014 In the human acute promyelocytic leukemia cell line NB4, nuclear AKT activity increases during all-trans retinoic acid (ATRA)-mediated differentiation. Tretinoin 120-124 AKT serine/threonine kinase 1 Homo sapiens 65-68 24522204-3 2014 As nuclear AKT activity is associated with differentiation, we sought to identify the nuclear substrates of AKT that were phosphorylated after ATRA treatment. Tretinoin 143-147 AKT serine/threonine kinase 1 Homo sapiens 11-14 24522204-3 2014 As nuclear AKT activity is associated with differentiation, we sought to identify the nuclear substrates of AKT that were phosphorylated after ATRA treatment. Tretinoin 143-147 AKT serine/threonine kinase 1 Homo sapiens 108-111 24522204-8 2014 Activation of nuclear AKT during ATRA-mediated differentiation results in the phosphorylation of several proteins, including PHB2, which may serve to coordinate nuclear-mitochondrial events during differentiation. Tretinoin 33-37 AKT serine/threonine kinase 1 Homo sapiens 22-25 24522204-4 2014 A proteomics-based search for nuclear substrates of AKT in ATRA-treated NB4 cells was undertaken by using 2D-electrophoresis/mass spectrometry (MS) in combination with an anti-AKT phospho-substrate antibody. Tretinoin 59-63 AKT serine/threonine kinase 1 Homo sapiens 52-55 24522204-4 2014 A proteomics-based search for nuclear substrates of AKT in ATRA-treated NB4 cells was undertaken by using 2D-electrophoresis/mass spectrometry (MS) in combination with an anti-AKT phospho-substrate antibody. Tretinoin 59-63 AKT serine/threonine kinase 1 Homo sapiens 176-179 24791595-0 2014 The effect to IL-3Ralpha, downstream PI3k/Akt signaling of all-trans retinoic acid and arsenic trioxide in NB4 cells. Tretinoin 69-82 AKT serine/threonine kinase 1 Homo sapiens 42-45 24406248-5 2014 ATRA treatment caused decreased Mcl-1, caspase-3 activation, and PARP cleavage following the inactivation of phosphatidylinositol 3-kinase/AKT and the activation of GSK-3beta. Tretinoin 0-4 AKT serine/threonine kinase 1 Homo sapiens 139-142 25118897-5 2014 These findings suggested that JAK2/STAT3, as well as PI3K/Akt, play important roles in mediating the survival and neurite growth response of RA-predifferentiated cells to CNTF. Tretinoin 141-143 AKT serine/threonine kinase 1 Homo sapiens 58-61 24300824-10 2014 Furthermore, ATRA and BMP9 synergistically repressed glycogen synthase kinase 3beta (GSK3beta) activity and promoted Akt phosphorylation, and inhibited expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) that antagonizes phosphatidylinositol-3-kinase (PI3K) function, suggesting that Wnt/beta-catenin signaling was activated at least partly through PI3K/Akt/GSK3beta pathway. Tretinoin 13-17 AKT serine/threonine kinase 1 Homo sapiens 117-120 24300824-10 2014 Furthermore, ATRA and BMP9 synergistically repressed glycogen synthase kinase 3beta (GSK3beta) activity and promoted Akt phosphorylation, and inhibited expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) that antagonizes phosphatidylinositol-3-kinase (PI3K) function, suggesting that Wnt/beta-catenin signaling was activated at least partly through PI3K/Akt/GSK3beta pathway. Tretinoin 13-17 AKT serine/threonine kinase 1 Homo sapiens 381-384 23998581-3 2013 ATRA could promote phosphorylation of AKT in NB4 cells at short time, but not had effect on phosphorylation of AKT in NB4-R1 cells; the curcumin could enhance the phosphorylation of AKT in NB4-1R cells, the curcumin combined with ATRA could further enhance the phosphorylation of AKT. Tretinoin 0-4 AKT serine/threonine kinase 1 Homo sapiens 38-41 24030392-7 2013 Our results demonstrate that the proline-rich region can also enhance cell proliferation and retinoic acid (RA)-induced neuronal differentiation and it is also involved in NEU4 interaction with Akt, as well as in substrate recognition, modifying directly or through the interaction with other protein(s) the enzyme specificity toward sialylated glycoprotein(s). Tretinoin 93-106 AKT serine/threonine kinase 1 Homo sapiens 194-197 24030392-7 2013 Our results demonstrate that the proline-rich region can also enhance cell proliferation and retinoic acid (RA)-induced neuronal differentiation and it is also involved in NEU4 interaction with Akt, as well as in substrate recognition, modifying directly or through the interaction with other protein(s) the enzyme specificity toward sialylated glycoprotein(s). Tretinoin 108-110 AKT serine/threonine kinase 1 Homo sapiens 194-197 24030392-8 2013 On the whole, our results suggest that N4L could be a downstream component of the PI3K/Akt signaling pathway required for RA-induced differentiation of neuroblastoma SK-N-BE cells. Tretinoin 122-124 AKT serine/threonine kinase 1 Homo sapiens 87-90 23849428-0 2013 Calcium prevents retinoic acid-induced disruption of the spectrin-based cytoskeleton in keratinocytes through the Src/PI3K-p85alpha/AKT/PKCdelta/beta-adducin pathways. Tretinoin 17-30 AKT serine/threonine kinase 1 Homo sapiens 132-135 23849428-5 2013 RA also enhanced AKT expression and dramatically induced phosphorylation of AKT((Thr308)), accompanied by phosphorylation of both PKCdelta((Thr505)) and beta-adducin((Ser662)) and upregulated cyclin D2 and down-regulated cyclin B1. Tretinoin 0-2 AKT serine/threonine kinase 1 Homo sapiens 17-20 23849428-5 2013 RA also enhanced AKT expression and dramatically induced phosphorylation of AKT((Thr308)), accompanied by phosphorylation of both PKCdelta((Thr505)) and beta-adducin((Ser662)) and upregulated cyclin D2 and down-regulated cyclin B1. Tretinoin 0-2 AKT serine/threonine kinase 1 Homo sapiens 76-79 23849428-6 2013 On the other hand, Ca2+ overcame the inhibitory effects of RA on expression of Src, PI3K-p85alpha and cyclin B1 by maintaining high levels of phosphorylation of both Src((Tyr527)) and PI3K-p85alpha and preventing phosphorylation of AKT((Thr308)), PKCdelta((Thr505)) and beta-adducin((Ser662)). Tretinoin 59-61 AKT serine/threonine kinase 1 Homo sapiens 232-235 23693014-0 2013 Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells. Tretinoin 69-82 AKT serine/threonine kinase 1 Homo sapiens 14-17 23693014-6 2013 In this study, we explored the hypothesis that activation of the Akt pathway promotes resistance to ATRA treatment at the inhibition of cell survival and invasion in lung cancer. Tretinoin 100-104 AKT serine/threonine kinase 1 Homo sapiens 65-68 23693014-9 2013 We found that ATRA treatment promotes PI3k-Akt pathway activation through transcription-independent mechanisms. Tretinoin 14-18 AKT serine/threonine kinase 1 Homo sapiens 43-46 23693014-10 2013 Interestingly, ATRA treatment induces the translocation of RARalpha to the plasma membrane, where it colocalizes with Akt. Tretinoin 15-19 AKT serine/threonine kinase 1 Homo sapiens 118-121 23693014-12 2013 Activation of the PI3k-Akt pathway by ATRA promotes invasion through Rac-GTPase, whereas pretreatment with 15e (PI3k inhibitor) or over-expression of the inactive form of Akt blocks ATRA-induced invasion. Tretinoin 38-42 AKT serine/threonine kinase 1 Homo sapiens 23-26 23693014-12 2013 Activation of the PI3k-Akt pathway by ATRA promotes invasion through Rac-GTPase, whereas pretreatment with 15e (PI3k inhibitor) or over-expression of the inactive form of Akt blocks ATRA-induced invasion. Tretinoin 182-186 AKT serine/threonine kinase 1 Homo sapiens 171-174 23693014-13 2013 We also found that treatment with ATRA induces cell survival, which is inhibited by 15e or over-expression of an inactive form of Akt, through a subsequent increase in the levels of the active form of caspase-3. Tretinoin 34-38 AKT serine/threonine kinase 1 Homo sapiens 130-133 23693014-15 2013 In contrast, over-expression of the inactive form of Akt restores RARbeta2 expression in cells treated with ATRA, indicating that activation of the PI3k-Akt pathway inhibits the expression of ATRA target genes. Tretinoin 108-112 AKT serine/threonine kinase 1 Homo sapiens 53-56 23693014-15 2013 In contrast, over-expression of the inactive form of Akt restores RARbeta2 expression in cells treated with ATRA, indicating that activation of the PI3k-Akt pathway inhibits the expression of ATRA target genes. Tretinoin 108-112 AKT serine/threonine kinase 1 Homo sapiens 153-156 23693014-16 2013 CONCLUSION: Our results demonstrate that rapid activation of Akt blocks transcription-dependent mechanism of ATRA, promotes invasion and cell survival and confers resistance to retinoic acid treatment in lung cancer cells. Tretinoin 109-113 AKT serine/threonine kinase 1 Homo sapiens 61-64 23693014-16 2013 CONCLUSION: Our results demonstrate that rapid activation of Akt blocks transcription-dependent mechanism of ATRA, promotes invasion and cell survival and confers resistance to retinoic acid treatment in lung cancer cells. Tretinoin 177-190 AKT serine/threonine kinase 1 Homo sapiens 61-64 23319320-4 2013 Western blotting showed a loss of NF-kappaB, Bcl-2 and p-Akt, and the accumulation of Bad and Akt in cytoplasm of ATRA-treated AML-I preadipocytes. Tretinoin 114-118 AKT serine/threonine kinase 1 Homo sapiens 57-60 23022267-0 2013 Tyrosine phosphatase inhibitors combined with retinoic acid can enhance differentiation of neuroblastoma cells and trigger ERK- and AKT-dependent, p53-independent senescence. Tretinoin 46-59 AKT serine/threonine kinase 1 Homo sapiens 132-135 23319320-4 2013 Western blotting showed a loss of NF-kappaB, Bcl-2 and p-Akt, and the accumulation of Bad and Akt in cytoplasm of ATRA-treated AML-I preadipocytes. Tretinoin 114-118 AKT serine/threonine kinase 1 Homo sapiens 94-97 22766505-8 2012 Importantly, we found that the PI3K/AKT pathway is required for RA-induced neuroblastoma cell differentiation. Tretinoin 64-66 AKT serine/threonine kinase 1 Homo sapiens 36-39 23142153-0 2013 Retinoic acid protects against proteasome inhibition associated cell death in SH-SY5Y cells via the AKT pathway. Tretinoin 0-13 AKT serine/threonine kinase 1 Homo sapiens 100-103 23142153-8 2013 In addition, although RA activates both the AKT and ERK phosphorylation signaling pathways, only pretreatment with LY294002, an inhibitor of PI3-kinase in the AKT pathway, removed the protective effect of RA from the cells. Tretinoin 22-24 AKT serine/threonine kinase 1 Homo sapiens 44-47 23142153-8 2013 In addition, although RA activates both the AKT and ERK phosphorylation signaling pathways, only pretreatment with LY294002, an inhibitor of PI3-kinase in the AKT pathway, removed the protective effect of RA from the cells. Tretinoin 205-207 AKT serine/threonine kinase 1 Homo sapiens 159-162 23142153-9 2013 This finding implies that RA activation of the AKT signaling cascade takes precedence over its activation of ERK1/2 phosphorylation, and that this selective effect of RA is key to its protection of epoxomicin-treated cells. Tretinoin 26-28 AKT serine/threonine kinase 1 Homo sapiens 47-50 22229477-0 2012 Combination of valproic acid and ATRA restores RARbeta2 expression and induces differentiation in cervical cancer through the PI3K/Akt pathway. Tretinoin 33-37 AKT serine/threonine kinase 1 Homo sapiens 131-134 21354561-1 2011 OBJECTIVE: To detect changes induced by all-trans-retinoic acid (ATRA) on the expression and activation of target proteins of the retinoic acid (RA) and PI3K/Akt pathways involved in leiomyoma growth. Tretinoin 40-63 AKT serine/threonine kinase 1 Homo sapiens 158-161 22391160-4 2012 The results demonstrated that in ATRA-induced differentiation, the transcriptional level of CD44v6 was dominantly down-regulated, the translational level of CD44v6 did not change and the PI3K/Akt signal axis was activated. Tretinoin 33-37 AKT serine/threonine kinase 1 Homo sapiens 192-195 22391160-2 2012 This study was purposed to investigate the effects of all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) on the expression of CD44v6 and the associated signal pathway phosphatidylinositol 3-kinase (PI3K)/Akt in acute promyelocytic leukemia (APL) cell line NB4 cells. Tretinoin 54-77 AKT serine/threonine kinase 1 Homo sapiens 213-216 22391160-2 2012 This study was purposed to investigate the effects of all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) on the expression of CD44v6 and the associated signal pathway phosphatidylinositol 3-kinase (PI3K)/Akt in acute promyelocytic leukemia (APL) cell line NB4 cells. Tretinoin 79-83 AKT serine/threonine kinase 1 Homo sapiens 213-216 21354561-1 2011 OBJECTIVE: To detect changes induced by all-trans-retinoic acid (ATRA) on the expression and activation of target proteins of the retinoic acid (RA) and PI3K/Akt pathways involved in leiomyoma growth. Tretinoin 65-69 AKT serine/threonine kinase 1 Homo sapiens 158-161 21354561-1 2011 OBJECTIVE: To detect changes induced by all-trans-retinoic acid (ATRA) on the expression and activation of target proteins of the retinoic acid (RA) and PI3K/Akt pathways involved in leiomyoma growth. Tretinoin 50-63 AKT serine/threonine kinase 1 Homo sapiens 158-161 21354561-1 2011 OBJECTIVE: To detect changes induced by all-trans-retinoic acid (ATRA) on the expression and activation of target proteins of the retinoic acid (RA) and PI3K/Akt pathways involved in leiomyoma growth. Tretinoin 67-69 AKT serine/threonine kinase 1 Homo sapiens 158-161 21354561-7 2011 RESULT(S): Applying our cell culture model, we demonstrated that ATRA induced changes in the expression and activation of the RA and PI3K/Akt pathway proteins in leiomyoma cells, with significant increases of alcohol dehydrogenase 1 and cyclin D2 protein levels. Tretinoin 65-69 AKT serine/threonine kinase 1 Homo sapiens 138-141 21086135-3 2010 We show that PKC activates telomerase and is, itself, activated following VD3- or ATRA-induced differentiation of HL60 cells, as was observed for PI3K/Akt. Tretinoin 82-86 AKT serine/threonine kinase 1 Homo sapiens 151-154 20225234-7 2010 The inhibition of the PI3K/Akt pathway by Ly294002 abrogated the protective effects induced by either Epo or atRA. Tretinoin 109-113 AKT serine/threonine kinase 1 Homo sapiens 27-30 16617325-2 2006 However, several studies demonstrated the activation of PI3K in the nuclei of all-trans-retinoic acid (ATRA) - differentiated HL-60 cells, raising the possibility that PI3K/Akt-inhibitors may block antitumor properties of retinoids. Tretinoin 78-101 AKT serine/threonine kinase 1 Homo sapiens 173-176 19726747-0 2009 Retinoic acid-induced nNOS expression depends on a novel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells. Tretinoin 0-13 AKT serine/threonine kinase 1 Homo sapiens 62-65 19726747-8 2009 RA treatment increases DAX1 expression via PI3K/Akt signaling. Tretinoin 0-2 AKT serine/threonine kinase 1 Homo sapiens 48-51 19056420-7 2009 While undifferentiated SH-SY5Y cells were susceptible to 6-OHDA and MPP+, RA-differentiation conferred SH-SY5Y cells higher tolerance, potentially by up-regulating survival signaling, including Akt pathway as inhibition of Akt removed RA-induced neuroprotection against 6-OHDA. Tretinoin 74-76 AKT serine/threonine kinase 1 Homo sapiens 194-197 19056420-7 2009 While undifferentiated SH-SY5Y cells were susceptible to 6-OHDA and MPP+, RA-differentiation conferred SH-SY5Y cells higher tolerance, potentially by up-regulating survival signaling, including Akt pathway as inhibition of Akt removed RA-induced neuroprotection against 6-OHDA. Tretinoin 74-76 AKT serine/threonine kinase 1 Homo sapiens 223-226 18491231-6 2008 ATRA and ATO-induced expression of DAP5/p97 was associated with inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Tretinoin 0-4 AKT serine/threonine kinase 1 Homo sapiens 119-122 18491231-9 2008 Together, our data reveal new roles for DAP5/p97 in ATRA-induced differentiation and ATO-induced apoptosis in APL and suggest a novel regulatory mechanism by which PI3K/Akt/mTOR pathway inhibition mediates ATRA- and ATO-induced expression of DAP5/p97. Tretinoin 52-56 AKT serine/threonine kinase 1 Homo sapiens 169-172 18491231-9 2008 Together, our data reveal new roles for DAP5/p97 in ATRA-induced differentiation and ATO-induced apoptosis in APL and suggest a novel regulatory mechanism by which PI3K/Akt/mTOR pathway inhibition mediates ATRA- and ATO-induced expression of DAP5/p97. Tretinoin 206-210 AKT serine/threonine kinase 1 Homo sapiens 169-172 17293044-4 2007 Treatment of the cells with all trans retinoic acid (RA) generates a neuron-like, morphological change of differentiation, and results in the activation of ERK and Akt pathways, an inhibition of the nuclear translocation of p53 induced by GA, and induces higher resistance to the GA-induced apoptosis. Tretinoin 38-51 AKT serine/threonine kinase 1 Homo sapiens 164-167 17616812-0 2007 Combination of all-trans retinoic acid and interferon-gamma suppressed PI3K/Akt survival pathway in glioblastoma T98G cells whereas NF-kappaB survival signaling in glioblastoma U87MG cells for induction of apoptosis. Tretinoin 25-38 AKT serine/threonine kinase 1 Homo sapiens 76-79 17616812-5 2007 Treatment with ATRA plus IFN-gamma stimulated PTEN expression and suppressed Akt activation in T98G cells, whereas no PTEN expression but Akt activation in U87MG cells under the same conditions. Tretinoin 15-19 AKT serine/threonine kinase 1 Homo sapiens 77-80 17449938-7 2007 In addition, minoxidil plus ATRA elevated phosphorylated Erk, phosphorylated Akt and the ratio of Bcl-2/Bax, but decreased the expressions of P53 and P21 more effectively than by minoxidil alone. Tretinoin 28-32 AKT serine/threonine kinase 1 Homo sapiens 77-80 17449938-8 2007 Our results suggest that minoxidil plus ATRA would additively enhance hair growth by mediating dual functions: 1) the prolongation of cell survival by activating the Erk and Akt signaling pathways, and 2) the prevention of apoptosis of DPCs and epithelial cells by increasing the ratio of Bcl-2/Bax and downregulating the expressions of P53 and P21. Tretinoin 40-44 AKT serine/threonine kinase 1 Homo sapiens 174-177 16456186-11 2006 ATRA suppressed PDGF-induced Akt activation without influencing ERK activation. Tretinoin 0-4 AKT serine/threonine kinase 1 Homo sapiens 29-32 16456186-13 2006 These results suggest that retinoic acid inhibits airway SMC migration through the modulation of the PI3K/Akt pathway. Tretinoin 27-40 AKT serine/threonine kinase 1 Homo sapiens 106-109 16617325-2 2006 However, several studies demonstrated the activation of PI3K in the nuclei of all-trans-retinoic acid (ATRA) - differentiated HL-60 cells, raising the possibility that PI3K/Akt-inhibitors may block antitumor properties of retinoids. Tretinoin 103-107 AKT serine/threonine kinase 1 Homo sapiens 173-176 16617325-3 2006 The aim of the present study was to investigate the possible activation of nuclear Akt in ATRA-treated cells and to test the effects of Akt-inhibitors on ATRA-mediated differentiation. Tretinoin 90-94 AKT serine/threonine kinase 1 Homo sapiens 83-86 16617325-3 2006 The aim of the present study was to investigate the possible activation of nuclear Akt in ATRA-treated cells and to test the effects of Akt-inhibitors on ATRA-mediated differentiation. Tretinoin 154-158 AKT serine/threonine kinase 1 Homo sapiens 136-139 16617325-5 2006 The down-modulation of the expression of Akt protein in HL-60 cells using siRNA reduces the CD11b expression in ATRA-treated cells. Tretinoin 112-116 AKT serine/threonine kinase 1 Homo sapiens 41-44 16617325-6 2006 The treatment of both cell lines with the commercially available Akt inhibitors inhibited the growth of both control and ATRA-treated cells. Tretinoin 121-125 AKT serine/threonine kinase 1 Homo sapiens 65-68 16617325-8 2006 In contrast, the presence of Akt inhibitors reduced the expression of CD11b in ATRA-treated NB4 cells. Tretinoin 79-83 AKT serine/threonine kinase 1 Homo sapiens 29-32 16274701-4 2006 Similarly, the increase of Akt activation, as well as PTEN inactivation, was accompanied both by a decrease of CKIepsilon expression induced by all-trans retinoic acid and by the addition of a specific inhibitor for CKIepsilon in HL-60 cells. Tretinoin 154-167 AKT serine/threonine kinase 1 Homo sapiens 27-30 16304046-5 2006 Conversely, separate blockage of the Akt/mTor-signaling pathway was a prerequisite for overcoming apoptosis resistance to VPA/ATRA in FLT3-ITD cells, and primary AML blasts (n = 9). Tretinoin 126-130 AKT serine/threonine kinase 1 Homo sapiens 37-40 15375520-1 2004 We showed that the HER2/Grb2/Akt pathway induces all-trans retinoic acid (ATRA) resistance in breast cancer cells by suppressing the DNA binding activity of retinoic acid receptors (RAR). Tretinoin 59-72 AKT serine/threonine kinase 1 Homo sapiens 29-32 16043647-0 2005 Upregulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase/Akt pathway. Tretinoin 83-96 AKT serine/threonine kinase 1 Homo sapiens 135-138 16043647-16 2005 CONCLUSIONS: ATRA increases NO production by eNOS phosphorylation through RAR-mediated PI3K/Akt pathway activation in vascular ECs and possibly plays beneficial roles in vascular endothelium. Tretinoin 13-17 AKT serine/threonine kinase 1 Homo sapiens 92-95 15375520-1 2004 We showed that the HER2/Grb2/Akt pathway induces all-trans retinoic acid (ATRA) resistance in breast cancer cells by suppressing the DNA binding activity of retinoic acid receptors (RAR). Tretinoin 74-78 AKT serine/threonine kinase 1 Homo sapiens 29-32 12032135-0 2002 Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor gamma 2. Tretinoin 80-93 AKT serine/threonine kinase 1 Homo sapiens 53-56 14612949-0 2003 HER2/neu uses Akt to suppress retinoic acid response element binding activity in MDA-MB-453 breast cancer cells. Tretinoin 30-43 AKT serine/threonine kinase 1 Homo sapiens 14-17 12970779-0 2003 A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells. Tretinoin 99-122 AKT serine/threonine kinase 1 Homo sapiens 16-19 12970779-9 2003 Our findings demonstrate that, at a concentration which does not affect PI3K activity, the Akt inhibitor markedly reduced resistance of HL60AR cells to etoposide, cytarabine, TRAIL, ATRA, and ionizing radiation. Tretinoin 182-186 AKT serine/threonine kinase 1 Homo sapiens 91-94 12556562-0 2003 The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells. Tretinoin 71-90 AKT serine/threonine kinase 1 Homo sapiens 30-34 12556562-6 2003 Resistant cells overexpressing either dominant negative PI3K or dominant negative AKT1 became sensitive to drugs and ATRA. Tretinoin 117-121 AKT serine/threonine kinase 1 Homo sapiens 82-86 12776186-0 2003 Retinoic acid-induced growth arrest of MCF-7 cells involves the selective regulation of the IRS-1/PI 3-kinase/AKT pathway. Tretinoin 0-13 AKT serine/threonine kinase 1 Homo sapiens 110-113 12776186-6 2003 Downstream signaling events were also selectively reduced, as RA abrogated IGF-I-stimulated AKT activation but did not alter erk1/2 activation. Tretinoin 62-64 AKT serine/threonine kinase 1 Homo sapiens 92-95 12776186-9 2003 This suggests that RA-mediated growth inhibition requires the selective downregulation of IRS-1 and AKT. Tretinoin 19-21 AKT serine/threonine kinase 1 Homo sapiens 100-103 12776186-10 2003 Therapeutic agents targeting the IRS-1/PI 3-kinase/AKT pathway may enhance the cytostatic effects of RA in breast cancer, since overexpression of IRS-1 and AKT have been reported in primary breast tumors. Tretinoin 101-103 AKT serine/threonine kinase 1 Homo sapiens 51-54 12776186-10 2003 Therapeutic agents targeting the IRS-1/PI 3-kinase/AKT pathway may enhance the cytostatic effects of RA in breast cancer, since overexpression of IRS-1 and AKT have been reported in primary breast tumors. Tretinoin 101-103 AKT serine/threonine kinase 1 Homo sapiens 156-159 12149644-5 2002 We then determined whether Her2/neu uses Grb2 and Akt proteins to induce ATRA resistance. Tretinoin 73-77 AKT serine/threonine kinase 1 Homo sapiens 50-53 12149644-7 2002 When incubated with L-Grb2 or transfected with the DN AKT mutant, ATRA-resistant, Her2/neu-overexpressing cells became sensitive to ATRA. Tretinoin 66-70 AKT serine/threonine kinase 1 Homo sapiens 54-57 12149644-7 2002 When incubated with L-Grb2 or transfected with the DN AKT mutant, ATRA-resistant, Her2/neu-overexpressing cells became sensitive to ATRA. Tretinoin 132-136 AKT serine/threonine kinase 1 Homo sapiens 54-57 12149644-8 2002 Our results indicate that Her2/neu utilizes Grb2 and Akt proteins to induce ATRA resistance in breast cancer cells. Tretinoin 76-80 AKT serine/threonine kinase 1 Homo sapiens 53-56 12000752-0 2002 Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells. Tretinoin 73-86 AKT serine/threonine kinase 1 Homo sapiens 48-51 12000752-7 2002 RA treatment activates the PI3K/Akt signaling pathway, resulting in increased PI3K activity in extracts from RA-treated cells and a rapid increase in phosphorylation of Akt in Ser-473. Tretinoin 0-2 AKT serine/threonine kinase 1 Homo sapiens 32-35 12000752-7 2002 RA treatment activates the PI3K/Akt signaling pathway, resulting in increased PI3K activity in extracts from RA-treated cells and a rapid increase in phosphorylation of Akt in Ser-473. Tretinoin 0-2 AKT serine/threonine kinase 1 Homo sapiens 169-172 12000752-7 2002 RA treatment activates the PI3K/Akt signaling pathway, resulting in increased PI3K activity in extracts from RA-treated cells and a rapid increase in phosphorylation of Akt in Ser-473. Tretinoin 109-111 AKT serine/threonine kinase 1 Homo sapiens 32-35 12000752-9 2002 We propose that RA, by activating the PI3K/Akt signaling pathway, plays an important role in the regulation of neuronal cell survival. Tretinoin 16-18 AKT serine/threonine kinase 1 Homo sapiens 43-46 12032135-3 2002 We show here that this RA-induced phosphorylation of RARgamma2 resulted from the down-regulation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Tretinoin 23-25 AKT serine/threonine kinase 1 Homo sapiens 141-144 12032135-4 2002 By overexpressing Akt and by using agents that activated or inhibited the PI3K/Akt pathway, we also demonstrated that the RA-induced down-regulation of the PI3K/Akt pathway targeted not only the phosphorylation of RARgamma2 but also the turnover and transcriptional activity of the receptor. Tretinoin 122-124 AKT serine/threonine kinase 1 Homo sapiens 18-21 12032135-4 2002 By overexpressing Akt and by using agents that activated or inhibited the PI3K/Akt pathway, we also demonstrated that the RA-induced down-regulation of the PI3K/Akt pathway targeted not only the phosphorylation of RARgamma2 but also the turnover and transcriptional activity of the receptor. Tretinoin 122-124 AKT serine/threonine kinase 1 Homo sapiens 79-82 12032135-4 2002 By overexpressing Akt and by using agents that activated or inhibited the PI3K/Akt pathway, we also demonstrated that the RA-induced down-regulation of the PI3K/Akt pathway targeted not only the phosphorylation of RARgamma2 but also the turnover and transcriptional activity of the receptor. Tretinoin 122-124 AKT serine/threonine kinase 1 Homo sapiens 79-82 12032135-5 2002 Altogether these data indicate that the PI3K/Akt pathway plays an important role in retinoic acid signaling. Tretinoin 84-97 AKT serine/threonine kinase 1 Homo sapiens 45-48 35278669-7 2022 ATRA also blocked autophagic flow by activating the AKT/mTOR pathway, leading to an excessive accumulation of ROS, which further activated the NLRP3 inflammasome. Tretinoin 0-4 AKT serine/threonine kinase 1 Homo sapiens 52-55 12027902-0 2002 Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid. Tretinoin 134-157 AKT serine/threonine kinase 1 Homo sapiens 53-56 12027902-5 2002 The amount of Rac identified in the two fractions was also markedly enhanced by ATRA- induced differentiation. Tretinoin 80-84 AKT serine/threonine kinase 1 Homo sapiens 14-17 10501184-3 1999 Acute stimulation of RA-predifferentiated SH-SY5Y cells with brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), or neurotrophin 4/5 (NT-4/5), but not nerve growth factor (NGF), induces Trk autophosphorylation, followed by phosphorylation of Akt and the extracellular signal-regulated kinases (ERKs) 1 and 2. Tretinoin 21-23 AKT serine/threonine kinase 1 Homo sapiens 255-258 34355652-6 2021 Therefore, STAT3, Akt, and JNK signaling pathways were involved in tra-ATRA-induced differentiation in HL-60, U937, and HL-60Res cells, respectively. Tretinoin 67-70 AKT serine/threonine kinase 1 Homo sapiens 18-21 34355652-6 2021 Therefore, STAT3, Akt, and JNK signaling pathways were involved in tra-ATRA-induced differentiation in HL-60, U937, and HL-60Res cells, respectively. Tretinoin 71-75 AKT serine/threonine kinase 1 Homo sapiens 18-21 34579932-0 2021 Expression of concern: "Tyrosine phosphatase inhibitors combined with retinoic acid can enhance differentiation of neuroblastoma cells and trigger ERK- and AKT-dependent, p53-independent senescence" Cancer Letters, Volume 328, Issue 1, 1 January 2013, Pages 44-54. Tretinoin 70-83 AKT serine/threonine kinase 1 Homo sapiens 156-159 32424865-10 2020 Mechanistically, RA could activate the AKT/GSK3beta/beta-catenin pathway during the process of iPSCs osteogenesis. Tretinoin 17-19 AKT serine/threonine kinase 1 Homo sapiens 39-42 33074481-5 2021 Moreover, combining ATRA and SIK inhibition synergistically activated the Akt signaling pathway but not the MAPK pathway. Tretinoin 20-24 AKT serine/threonine kinase 1 Homo sapiens 74-77 33276438-5 2020 These genes were enriched in schizophrenia-associated signalling pathways, including PI3K/Akt, axon guidance, and signalling by retinoic acid. Tretinoin 128-141 AKT serine/threonine kinase 1 Homo sapiens 90-93 32630207-8 2020 We show that ATRA alleviates the negative feedback loop effect of IL-10 anti-inflammatory cytokine on NLRP3 inflammasome function by inhibiting the Akt-mTOR-STAT3 signaling axis. Tretinoin 13-17 AKT serine/threonine kinase 1 Homo sapiens 148-151 31322252-0 2019 All-trans-retinoic acid modulates TGF-beta-induced apoptosis, proliferation, migration and extracellular matrix synthesis of conjunctival fibroblasts by inhibiting PI3K/AKT signaling. Tretinoin 0-23 AKT serine/threonine kinase 1 Homo sapiens 169-172 31500289-6 2019 Here, we demonstrated that inhibition of Cdc42 or Rac not only prevented growth cone turning toward retinoic acid but could also induce a switch in growth cone responsiveness to chemorepulsion or growth cone collapse. Tretinoin 100-113 AKT serine/threonine kinase 1 Homo sapiens 50-53 31500289-9 2019 These data strongly suggest that Cdc42 and Rac are downstream effectors of retinoic acid during growth cone guidance. Tretinoin 75-88 AKT serine/threonine kinase 1 Homo sapiens 43-46 31322252-8 2019 ATRA treatment resulted in an increased level of HConF apoptosis, reduced proliferation and migration, decreased collagen I and fibronectin expression, and decreased phosphorylation of PI3K and AKT. Tretinoin 0-4 AKT serine/threonine kinase 1 Homo sapiens 194-197 31322252-9 2019 Thus, the present study showed a role for ATRA in inhibiting HConF migration, proliferation and ECM synthesis, and in promoting HConF apoptosis through the inhibition of the PI3K/AKT signaling pathway. Tretinoin 42-46 AKT serine/threonine kinase 1 Homo sapiens 179-182 28379293-4 2017 We recently found that RA stimulation of the Phosphatidylinositol 3-kinase (PI3K)/AKT/Mammalian target of rapamycin (mTOR) kinase signaling pathway is required for differentiation, and that short-term inhibition of mTOR complex 1 (mTORC1) by rapamycin blocked spermatogonial differentiation in vivo and prevented RA-induced translational activation. Tretinoin 23-25 AKT serine/threonine kinase 1 Homo sapiens 82-85 30359286-11 2018 This effect of UCHL1 was associated with positively regulating RA-induced AKT and ERK1/2 signaling activation. Tretinoin 63-65 AKT serine/threonine kinase 1 Homo sapiens 74-77 29305588-5 2018 Our findings show that RA inhibits the Wnt canonical pathway and positively modulates the Akt/mTOR signaling, explaining why such perturbations, under our experimental conditions, do not lead to hiPSCs differentiation. Tretinoin 23-25 AKT serine/threonine kinase 1 Homo sapiens 90-93 28656276-7 2017 Further investigations indicated that with ATRA-induced expression of RIG-I, levels of phosphorylated (p)AKT-Thr308 and pForkhead Box (FOX) O3A-Thr32 were decreased, the expression levels of cell cycle arrest protein p27 and the apoptotic protein, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), directly transcribed by FOXO3A were increased. Tretinoin 43-47 AKT serine/threonine kinase 1 Homo sapiens 105-108 28656276-9 2017 Taken together, these results showed that the knockdown of RIG-I reduced the inhibition of cell proliferation, cell cycle arrest and apoptosis in the ATRA-induced NB4 cells via the AKT-FOXO3A signaling pathway. Tretinoin 150-154 AKT serine/threonine kinase 1 Homo sapiens 181-184 30536958-6 2019 We show that in vitro treatment of PML/RARA expressing cells with all-trans retinoic acid (ATRA) up-regulates HSP90 expression and stabilizes AKT. Tretinoin 76-89 AKT serine/threonine kinase 1 Homo sapiens 142-145 30536958-6 2019 We show that in vitro treatment of PML/RARA expressing cells with all-trans retinoic acid (ATRA) up-regulates HSP90 expression and stabilizes AKT. Tretinoin 91-95 AKT serine/threonine kinase 1 Homo sapiens 142-145 30536958-7 2019 Addition of the HSP90-inhibitor 17-(allylamino)-17-demethoxygeldanamycin in combination with ATRA, blocks upregulation of AKT protein, indicating that HSP90 is necessary for ATRA action on AKT. Tretinoin 93-97 AKT serine/threonine kinase 1 Homo sapiens 122-125 30536958-7 2019 Addition of the HSP90-inhibitor 17-(allylamino)-17-demethoxygeldanamycin in combination with ATRA, blocks upregulation of AKT protein, indicating that HSP90 is necessary for ATRA action on AKT. Tretinoin 93-97 AKT serine/threonine kinase 1 Homo sapiens 189-192 30536958-7 2019 Addition of the HSP90-inhibitor 17-(allylamino)-17-demethoxygeldanamycin in combination with ATRA, blocks upregulation of AKT protein, indicating that HSP90 is necessary for ATRA action on AKT. Tretinoin 174-178 AKT serine/threonine kinase 1 Homo sapiens 122-125 30536958-7 2019 Addition of the HSP90-inhibitor 17-(allylamino)-17-demethoxygeldanamycin in combination with ATRA, blocks upregulation of AKT protein, indicating that HSP90 is necessary for ATRA action on AKT. Tretinoin 174-178 AKT serine/threonine kinase 1 Homo sapiens 189-192 26541884-9 2016 In addition, a rapid and non-genomic activation of the ERK 1/2 and PI3K/AKT pathways revealed to be equally required to promote NRF2 activation and necessary for RA-induced differentiation. Tretinoin 162-164 AKT serine/threonine kinase 1 Homo sapiens 72-75 27919568-4 2016 Cell attachment on FN activated PI3K/Akt and MAPK cascades, whereas ATRA pretreatment blunted the early phosphorylation of Akt and MAPK signaling mediators including p38 MAPK, JNK1/2, and ERK1/2. Tretinoin 68-72 AKT serine/threonine kinase 1 Homo sapiens 123-126 26257239-7 2015 Furthermore, all-trans retinoic acid decreased AKT activity, reduced the epithelial cell adhesion molecule-positive cell population enriched by sorafenib, and potentiated the therapeutic effect of sorafenib in the patient-derived xenograft model. Tretinoin 23-36 AKT serine/threonine kinase 1 Homo sapiens 47-50 26747727-0 2016 All-trans retinoic acid modulates Wnt3A-induced osteogenic differentiation of mesenchymal stem cells via activating the PI3K/AKT/GSK3beta signalling pathway. Tretinoin 10-23 AKT serine/threonine kinase 1 Homo sapiens 125-128